Study of clinical and biochemical profile of acute alcoholic liver disease in a teaching hospital in Telangana

Background: Chronic alcohol consumption gives rise to various health risks that include liver disease, heart disease, pancreatitis, central nervous system disorders and certain forms of cancer. Alcoholic liver disease (ALD) is a spectrum of clinicopathological abnormalities, reflecting an acute or chronic inflammation of the liver parenchyma induced by alcohol use. It is associated with changes in various biochemical parameters and also various clinical manifestations in the patients. The objective of the present study to evaluate clinical and biochemical profile of acute alcoholic liver disease.Methods: The prospective hospital-based case control study was done at MNR Medical College, in the department of General Medicine for duration of one year from March 2017 to April 2018. A total of 120 cases diagnosed clinically and biochemically as Acute alcoholic liver disease were included in the study.Results: The age group ranged from 20 to 60 years and the male to female ratio was 2.42. Majority of the patients were in the age group of 30-40 years (54.1%). Majority of the patients (66.6%) consumed >60 grams/24hours of alcohol. Jaundice, nausea and vomiting were seen in 83.3% cases followed by hepatomegaly in 66.6% cases. Majority of them had been consuming alcohol for more than 5 years.Conclusions: Chronic alcohol consumption is more common in adult males. Chronic alcoholics consume more amount of alcohol. Alcoholic liver disease has a varied clinical presentation and is associated with deranged biochemical parameters.

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Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice

Frontiers in Physiology ◽

10.3389/fphys.2019.01042 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 5

Author(s):

Yue Ma ◽

Hui Chai ◽

Qinchao Ding ◽

Qianyu Qian ◽

Zhaoyuan Yan ◽

...

Keyword(s):

Liver Disease ◽

Alcohol Consumption ◽

Alcoholic Liver Disease ◽

Chronic Alcohol ◽

Chronic Alcohol Consumption

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Regulatory T cells suppress excessive lipid accumulation in alcoholic liver disease

The Journal of Lipid Research ◽

10.1194/jlr.m083568 ◽

2019 ◽

Vol 60 (5) ◽

pp. 922-936 ◽

Cited By ~ 3

Author(s):

Hongwu Wang ◽

Ting Wu ◽

Yaqi Wang ◽

Xiaoyang Wan ◽

Junying Qi ◽

...

Keyword(s):

Oxidative Stress ◽

T Cells ◽

Liver Disease ◽

Alcohol Consumption ◽

Regulatory T Cells ◽

Alcoholic Liver Disease ◽

Lipid Accumulation ◽

Chronic Alcohol ◽

Chronic Alcohol Consumption ◽

Alcoholic Fatty Liver

Sensitization of hepatic immune cells from chronic alcohol consumption gives rise to inflammatory accumulation, which is considered a leading cause of liver damage. Regulatory T cells (Tregs) are an immunosuppressive cell subset that plays an important role in a variety of liver diseases; however, data about pathological involvement of Tregs in liver steatosis of alcoholic liver disease (ALD) is insufficient. In mouse models of ALD, we found that increased lipid accumulation by chronic alcohol intake was accompanied by oxidative stress, inflammatory accumulation, and Treg decline in the liver. Adoptive transfer of Tregs relieved lipid metabolic disorder, oxidative stress, inflammation, and, consequently, ameliorated the alcoholic fatty liver. Macrophages are a dominant source of inflammation in ALD. Aberrant macrophage activation and cytokine production were activated during chronic alcohol consumption, but were significantly inhibited after Treg transfer. In vitro, macrophages were co-activated by alcohol and lipopolysaccharide to mimic a condition for alcoholic liver microenvironment. Tregs suppressed monocyte chemoattractant protein-1 and TNF-α production from these macrophages. However, such effects of Tregs were remarkably neutralized when interleukin (IL)-10 was blocked. Altogether, our data uncover a novel role of Tregs in restoring liver lipid metabolism in ALD, which partially relies on IL-10-mediated suppression of hepatic pro-inflammatory macrophages.

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Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes

PLoS ONE ◽

10.1371/journal.pone.0261675 ◽

2022 ◽

Vol 17 (1) ◽

pp. e0261675

Author(s):

Afroza Ferdouse ◽

Rishi R. Agrawal ◽

Madeleine A. Gao ◽

Hongfeng Jiang ◽

William S. Blaner ◽

...

Keyword(s):

Cytochrome P450 ◽

Retinoic Acid ◽

Liver Disease ◽

Alcohol Consumption ◽

Vitamin A ◽

Alcohol Exposure ◽

Chronic Alcohol ◽

Wild Type ◽

Chronic Alcohol Consumption ◽

Retinyl Esters

Chronic alcohol consumption leads to a spectrum of liver disease that is associated with significant global mortality and morbidity. Alcohol is known to deplete hepatic vitamin A content, which has been linked to the pathogenesis of alcoholic liver disease. It has been suggested that induction of Cytochrome P450 2E1 (CYP2E1) contributes to alcohol-induced hepatic vitamin A depletion, but the possible contributions of other retinoid-catabolizing CYPs have not been well studied. The main objective of this study was to better understand alcohol-induced hepatic vitamin A depletion and test the hypothesis that alcohol-induced depletion of hepatic vitamin A is due to CYP-mediated oxidative catabolism. This hypothesis was tested in a mouse model of chronic alcohol consumption, including wild type and Cyp2e1 -/- mice. Our results show that chronic alcohol consumption is associated with decreased levels of hepatic retinol, retinyl esters, and retinoic acid. Moreover, the depletion of hepatic retinoid is associated with the induction of multiple retinoid catabolizing CYPs, including CYP26A1, and CYP26B1 in alcohol fed wild type mice. In Cyp2e1 -/- mice, alcohol-induced retinol decline is blunted but retinyl esters undergo a change in their acyl composition and decline upon alcohol exposure like WT mice. In conclusion, the alcohol induced decline in hepatic vitamin A content is associated with increased expression of multiple retinoid-catabolizing CYPs, including the retinoic acid specific hydroxylases CYP26A1 and CYP26B1.

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Evaluation of the effectiveness of the drug Samelix in patients with cholestasis in chronic alcoholic liver disease

Medical Council ◽

10.21518/2079-701x-2019-14-52-57 ◽

2019 ◽

pp. 52-57

Author(s):

O. N. Minushkin ◽

L. V. Maslovsky ◽

M. I. Bulanova ◽

O. F. Shaposhnikovа

Keyword(s):

Quality Of Life ◽

Liver Disease ◽

Clinical Efficacy ◽

Alcoholic Liver Disease ◽

Biochemical Parameters ◽

Clinical Manifestations ◽

Efficacy And Safety ◽

Chronic Alcoholic ◽

The Individual

A study of the clinical efficacy and safety of the drug Samelix (ademetionine, manufacturer – JSC «Canonfarma production», Russia) in 30 patients with chronic alcoholic liver disease (steatohepatitis mild to moderate currents, cirrhosis of the liver grade a ChildPugh) with the syndrome of cholestasis. Purpose of the study: evaluate the clinical efficacy and safety of Samelix (ademetionine) in 30 patients with chronic alcoholic liver disease. Objectives of the study: evaluate the effect of the drug on biochemical parameters, evaluate the effect of the drug on the clinical manifestation of the disease based on the individual diary data during the course therapy, assess the quality of life through the SF-36 questionnaire before and after treatment; report adverse events. The results of the study showed that therapy with this drug leads to a significant positive dynamics of biochemical parameters, regression of clinical manifestations of the disease, a significant increase in the quality of life. Good and excellent results of therapy were observed in 76.7% of cases. The drug is safe and well tolerated.

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Study of viral markers, clinical and biochemical profile of viral hepatitis in patients of alcoholic liver disease

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20196074 ◽

2020 ◽

Vol 7 (2) ◽

pp. 196

Author(s):

Narendra M. Uma ◽

Mahendra C. Parmar ◽

Parth Shanishwara ◽

Sonal M. Dindod

Keyword(s):

Liver Disease ◽

Alcohol Consumption ◽

Viral Hepatitis ◽

Alcoholic Liver Disease ◽

Hepatitis Virus ◽

Synergistic Effects ◽

Biochemical Profile ◽

Hepatitis Viruses ◽

Cross Sectional ◽

Targeted Interventions

Background: There is a significant worldwide burden of Alcoholic Liver Disease (ALD). Both alcohol abuse and infection with hepatitis viruses can lead to liver disease. Alcohol and hepatitis viruses have synergistic effects in the development of liver disease. Thus, early detection of virus hepatitis and targeted interventions can improve prognosis in ALD.Methods: This cross-sectional study was conducted among 180 patients coming to Baroda medical college and SSG hospital, Vadodara having alcoholic liver disease were studied and evaluated for markes of viral hepatitis and its clinical and biochemical profile in alcoholic liver disease.Results: our study we had taken 180 patients of alcoholic liver disease out of which male were 92% and female were 8%. Prevalence of viral hepatitis was 27.7% in ALD patients. Out of which hepatitis E was 13% followed by hepatitis A 11%, hepatitis B 4.44% and least was Hepatitis C 0.5%. In clinical profile fever was significantly higher in patients of viral hepatitis with ALD than patients without viral hepatitis. Bilirubin was not significant differ in both groups of patients but SGOT and SGPT had higher values in patients of viral hepatitis with ALD and thus ratio of SGOT/SGPT was also affected due to higher value of SGOT and SGPT.Conclusions: Alcohol consumption and hepatitis virus infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. Patients starting treatment for chronic viral hepatitis infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy specially in chronic hepatitis.

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Rasio AST/ALT pada Laki-Laki Pengkonsumsi Alkohol di Jalan Mendawai Kota Palangka Raya

Borneo Journal of Medical Laboratory Technology ◽

10.33084/bjmlt.v1i2.710 ◽

2019 ◽

Vol 1 (2) ◽

pp. 46-51 ◽

Cited By ~ 1

Author(s):

Dwi Purbayanti ◽

Muhammad Rizwan Nafarin

Keyword(s):

Liver Disease ◽

Alcohol Consumption ◽

Liver Damage ◽

Alcoholic Liver Disease ◽

Alanine Aminotransferase ◽

Descriptive Study ◽

Age Group ◽

Heavy Drinkers ◽

Increased Activity

Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) are enzymes predominantly found in hepatocytes, the increased activity in the serum shows liver damage. The AST / ALT ratio is used as a marker for alcoholic liver disease. This study aims to determine the effects of long-term alcohol consumption on the risk of alcoholic liver disease. This study was a descriptive study, involving 20 alcoholic drinkers aged 25-45 years, had consumed alcohol> 5 years and consumed alcohol every day. Our results showed a significant increase (p <0.05) in AST and ALT values based on age group, duration of consumption and dose. While the ratio of AST / ALT, a significant increase was found in the age group and period. In alcohol drinkers, the AST value is higher than ALT. The AST / ALT ratio for heavy drinkers is 1.64. Conclusion: Alcohol-consuming subjects in our study, especially heavy drinkers, were suspected of having a risk of alcoholic liver disease because most had an AST / ALT ratio > 1,5.

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