scholarly journals The efficacy of intralesional injection of autologous platelet rich plasma versus normal saline dressing in chronic non-healing ulcers

2020 ◽  
Vol 8 (1) ◽  
pp. 300
Author(s):  
Narender Singh ◽  
Shaitan S. Rathore ◽  
Garima Choudhary ◽  
Lakhan K. Purohit
Keyword(s):  
Normal Saline ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Age Groups ◽  
Intralesional Injection ◽  
Healing Ulcer ◽  
Ulcer Size ◽  
End Of Treatment ◽  
Rapid Healing ◽  
Type Size

Background: Platelet-rich plasma (PRP) can potentially enhance healing of chronic non-healing ulcer by increasing the delivery of various growth factors from the α-granules contained in platelets. Aim of this prospective randomized study was to evaluate the efficacy of autologous PRP versus normal saline (NS) at chronic non healing ulcer in relation to wound healing on the basis of ulcer size reduction, duration of healing, complete or partial healing and side effectsMethods: Fifty four patients with chronic non-healing ulcer were randomly divided into two equal groups: PRP group (treated with PRP) and NS group. Observations were made regarding pain, slough, discharge, granulation, reduction in ulcer size and volume on every 7th day till 4 weeks.Results: Reduction in area and volume of ulcers at the end of treatment was 12.27±4.10 cm2 and 6.88±5.26 cm3 in PRP group and 9.25±1.89 cm2 and 4.25 ±1.05 cm3 in NS group. In PRP group 59.25% had no discharge, 74.08% had no slough, 62.97% had no pain while in NS group no patient was without discharge, 14.81% patient had no slough, 74.07% had minimal pain on 28th day. In PRP group 22.22% ulcers were completely healed while in NS groups all ulcers were partially healed.Conclusions: PRP is more effective than NS on chronic non-healing ulcers as it causes more rapid healing, rapid relief from pain and early decrease in discharge and slough in all age groups and sex; irrespective of type, size, site, duration and etiology of ulcer.

scholarly journals Study comparing the efficacy of platelet rich plasma versus steroid versus placebo in lateral epicondylitis

2017 ◽  
Vol 3 (2) ◽  
pp. 207
Author(s):  
Ganesh Kumar Reddy Mundla ◽  
Praveen Kumar Venkataramana ◽  
Manoj Kumar Reddy Koduru ◽  
Biju Ravindran
Keyword(s):  
Normal Saline ◽  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Lateral Epicondylitis ◽  
College Hospital ◽  
Elbow Pain ◽  
Therapy Assessment ◽  
Medical College ◽  
Pre Treatment

<p><strong>Background: </strong>Lateral epicondylitis is seen more commonly in non-athletes than athletes. Non-operative methods are the mainstay of treatment being effective in more than 95% of cases. Platelet rich plasma (PRP) has shown promising results in many studies as compared to steroid injection &amp; other modes of conservative management. Hence, this study was done to evaluate PRP efficacy in our clinical setup and in the people of age group most commonly being affected.<strong></strong></p><p><strong>Methods: </strong>This randomized study was conducted at Narayana Medical College Hospital, Nellore, for a period of two years from December 2014 to June 2016 on 150 consenting patients diagnosed as suffering from lateral epicondylitis. Using lottery method for randomization the patients were divided into three groups, based on which the treatment was received. Group –N with 50 patients received 3 ml of normal saline as placebo. Group –P with 50 patients received 3 ml of extracted PRP injection. Group –S with 50 patients received depot preparation of 40 mg of methyl prednisiolone injected into the affected area. The data collected and recorded in the appropriate proforma. Post therapy assessment was done using with Oxford elbow score.</p><p><strong>Results:  </strong>The overall mean ages of the patients in the three groups (Group P, Group S and Group N) are 38.62±7.53, 37.82±7.79 and 36.3±6.93 respectively. Female preponderance was observed in all the groups. Most common presenting complaint was elbow pain seen in 100% of cases. Most common side involved was the dominant side, right side involvement was seen in 136 cases and left side in 14 cases. The Oxford elbow score pre-treatment in all the groups was not statistically significant and the Oxford elbow score at the end of 12 weeks and 24 weeks treatment showed that PRP and steroid was better than normal saline in control of pain.<strong></strong></p><p><strong>Conclusion: </strong>Lateral epicondylitis or tennis elbow is a painful debilitating condition of elbow, which creates disturbance in functional activities. A single injection of PRP at the site of the elbow pain resulted in relief of pain in patients with longer duration as compared to local steroids to other conservative treatments.</p>

scholarly journals A comparative study between platelet rich plasma and conventional dressing in chronic non healing leg ulcers

2020 ◽  
Vol 7 (3) ◽  
pp. 751
Author(s):  
Ramakrishna Reddy Gade ◽  
Venkata Reddy M. ◽  
Padmanabh Inamdar
Keyword(s):  
Wound Healing ◽  
Normal Saline ◽  
Platelet Rich Plasma ◽  
P Value ◽  
Leg Ulcers ◽  
Major Health Problem ◽  
Ulcer Size ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Background: Chronic non-healing leg ulcers are a major health problem worldwide and have great impact on personal, professional and social levels, with high cost in terms of human and material resources. The present study was conducted with an aim to demonstrate the efficacy of autologous platelet rich plasma (PRP) in chronic non-healing leg ulcers in comparison to conventional dressings.Methods: A total of 50 patients with leg ulcers were randomized into two groups (A and B) with each group comprising of 25 patients each. Group A were treated with autologous platelet rich plasma (PRP) dressings and group B were treated with conventional dressings using normal saline. Ulcer measurements were taken on day 1, day 7, days 15 and after 30 days. The end point of study was complete wound epithelialization or appearance of granulation tissue, which ultimately lead to spilt skin grafting or secondary healing; whichever is earlier.Results: There was statistically significant difference in the average time taken for complete healing of ulcer in PRP dressings, 3.68 weeks against 6.2 weeks in conventional dressing group (p value <0.0001). PRP dressing group showed a 43.96% reduction in ulcer size as compared to 13.81% in conventional dressing group (p <0.0001). It was observed that PRP dressing group has faster wound healing and contraction of wound.Conclusions: PRP dressing of leg ulcers was better than conventional normal saline dressing as it leads to early reduction of ulcer size and enhances rate of wound healing. 

The Effect of Collagen Mediated Platelet Release on Plasma Prekallikrein Activation

1984 ◽  
Vol 51 (01) ◽  
pp. 037-041 ◽  
Author(s):  
K M Weerasinghe ◽  
M F Scully ◽  
V V Kakkar
Keyword(s):  
Platelet Aggregation ◽  
Healthy Volunteers ◽  
Platelet Rich Plasma ◽  
Age Groups ◽  
Inhibitory Effect ◽  
Age Group ◽  
Platelet Factor ◽  
Activated Platelets ◽  
Platelet Release ◽  
Collagen Treatment

SummaryCollagen mediated platelet aggregation caused -5.6 ± 6.7% inhibition and +39.1 ± 15.2% potentiation of prekallikrein activation in plasma from normal healthy volunteers between 20–40 and 50–65 years of age, respectively (n = 15, p <0.01). The amouns of platelet factor-four (PF4) released in the two groups were not significantly different. Collagen treatment in the presence of indomethacin caused +11.5 ± 3.6% and +59.6 ± 19.5% potentiation in the 20–40 and 50–65 age groups respectively (p <0.02). Adrenaline mediated platelet aggregation caused -55.2 ± 7.1% and -35.2 ± 8.3% inhibition in the 20–40 and 50–65 age groups, respectively. Collagen treatment of platelet-deficient-plasma and platelet-rich-plasma in EDTA also caused potentiation of prekallikrein activation.The results indicate that the observed degree of prekallikrein activation after platelet aggregation is a net result of the inhibitory effect of PF4 and the potentiatory effect of activated platelets. The potentiatory effect was greater after collagen treatment as compared to adrenaline treatment, and in the 50–65 age group as compared to the 20–40 age group.

scholarly journals The Clinical Effectiveness of Intralesional Injection of 2% Zinc Sulfate Solution in the Treatment of Common Warts

Scientifica ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Essam-elden Mohamed Mohamed ◽  
Khaled Mohamed Tawfik ◽  
Asmaa Moneir Mahmoud
Keyword(s):  
Zinc Sulfate ◽  
Randomized Study ◽  
Clinical Effectiveness ◽  
Sulfate Solution ◽  
Late Complications ◽  
Intralesional Injection ◽  
Significant Relation ◽  
Zinc Sulfate Solution ◽  
Common Warts ◽  
Postinflammatory Hyperpigmentation

Objective.To investigate the clinical efficacy and safety of intralesional injection of 2% zinc sulfate solution in the treatment of common warts.Patients and Methods.One hundred and twenty patients (78 females and 42 males) aged 5–55 years with 225 common warts participated in this prospective monocentric randomized study. All lesions were treated with intralesional injection of 2% zinc sulfate.Results.From 225 warts injected, 135 warts (60%) cured from the first session, 51 warts (22.67%) cured from the second session, and 12 warts (5.33%) cured from the third session. There is no significant relation between improvement and patient’s ages, duration, or number of warts (P<0.05). All patients complained from pain during injection, and all treated lesions showed redness, tenderness, and swelling in the first 3 days after injection. Late complications were postinflammatory hyperpigmentation in 90 patients (75%), scaring in 9 patients (7.5%), and ulceration in 3 patients (2.5%). Recurrence occurred in 3 lesions (1.33%).Conclusion.The clinical data indicate that intralesional injection of 2% zinc sulfate is an effective maneuver in the treatment of common warts; however, its associated complications limit its use.

Controlled Evaluation of Intravenous Drugs in the Specific Desensitization of Phobias

1973 ◽  
Vol 18 (1) ◽  
pp. 47-53 ◽  
Author(s):  
J. Trevor Silverstone ◽  
M.R. Salkind
Keyword(s):  
Normal Saline ◽  
Rating Scales ◽  
Behaviour Therapy ◽  
Social Phobias ◽  
General Anxiety ◽  
Drug Of Choice ◽  
End Of Treatment ◽  
Specific Phobias ◽  
Controlled Evaluation

The present study was undertaken to compare intravenous methohexitone, given as an adjunct to the behaviour therapy of phobias, with another centrally-acting, rapidly metabolised intravenous agent, propanidid, and also with normal saline. Thirty-five patients were included in the trial, all of whom had had phobic symptoms of at least one year's duration which were seriously interfering with their lives — 15 had specific phobias, 9 had social phobias and 11 had agoraphobia. Treatment consisted of twelve weekly drug-assisted desensitization treatments, using either 1 per cent methohexitone, 2.5 per cent propanidid or normal saline. Within each diagnostic group the drugs were randomly allocated. All treatments were conducted by one of the authors and all assessments by the other (who did not know which of the three preparations the patient had received). In addition to monthly ratings of the phobic symptoms, assessments of anxiety and depression were made, using self-rating scales. Patients were followed up six months after the end of treatment. Patients with specific phobias fared best, 9 out of the 13 who completed being considered to be markedly improved. Although the numbers are small there was a suggestion that patients receiving the two active drugs did better than those on the placebo. While methohexitone and propanidid were similarly effective, recovery time was much more rapid with propanidid. No patient in the specific phobia group relapsed significantly during the six months follow-up period. Furthermore, as the phobia improved the general anxiety level fell. Few depressive symptoms arose during successful desensitization, and there was no evidence of symptom substitution. Patients with social phobias and agoraphobia did far less well. In neither case did the active drugs appear to possess any advantage over placebo. Furthermore, of the 7 patients with agoraphobia who had improved, 4 relapsed within six months. It was concluded that drug-assisted desensitization is likely to be of greatest benefit in the management of specific phobias, with propanidid being the drug of choice.

scholarly journals Occurrence of the Elongated Styloid Process on Digital Panoramic Radiographs in the Riyadh Population

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Lingam Amara Swapna ◽  
Nada Tarek AlMegbil ◽  
Alhanouf Othman Almutlaq ◽  
Pradeep Koppolu
Keyword(s):  
Demographic Data ◽  
Randomized Study ◽  
Age Groups ◽  
Styloid Process ◽  
Panoramic Radiographs ◽  
Elongated Styloid Process ◽  
Digital Radiographs ◽  
Dental Hospital ◽  
Orofacial Region ◽  
Measuring Tool

Background. Patients with an elongated styloid process might present with dysphagia and pain in the cervicofacial region. These patients could be misdiagnosed as other orofacial pathologies. Aim. The present study attempted to assess the prevalence of the elongated styloid process on digital panoramic radiographs in the Riyadh population. Materials and Methods. The present prospective randomized study was conducted on the panoramic digital radiographs of 300 randomly selected patients visiting a private dental hospital to identify any elongation of the styloid process. Only the radiographs without any magnification errors were considered. The styloid process length was measured using the Sidexis measuring tool and entered in an Excel spreadsheet with other demographic data. A length beyond 30 mm was considered styloid process elongation. The data were subjected to statistical analysis. Results. The symptoms of styloid process elongation were higher among females (78.6%), and this difference was statistically significant (χ2 = 7.182; P = 0.007 ). No statistically significant association was observed between styloid process elongation and symptoms between different age groups. Females exhibited a significant longer mean length of the styloid process than males. The present study exhibited a 27.3% prevalence for the elongation and calcification of the styloid process. Conclusion. Given the significant prevalence of the elongated styloid process in our study, we recommend it to be considered as one of the differential diagnosis for pain or discomfort in the orofacial region.

scholarly journals STUDY COMPARING THE EFFICACY OF PLATELET RICH PLASMA VERSUS TRIAMCINOLONE IN TREATING TENNIS ELBOW

2019 ◽  
Vol 3 (7) ◽  
Author(s):  
Pratush Kumar Goyal ◽  
Anil Kumar Pandey ◽  
Akhil Bansal ◽  
Mohammad Zuber
Keyword(s):  
Tennis Elbow ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Lateral Epicondylitis ◽  
Age Group ◽  
Elbow Pain ◽  
Therapy Assessment ◽  
Pre Treatment ◽  
Gandhi Medical College ◽  
Group 1

Background: Lateral epicondylitis is seen more commonly in non-athletes than athletes. Non-operative methods are the mainstay of treatment being effective in more than 95% of cases. Platelet rich plasma (PRP) has shown promising results in many studies as compared to steroid injection & other modes of conservative management. Hence, this study was done to evaluate PRP efficacy in our clinical setup and in the people of age group most commonly being affected. Methods: This randomized study was conducted at Gandhi Medical College & Hamidia Hospital, Bhopal, for a period of two years from Aug 2015 to Sep 2017 on 60 consenting patients diagnosed as suffering from lateral epicondylitis. Using lottery method for randomization the patients were divided into two groups, based on which the treatment was received. Group –1 with 30 patients received 2 ml of PRP. Group –2 with 30 patients received 2 ml of Triamcinolone injection. The data collected and recorded in the appropriate proforma. Post therapy assessment was done using with Oxford elbow score. Results:  Average age at presentation was 31.11 years, Range of age was from 20 to 40 years. Maximum incidence was in the age group of 35 to 40 years. Female preponderance was observed in Group 1. Most common presenting complaint was elbow pain seen in 100% of cases. Most common side involved was the dominant side right side involvement was seen in 41 cases and left side in 19 cases. The Oxford elbow score pre-treatment in all the groups was not statistically significant and the Oxford elbow score at the end of 6 weeks,12 weeks and 24 weeks treatment showed that PRP is better than  steroid  in control of pain. Conclusion: Lateral epicondylitis/Tennis elbow is a painful debilitating condition of elbow, which creates disturbance in functional activities. A single injection of PRP at the site of the elbow pain resulted in relief of pain in patients with longer duration as compared to local steroids to other conservative treatments. Keywords: Tennis elbow, Platelet rich plasma, Steroid, Triamcinolone, Lateral epicondylitis

The Effect of Platelet Rich Plasma on the Treatment Outcome of Minigraft/NB-UVB Therapy in Stable Vitiligo: Clinical Evaluation and Effect on Tissue levels of bFGF

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Samar Abdallah Mohamed Salem ◽  
Marwa Yassin Soltan ◽  
Nashwa El Khazragy ◽  
Tabarek Abdulkhaleq Fezea
Keyword(s):  
Treatment Outcome ◽  
Platelet Rich Plasma ◽  
University Hospital ◽  
Similar Response ◽  
Ethical Aspects ◽  
Progressive Loss ◽  
End Of Treatment ◽  
Before And After ◽  
Additive Treatment

Abstract Background Vitiligo is an acquired pigmentary disorder resulting from loss of melanocytes which causes depigmentation of the skin. Clinically, it is characterized by the progressive loss of melanocytes causing the appearance of well-circumscribed milky white cutaneous macules and patches Aim of the Work to evaluate the efficacy of PRP as an additive treatment to the minigraft/NB-UVB treatments for stable localized vitiligo and the effect of this treatment on the expression of bFGF in the lesional treated vitiliginous skin compared before and after the course of treatment. Patients and Methods The study represents a prospective interventional comparative study. It was conducted on 17 patients diagnosed as stable vitiligo. All patients were selected from the dermatology outpatient vitiligo clinic of Ain-Shams University hospital from April 2018 to June 2019. All subjects who participated in this study gave written informed consents. The study was approved by the research ethical committee of Ain-Shams University (Approval Number: FWA 000017585) and fulfilled all the ethical aspects required in human research. Results We found that the addition of PRP to minigraft resulted in earlier repigmentation as assessed by VESTA score; however, at the follow up end (one month following the end of treatment), both modalities resulted in a similar response as regards the repigmentation percent and improvement in VESTA score. The addition of the PRP to the minigraft didn’t result in a superior improvement than minigraft alone. Conclusion Both minigraft and PRP-assisted minigraft followed by NB-UVB sessions are effective method to induce repigmentation in stable vitiligo.

scholarly journals Effects and mechanism of platelet-rich plasma on military drill injury: a review

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Peng-Cheng Xu ◽  
Min Xuan ◽  
Biao Cheng
Keyword(s):  
Platelet Rich Plasma ◽  
Therapeutic Modality ◽  
Training Methods ◽  
Invasive Treatment ◽  
Injury Repair ◽  
Reasonable Cost ◽  
Rapid Healing ◽  
Underlying Mechanisms ◽  
The Ideal

AbstractMilitary drill injury is a significant part of military medical research. The increase of training intensity and changes in training methods lead to differences in injury types. The ideal therapeutic modality should allow rapid healing at a reasonable cost and minimize impact on patients’ life. Platelet -rich plasma (PRP), a platelet concentrate, is rich in a variety of growth factors and widely used clinically as a minimally invasive treatment. It plays an important role in injury repair and rehabilitation. In this article, we review the therapeutic role of PRP in military drill injury and its possible underlying mechanisms, with a focus on plantar fasciitis, stress fractures and other common injuries, in order to provide basic support for military reserve.

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