Study of prevalence and impact of hyperuricemia in a patient of hypertension

Background: The association of raised serum uric acid levels with various cardiovascular risk factors has often led to the debate of whether raised serum uric acid levels could be an independent risk factor in essential hypertension. Hence we carried out a study to examine the possibility of hyperuricemia causing hypertension, to see if there is a relationship between the serum uric acid levels and severity and duration of hypertension.Methods: The study was carried out in Smt. SCL Hospital, Saraspur, Ahmedabad, India, the study period from September 2012 to June 2014, a total of 100 patients were studied. The patients were included if they satisfied the JNC VII criteria for hypertension. They were excluded if they were having any other condition known to cause raised serum uric acid levels and secondary hypertension.Results: With the result based on the study carried out we concluded that there can be a direct relation between hyperuricemia and hypertension. Also the study showed that the SUA levels were significantly increased in patient with stage 2 hypertension in comparasion with those with stage 1 hypertension, showing that the severity of hypertension also related to the SUA levels.Conclusions: Based on the study carried out we concluded that SUA can be used as an early biochemical marker to determine the severity and duration of hypertension.

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Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study

Hypertension ◽

10.1161/hyp.70.suppl_1.p146 ◽

2017 ◽

Vol 70 (suppl_1) ◽

Author(s):

Masanari Kuwabara ◽

Shigeko Hara ◽

Koichiro Niwa ◽

Minoru Ohno ◽

Ichiro Hisatome

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Uric Acid ◽

Risk Factor ◽

Cohort Study ◽

Serum Uric Acid ◽

Independent Risk Factor ◽

Drinking Habits

Objectives: Prehypertension frequently progresses to hypertension and is associated with cardiovascular diseases, stroke, excess morbidity and mortality. However, the identical risk factors for developing hypertension from prehypertension are not clarified. This study is conducted to clarify the risks. Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid. We also evaluated whether serum uric acid (hyperuricemia) provided an independent risk for developing hypertension. Results: The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%, but there were no significant differences between women and men (24.4% vs 26.0%, p=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=726) was significantly higher than those without hyperuricemia (n=2,858) (30.7% vs 24.0%, p<0.001). After multivariable adjustments, the risk factors for developing hypertension from prehypertension were age (OR per 1 year increased: 1.023; 95% CI, 1.015-1.032), women (OR versus men: 1.595; 95% CI, 1.269-2.005), higher body mass index (OR per 1 kg/m 2 increased: 1.051; 95% CI 1.021-1.081), higher baseline systolic blood pressure (OR per 1 mmHg increased: 1.072; 95% CI, 1.055-1.089) and diastolic blood pressure (OR per 1 mmHg increased: 1.085; 95% CI, 1.065-1.106), and higher serum uric acid (OR pre 1 mg/dL increased: 1.149; 95% CI, 1.066-1.238), but not smoking and drinking habits, diabetes mellitus, dyslipidemia, and chronic kidney diseases. Conclusions: Increased serum uric acid is an independent risk factor for developing hypertension from prehypertension. Intervention studies are needed to clarify whether the treatments for hyperuricemia in prehypertensive subjects are useful.

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Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

Hypertension Research ◽

10.1038/hr.2012.99 ◽

2012 ◽

Vol 35 (11) ◽

pp. 1087-1092 ◽

Cited By ~ 33

Author(s):

Tatsuo Kawai ◽

Mitsuru Ohishi ◽

Yasushi Takeya ◽

Miyuki Onishi ◽

Norihisa Ito ◽

...

Keyword(s):

Cardiovascular Disease ◽

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Independent Risk Factor ◽

Hypertensive Patients

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Uric acid levels are critical for non-alcoholic fatty liver disease

10.21203/rs.2.23270/v1 ◽

2020 ◽

Author(s):

Guanqun Chao ◽

Yue Zhu ◽

Lizheng Fang

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Risk Factor ◽

Fatty Liver ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Density Lipoprotein ◽

Diagnostic Threshold

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

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Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.02.014 ◽

2018 ◽

Vol 272 ◽

pp. 233-239 ◽

Cited By ~ 11

Author(s):

Ji Eun Jun ◽

You-Bin Lee ◽

Seung-Eun Lee ◽

Ji Yeon Ahn ◽

Gyuri Kim ◽

...

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Coronary Artery Calcification ◽

Elevated Serum

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Uric acid and uric acid/creatinine ratio and their correlations with the hemorheological determinants in subjects with subclinical carotid atherosclerosis

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-211322 ◽

2022 ◽

pp. 1-9

Author(s):

Gregorio Caimi ◽

Caterina Urso ◽

Salvatore Brucculeri ◽

Corrado Amato ◽

Rosalia Lo Presti ◽

...

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Carotid Atherosclerosis ◽

Erythrocyte Aggregation ◽

Creatinine Ratio ◽

Serum Uric Acid Concentration

BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. In the whole group and in the subgroups of subclinical carotid atherosclerosis subjects, serum uric acid and serum uric acid/creatinine ratio show significant correlation, besides with whole blood viscosity, with plasma viscosity and erythrocyte aggregation. The influence of the serum uric acid on the erythrocyte aggregability that is a part of the erythrocyte aggregation is to ascribe to the action carried out by serum uric acid on the erythrocyte zeta potential. CONCLUSIONS: it is reasonable to think that the treatment of the asymptomatic or symptomatic hyperuricemia with the urate-lowering therapy that reduces the serum uric acid concentration may reflect on the hemorheological profile which role on the atherosclerotic cardiovascular disease is well known.

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Serum uric acid is associated with common cardiovascular risk factors in Uygur population

International Journal of Cardiology ◽

10.1016/j.ijcard.2009.09.173 ◽

2009 ◽

Vol 137 ◽

pp. S52

Author(s):

HONGMEI WANG ◽

NANFANG LI ◽

JING HONG ◽

LING ZHOU

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Uygur Population

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Association of High Serum Uric Acid and Increased Arterial Stiffness is Dependent on Cardiovascular Risk Factors in Female Population

Hormone and Metabolic Research ◽

10.1055/a-0882-7382 ◽

2019 ◽

Vol 51 (06) ◽

pp. 367-374 ◽

Cited By ~ 3

Author(s):

Yin Yuan ◽

Feng Huang ◽

Fan Lin ◽

Min Lin ◽

Pengli Zhu

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Pulse Wave ◽

Elevated Serum ◽

High Serum ◽

Female Population

AbstractAn elevated serum uric acid (SUA) level is closely associated with increased arterial stiffness. However, whether this association is independent of conventional cardiovascular risk factors is controversial. This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m2. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular risk factors. In female subjects with more than two cardiovascular risk factors, compared with the first quartile of SUA, higher SUA quartiles were associated with a higher probability of increased baPWV (OR=1.500, 1.478, 1.774 for SUA Q2–Q4). In further stratified association analysis, compared with Q1, SUA quartiles showed a graded association with increased baPWV in subjects with TC≥5.2 mmol/l (OR=1.758, 1.942, 2.354 for Q2, Q3, and Q4 respectively), LDL-C≥3.3 mmol/l (OR=1.510, 2.255 for Q3 and Q4) and FBG≥7.0 mmol/l (OR=1.516, 1.748 for Q3 and Q4). In the Chinese coastal female population, the association of high SUA and increased arterial stiffness is dependent on the coexistence of at least one cardiovascular risk factor, especially hypercholesterolemia.

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