scholarly journals Cutting-edge therapies in the treatment of surgical wounds

2021 ◽  
Author(s):  
Jose M. Zepeda ◽  
Javier Contreras ◽  
Felix Osuna ◽  
Melany Jimenez ◽  
Alejandro Murrieta
Keyword(s):  
Gene Therapy ◽  
Wound Care ◽  
Cutting Edge ◽  
Risk Of Infection ◽  
Early Recovery ◽  
Basic Part ◽  
Surgical Wounds ◽  
The Face ◽  
Cosmetic Outcomes ◽  
Near Future

Wounds are inherent to being alive and also a reminder of our fragility in the face of the hostilities of this planet. Annually, it is estimated that 4511 operations are performed per 100,000 population, or 1 surgical procedure every year for every 22 people. There is an art to treating wounds. The support by the doctor for wound healing favors the early recovery of this, in addition to minimizing the risk of infection and gives an aesthetically pleasing appearance, the care that is used today ranging from the cleaning of the wound, the approximation of the edges thanks to the sutures, etc. The following is a review of cutting-edge therapies in this area of medicine, such as biotechnologies, growth factors, gene therapy, and stem cells. Projections indicate an increasing decrease in morbidity and mortality associated with surgical wounds and their repair, as well as more favorable cosmetic outcomes for patients. The results showed that all the described techniques, although not perfect, are perfectible, and with the pertinent precautions can be maximized in favor of care. There is the possibility in the near future, to be a basic part of wound care, in terms of protocols of care, but also in the individualization of treatment.

scholarly journals Nanotechnology-Based Therapies for Skin Wound Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ilaria Tocco ◽  
Barbara Zavan ◽  
Franco Bassetto ◽  
Vincenzo Vindigni
Keyword(s):  
Wound Healing ◽  
Medical Care ◽  
Wound Care ◽  
Progressive Increase ◽  
Skin Wound ◽  
Cutting Edge ◽  
Near Future ◽  
Nanoparticulate Systems ◽  
Nanoscale Level

The cutting-edge combination of nanotechnology with medicine offers the unprecedented opportunity to create materials and devices at a nanoscale level, holding the potential to revolutionize currently available macroscale therapeutics. Nanotechnology already provides a plethora of advantages to medical care, and the success of nanoparticulate systems suggests that a progressive increase in the exploration of their potential will take place in the near future. An overview on the current applications of nanotechnology to wound healing and wound care is presented.

Development of specialized carriers capable of delivering effective RNAi and siRNA gene therapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Gene Therapy ◽  
Degradation Process ◽  
The Body ◽  
Sequential Treatment ◽  
Sufficient Stability ◽  
Near Future

New cationic carriers must be molecularly designed to enable selective RNAi and siRNA transport and administration. Because at some time, the carriers will have to be removed from the cells and perfused out of the body, sophisticated, temporarily controllable biodegradable carriers are necessary. This indicates that the degradation process must be well regulated and possibly in several steps to destroy the carrier in a controlled manner.Moreover, multifunctional cationic carriers must be molecularly designed to carry and steer two independent kinds of siRNAs delivered at two very different rates. This allows sequential treatment of some diseases. Nanosized carriers must be enhanced to provide sufficient stability for the therapeutic duration of the system. In addition, there is the recurring issue of cationic carrier toxicity to be addressed in the near future. Despite the courageous and robust field efforts, a lot of difficulties still need to be resolved.

A new dimension for deployment

2019 ◽  
Vol 35 (6) ◽  
pp. 21-23
Keyword(s):  
Case Studies ◽  
Design Methodology ◽  
Reading Time ◽  
Cutting Edge ◽  
Content Type ◽  
Commercial Use ◽  
Course Of Action ◽  
The Face ◽  
Pertinent Information ◽  
Practical Implications

Purpose This paper aims to review the latest management developments across the globe and pinpoints the practical implications from cutting-edge research and case studies. Design/methodology/approach This briefing is prepared by an independent writer who adds their own impartial comments and places the articles in context. Findings There is often a disconnect between science and business that is hard to fathom. Sometimes, of course, it is easy to see why two parties can seem so far apart – the scientist in search of truth and uninterested in any practical or commercial use of an invention – the industrialist who is dedicated to one course of action and unwilling to learn from research, which can prove it is the wrong one. Both people are as guilty as each other of missing what is staring them in the face. And yet, this dogged pursuit of a single goal is what represents them and perhaps enables them to more successful than other at what they choose to do. Originality/value The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.

Use of a transforming powder dressing in the lower leg wounds of two older patients: case studies

2019 ◽  
Vol 28 (Sup7) ◽  
pp. S40-S43 ◽  
Author(s):  
Steven P. Smith
Keyword(s):  
Case Studies ◽  
Older Patients ◽  
Wound Care ◽  
Lower Leg ◽  
Surgical Wounds

This report describes the use of a transforming powder dressing to treat lower leg surgical wounds occurring in two older patients. Wounds in this location are difficult and slow to heal. Both of these wounds exhibited complete granulation within two weeks of powder application and total healing in under four weeks, all while requiring no patient or nursing wound care.

Presentation and Management of Staphylococcal Scalded Skin Syndrome in a Child After a Burn Injury: A Case Report

2019 ◽  
Author(s):  
Thomas Edward Pidgeon ◽  
Federica D’Asta ◽  
Malobi Ogboli ◽  
Yvonne Wilson
Keyword(s):  
Case Report ◽  
Burn Injury ◽  
Wound Care ◽  
Total Body Surface Area ◽  
Granular Cell ◽  
Burn Wound ◽  
Staphylococcal Scalded Skin Syndrome ◽  
The Face ◽  
Total Body ◽  
Learning Points

Abstract This case report describes the clinical course of a child who developed staphylococcal scalded skin syndrome (SSSS) after a burn injury. The intent is to aid other units in recognizing the presentation of SSSS after a pediatric burn and to optimize subsequent management. The main clinical finding was of rapid, progressive, superficial epidermal loss at sites separate from the original burn, involving 55% of the total body surface area, 13 days after a 6% scald burn to the face, neck, and chest. Diagnosis was confirmed by multidisciplinary team clinical assessment and histopathology of an intraoperative skin biopsy. This confirmed epidermal cleavage at the granular cell layer. These findings were later supported by Staphylococcus aureus cultured from the burn wound, and a positive epidermolytic toxin A assay. Management was with general medical supportive care, clindamycin and flucloxacillin intravenous antibiotic therapy, and cleansing and dressing of the areas of epidermal loss. Key learning points from this case were that SSSS presented after a burn injury and that 13 days elapsed between the burn and SSSS. Factors differentiating it from toxic epidermal necrolysis are described, including the value of histopathology in confirming the diagnosis. The prompt use of antibiotics and attentive wound care are advocated as an effective management strategy.

scholarly journals Gauze Packing of Open Surgical Wounds: Empirical or Evidence-Based Practice?

2006 ◽  
Vol 88 (1) ◽  
pp. 33-36 ◽  
Author(s):  
F Dinah ◽  
A Adhikari
Keyword(s):  
Wound Dressing ◽  
Long Term Care ◽  
Wound Care ◽  
Operating Theatre ◽  
Evidence Based ◽  
Term Care ◽  
Community Or ◽  
Secondary Intention ◽  
Surgical Wounds

INTRODUCTION Most surgical wounds are closed primarily, but some are allowed to heal by secondary intention. This usually involves repeated packing and dressing of the raw wound surfaces. Although the long-term care of such wounds has devolved to the care of nurses in the community or out-patient setting, the initial wound dressing or cavity packing is done by the surgeon in the operating theatre. Many surgeons are unaware of the growth of the discipline of wound care, and still use traditional soaked gauze for dressing and packing open surgical wounds and cavities. RESULTS This review summarises the some of the modern alternatives available and the evidence – or the lack of it – for their use in both the acute and chronic setting.

The electricity–water nexus: is a crisis imminent?

Water Policy ◽  
2015 ◽  
Vol 17 (6) ◽  
pp. 1163-1175 ◽  
Author(s):  
Mark Berkman
Keyword(s):  
New Technology ◽  
Electricity Production ◽  
Market Failures ◽  
Water Shortages ◽  
Demand And Supply ◽  
Water Demand And Supply ◽  
The Face ◽  
The Usa ◽  
Water Withdrawals ◽  
Near Future

Several recent studies have warned that there will be widespread water shortages in many regions of the USA in the near future largely because of high demand for water in the production of electricity. This study reviews studies addressing electricity generation and water availability and concludes that electricity production is not likely to lead to water shortages in most regions for several reasons. First, the alarmist studies erroneously rely on water withdrawals rather than water consumption to measure gaps between water demand and supply. Second, these studies fail to account for market dynamics, which will lead to improvements in greater water recycling and reuse as well as new resources on the supply side, and conservation and improved efficiency via new technology on the demand side. Electricity is increasingly generated by low water use technologies such as solar and wind. In addition, fossil-fired power plant technologies exist that greatly reduce water withdrawals and consumption. As water prices rise in the face of tighter supplies these technologies will become more attractive. Third, policies designed to overcome market failures related to pricing regulation, water rights, and government boundaries can reduce, if not eliminate, widespread electricity and water shortages.

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