scholarly journals Nanotechnology-Based Therapies for Skin Wound Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Ilaria Tocco ◽  
Barbara Zavan ◽  
Franco Bassetto ◽  
Vincenzo Vindigni
Keyword(s):  
Wound Healing ◽  
Medical Care ◽  
Wound Care ◽  
Progressive Increase ◽  
Skin Wound ◽  
Cutting Edge ◽  
Near Future ◽  
Nanoparticulate Systems ◽  
Nanoscale Level

The cutting-edge combination of nanotechnology with medicine offers the unprecedented opportunity to create materials and devices at a nanoscale level, holding the potential to revolutionize currently available macroscale therapeutics. Nanotechnology already provides a plethora of advantages to medical care, and the success of nanoparticulate systems suggests that a progressive increase in the exploration of their potential will take place in the near future. An overview on the current applications of nanotechnology to wound healing and wound care is presented.

scholarly journals Electrospun PCL/PLA Scaffolds Are More Suitable Carriers of Placental Mesenchymal Stromal Cells Than Collagen/Elastin Scaffolds and Prevent Wound Contraction in a Mouse Model of Wound Healing

2020 ◽  
Vol 8 ◽  
Author(s):  
Eva Vonbrunn ◽  
Marc Mueller ◽  
Melanie Pichlsberger ◽  
Monika Sundl ◽  
Alexander Helmer ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mouse Model ◽  
Stromal Cells ◽  
Wound Care ◽  
Skin Wound ◽  
Beneficial Effects ◽  
New Therapeutic Approaches

Mesenchymal stem/stromal cells (MSCs) exert beneficial effects during wound healing, and cell-seeded scaffolds are a promising method of application. Here, we compared the suitability of a clinically used collagen/elastin scaffold (Matriderm) with an electrospun Poly(ε-caprolactone)/poly(l-lactide) (PCL/PLA) scaffold as carriers for human amnion-derived MSCs (hAMSCs). We created an epidermal-like PCL/PLA scaffold and evaluated its microstructural, mechanical, and functional properties. Sequential spinning of different PCL/PLA concentrations resulted in a wide-meshed layer designed for cell-seeding and a dense-meshed layer for apical protection. The Matriderm and PCL/PLA scaffolds then were seeded with hAMSCs, with or without Matrigel coating. The quantity and quality of the adherent cells were evaluated in vitro. The results showed that hAMSCs adhered to and infiltrated both scaffold types but on day 3, more cells were observed on PCL/PLA than on Matriderm. Apoptosis and proliferation rates were similar for all carriers except the coated Matriderm, where apoptotic cells were significantly enhanced. On day 8, the number of cells decreased on all carrier types except the coated Matriderm, which had consistently low cell numbers. Uncoated Matriderm had the highest percentage of proliferative cells and lowest apoptosis rate of all carrier types. Each carrier also was topically applied to skin wound sites in a mouse model and analyzed in vivo over 14 days via optical imaging and histological methods, which showed detectable hAMSCs on all carrier types on day 8. On day 14, all wounds exhibited newly formed epidermis, and all carriers were well-integrated into the underlying dermis and showing signs of degradation. However, only wounds treated with uncoated PCL/PLA maintained a round appearance with minimal contraction. Overall, the results support a 3-day in vitro culture of scaffolds with hAMSCs before wound application. The PCL/PLA scaffold showed higher cell adherence than Matriderm, and the effect of the Matrigel coating was negligible, as all carrier types maintained sufficient numbers of transplanted cells in the wound area. The anti-contractive effects of the PCL/PLA scaffold offer potential new therapeutic approaches to wound care.

Bariatric Skin & Wound Care Obesity: Impediment to Postsurgical Wound Healing: Preplanning with Protocols for Skin and Wound Care in Obese Patients

2004 ◽  
Vol 17 (8) ◽  
pp. 441-443
Author(s):  
Joyce A. Wilson ◽  
Jan J. Clark ◽  
Susan Gallagher ◽  
Charlotte Langlois ◽  
David W. Spacht ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Skin Wound ◽  
Obese Patients

scholarly journals Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 780
Author(s):  
Martin Matter ◽  
Sebastian Probst ◽  
Severin Läuchli ◽  
Inge Herrmann
Keyword(s):  
Wound Healing ◽  
Small Molecule ◽  
Wound Care ◽  
Active Agent ◽  
Skin Wound ◽  
Inorganic Materials ◽  
Small Molecule Drugs ◽  
Standards Of Living ◽  
Inorganic Nanomaterials ◽  
The Stability

Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

scholarly journals Green Peptide–nanomaterials; A Friendly Healing Touch for Skin Wound Regeneration

2019 ◽  
Vol 2 (1) ◽  
pp. 14-31 ◽  
Author(s):  
Debjani Nath ◽  
Pratyusha Banerjee ◽  
Anugrah Ray ◽  
Baishakhi Bairagi
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Skin Wound ◽  
The Body ◽  
Wound Healing Process ◽  
Present Moment ◽  
Developmental Study ◽  
Matrix Remodeling ◽  
Natural Peptides

The complex phenomenon by which the body responds to any injury of skin or tissue is known as wound healing. A number of phases like exudative, proliferative, and extracellular matrix remodeling are orchestrated events to be occurred involving blood cells, parenchymal cells, and different soluble mediators. Different internal, as well as external factors, regulate the speed and quality of healing. The delay in wound healing process causes the chronic wound or scar formation. At the present moment, the upscale research for identification of agents causing accelerated healing is important. Moreover, the biocompatibility of the accelerators needs to be investigated. Recent biomedical researches for wound care target to provide antimicrobial protection as well as matrix scaffolding for quick repairing of the skin tissue. In recent studies with natural peptides have shown that they are important components in developing the nano-medicines for their usefulness and therapeutic efficiency. New therapeutic formulations can be developed using these natural peptides utilizing different nanoparticle delivery system. This review deals with the developmental study on efficient wound care system where the possible use of natural peptides in combination with nanomaterials has been explored. A trial has also been made on the findings made over the past few years on the use of peptides as tissue regenerating agents through effective wound healing pathway.

scholarly journals Topical Application of Curcumin Augments Healing of Deep Dermal Excision Wound of Mice Exposed To Whole-Body Gamma Radiation

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Wound Healing ◽  
Topical Application ◽  
Wound Care ◽  
Healing Time ◽  
Skin Wound ◽  
Complete Healing ◽  
Wound Contraction ◽  
Whole Body ◽  
The Mean ◽  
Wound Healing Time

Exposures of wounds to ionizing radiations have been found to prolong the healing and also cause defective healing of irradiated wounds. Although, the descriptions of wound care techniques have been found in some of the oldest archeological findings, little attention has been given to capitalize on the conservative wound therapies in the treatment of irradiated wounds. Therefore, the present study was designed to enunciate the effect of topical application of 0.5, 2, 5 and 10 % curcumin ointment on wound contraction and mean wound healing time of excision skin wound in mice whole-body exposed to 6 Gy γ-radiations. The topical application of curcumin ointment increased the wound contraction and reduced mean wound healing time by 2.2 days in normal unirradiated wounds. The irradiation of mice to 6 Gy resulted in the retardation in healing of the wounds, whereas topical application of different concentrations of curcumin ointment resulted in a concentration dependent rise in the wound contraction at different post-irradiation times and a maximum wound contraction was detected in the wounds receiving topical application of 7% curcumin twice a day. A similar effect was observed in the mean wound healing time, which showed a reduction of 1.5 days for 5% curcumin ointment. Observations demonstrated that topical application of curcumin twice daily until complete healing of wound significantly improved contraction of irradiated wound and decreased the mean healing time.

scholarly journals Cutting-edge therapies in the treatment of surgical wounds

2021 ◽  
Author(s):  
Jose M. Zepeda ◽  
Javier Contreras ◽  
Felix Osuna ◽  
Melany Jimenez ◽  
Alejandro Murrieta
Keyword(s):  
Gene Therapy ◽  
Wound Care ◽  
Cutting Edge ◽  
Risk Of Infection ◽  
Early Recovery ◽  
Basic Part ◽  
Surgical Wounds ◽  
The Face ◽  
Cosmetic Outcomes ◽  
Near Future

Wounds are inherent to being alive and also a reminder of our fragility in the face of the hostilities of this planet. Annually, it is estimated that 4511 operations are performed per 100,000 population, or 1 surgical procedure every year for every 22 people. There is an art to treating wounds. The support by the doctor for wound healing favors the early recovery of this, in addition to minimizing the risk of infection and gives an aesthetically pleasing appearance, the care that is used today ranging from the cleaning of the wound, the approximation of the edges thanks to the sutures, etc. The following is a review of cutting-edge therapies in this area of medicine, such as biotechnologies, growth factors, gene therapy, and stem cells. Projections indicate an increasing decrease in morbidity and mortality associated with surgical wounds and their repair, as well as more favorable cosmetic outcomes for patients. The results showed that all the described techniques, although not perfect, are perfectible, and with the pertinent precautions can be maximized in favor of care. There is the possibility in the near future, to be a basic part of wound care, in terms of protocols of care, but also in the individualization of treatment.

Experience of negative pressure wound therapy over sternal wound healing: A retrospective review

WCET Journal ◽  
2019 ◽  
Vol 39 (2) ◽  
pp. 9-18
Author(s):  
Wai Sze Ho ◽  
Wai Kuen Lee ◽  
Ka Kay Chan ◽  
Choi Ching Fong
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Assessment Tool ◽  
Wound Care ◽  
Wound Therapy ◽  
Treatment Pathways ◽  
Wound Assessment ◽  
One Year

Objectives The aim of this study was to retrospectively review the effectiveness of negative pressure wound therapy (NPWT) in sternal wound healing with the use of the validated Bates-Jensen Wound Assessment Tool (BWAT), and explore the role of NPWT over sternal wounds and future treatment pathways. Methods Data was gathered from patients' medical records and the institution's database clinical management system. Seventeen subjects, who had undergone cardiothoracic surgeries and subsequently consulted the wound care team in one year were reviewed. Fourteen of them were included in the analysis. Healing improvement of each sternal wound under continuous NPWT and continuous conventional dressings was studied. In total, 23 continuous NPWT and 13 conventional dressing episodes were analysed with the BWAT. Results Among conventional dressing episodes, sternal wound improvement was 2.5–3% over 10 days to 3.5 weeks, whereas 4–5% sternal healing was achieved in 5 days to 2 weeks with sternal wire presence. Better healing at 11% in 1 week by conventional dressing was attained after sternal wire removal. In NPWT episodes, 8–29%, 13–24%, and 15–46% of healing was observed in 2 weeks, 3.5 to 5 weeks and 6 to 7 weeks, respectively. Only 39% wound healing was acquired at the 13th week of NPWT in one subject. With sternal wire present, 6%–29% wound healing progress was achieved by NPWT in 1–4 weeks, and 16–23% wound improvement in 2 to 4.5 weeks by NWPT after further surgical debridement. After sternal wire removal, 6–34% sternal wound healing occurred by continuous NPWT for 1–2 weeks, and maximum healing at 46% after 2.5 weeks of NPWT were observed. Conclusions Better wound healing was achieved in the NPWT group in comparison to conventional dressings alone. However, suboptimal sternal wound healing by NPWT alone was observed. Removal of sternal wire may improve the effectiveness of NPWT. Successful tertiary closure after NPWT among subjects supports the important bridging role of NPWT in sternal wound healing. Factors causing stagnant sternal wound healing by NPWT alone are discussed.

Short Report: The Moisture Balance with Aloe Vera Gel in Diabetic Wound Healing

2018 ◽  
Vol 1 (1) ◽  
pp. 21-23
Author(s):  
Fahrianto Selamet ◽  
Andi Mayasari Usman ◽  
Rian Adi Pamungkas
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Wound Care ◽  
Aloe Vera ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Short Report ◽  
Bacterial Reduction ◽  
Moisture Balance ◽  
Patients With Diabetes

Diabetic foot ulcer (DF) is a chronic complication of diabetes mellitus (DM), which impact on the morbidity, mortality and quality of patients’ lives.Of those patients with diabetes mellitus, approximately 15% to 25% developed to the foot ulcer. Beside has the infection and debridement of devitalized tissue downloading; the moisture imbalance becomes the factors of recalcitrant to healing. Moist wound healing is often contraindicated to the non-healable wounds. While wound care involves the debridement, bacterial reduction, and moisture balance in order to achieve the good granulation of the tissue development and adequate blood supply.

scholarly journals Overexpression of the Oral Mucosa-Specific microRNA-31 Promotes Skin Wound Closure

2019 ◽  
Vol 20 (15) ◽  
pp. 3679 ◽  
Author(s):  
Lin Chen ◽  
Alyne Simões ◽  
Zujian Chen ◽  
Yan Zhao ◽  
Xinming Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Wound Closure ◽  
Expression Patterns ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Specific Expression ◽  
Keratinocyte Proliferation

Wounds within the oral mucosa are known to heal more rapidly than skin wounds. Recent studies suggest that differences in the microRNAome profiles may underlie the exceptional healing that occurs in oral mucosa. Here, we test whether skin wound-healing can be accelerating by increasing the levels of oral mucosa-specific microRNAs. A panel of 57 differentially expressed high expresser microRNAs were identified based on our previously published miR-seq dataset of paired skin and oral mucosal wound-healing [Sci. Rep. (2019) 9:7160]. These microRNAs were further grouped into 5 clusters based on their expression patterns, and their differential expression was confirmed by TaqMan-based quantification of LCM-captured epithelial cells from the wound edges. Of these 5 clusters, Cluster IV (consisting of 8 microRNAs, including miR-31) is most intriguing due to its tissue-specific expression pattern and temporal changes during wound-healing. The in vitro functional assays show that ectopic transfection of miR-31 consistently enhanced keratinocyte proliferation and migration. In vivo, miR-31 mimic treatment led to a statistically significant acceleration of wound closure. Our results demonstrate that wound-healing can be enhanced in skin through the overexpression of microRNAs that are highly expressed in the privileged healing response of the oral mucosa.

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