scholarly journals A clinical and biochemical laboratory profile to measure the severity of dengue fever and their outcome

2020 ◽  
Vol 8 (1) ◽  
pp. 108
Author(s):  
Maddipatla Sushma ◽  
M. V. Nagabhushana ◽  
M. Dharaneedhar Reddy
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Elevated Serum ◽  
Dengue Shock Syndrome ◽  
Positive Outcome ◽  
Acute Onset ◽  
Presenting Symptoms ◽  
Elevated Liver Enzymes ◽  
The Common ◽  
Diagnostic Modalities

Background: To identify various manifestations of dengue fever, complications, and to measure their association with laboratory findings.Methods: 100 cases of suspected adults between 20-70 years of age with clinical features suggestive of dengue infection and patients presenting with fever of acute onset (<2 weeks), pain abdomen, vomiting, rash, flushed appearance and bleeding manifestation were studied. All cases were followed up for the clinical and laboratory parameters and treated according to WHO guidelines.Results: 36 were classified as classical dengue fever, 33 as dengue haemorrhagic fever (DHF), 15 as dengue shock syndrome (DSS), and 16 as dengue-like illness (DLI) and the common age group was 30-40 year (50%). Most (66%) of the patients were male. The common presenting symptoms was fever 65%, vomiting (40%), abdominal pain (40%), myalgia (7%), etc. Hepatomegaly (53%), ascites (1%), splenomegaly (8%) was noted. The mean platelet in the present study was 41870 cells/cu mm. Elevated liver enzymes and elevated serum creatinine was found in complicated forms of disease. The prothrombin time ranged from 11-60 sec with a mean of 19.5 sec.Conclusions: The treatment of dengue is mainly supportive, but early institution and meticulous monitoring are the important steps for positive outcome. Much more awareness, vigilance and research in the diagnostic modalities are further needed to avoid unnecessary panic and platelet transfusions.

scholarly journals A clinical and biochemical laboratory profile to measure the severity of dengue fever in paediatric population and their outcome

2021 ◽  
Vol 8 (3) ◽  
pp. 535
Author(s):  
Sandhya Rani Talari ◽  
Gangadhar Belavadi
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Elevated Serum ◽  
Clinical Manifestations ◽  
Paediatric Population ◽  
Positive Outcome ◽  
Clinical Findings ◽  
Total Leukocyte Count ◽  
Presenting Symptoms ◽  
Elevated Liver Enzymes

Background: Aim of the study was to assess various clinical manifestations of dengue fever, and complications, to establish the diagnosis of dengue fever based on dengue antigen (NS 1) and antibody (IgM, IgG) and to find the association between the clinical findings with laboratory findings.Methods: 100 cases of suspected children below 18 years of age with clinical features suggestive of dengue infection and children presenting with fever of acute onset (<2 weeks), pain abdomen, vomiting, rash, flushed appearance and bleeding manifestation were studied. The cases were followed up for the clinical and laboratory parameters and were treated according to WHO guidelines.Results: Out of total 100 cases studied 36 were classified as classical dengue fever, 33 as DHF, 15 as DSS, 16 as DLI. It was observed that the disease was common in age group of 5-11 year (54%). Most of the patients were male (66%) with an M:F ratio of 1.94:1. The common presenting symptoms were fever (96%), vomiting (49%), abdominal pain (42%), headache (12%), myalgia (7%), arthralgia (4%), retro orbital pain (1%). General physical examination revealed presence of hypotension, tachycardia, rashes, facial puffiness (28%), pedal oedema (21%), and conjunctival congestion (18%). The skin bleeding was the most common manifestation noted in 12 cases (12%) followed by GIT bleeding like hematemesis 4 cases (4%) followed by epistaxis 4 cases (4%), haematuria 2 cases (2%) and gum bleeds 2 cases (2%). In systemic examination patients were found to have hepatomegaly (53%), ascites (13%), splenomegaly (8%), and pleural effusion (27%). 36 (36%) patients in the study had leucopoenia and mean total leukocyte count of 6014.5 cells/cu mm. The highest and lowest TLC was 22000 and 1400 cells/cumm respectively. 85% cases had thrombocytopenia in the present study. The mean platelet in the present study was 41870 cells/cu mm. Elevated liver enzymes and elevated serum creatinine count was found in complicated forms of disease.Conclusions: The treatment of dengue is mainly supportive, but early institution and meticulous monitoring are the corner stone for positive outcome. Much more awareness, vigilance and research in the diagnostic modalities is further needed to avoid unnecessary panic and platelet transfusions.

scholarly journals Dengue fever complicated with acute liver failure: A case report of expanded dengue syndrome and literature review

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091342 ◽  
Author(s):  
Navaneethakrishnan Suganthan ◽  
Gajawathana Sakthilingham ◽  
Thirunavukarasu Kumanan
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Acute Hepatic Failure ◽  
Fresh Frozen Plasma ◽  
Uneventful Recovery ◽  
Fresh Frozen ◽  
Plasma Leakage

Dengue is the most common arboviral disease, the presentation of which ranges from asymptomatic illness to dengue shock syndrome. Liver is the most common organ affected in dengue, and liver involvement is asymptomatic in majority. Dengue fever is a rare, but a leading cause for acute liver failure in endemic regions. Here, we report a case of a 34-year-old male ethanol user (16 units per week), presented with typical features of dengue infection, which was confirmed serologically, complicated with acute liver failure without clinical, radiological or laboratory evidence of plasma leakage. He was managed with intravenous fresh frozen plasma and N-acetyl cysteine along with other recommended supportive therapies for acute hepatic failure. He made an uneventful recovery.

scholarly journals Clinical Profiles of Dengue Infection during an Outbreak in Northern India

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Anish Laul ◽  
Poonam Laul ◽  
Vamsi Merugumala ◽  
Ravi Pathak ◽  
Urvashi Miglani ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Acalculous Cholecystitis ◽  
Signs And Symptoms ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Mosquito Vector ◽  
Diagnostic Dilemma ◽  
Atypical Presentations

Introduction.Dengue fever is an arboviral disease, which is transmitted by mosquito vector and presents as varied clinical spectrum of dengue fever (DF), dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), and expanded dengue syndrome (EDS) with atypical presentations, thus posing a diagnostic dilemma. Unless we are aware of these presentations, diagnosis as well as early initiation of treatment becomes difficult. We studied the various clinical presentations of dengue infection during an outbreak of disease in 2015.Materials and Methods. A total of 115 confirmed cases of dengue infection from Department of Medicine of Deen Dayal Upadhyay Hospital, New Delhi, were enrolled in this observational study.Results.The common signs and symptoms of dengue infection were fever, headache, body ache, backache, retro-orbital pain, bleeding manifestations, and rash in 100%, 87%, 86%, 58%, 41%, 21%, and 21%, respectively. Nonspecific or warning signs and symptoms included vomiting, weakness, abdominal pain, breathlessness, vertigo, sweating, and syncope. Other possible signs and symptoms of coinfections, comorbidities, or complications included diarrhea, sore throat, and neurological manifestations. There were seven patients with coinfections and four with comorbidities. The final diagnosis of these patients was DF (73%), DHF (16.5%), DSS (1.7%), and EDS (4.3%). Among EDS patients, the atypical presentations included encephalopathy, lateral rectus nerve palsy, acalculous cholecystitis, and myocarditis. Four patients required ICU care and there was no death in this study.Conclusion. Knowledge of atypical presentations is a must for early diagnosis and timely intervention to prevent life-threatening complications.

scholarly journals Effect of Prior Symptomatic Dengue Infection on Dengue Haemorrhagic Fever (DHF) in Children

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Randula Ranawaka ◽  
Chamara Jayamanne ◽  
Kavinda Dayasiri ◽  
Dinuka Samaranayake ◽  
Udara Sandakelum ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Past History ◽  
Secondary Infection ◽  
Severe Disease ◽  
Dengue Infection ◽  
Dengue Shock Syndrome ◽  
Dengue Haemorrhagic Fever ◽  
Severe Dengue ◽  
Haemorrhagic Fever ◽  
History Of

Pathogenesis of dengue haemorrhagic fever is not fully understood, but it is thought that there is antibody enhancement during the secondary infection, which causes severe dengue haemorrhagic fever (DHF). Therefore, patients who have DHF should have a documented history of symptomatic dengue infection in the past. A retrospective descriptive-analytical study was conducted at the University Paediatric Unit at Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. All children who had fulfilled the criteria for DHF admitted to the unit from April 2018 to September 2018 were recruited into the study. Relevant data were collected from bed head tickets. One hundred and eighty-four children were included in the final analysis. Thirty-three (17.9%) had a past history of documented symptomatic dengue infection, while 82.1% did not have a documented dengue infection. Twelve patients had dengue shock syndrome, and none of them had previously documented symptomatic dengue fever. Dextran was used in 96 patients in the critical phase. Twelve (42%) patients with past documented symptomatic dengue fever needed dextran while 84 (54.9%) patients without a documented past history of dengue fever needed dextran. In our clinical observation, we noticed that children with DHF mostly did not have a documented symptomatic prior dengue infection, while those with a documented symptomatic prior infection had a milder subsequent illness. In fact, the majority (82.1%) of patients with DHF did not have documented previous symptomatic dengue infection. It was also observed that the clinical course of subsequent dengue infection was less severe in patients with previously documented symptomatic dengue fever. This finding should be further evaluated in a larger scale study minimizing the all-confounding factors. This fact is more important in selecting recipients for vaccines against the dengue virus, which are supposed to produce immunity against the virus without causing the severe disease.

scholarly journals Importance of Platelet Count and Hematocrit in Dengue Fever in Children

2021 ◽  
Vol 44 (2) ◽  
pp. 74-77
Author(s):  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Kazi Iman ◽  
UK Ghosh ◽  
NK Ghosh
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Care Hospital ◽  
Pediatric Age Group

Background: Dengue fever has become one of the most important public health concerns now a day due to increasing complications and fatal outcomes. Dengue hemorrhagic fever and dengue shock syndrome are life threatening but reversible complications of dengue fever. Objectives: This study was performed to evaluate the relationship between platelet count and hematocrit with the severity of dengue infection in pediatric age group. Materials & Methods: This was a prospective observational study which included 280 dengue seropositive children of 1 month to 15 years, conducted during 1st June to 30th November, 2018 in a tertiary care hospital of Dhaka. Results: Out of 280 dengue cases, 187(66.78%) had thrombocytopenia and 88(47%) had raised hematocrit. Among the thrombocytopenic patients 44% had dengue fever, 47% had dengue hemorrhagic fever and 9% dengue shock syndrome. A significant co-relation was observed between the severities of thrombocytopenia and raised hematocrit with the appearance of dengue warning signs in case of dengue hemorrhagic fever. Conclusion: Thrombocytopenia and raised hematocrit were related to the severity of dengue hemorrhagic fever. Bangladesh J Child Health 2020; VOL 44 (2) :74-77

scholarly journals Evaluation of Dengue Fever in A Tertiary Care Children Hospital of Bangladesh

2018 ◽  
Vol 9 (1) ◽  
pp. 274-277
Author(s):  
Mohammed Reaz Mobarak ◽  
Md Rafiqul Islam ◽  
AKM Tajuddin Bhuiyan ◽  
Nabila Akand ◽  
Ferdousi Begum
Keyword(s):  
Dengue Fever ◽  
Eastern Mediterranean ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Febrile Illness ◽  
Study Patient ◽  
Major Public Health Problem ◽  
Age Group ◽  
Presenting Symptoms

Background : Dengue is a mosquito-borne (Ades Agepti) infection which in recent years has become a major public health problem. It is now endemic in more than 100 countries in Africa, America, Eastern Mediterranean, South-East Asia and Western Pacific areas. According to WHO currently approximately 50 million cases of dengue fever occur every year.Objective : To evaluate the current clinical picture, outcome and serology of children suffering from dengue fever admitted in a tertiary care children hospital.Methodology : It is a hospital based prospective observational study carried out among the children having Dengue infection admitted during the period of June to December 2016 in Dhaka Shishu (Children) Hospital. After obtaining informed consent 78 suspected cases of dengue fever patients were enrolled for this study. Patient with any identified specific infection or febrile illness more than 14 days and serologically dengue negative cases were excluded from the study. A detailed history, demographic variables, clinical examination and relevant laboratory investigations were assessed. The data were collected in a predesigned structured questionnaire and were analyzedwith the help of SPSS-21.Result : Out of 78 suspected dengue cases a total of 56 cases were serologically dengue positive. Therefore 22 serologically dengue negative cases were excluded. Most common presenting symptoms were fever (100%) followed by myalgia76.79%, retro-orbital pain73.21%, and conjunctival hemorrhage 55.35%, skin rash 55.35%, with other symptoms constituting the rest. Among the serologically positive dengue cases those who presented with fever for 3 days or of lesser duration, NS1 Ag was positive in 34 cases ( 43.58%) and those who presented with fever for 6 days or more, 14 cases (17.95%) were dengue IgM positive and 8 cases (10.25%) were dengue IgG positive with accompanying low level IgM positive; platelet count 94333/mm3 (±68330), PCV 35 (±3.95) and SGPT 210 U/L(±80).Among 56 dengue positive cases 31(55.4%) were male and 25 (44.6%) were female, The age range was 1 years to 18 years with mean 6.66 ±3.69, predominant age group was 6 years to 12 years. Final diagnosis according to WHO classification were DF 42.68%, DHF-l 32.14%, DHF–ll 16.07%,DHF-lll 8.93%. Outcome of the disease were 89.3% discharge with advice (DA),7.1% discharge on request(DOR), 3.6% left against medical advice(LAMA) and no death.Conclusion : The trend of Dengue infection in Bangladesh has been changing very rapidly. In this study our observation was incidence of dengue was more in male child, peak age group being 6 years to 12 years with most admissions during the month of September. Fever with pain (body ache, retro orbital pain), headache and maculopapular rash, positive NS1Ag and dengue IgM were the main findings found in children with dengue. Most of the dengue cases were DF and DHF-l in our study.Northern International Medical College Journal Vol.9(1) July 2017: 274-277

scholarly journals A study of various hepatic manifestations in dengue fever and their correlation with severity of dengue fever

2020 ◽  
Vol 7 (3) ◽  
pp. 527
Author(s):  
Shravya Dhanwada ◽  
Samba Siva Reddy R.
Keyword(s):  
Dengue Fever ◽  
Complete Blood Count ◽  
Dengue Infection ◽  
Liver Function Tests ◽  
Warning Signs ◽  
Severe Dengue ◽  
Serum Total Bilirubin ◽  
Hepatic Involvement ◽  
Elevated Liver Enzymes ◽  
A Prospective Study

Background: Hepatic involvement in Dengue is known with protean of manifestations ranging from hepatomegaly, elevated liver enzymes to fulminant hepatic failure. Aim of the study was to study the hepatic manifestations in children with dengue illness.Methods: This is a prospective Study with 60 Patients hospitalized with Dengue infection (Seropositive for Dengue). Dengue Seropositive patients are selected and examined for Hepatomegaly and Jaundice and subjected to complete blood count and Liver function tests were analysed.Results: Of 60 serologically confirmed cases hospitalized with dengue, were classified into (i)(DF), (ii) DHF I (iii) DHF II (iv) DHF III and (v) DHF IV.  In our study, upon 60 seropositive cases were reported at our hospital during the study period of which 18 were DF, 12 were DHF I, 15 were DHFII, 8 were DHF III and 7 were DHF IV respectively. The Hematocrit levels were raised 20% from the baseline in four classes of Dengue and not raised in DF. Most commonly occurred in age group of 5-7 years. Hepatomegaly was the commonest clinical sign seen. Thrombocytopenia was seen in 88% of all cases. Serum total bilirubin was raised in 10% of subjects with severe dengue infection in DHF III and DHF IV. Serum SGOT and SGPT was raised in 63.3% and 56.7% of patients with dengue of all classes including DF respectively. Thrombocytopenia occurred in 75% of patients with dengue fever, 98% with warning signs and 100% in severe dengue.Conclusions: In developing country like India, incidence of dengue outbreaks is increasing. Hepatic involvement of varying degrees have been reported. As hepatic dysfunction in dengue is transient and reversible, early identification of the same would help to reduce life threatening complications. The role of hepato protective drugs in reducing morbidity and mortality should be analysed by further studies. 

scholarly journals Clinico-laboratory profile and outcome of dengue fever among children attending a tertiary care hospital of rural Telangana, India

2020 ◽  
Vol 7 (2) ◽  
pp. 382 ◽  
Author(s):  
V. Shekar ◽  
K. Praveen Kumar ◽  
C. Soren ◽  
K. Venkataramana Reddy ◽  
N. Dharani
Keyword(s):  
Dengue Fever ◽  
Tertiary Care Hospital ◽  
Early Recognition ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Warning Signs ◽  
Severe Dengue ◽  
Severe Thrombocytopenia ◽  
Care Hospital ◽  
Presenting Symptoms

Background: Dengue is a self-limiting, vector-borne disease transmitted by Aedes mosquito, causing a major public health threat globally. The objective of this study is to assess the clinical profile and outcome of the dengue infection in children less than 14 years of age September 2018 to August 2019 at the Pediatric Department of S.V.S. Medical College, the tertiary care hospital in Mahabubnagar, Telanagana.Methods: Prospective study of 82 hospitalized children of <14 years with the diagnosis of dengue illness. Children with diagnosis of dengue were classified further in to two groups as per WHO guidelines, Non-severe dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (Dengue Haemorrhagic Fever and/or Dengue Shock Syndrome (DHF/DSS). A separate questionnaire form used for documenting clinical history, laboratory parameters. Haematological parameters were noted, chest x-ray, ultra-sonogram in required cases was done. Children were managed as per WHO protocol. The outcomes of the cases were mentioned as discharge, left against medical advice and death.Results: A total of 82 children with dengue were divided in to 55(67%) non severe dengue and 27(33%) severe dengue with males 56(68.2%) and females 26(31.7%). The most common age of presentation was between 6-10 years 34(41.5%). Fever 73(89%) was the most common presenting symptoms. Pleural effusion and hepatomegaly were the commonest clinical findings 28(34.1%) each, which were more among the severe dengue patients. Gall bladder edema 29(35.3%) was the most common ultra-sonogram finding. Significant elevation of transaminases (SGOP, SGPT) was seen in 39(47.5%). Severe thrombocytopenia was observed in 22(26.8%) children. Management was by administration of colloids and crystalloids.Conclusions: Dengue is a global problem. Presenting features include high grade fever, vomiting, abdominal pain, skin rash. Early recognition of symptoms and proper management can reduce the mortality.

Dengue Fever and Thrombocytopenia: A Deadly Duo.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3978-3978
Author(s):  
Ajit Lale ◽  
Seema Lale ◽  
Rodger Bick ◽  
Jawed Fareed
Keyword(s):  
Early Detection ◽  
Dengue Fever ◽  
Laboratory Finding ◽  
Vascular Complications ◽  
Supportive Therapy ◽  
Dengue Shock Syndrome ◽  
Close Monitoring ◽  
Transfusion Therapy ◽  
Elevated Liver Enzymes ◽  
Platelet Transfusions

Abstract Dengue fever (DF) is one of the most ill understood diseases of Asian Pacific countries which is associated with reversible vascular complications. These complications are part of severe manifestations of Dengue Haemorregic Fever (DHF) and Dengue Shock Syndrome (DSS) which can be prevented with early detection and appropriate interventions. Increased hematocrit, elevated liver enzymes, altered coagulation profile and decreased platelet count are some of the parameters which predicts severity of this disease. Thrombocytopenia is always considered a predictive parameter for the inpatient management of dengue fever as well as recovery parameter in DHF and DSS. We examined 28 reviews and original articles out of 175 listed in “Pub med” on Dengue Fever and thrombocytopenia to find any possible relevance with the pathophysiology of thrombocytopenia and clinical bleeding in dengue across the spectrum of disease. Correlation between platelet counts and development of clinical bleeding was also studied as well as diagnostic markers for early detection. Finally, we summarize recent reports on treatment of thrombocytopenia, including evidence for conservative use of platelet transfusions and briefly complications of platelet transfusions. Thrombocytopenia is the most common laboratory finding in dengue patients, most patients manifesting petechiae, epistaxis, and mild mucosal bleeding. Severe hemorrhage is catastrophic and associated high mortality. Close monitoring of the patient for hemorrhagic manifestations and marked thrombocytopenia is strongly recommended. Other modalities include transfusion therapy with supportive therapy.

scholarly journals Study of incidence, manifestations and complications of dengue fever

2018 ◽  
Vol 5 (1) ◽  
pp. 137
Author(s):  
Jahnavi K. ◽  
Srinivasulu T.
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Simple Random Sampling ◽  
Study Data ◽  
World Health ◽  
Care Hospital

Background: Dengue is endemic in India and epidemics are common. Due to poor availability of resources, there is increased morbidity and mortality related to dengue. The objective of the research to study the incidence, manifestations and complications of dengue fever.Methods: Patients admitted in medicine wards of a tertiary care hospital during the study period of two years with the history of fever with other nonspecific symptoms were included in the present study. Data was collected in a pre-tested proforma by meeting objectives of the present study. 100 patients who fulfilled World Health Organization criteria for dengue fever were selected by simple random sampling method.Results: In 75 patients the platelet count was above 150000cell/cumm. Most of them had dengue fever. 12 patients showed platelet count between 20000-100000cells/cumm. and among them 10 were DHF and 2 were simple dengue infection. Five patients showed platelet count less than 20000cells/cumm. and among them 2 were DHF and 3 were DSS. Most of the bleeding skin manifestations were seen when platelet count was below 50000cells/cumm. Mucosal bleeding was observed when the platelet count was below 30000cells/cumm. Abnormal coagulation profile was noted in 18% of the patients and 6% patients were in acute renal failure. Mortality was 0% in dengue fever, 44% in DHF and 100% in DSS.Conclusions: Platelet count was directly related to the number of complications. Dengue shock syndrome and dengue hemorrhagic fever was associated with increased mortality.

Sign in / Sign up

Export Citation Format

Share Document