scholarly journals Pheochromocytoma related intracerebral hemorrhage, hypertrophic obstructive cardiomyopathy and diabetes mellitus

2021 ◽  
Vol 8 (4) ◽  
pp. 611
Author(s):  
Arundhati Diwan ◽  
Chandrakant Chavan ◽  
Varsha Jagtap ◽  
Preeti Dave ◽  
Sampada Karne ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Intracerebral Hemorrhage ◽  
Neuroendocrine Tumors ◽  
Early Recognition ◽  
Young Patients ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Clinical Complications ◽  
Catecholamine Excess

Pheochromocytomas are rare catecholamine secreting neuroendocrine tumors that can cause intracerebral hemorrhage sometimes and can very rarely cause cardiomyopathy simulating hypertrophic obstructive cardiomyopathy. We report a case of combination of these rare clinical complications occurring in a patient with pheochromocytoma. This case illustrates importance of early recognition of classic symptoms of catecholamine excess in young patients with hypertension. 

scholarly journals Diabetes Mellitus and Its Effects on All-Cause Mortality After Radiopeptide Therapy for Neuroendocrine Tumors

2016 ◽  
Vol 58 (1) ◽  
pp. 97-102 ◽  
Author(s):  
Maria Umlauft ◽  
Piotr Radojewski ◽  
Petar-Marko Spanjol ◽  
Rebecca Dumont ◽  
Nicolas Marincek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Neuroendocrine Tumors ◽  
Radiopeptide Therapy ◽  
All Cause Mortality

scholarly journals Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know?

2021 ◽  
Vol 32 (1) ◽  
pp. 154-168 ◽  
Author(s):  
Marco Volante ◽  
Ozgur Mete ◽  
Giuseppe Pelosi ◽  
Anja C. Roden ◽  
Ernst Jan M. Speel ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Young Patients ◽  
Carcinoid Tumors ◽  
Neuroendocrine Neoplasms ◽  
Grey Zone ◽  
Cell Hyperplasia ◽  
Ki 67 ◽  
Familial Form ◽  
Well Differentiated ◽  
Neuroendocrine Carcinomas

AbstractThoracic (pulmonary and thymic) neuroendocrine tumors are well-differentiated epithelial neuroendocrine neoplasms that are classified into typical and atypical carcinoid tumors based on mitotic index cut offs and presence or absence of necrosis. This classification scheme is of great prognostic value but designed for surgical specimens, only. Deep molecular characterization of thoracic neuroendocrine tumors highlighted their difference with neuroendocrine carcinomas. Neuroendocrine tumors of the lung are characterized by a low mutational burden, and a high prevalence of mutations in chromatin remodeling and histone modification-related genes, whereas mutations in genes frequently altered in neuroendocrine carcinomas are rare. Molecular profiling divided thymic neuroendocrine tumors into three clusters with distinct clinical outcomes and characterized by a different average of copy number instability. Moreover, integrated histopathological, molecular and clinical evidence supports the existence of a grey zone category between neuroendocrine tumors (carcinoid tumors) and neuroendocrine carcinomas. Indeed, cases with well differentiated morphology but mitotic/Ki-67 indexes close to neuroendocrine carcinomas have been increasingly recognized. These are characterized by specific molecular profiles and have an aggressive clinical behavior. Finally, thoracic neuroendocrine tumors may arise in the background of genetic susceptibility, being MEN1 syndrome the well-defined familial form. However, pathologists should be aware of rarer germline variants that are associated with the concurrence of neuroendocrine tumors of the lung or their precursors (such as DIPNECH) with other neoplasms, including but not limited to breast carcinomas. Therefore, genetic counseling for all young patients with thoracic neuroendocrine neoplasia and/or any patient with pathological evidence of neuroendocrine cell hyperplasia-to-neoplasia progression sequence or multifocal disease should be considered.

MCP-1and IL-1β expression in the myocardia of two young patients with Type 1 diabetes mellitus and fatal diabetic ketoacidosis

2014 ◽  
Vol 96 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Jianli Niu ◽  
M.G.F. Gilliland ◽  
Zhuqing Jin ◽  
Pappachan E. Kolattukudy ◽  
William H. Hoffman
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Young Patients

Increased Collagen-Linked Fluorescence in Skin of Young Patients With Type I Diabetes Mellitus

Diabetes Care ◽  
1990 ◽  
Vol 13 (5) ◽  
pp. 468-472 ◽  
Author(s):  
M. H. Dominiczak ◽  
J. Bell ◽  
N. H. Cox ◽  
D. C. McCruden ◽  
S. K. Jones ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Young Patients ◽  
Type I Diabetes Mellitus ◽  
Type I

CLINICAL PROFILE OF PATIENTS OF YOUNG STROKE.

2021 ◽  
pp. 68-70
Author(s):  
Nitin Hiraman Suryawanshi ◽  
Amit Aggarwal ◽  
Abhijit Kadam
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Young Patients ◽  
Behavioural Pattern ◽  
Long Term Outcomes ◽  
Short Term ◽  
Traditional Risk Factors ◽  
The Individual ◽  
Stroke In Young

A study of stroke in young patients has recently become a subject of interest. This is due to a lot of impact on the individual and society. Study of stroke in young patients can lead to therapeutical results affecting both short term and long-term outcomes. Our study is hospital based retrospective study for duration of 1 year. Thi Methods: Results: s study revealed stroke in young in 25.16% of all stroke cases, with cerebral infarction in 56% and followed by intracerebral haemorrhage in 25.64%, and cerebral venous thrombosis in 18%. The most common presenting symptom was hemiparesis. The most prevalent risk factor for stroke in young was hypertension followed by diabetes mellitus, alcohol consumption and smoking. Stroke in young requires a differe Conclusion: nt approach to investigate and treat. This is due to different underlying etilogy as compared to elderly. Although traditional risk factors are associated with stroke, behavioural pattern such as smoking and alcohol may cause and promote development of stroke in young.

scholarly journals A study to assess the clinicopathological spectrum of acute complications of diabetes mellitus type II

2020 ◽  
Vol 8 (9) ◽  
pp. 3246
Author(s):  
Kunal Lala ◽  
Viren Bhati ◽  
Divya Lala ◽  
Smita Patil
Keyword(s):  
Diabetes Mellitus ◽  
Early Recognition ◽  
Diabetes Mellitus Type ◽  
Morbidity And Mortality ◽  
Type Ii ◽  
Metabolic Complications ◽  
Complications Of Diabetes ◽  
Diabetes Mellitus Type Ii ◽  
Acute Complications ◽  
Study Population

Background: The acute metabolic complications of diabetes consist of diabetic ketoacidosis (DKA), hyperosmolar non-ketotic coma (HNC), lactic acidosis (LA), and hypoglycemia. All of these are associated with significant morbidity and mortality. These can easily be prevented by early recognition and prompt management. Therefore, this study was conducted to assess the clinicopathological spectrum of acute complications of diabetes mellitus type II.Methods: This observational, analytical study was conducted on 100 patients aged more than 18 years admitted in the ICU with acute complication of Diabetes mellitus Type II. Medical history was recorded. Physical examination and investigations were done and recorded.Results: The mean age of the study population was 55.26±13.13 years. Hypoglycemia was more common (63%) than DKA (37%). Fever and sweating had the overall highest incidence (and were more in patients with hypoglycemia) while stupor, nausea and abdominal pain had the lowest incidence (and were more in patients with DKA). On examination, only one patient of DKA was drowsy. Mean temperature, pulse and respiratory rate were higher in the patients having DKA while blood pressure was higher in patients having hypoglycemia.Conclusions: It can be effectively concluded from the present study that DKA and hypoglycaemia have a broad spectrum of clinicopathological features. But the incidences vary widely. This may help in early recognition of the impending complication and thereby enabling prompt management of the same, reducing the associated morbidity and mortality.  

Sign in / Sign up

Export Citation Format

Share Document