scholarly journals Serum uric acid levels in essential hypertension and its correlation with the severity of hypertension

2020 ◽  
Vol 7 (11) ◽  
pp. 1738
Author(s):  
Waseem Ramzan Dar ◽  
Sunil Kumar Gupta ◽  
Afzal Ahmad
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Laboratory Data ◽  
Social Software ◽  
National Committee ◽  
Hypertensive Patients ◽  
Co Morbidity ◽  
Significant Difference

Background: Serum uric acid has been closely linked and considered as an independent risk factor for development of hypertension. This study was carried out to assess the serum uric acid levels in essential hypertension and its correlation with the severity and known duration of hypertension.Methods: The present observational case control study was conducted between November 2019 to February 2020 on total 100 out patients (30-65 years) of which 50 known cases of essential hypertension irrespective of treatment status and were graded into different stages of hypertension as per Joint National Committee VII (JNC VII) guidelines. Rest 50 patients who were age- sex matched and without any co-morbidity were included as control. Relevant clinical and laboratory data were recorded using proforma. Statistical analysis was done using Statistical package for social software (SPSS) software.Results: Mean systolic/diastolic blood pressure (BP) was found significantly higher in cases 168/102 mmHg compare to control 114/74 mmHg. Among cases maximum patients were found in stage 2 hypertension which has significant difference in mean systolic/diastolic BP (186/112 mmHg, p<0.001) compare with stage 1 (146/94 mmHg) and isolated hypertensive patients (148/85 mmHg). Serum uric acid levels were significantly higher in stage 2 than other two hypertensive stages among cases and also compare to controls. Patients with >5 years of hypertension also has significant high serum uric acid level than <5 years of hypertension.Conclusions: Serum uric acid can be used probably as an early biochemical marker to determine the severity of hypertension as stage 2 hypertensive had more elevation in serum uric acid levels as compared to other hypertensive patients.

Serum Uric Acid and Its Association with Coronary Artery Disease

2012 ◽  
Vol 5 (1) ◽  
pp. 12-17 ◽  
Author(s):  
MAK Akanda ◽  
KN Choudhury ◽  
MZ Ali ◽  
S Naher ◽  
ASME Islam ◽  
...  
Keyword(s):  
Uric Acid ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Gensini Score ◽  
Significant Difference ◽  
Artery Disease ◽  
High Uric Acid

Background: Few studies have assessed the relation of uric acid level with the severity of coronary  artery disease (CAD). This study investigated the association between high uric acid levels with the  presence and severity of CAD.Materials and Methods: This study was designed as an observational cohort study. The study was  composed of 180 patients admitted at our institution due to symptoms related to CAD. Patients  having angiographic evidence of stenosis in coronary artery were as case group and without stenosis  control group. Patients with high uric acid (hyperuricemia) were defined as serum uric acid  concentration ?7.0mg/dl or ?420 ?mol/L in men and ?6mg/dl or ?360 ? mol/L in women. The  presence of CAD has been defined as the Gensini score being ?1.  Results: There was a statistically significant difference between the mean uric acid levels of patients  with and without CAD (358.23±71.11 ?mol/l vs251.32±54.92 ?mol/l respectively, p<0.001). There  was a statistically significant difference between ejection fraction of patients with and without CAD  (54.50±9.25 vs. 63.16±6.56 respectively, p?0.001). Spearman correlation analysis demonstrated a  positive correlation between the serum uric acid level and the severity of CAD (p=?0.001, r=0.39).  When patients were classified into four groups according to their Gensini score, mean serum uric  acid level was found to be significantly increased across the tertiles, and a statistically significant  difference was detected between the tertiles (p= ?0.001).  Conclusion: In conclusion, a significant association has been found between serum uric acid level  and the presence and severity of CAD. In addition to the evaluation of conventional risk factors in  daily clinical practice, the measurement of uric acid level might provide significant prognostic  benefits in terms of global cardiovascular risk and management of the patients. DOI: http://dx.doi.org/10.3329/cardio.v5i1.12206 Cardiovasc. j. 2012; 5(1): 12-17

scholarly journals Association of Serum Uric Acid Level With Blood Pressure Variability in Newly Diagnosed Essential Hypertension

2015 ◽  
Vol 17 (12) ◽  
pp. 929-935 ◽  
Author(s):  
Kumral Çağlı ◽  
Osman Turak ◽  
Uğur Canpolat ◽  
Fırat Özcan ◽  
Derya Tok ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Blood Pressure Variability ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Newly Diagnosed

scholarly journals Serum uric acid level in Bangladeshi adults with essential hypertension

2020 ◽  
Vol 7 (7) ◽  
pp. 1136
Author(s):  
SK. Kabir Ahammed ◽  
A. B. M. Kamrul Hasan ◽  
Mohammed Ruhul Kabir ◽  
Gunosindhu Paul ◽  
Shishir Kumar Basak ◽  
...  
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Cross Sectional ◽  
Hypertensive Group ◽  
Positive Correlations

Background: The association of hyperuricemia with various cardiovascular risk factors has often led to the debate of whether hyperuricemia is an independent risk factor for essential hypertension (HTN).  The current study was conducted to see the relationship between serum uric acid and essential HTN in Bangladeshi adults.Methods: In this cross-sectional study, conducted in a tertiary hospital of Bangladesh, 155 patients with essential hypertension (newly detected or on treatment) aged ≥18 years and 100 age-sex matched normotensive subjects were investigated. Serum uric acid, plasma glucose, serum creatinine, and lipid profile were measured in all in fasting samples.Results: The frequency of hyperuricemia was higher in the hypertensive group in comparison to the normotensive control group (29.7% vs. 6.0%, p<0.001). Serum uric acid level was higher in the hypertensive subjects than the controls (6.10±0.88 vs. 5.38±0.54 mg/dL, mean±SD, p<0.001). In the hypertensive group, subjects with stage II HTN had higher serum uric acid than those with stage I HTN (6.46±0.83 vs. 5.72±0.78 mg/dL, mean±SD, p<0.001). In the hypertensive group, uric acid level showed significant positive correlations with both systolic and diastolic blood pressure though in the control group uric acid showed such correlation with systolic BP only.Conclusion: Patients with essential hypertension had higher serum uric acid compared to normotensive controls; uric acid level showed positive correlations with systolic and diastolic BP in the hypertensive subjects.

scholarly journals Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

2018 ◽  
Vol 9 (2) ◽  
pp. 49-53
Author(s):  
S Ferdous ◽  
K Begum ◽  
MA Muttalib
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Stone Formation ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Normal Serum ◽  
Significant Difference

Hyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, serum creatinine and blood urea between groups.Bangladesh J Med Biochem 2016; 9(2): 49-53

scholarly journals SERUM URIC ACID AND TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSION AT MEDICINE DEPARTMENT OF GMC, BETTIAH, BIHAR

2020 ◽  
pp. 1-3
Author(s):  
Mahendra Kumar ◽  
Dharmendra Prasad ◽  
Parshuram Yugal ◽  
Debarshi Jana
Keyword(s):  
Uric Acid ◽  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Serum Uric Acid ◽  
Ventricular Hypertrophy ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Hypertensive Patients

Background Hypertension is a major risk factor for cardiovascular mortality, as it acts through its effects on target organs, such as the heart and kidneys. Hyperuricemia increases cardiovascular risk in patients with hypertension. Objective To assess the relationship between serum uric acid and target organ damage (left ventricular hypertrophy and microalbuminuria) in untreated patients with essential hypertension. Patients and methods: A cross-sectional study was carried out in 130 (85 females, 45 males) newly diagnosed, untreated patients with essential hypertension. Sixty-five healthy age- and sex-matched non-hypertensive individuals served as controls for comparison. Left ventricular hypertrophy was evaluated by cardiac ultrasound scan, and microalbuminuria was assessed in an early morning midstream urine sample by immunoturbidimetry. Blood samples were collected for assessing uric acid levels. Results Mean serum uric acid was significantly higher among the patients with hypertension (379.7±109.2 μmol/L) than in the controls (296.9±89.8 μmol/L; P<0.001), and the prevalence of hyperuricemia was 46.9% among the hypertensive patients and 16.9% among the controls (P<0.001). Among the hypertensive patients, microalbuminuria was present in 54.1% of those with hyperuricemia and in 24.6% of those with normal uric acid levels (P=0.001). Similarly, left ventricular hypertrophy was more common in the hypertensive patients with hyperuricemia (70.5% versus 42.0%, respectively; P=0.001). There was a significant linear relationship between mean uric acid levels and the number of target organ damage (none versus one versus two: P=0.012). Conclusion These results indicate that serum uric acid is associated with target organ damage in patients with hypertension, even at the time of diagnosis; thus, it is a reliable marker of cardiovascular damage in our patient population.

scholarly journals Prevalence of Hyperuricemia and its Association with Sociodemography among Hypertensive Patients at Birat Medical College Teaching Hospital

2021 ◽  
Vol 6 (1) ◽  
pp. 1388-1391
Author(s):  
Ram Kumar Mehta ◽  
Ram L Mallick ◽  
Surya Parajuli ◽  
Rajneesh Jha
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Teaching Hospital ◽  
Serum Uric Acid Level ◽  
College Teaching ◽  
Cardiovascular Morbidity ◽  
Morbidity And Mortality ◽  
Hypertensive Patients ◽  
Medical College ◽  
Cardiovascular Morbidity And Mortality

Introduction: Hypertension is the most common cardiovascular diseases. In only 5-10 % of hypertensive patients, underlying cause can be identified (secondary hypertension). Serum uric acid is thought to play a pathogenic role in development of hypertension and is also a commonly associated condition in patients with hypertension. Management of hyperuricemia will ultimately help in reducing cardiovascular morbidity and mortality. Objectives: To determine the prevalence of hyperuricemia among hypertensive patients atiending Birat Medical College Teaching Hospital and also to find association between hyperuricemia and socio-demographic variables. Methodology: This was a descriptive hospital based cross-sectional study conducted in 168 hypertensive patients at Birat Medical College Teaching Hospital, Nepal for a period of 6 months from 1 September 2020 to 28th February 2021. Sociodemographic variables were recorded and serum uric acid level was obtained based on the pre-structured questionnaires. Data were analyzed by Statistical Package for the Social Sciences version 20 (SPSS 20). Result: Prevalence of hyperuricemia was 42 (25%) among hypertensive patients with more prevalent in male 33 (30.8%) than female 9 (14.8%). Hyperuricemia was more prevalent in patients having higher BMI and patients aged more than 60 years i.e. 38 (34.5%) and 25 (41.7%) respectively. It was more prevalent among patients with hypertension for more than 15 years 10 (41.7%) and non-vegetarian 33 (25.8%). Hyperuricemia was significantly associated with those aged more than 60 years (p=0.002) and BMI >25 kg/m2 (p=0.002). Conclusion: Hyperuricemia was common associated condition among hypertensive patients. Hyperuricemia is mainly associated with male gender, non-vegetarian and patients with longer duration of hypertension. Similarly, it was strongly associated with older age and patients having higher BMI. Monitoring of serum uric acid and management of hyperuricemia might be helpful in management of hypertension and thus decreasing cardiovascular morbidity and mortality. 

scholarly journals ESSENTIAL HYPERTENSION

2015 ◽  
Vol 22 (07) ◽  
pp. 854-858
Author(s):  
Muhammad Iqbal Shah ◽  
Ramesh Kumar Suthar ◽  
Mukhtiar Ahmed Soomro
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
High Blood Pressure ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Research Studies

Background: Little and sparse information is present in our population onassociation between serum uric acid and essential hypertension .Increased serum uric acid isrelated with elevated blood pressure in different research studies. The relationship betweenserum uric acid level and high blood pressure can be difficult to assess because drugs for highblood pressure usually affect uric acid level. Objectives: The objective of our study is to evaluatethe association of serum uric acid to severity and duration of essential hypertension at LiaquatUniversity Hospital (tertiary care) Hyderabad / Jamshoro Methodology: Study Design: Casecontrol and prospective study. Setting: Medical wards and Out Patient Medicine Department ofLiaquat University Hospital Hyderabad / Jamshoro. Period: One year i.e. from 20th March 2013to 19th February 2014. Methodology: A total of 75 high blood pressure subjects aged 35 yearsand above were included as cases with same number(75) of age & sex matched normal bloodpressure subjects as controls after excluding, Secondary hypertension, metabolic syndrome,Diabetes Mellitus, age <40 ;>70 years, hypothyroidism, hyperparathyroidism, Ischemic heartdisease, congestive cardiac failure,Alcohol abuse, Renal Insufficiency, glomerulonephritis,pyelonephritis, hereditary nephropathy, patients on drugs –, ethambutol,levodopa pyrazinamide,low dose asprin, Cytotoxic drugs, nicotinic acid ,thiazide diuretics.. Qualitative and quantitativedata were evaluated in SPSS version 16.0. Results: The mean serum uric acid level was 6.3± 1.4 mg/dl vs 4.5 ± 1.2 mg/dl in case (n = 75) and control patients (n = 75) respectively. Atotal of 23 (30.6%, n = 75) patients in cases and 8 (10.6%) subjects in control had high serumuric acid (Odds Ratio 2.13, p <0.05). Therefore, the frequency of increased serum uric acidlevel subjects & mean serum uric acid level were significantly greater in hypertensive cases,as compared to those of healthy normal blood pressure Controls. Serum uric acid correlatedpositively with both systolic blood pressure (r=0.132, p<0.01) and diastolic blood pressure(r=0.214; p<0.01). Conclusion: High serum uric acid is frequent in our populace with essentialhypertension and there is relationship between serum uric acid level and blood pressure.Further large scale research studies on the pathophysiologic significance of high serum uricacid in these high blood pressure patients are in further need.

scholarly journals Analysis of Serum Uric Acid Level in Patients with and without Diabetic Nephropathy

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Erika Rosaria Simbolon ◽  
Suci Aprianti ◽  
Nurahmi Nurahmi ◽  
Liong Boy Kuniawan
Keyword(s):  
Uric Acid ◽  
Diabetic Nephropathy ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Microvascular Complications ◽  
Serum Levels ◽  
Significant Difference

Diabetic nephropathy is one of the microvascular complications in type 2 Diabetes Mellitus (DM). Diagnosis of diabeticnephropathy is based on any history of DM, a decrease in Glomerular Estimation Filtrate Rate (eGFR) using the CKD-Epiformula, and albuminuria. The role of serum uric acid level in diabetic nephropathy remains an ongoing debate. Serum uricacid levels may be the cause or the result of diabetic nephropathy. This study aimed to analyze serum uric acid levels inpatients with and without diabetic nephropathy and determine its correlation with diabetic nephropathy. This study wasperformed at Dr. Wahidin Sudirohusodo Hospital, Makassar, by taking the data from the medical record of type 2 DMpatients from January to April 2018. Fifty-nine patients with diabetic nephropathy and 150 patients without diabeticnephropathy participated in this study. An independent T-test and Pearson's correlation test were used for statisticalanalysis. There was a significant difference in uric acid level between patients with and without diabetic nephropathy(9.57±3.42 mg/dL vs. 6.41±2.86 mg/dL, p < 0.001). There was significant correlation between uric acid serum levels with urea(p < 0.001, r=0.585), creatinine (p<0.001, r=0.413) and eGFR (p < 0.001, r=-0.525) in patients with diabetic nephropathy. Uricacid levels in patients with diabetic nephropathy were higher than patients without diabetic nephropathy. Higher levels ofurea and the serum creatinine led to higher levels of serum uric acid. Contrastingly, a lower eGFR rate led to higher levels ofuric acid.

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