scholarly journals A cross-sectional observational study assessing the liver function in malarial patients

2021 ◽  
Author(s):  
Dhara P. Mehta ◽  
Purva C. Shah ◽  
Meena Daveshwar
Keyword(s):  
Plasmodium Falciparum ◽  
Liver Function ◽  
Plasmodium Vivax ◽  
Febrile Illness ◽  
Cross Sectional Study ◽  
Central Laboratory ◽  
Cross Sectional ◽  
Mean Values ◽  
Correct Path ◽  
Altered Liver

Background: Malaria is a major cause of morbidity in the tropics, being a disease of global importance that results in 300-500 million cases annually. Liver involvement manifests as jaundice, hyperbilirubinemia, hepatomegaly and elevated enzymes (transaminases and alkaline phosphatase). Our objective in this study was to evaluate the role of liver function as an indicator of malaria in endemic regions and as a marker of disease severity.Methods: This was an observational cross-sectional study conducted in central laboratory, department of pathology, central laboratory, department of biochemistry, and out-patient department, department of medicine, medical college Baroda and SSG hospital over a period of ten months, from February, 2019 to November, 2019 and included 137 microscopy proven malaria positive cases. The parasite density on peripheral smear was graded as scanty, moderate and heavy.  After procuring the records of serum bilirubin, SGPT and SGOT, statistical analysis of the data was performed.Results: All the 3 parameters show maximum derangement in severe parasitemia with mean values of 3.57, 81.44, and 92.9. While comparing vivax and falciparum malaria, all the LFTs studied show greater derangement in Plasmodium Falciparum when compared to Plasmodium vivax, with greatest difference seen in bilirubin levels (27.78% cases with hyperbilirubinemia in Plasmodium vivax versus 71.43% cases of Plasmodium falciparum showing hyperbilirubinemia).Conclusions: We conclude that altered liver function in form of hyperbilirubinemia and increased liver enzymes in a patient with acute febrile illness increase the probability of malaria, hence directing the clinician along the correct path of further work-up and accurate treatment.

scholarly journals Species of plasmodium (P. Falciparum and P. Vivax) involved in children with malaria: An experience from a tertiary childcare hospital.

2021 ◽  
Vol 28 (7) ◽  
pp. 997-1001
Author(s):  
Muhammad Shahzad Maqsood ◽  
◽  
Safdar Hussain ◽  
Asim Khurshid ◽  
Sana Waqar ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Rural Areas ◽  
Family Income ◽  
Complete Blood Count ◽  
Venous Blood ◽  
Previous History ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
History Of Use

Objective: To find out different species of plasmodium (P. falciparum and P. vivax) involved in children with malaria at a tertiary childcare hospital. Study Design: Descriptive, Cross-sectional study. Setting: Department of Paediatric Medicine, The Children’s Hospital and Institute of Child Health, Multan. Period: October 2019 to March 2020. Material & Methods: A total of 281 cases of either gender, aged 1 to 12 years and patients with malaria were enrolled. A special template was designed to record study information. Venous blood as five ml sample was drawn and dispatched to institutional laboratory for ICT malaria, complete blood count and giemsa stain smear and observed under light microscope. Data analysis was performed employing SPSS version 24.0. Results: Out of a total of 281 cases, 177 (63.0%) were male ande 104 (37.0%) female. Mean age of study participants was 4.29±2.48 years. A total of 135 (48.0%) children belonged to rural areas and 197 (70.1%) had monthly family income < 25000 rupees. Mean duration of illness was 4.21 ± 2.12 days. Previous history of use of anti-malarial drugs was noted in 62 (22.1%) of our study cases. Plasmodium falciparum was observed in 52 (18.5%) cases and plasmodium vivax in 229 (81.5%). Conclusion: Plasmodium vivax is predominantly more prevalent in our population as compared with plasmodium falciparum in children with malaria. Plasmodium falciparum and plasmodium vivax were significantly linked with age and disease duration. Malaria was noted to be more prevalent among poor families living in slum areas having inadequate sanitation facilities.

scholarly journals Gambaran Diagnosis Malaria pada Dua Laboratorium Swasta di Kota Padang Periode Desember 2013 – Februari 2014

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Hans Everald ◽  
Nurhayati Nurhayati ◽  
Elizabet Bahar
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Laboratory Personnel ◽  
Comparison Results ◽  
Private Laboratory ◽  
Kappa Value ◽  
Examination Preparation

Abstrak Pengobatan malaria membutuhkan ketepatan metode pemeriksaan laboratorium yang akurat oleh tenaga laboratorium. Kemampuan tenaga laboratorium perlu dilakukan pengamatan dan pemantauan secara terus menerus untuk menjaga efektivitas pemeriksaan sediaan. Tujuan penelitian ini adalah mengetahui efektivitas diagnosis malariadi laboratorium swasta di Kota Padang. Penelitian ini merupakan uji diagnostik dengan rancangan penelitian Cross Sectional Study terhadap laboratorium swasta di Kota Padang. Sampel yang didapatkan dalam penelitian ini berjumlah 53 slide lalu slide tersebut dibandingkan dengan Cross Checker. Dalam penelitian ini ditemukan bahwa spesiesterbanyak adalah Plasmodium vivax dan Plasmodium falciparum. Hasil perhitungan nilai Kappa adalah 0,5 dan perbandingan hasil pemeriksaan parasit P. falciparum pada laboratorium swasta adalah 17,8% dan pemeriksaan Cross checker 1,88%. Untuk P. vivax pada laboratorium swasta adalah 43,01% dan pemeriksaan Cross Checker 13,2%. Kesimpulan hasil ini adalah P. faciparum dan P. vivax adalah spesies yang sering ditemukan dengan nilai perhitungan Kappa menunjukkan hasil sedang dan terdapat perbedaan hasil pembacaan sediaan antara laboratorium swasta dengan yang dilakukan Cross checker. Kata kunci: malaria, efektivitas, plasmodium falciparum, plasmodium vivaxAbstract  Treatment of malaria need the accuracy of laboratory examination method by a laboratory personnel. The ability of laboratory personnel is need to doing observation and monitoring continuously to maintain the effectiveness of examination preparation. The objective of this study was to determine the effectiveness diagnosis of malaria in a private laboratory in Padang. This was a diagnostic test with a cross sectional study research design to a private laboratories in the city of Padang. Samples obtained in this study amounted to 53 slides and the slides were comparedwith Cross Checker. In this study it was found that most species were Plasmodium vivax and Plasmodium falciparum. The result of kappa value was 0,5 and the comparison results of the parasite P. falciparum in private laboratories were 17,8% and the Checker Cross examination are 1,88%.   P. vivax in private laboratories are 43,01% and the checker cross examination are 13,2%. The conclusion is P. vivax and P. faciparum are species that is often found by calculating Kappa values showed moderate results and there is a difference between the dosage readings with aprivate laboratory that performed Cross checker.Keywords: malaria, effectiveness, plasmodium falciparum, plasmodium vivax.

Effect of Medialization of the Trochlear Groove and Lateralization of the Tibial Tubercle on TT-TG Distance: A Cross-sectional Study of Dysplastic and Nondysplastic Knees

2021 ◽  
pp. 036354652098781
Author(s):  
Mathias Paiva ◽  
Lars Blønd ◽  
Per Hölmich ◽  
Kristoffer Weisskirchner Barfod
Keyword(s):  
Trochlear Dysplasia ◽  
Cross Sectional Study ◽  
Magnetic Resonance Images ◽  
Tibial Tubercle ◽  
Control Group ◽  
Trochlear Groove ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean

Background: Tibial tubercle–trochlear groove (TT-TG) distance is often used as a measure of lateralization of the TT and is important for surgical planning. Purpose: To investigate if increased TT-TG distance measured on axial magnetic resonance images is due to lateralization of the TT or medialization of the TG. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 84 knees (28 normal [NK], 28 with trochlear dysplasia [TD], and 28 with patellar dislocation without TD [PD]) were examined. The medial border of the posterior cruciate ligament (PCL) was chosen as the central anatomic landmark. The distance from the TT to PCL (TT-PCL) was measured to examine the lateralization of the TT. The distance from the TG to the PCL (TG-PCL) was measured to examine the medialization of the TG. Between-group differences were investigated by use of 1-way analysis of variance. Results: The mean values for TT-TG distance were 8.7 ± 3.6 mm for NK, 12.1 ± 6.0 mm for PD, and 16.7 ± 4.3 mm in the TD group ( P < .01). The mean values for TT-PCL distance were 18.5 ± 3.6 mm for NK, 18.5 ± 4.5 mm for PD, and 21.2 ± 4.2 mm in the TD group ( P = .03). The mean values for TG-PCL distance were 9.6 ± 3.0 mm for NK, 7.1 ± 3.4 mm for PD, and 5.1 ± 3.3 mm in the dysplastic group ( P < .01). Conclusion: The present results indicate that increased TT-TG distance is due to medialization of the TG and not lateralization of the TT. Knees with TD had increased TT-TG distance compared with the knees of the control group and the knees with PD. The TT-PCL distance did not differ significantly between groups, whereas the TG-PCL distance declined with increased TT-TG.

scholarly journals The epidemiology and detectability of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in low, moderate and high transmission settings in Ethiopia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Elifaged Hailemeskel ◽  
Surafel K Tebeje ◽  
Sinknesh W. Behaksra ◽  
Girma Shumie ◽  
Getasew Shitaye ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Age Groups ◽  
Diagnostic Tools ◽  
Asymptomatic Malaria ◽  
Rapid Diagnostics ◽  
Cross Sectional ◽  
Low Transmission ◽  
High Transmission ◽  
Study Sites

Abstract Background As countries move to malaria elimination, detecting and targeting asymptomatic malaria infections might be needed. Here, the epidemiology and detectability of asymptomatic Plasmodium falciparum and Plasmodium vivax infections were investigated in different transmission settings in Ethiopia. Method: A total of 1093 dried blood spot (DBS) samples were collected from afebrile and apparently healthy individuals across ten study sites in Ethiopia from 2016 to 2020. Of these, 862 were from community and 231 from school based cross-sectional surveys. Malaria infection status was determined by microscopy or rapid diagnostics tests (RDT) and 18S rRNA-based nested PCR (nPCR). The annual parasite index (API) was used to classify endemicity as low (API > 0 and < 5), moderate (API ≥ 5 and < 100) and high transmission (API ≥ 100) and detectability of infections was assessed in these settings. Results In community surveys, the overall prevalence of asymptomatic Plasmodium infections by microscopy/RDT, nPCR and all methods combined was 12.2% (105/860), 21.6% (183/846) and 24.1% (208/862), respectively. The proportion of nPCR positive infections that was detectable by microscopy/RDT was 48.7% (73/150) for P. falciparum and 4.6% (2/44) for P. vivax. Compared to low transmission settings, the likelihood of detecting infections by microscopy/RDT was increased in moderate (Adjusted odds ratio [AOR]: 3.4; 95% confidence interval [95% CI] 1.6–7.2, P = 0.002) and high endemic settings (AOR = 5.1; 95% CI 2.6–9.9, P < 0.001). After adjustment for site and correlation between observations from the same survey, the likelihood of detecting asymptomatic infections by microscopy/RDT (AOR per year increase = 0.95, 95% CI 0.9–1.0, P = 0.013) declined with age. Conclusions Conventional diagnostics missed nearly half of the asymptomatic Plasmodium reservoir detected by nPCR. The detectability of infections was particularly low in older age groups and low transmission settings. These findings highlight the need for sensitive diagnostic tools to detect the entire parasite reservoir and potential infection transmitters.

Comparative assessment of odontometric parameters for gender determination: A hospital based cross-sectional study

2021 ◽  
Vol 8 (3) ◽  
pp. 147-152
Author(s):  
Mosmi Lomi ◽  
Jonathan Daniel M
Keyword(s):  
Sexual Dimorphism ◽  
Cross Sectional Study ◽  
Mean Value ◽  
The Body ◽  
Central Incisor ◽  
Maxillary Canine ◽  
Cross Sectional ◽  
Mean Values ◽  
Gender Determination ◽  
Significant Difference

Determining gender is one of the most important procedure in forensics. Teeth are made of the most enduring mineralized tissues in the body, as such, they have an extraordinary resistance to putrefaction and the effects of external agents (physical, thermal, mechanical, chemical or biological) which makes them invaluable material for anthropological, genetic, odontologic and forensic examinations.i)To assess the degree of sexual dimorphism in maxillary canine using maxillary canine index, maxillary first molar and central incisor using mesiodistal (MD) and buccolingual/buccopalatal (BL) dimensions of the crown. ii) To determine the accuracy of maxillary canine index, first molar and central incisor dimensions (mesiodistal and buccolingual/buccopalatal) in determining sex.This study consisted of total 30 participants (males=15, females=15) of age group ranging from 20 to 35 yrs. Measurement of dimensions of selected teeth were performed on maxillary cast using digital Vernier caliper, resolution 0.01mm. Data thus obtained were analyzed statistically.The mean values of all the measurements in males were greater than females. There was statistical significant difference in mean value of bucco-lingual width of molar, mesiodistal width of canine (on left side, right side and average) and the inter-canine distance between males and females. The buccolingual width of molar showed the highest % of sexual dimorphism (5.33%) and the mesiodistal width of molar showed the least % of dimorphism (0.7%). Bucco-lingual width of molar posed the highest prediction accuracy for gender determination. We conclude that buccolingual width of maxillary first molar can be used to predict the gender when only teeth of maxillary arch are available for forensic examination.

Frequency of Suspected and Probable Case of Dengue in Adult Febrile Patients and their Knowledge about Dengue Fever

2021 ◽  
pp. 8-12
Keyword(s):  
Dengue Fever ◽  
Calculated Data ◽  
Febrile Illness ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Medical Intervention ◽  
Cross Sectional ◽  
Probable Case ◽  
Control Objective ◽  
Dengue Prevention

Background: Febrile illness is considered a frequent medical syndrome of dengue. Due to the increasing prevalence of dengue infectivity, appropriate diagnosis among patients helps regarding timely medical intervention, etiological examination as well as disease control. Objective: To estimate the frequency of suspected and probable cases of dengue in febrile patients and their knowledge about dengue fever, presenting at outdoor of Jinnah Hospital, Lahore. Methodology: It was a cross-sectional study, in which 400 adult febrile patients visiting at outdoor of Jinnah Hospital, Lahore were included. A convenient sampling technique was carried out. Among the total febrile patients included, the frequency of suspected and probable cases was calculated. Data was collected through a questionnaire, which was entered and analyzed using SPSS version 20.0. Results: Out of 400 patients, 36.5% were 21-30 years old and 53.5% were female. Among these patients, 100% had fever (>2 and <10 days), 31.8% had headache, 51.8% had myalgia and43.8% patients had arthralgia while 12.5% were suspected cases of dengue. Majority (97.2%) had knowledge that full sleeve shirt can prevent dengue, none of the respondents had knowledge regarding dengue symptoms and 76% of respondents had knowledge that dengue is fatal. For the majority (76%) of respondents, the main source of information regarding dengue was health teams. Conclusion: The study concluded that symptoms of dengue fever in the study patients, as well as the dengue, suspected cases were mainly headache, retro-orbital pain, myalgia, and arthralgia. The majority of the patients had knowledge about dengue prevention. Most of the adult febrile as well as suspected had no knowledge about the symptomology of dengue fever.

Detection of Genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria

2021 ◽  
Vol 42 (2) ◽  
pp. 206-213
Author(s):  
G.Y. Benjamin ◽  
H.I. Inabo ◽  
M.H.I. Doko ◽  
B.O. Olayinka
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Phylogenetic Tree ◽  
Genetic Markers ◽  
Cross Sectional Study ◽  
Sub Saharan Africa ◽  
Health Concern ◽  
Cross Sectional ◽  
Blood Samples ◽  
Test Kit

Malaria is a disease of public health concern in Nigeria and sub-Saharan Africa. It is caused by intracellular parasites of the genus Plasmodium. The aim of this study was to detect genetic markers associated with Plasmodium falciparum drug resistance among malaria patients in Kaduna State, Nigeria. The study was a cross-sectional study that lasted from May 2018 to October 2018. Three hundred blood samples were collected from consenting individuals attending selected hospitals, in the three senatorial districts of Kaduna State, Nigeria. Structured questionnaire were used to obtain relevant data from study participants. The blood samples were screened for malaria parasites using microscopy and rapid diagnostic test kit. Polymerase Chain Reaction was used for detection of the drug resistance genes. Pfcrt, pfmdr1, pfdhfr, pfdhps and pfatpase6 genes were detected at expected amplicon sizes from the malaria positive samples. The pfatpase6 PCR amplicons were sequenced and a phylogenetic tree was created to determine their relatedness. Result showed that Pfcrt (80%) had the highest prevalence, followed by pfdhfr (60%), pfmdr1 (36%) and pfdhps (8%). Pfatpase6 was also detected in 73.3% of the samples, and a phylogenetic tree showed relatedness between the pfatpase6  sequences in this study and those deposited in the GenBank. In conclusion, the study detected that Plasmodium falciparum genes were associated with drug resistance to commonly used antimalarials.

scholarly journals Turkish Midwifery Students’ Fear of Delivery Process

2019 ◽  
Vol 8 (3) ◽  
pp. 121-127
Author(s):  
Neslihan Keser Özcan ◽  
Nur Elçin Boyacıoğlu ◽  
Neriman Güdücü ◽  
Seda Göncü Serhatlıoğlu ◽  
Emine Yıldırım ◽  
...  
Keyword(s):  
Sampling Method ◽  
Cross Sectional Study ◽  
Normal Vaginal Delivery ◽  
Decision Making Process ◽  
Test Results ◽  
Cross Sectional ◽  
Wrong Decision ◽  
Mean Values ◽  
Breech Delivery ◽  
Spearman Correlation Test

Introduction: Fear affects a person’s decision-making process and causes a midwife to make a wrong decision about normal vaginal delivery and cesarean delivery, so research was carried out in order to determine the fields related to delivering process in which students experience the most fear and feel sufficient. Methods: A descriptive/cross-sectional study was performed between September and October 2017. The sample consisted of 732 students selected with the convenience maximum variation sampling method from six universities studying in the third and fourth years of a midwifery program. The study measured data collected with a questionnaire entitled “Midwives’ Fear of Delivery Process”. The data were analyzed in with the SPSS for Windows using percentage and mean values and Spearman correlation test. Results: In general, students are more afraid of practices with which they say they have more experience such as vaginal palpation (3.30 (0.884), rs=0.131, P*lt;0.001), and they are less afraid of practices (interventional) with which they have less experience such as breech delivery (1.70 (0.915), rs=0.048, P=0.197) or no experience at all and of cases in which they can get hurt. The students feel most sufficient when performing prenatal and postnatal practices. Conclusion: The results of our study parallel the conclusion in the literature that students are afraid of the fields that they have practiced most. Before clinical practice, instructors can determine students’ fears and deficiencies in relation to procedures and areas of practice and can develop approaches for alleviating their fears and weaknesses.

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