scholarly journals Comparative study of fluticasone propionate combined with azelastine versus fluticasone propionate alone as nasal spray in allergic rhinitis

2021 ◽  
Vol 7 (3) ◽  
pp. 487
Author(s):  
Dhanush H. C. ◽  
Santosh Malashetti ◽  
Chandrashekharayya S. H. ◽  
Prabhu Khavasi
Keyword(s):  
Allergic Rhinitis ◽  
Fluticasone Propionate ◽  
Nasal Spray ◽  
Case Series ◽  
Case Series Study ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Prospective Case Series ◽  
Group 1

<p><strong>Background: </strong>Allergic rhinitis (AR) is a symptomatic disorder of the nose induced after allergen exposure due to an IgE-mediated inflammation of membranes lining the nose. Allergic rhinitis is subdivided into intermittent (IAR) or persistent (PER) disease and the severity into mild or moderate/severe. The most widely used and effective medications to treat allergic rhinitis are oral or topical antihistamines and topical nasal steroids.</p><p><strong>Methods: </strong>This prospective case series study included 80 patients of PER divided randomly in to 2 groups of 40 each with group 1 receiving fluticasone propionate and azelastine and group 2 receiving fluticasone propionate alone. Individual symptom scores and total symptom score (TSS) were recorded before treatment and after 4 weeks of treatment.</p><p><strong>Results: </strong><strong> </strong>The difference in mean TSS before and after 4 weeks study period were statistically significant in both groups (p&lt;0.01 in both). Group 1 had TSS of 1.525±1.06 and group 2 had TSS of 3.275±1.75 after 4 weeks of treatment and the difference between them was statistically significant (p&lt;0.01).</p><p><strong>Conclusions: </strong>In allergic rhinitis, both fluticasone propionate + azelastine nasal spray and fluticasone propionate nasal spray are effective in relieving symptoms. But, fluticasone propionate and azelastine has significant reduction of symptoms when compared with fluticasone propionate alone.</p>

scholarly journals The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1337
Author(s):  
Joseph Yusin ◽  
Vivian Wang ◽  
Susanne M. Henning ◽  
Jieping Yang ◽  
Chi-Hong Tseng ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Spray ◽  
Placebo Tablet ◽  
Group 4 ◽  
Cytokine Levels ◽  
Before And After ◽  
Group 3 ◽  
Nasal Steroid ◽  
Group 2 ◽  
Broccoli Sprout

Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.

Effect of bandaging on postoperative swelling after tibial plateau levelling osteotomy

2010 ◽  
Vol 23 (04) ◽  
pp. 240-244 ◽  
Author(s):  
J.K. Roush ◽  
K. L. Bilicki ◽  
G.Baker. Baker ◽  
M.D. Unis
Keyword(s):  
Tibial Plateau ◽  
Case Series ◽  
Small Animal ◽  
Significant Linear Correlation ◽  
Significant Difference ◽  
Group 2 ◽  
Prospective Case Series ◽  
Distal Aspect ◽  
Postoperative Swelling ◽  
Group 1

Summary Objective: To compare the effects of bandaging on immediate postoperative swelling using a modified Robert-Jones bandage after tibial plateau levelling osteotomy (TPLO) in dogs. Study design: Prospective case series. Methods: Dogs undergoing a TPLO were randomly placed into two groups. Group 1 received a modified Robert-Jones bandage postoperatively for a 24 hour period and Group 2 was not bandaged. Hindlimb circumference was measured at the level of the mid-patella, the distal aspect of the tibial crest, the midpoint of the tibial diaphysis and the hock. Measurements were recorded and compared in each group preoperatively and at 24 hours and 48 hours post-operatively. Interobserver variability was compared between the two observers. Results: There was no significant difference in postoperative swelling, as measured by the percentage change in circumference, between bandaged and unbandaged operated limbs after the TPLO at 24 and 48 hours at any site. Some significant differences in measurement at particular sites were observed between the two different observers, but there was a significant linear correlation at all sites between observers. The observer with the least experience consistently had slightly higher measurements at these sites. Clinical relevance: The use of a modified Robert-Jones bandage after TPLO did not prevent statistically significant postoperative swelling, and thus may not be indicated for this purpose. Postoperative bandages placed to control swelling after other small animal orthopaedic procedures should be evaluated individually for efficacy.

scholarly journals Effect of Cycloplegia on Keratometric and Biometric Parameters in Keratoconus

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Nihat Polat ◽  
Abuzer Gunduz
Keyword(s):  
Axial Length ◽  
Healthy Subjects ◽  
Anterior Chamber Depth ◽  
Corneal Curvature ◽  
Corneal Surface ◽  
Biometric Parameters ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Purpose.To obtain information about effect of cycloplegia on keratometry and biometry in keratoconus.Methods.48 keratoconus (Group 1) and 52 healthy subjects (Group 2) were included in the study. We measured the flat meridian of the anterior corneal surface (K1), steep meridian of the anterior corneal surface (K2), lens thickness (LT), anterior chamber depth (ACD), and axial length (AL) using the Lenstar LS 900 before and after cycloplegia.Results.The median K1 in Group 1 was 45.64 D before and 45.42 D after cycloplegia, and the difference was statistically significant (P<0.05). The median K2 in Group 1 was 50.96 D before and 50.17 D after cycloplegia, and the difference was significant (P<0.05). The median K1 and K2 in Group 2 were 42.84 and 44.49 D, respectively, before cycloplegia, and 42.84 and 44.56 D after cycloplegia, and the differences were not statistically significant (allP>0.05). There were significant differences in SE, LT, ACD, and RLP between before and after cycloplegia in either Group 1 (allP<0.05) or Group 2 (allP<0.05). There were not statistically significant differences in AL between before cycloplegia and after cycloplegia in either Group 1 (P=0.533) or group 2 (P=0.529).Conclusions.Flattened corneal curvature and increase in ACD following cycloplegia in keratoconus patients were detected.

scholarly journals Effect of Duration of Silicone Oil Tamponade on Retinal Structure after Rhegmatogenous Retinal Detachment Surgery

2021 ◽  
pp. 1-8
Author(s):  
Chloé Dubroux ◽  
Julia Salleron ◽  
Karine Angioi-Duprez ◽  
Jean-Paul Berrod ◽  
Jean-Baptiste Conart
Keyword(s):  
Retinal Detachment ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Case Series ◽  
Retinal Layer ◽  
Before And After ◽  
Silicone Oil Tamponade ◽  
Group 2 ◽  
Change In Mean ◽  
Group 1

<b><i>Purpose:</i></b> The aim of the study was to investigate the effect of tamponade duration on retinal changes induced by silicone oil (SO) in patients who underwent successful rhegmatogenous retinal detachment (RRD) surgery. <b><i>Methods:</i></b> Retrospective comparative case series of 68 patients who underwent SO tamponade for RRD. Patients were divided into 2 groups based on timing of SO removal: &#x3c;6 months (group 1, <i>n</i> = 34) versus ≥6 months (group 2, <i>n</i> = 34). The main outcome measure was the change in central macular, inner, and outer retinal layer thickness (CMT, IRLT, and ORLT) before and after SO removal (SOR). <b><i>Results:</i></b> The median tamponade duration was 4 [Clin Ophthalmol. 2016;10:471–6, Zhonghua Yan Ke Za Zhi. 1997 Jan;33(1):39–41] months in group 1 and 8 [Arch Ophthalmol. 1994 Jun;112(6):778–85, Retina. 2004 Dec;24(6):871–7] months in group 2 (<i>p</i> &#x3c; 0.001). The mean CMT significantly increased from 245.3 ± 22.2 μm and 238.8 ± 41.6 μm under SO to 281.3 ± 60.2 μm and 259.0 ± 43.5 μm after SOR in group 1 (<i>p</i> = 0.009) and in group 2 (<i>p</i> = 0.007), respectively. Automated segmentation measurement revealed a significant increase in mean IRLT (<i>p</i> = 0.014 and <i>p</i> = 0.013) but no change in mean ORLT (<i>p</i> = 0.080 and <i>p</i> = 0.257) in both groups. After adjustment, there was no difference between the 2 groups in terms of mean final CMT, IRLT, and ORLT and mean retinal thickness changes after SOR. There was also no correlation between the tamponade duration and macular microstructural changes or visual recovery. <b><i>Conclusion:</i></b> SO tamponade causes a thinning of all retinal layers, mainly affecting the inner retinal layer. However, these changes resolved following SO extraction and were not affected by longer tamponade duration.

scholarly journals Clinical Research on Lens Cortex Removal Assisted by Hydropolish

2021 ◽  
Author(s):  
Lin Yao ◽  
Haiqing Bai
Keyword(s):  
Retrospective Study ◽  
Clinical Research ◽  
Cataract Surgery ◽  
Case Series ◽  
Time Saving ◽  
Group 2 ◽  
Prospective Case Series ◽  
Phacoemulsification Cataract Surgery ◽  
Entire Procedure ◽  
Group 1

Abstract Background: This retrospective study investigated the efficiency and safety of lens cortex removal assisted by a fluid-based capsular polishing technique, hydropolish. Study design: Prospective case series.Methods: Sixty patients were included in this study. All these patients underwent phacoemulsification cataract surgery using different sequences of surgical steps and were divided into two groups; hydropolish before irrigation/aspiration (I/A) (Group 1, 30 eyes) and I/A before hydropolish (Group 2, 30 eyes). Hydropolish and I/A cortex time, and time of the entire procedure were noted. Results: The hydropolish time was longer in group 1 than that in group 2 (P ≤ 0.001). The I/A cortex time and hydropolish and I/A cortex time together were not different between the two groups (P = 0.294 and P = 0.258, respectively). However, the time of the entire procedure was shorter in group 1 (P = 0.002). Conclusions: Lens cortex removal assisted by hydropolish is a safe, time saving, and simple surgery.

Preliminary assessment of low-intensity transcranial magnetic stimulation (TMS) during the treatment for brain glioblastomas.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 2545-2545
Author(s):  
Ivan A. Popov ◽  
Oleg I. Kit ◽  
Alla I. Shikhlyarova ◽  
Elena M. Frantsiyants ◽  
Eduard E. Rostorguev ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Low Frequency ◽  
Residual Tumor ◽  
Projection Area ◽  
Control Group ◽  
Perifocal Edema ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Group 1

2545 Background: The standard treatment of malignant brain gliomas, including surgical and radiation therapies, does not provide recovery and a long-time favorable prognosis. The development of technologies and international guidelines on the introduction of electric (TTF) and electromagnetic (TMS) fields in combination treatment for glioblastomas aims to improve immediate results, as shown in experiments on human glioblastoma cell culture. The TMS protocol requires further refinement in parameters of frequency, intensity, and exposure with an assessment of the immediate results of combined treatment. Methods: The study included 60 patients diagnosed with MBG receiving osteoplastic craniotomy with radical (within visible unchanged tissues) tumor removal. Starting from the second day after the surgery, patients of group 1 (n = 30) received 10 sessions of magnetotherapy in the double exposure mode. For the first morning exposure, we used an ultra-low-frequency magnetic field (ULFMF) (0.03 to 9.0 Hz) on the hypothalamus projection area to induce a general antistress reaction. After 2.5-3 hours, local (on the surgical site) TMS exposure with the Neuro-MSD system (Russia) was applied in the pulse algorithm, up to 1 GHz and 5 Hz, 15 mT, 3 min. The induction was reduced exponentially (C = 0.8). The control group 2 (n = 30) did not receive ULFMF or TMS. Magnetic resonance imaging (MRI) was used to determine the volume of tumors (Vt, cm3) and perifocal edema (Ve, cm3) calculated according to the Shrek’s formula for an ellipsoid (V = a×b×c×π/6). Results: Before surgery, Vt = 54.7±5.7cm3 in group 1, in group 2 - Vt = 60.9±8.5cm3 (no statistical differences). After surgery and the subsequent course of ULFMF and TMS, residual tumor volumes in group 1 were 2.5 times lower than in controls (p < 0.05). The difference between Ve values before and after treatment was on average 80.7 cm3 in group 1 and 41.8 cm3 in group 2 (p < 0.05). Conclusions: The inclusion of sequential ULFMF and TMS exposures into postoperative therapy for gliomas, taking into account various vectors of the influence on the projection of centers of homeostasis regulation and the surgical field, as well as the development of programmed modes of biotropic exposure parameters, improves antitumor and anti-edematous effects.

scholarly journals PELATIHAN MODEL BEEF CONCEPT DISERTAI PUSH UP DAN JOGGING LEBIH MENINGKATKAN KETEPATAN SHOOTING FREETHROW BOLA BASKET DARI PADA PELATIHAN MODEL BEEF CONCEPT DISERTAI DUMBEL DAN JOGGING

2019 ◽  
Author(s):  
I Kadek Arya Gangga Permana ◽  
Putu Astawa ◽  
Desak Made Wihandani ◽  
Ketut Tirtayasa ◽  
I Made Jawi ◽  
...  
Keyword(s):  
Test Group ◽  
Training Model ◽  
Concurrent Training ◽  
Free Throw ◽  
Basketball Game ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Group 1 ◽  
Push Up

ABSTRACTIntroduction: The objective of a basketball game is to insert the ball into the opponent's basket and keep our basket alone so as not to concede the ball. This becomes important because it determines points to improve the ability and maximize points in the game so this needs to be trained. Free throw shots can be done using one hand or two hands. Whereas a free throw is a shot given to a player for committing an offense. This shot is done in the exact position behind the line of free shots in accordance with the rules. Purpose:This study aims to compare training model 1 (beef concept with push up and jogging) and training model 2 (beef concept with dumble and jogging) to improve the accuracy of free throw shooting.This research was conducted on 40 students of SMP Negeri 1 Kuta Selatan who were chosen in simple random which has fulfilled inclusion and exclusion criteria. The sample was divided into two groups so that each group was 20 people and given different treatment for six weeks. Group 1 was given model 1 training and Group 2 was given a model 2 training. Methods:The data obtained were analyzed by paired t- test to find the difference between before and after training in both groups and t-independent test to find the difference of shooting free throw accuracy between groups both before and after the training. The meaning limit is 0.05. The research design used is experimental design Randomized Pre and Post test Group Design. According to Pocock's (2008) theory, each group consisted of 20 groups of 1 and group 2. All groups were given preliminary tests, between treatment one and two treatment were given concurrent training, then each treatment was observed.Results:The result showed that the accuracy of free throw shooting between groups after training was 3.85 ± 1.09 in group 1 and in group 2 was 2.90 ± 1.12. The average accuracy of free throw shooting in training model 1 was higher than with model 2 training which was statistically significantly different with p = 0,010 (p <0,05).Conclution:From the results of this study it is concluded that the training of model 1 further improves the accuracy of free throw shooting rather than training model 2, Suggestion: in practice it is suggested to use training model 1 to improve the accuracy of free throw shooting. Keywords: beef concept, push up, jogging, dumble, free throw shooting

scholarly journals Comparision of efficacy of local administration of contractubex & corticosteroids for hypertrophic scar in maxillofacial region

2016 ◽  
Vol 06 (03) ◽  
pp. 16-20
Author(s):  
Muralee Mohan ◽  
B. Rajendra Prasad ◽  
S. M. Sharma ◽  
Tripthi Shetty ◽  
Ashay Shah
Keyword(s):  
Hypertrophic Scar ◽  
Corticosteroid Treatment ◽  
Study Groups ◽  
Hypertrophic Scars ◽  
Treatment And Prevention ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Few Data ◽  
Group 1

AbstractHypertrophic scarring following surgical procedures & trauma are a great concern for patients and a challenging problem for clinicians. The therapeutic management of hypertrophic scars is a problem that has not yet been satisfactorily solved. Contractubex® ointment and intra lesional injection of corticosteroids have been used effectively for treatment and prevention of hypertrophic scars. However very few data is available to determine the efficacy of Contractubex® ointment and intra lesional injection of corticosteroids for the treatment of hypertrophic scar. Two study groups were made with 10 patients in each group. Patients in Group 1 treated with Contractubex® and patients in Group 2 treated with intra lesional corticosteroid (Triamcinolone acetonide). Scar was analyzed with Vancouver Scar Scale (VSS) at 2 weeks, 6 weeks and 12 weeks. The collected data was statistically analyzed. We found that the difference between before and after treatment scores for each of the groups was statistically significant (p < 0.05). The mean of the before and after treatment difference for the Group 1 (Contractubex® ) was 4.7 while that of group 2 (Corticosteroids) was 2.8. This demonstrated a significant superiority of the Contractubex® treatment compared to corticosteroid treatment. The difference between treatment responses for both the groups was statistically significant (p < 0.05). Excellent to good responses were reported in 90% of the Group 1 (Contractubex®) patients and 30% of Group 2 (Corticosteroids).

scholarly journals The use of tissue adhesive as an adjunct to wound closure in knee arthroplasty does not reduce wound ooze

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Mohamed A. Khalefa ◽  
Lindsay K. Smith ◽  
Riaz Ahmad
Keyword(s):  
Hospital Stay ◽  
Knee Arthroplasty ◽  
Case Series ◽  
Length Of Hospital Stay ◽  
Tissue Adhesive ◽  
Prolonged Length ◽  
Increased Risk ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Abstract Introduction Persistent wound ooze has been associated with prolonged length of hospital stay and increased risk of infection. Recently, the use of tissue adhesive after hip and knee arthroplasty has been described. We believe that knee arthroplasty wounds exhibit different behavior compared to hip arthroplasty due to the increased wound-margin tension associated with knee flexion. Patients and methods Forty-three patients undergoing total knee arthroplasty (TKA) by a single surgeon were studied. All wounds were closed using staples with or without tissue adhesive. Post-operatively, the wounds were reviewed daily for ooze. Dressings were changed only if soaked > 50% or if there was persistent wound discharge of more than 2 × 2 cm at 72 h. Results There were 21 patients in the tissue adhesive (group 1), 22 in the non-tissue adhesive (group 2) with the average age for group 1 of 72.2 years and for group 2 of 69.3 years. The median length of stay for both groups was 4 days (range of 3–7 days for group 1 and 2–6 days for group 2) (P = 0.960). The tissue adhesive group showed a statistically significant reduction in wound ooze on day 1 (P = 0.019); however, the difference was not significant on the following days. The median for the number of dressing changes for group 1 was zero changes and for group 2, one change. This was not statistically significant (P = 0.112). No complications were observed in both groups and there were no reactions to the tissue adhesive. Conclusion The data from this case series suggest that the use of tissue adhesive may reduce wound ooze on day 1 only. The latter is most likely due to significant tensile forces to which the knee arthroplasty wound is subjected in the immediate post-operative rehabilitation. Further, the cost of tissue adhesive is not offset by reduced dressing changes or length of hospital stay.

scholarly journals Combination of omega-3 polyunsaturated fatty acids and statins for the prevention of atrial fibrillation after coronary bypass surgery

2017 ◽  
Vol 95 (9) ◽  
pp. 817-823
Author(s):  
Olesya A. Rubanenko ◽  
O. V. Fatenkov ◽  
S. M. Khokhlunov ◽  
A. P. Semagin ◽  
D. V. Kuznetsov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Leukocyte Count ◽  
Coronary Bypass ◽  
Omega 3 ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Aim. To evaluate the influence of combination of omega-3 polyunsaturated fatty acids and atorvastatin on the risk of atrial fibrillation (AF) after coronary bypass surgery (CBS). Material and methods. The study included 114 patients divided into 2 groups, one comprised of 59 ones (75,6% men of mean age 62,0±7,3 yr given conventional medication), the other including 55 patients (80,0% men of mean age 59,4±6,7 yr given omega-3 polyunsaturated fatty acids 5 days before (2 g/d) and during 3 weeks after CBS (1 g/d)). All patients were treated with atorvastatin at the outpatient stage. IL-6,8, 10 and C-reactive protein (CRP), fibrinogen, troponin, NT-proBNP, superoxide dismutase (SOD), and myeloperoxidase were measured at admittance and on day 3.7±1.4 after surgery. Results. AF developed on day 5.9±4.9 (mean) after surgery. Patients of group 2 tended to have fewer new episodes of arrhythmia although no significant difference between the groups was documented (9,1% vs 18,6%, р=0,12). Group 2 included more smokers (74,5% vs 45,8%, р=0,002) and patients with atherosclerosis of lower limb arteries (87,3% vs 71,2%, р=0,03) but fewer those consuming nitrates (39,0% vs 18,2%, р=0,01) and Ca antagonists (45,8% vs 21,8%, р=0,006).Mean dose of atorvastatin given to patients of groups 1 and 2 was 24.7±12.5 and 25.1±10.5 mg/d respectively (р=0,2), duration of its intake 14.6±12.7 and 21.5±19.3 months (р<0,001). There. was no significant difference between leukocyte count, leukogram, IL-8, IL-10, NT-proBNP, and troponin levels before and after CBS. Surgical myocardial revascularization caused a rise in leukocyte count, shifted the leukogram toward predominance of stab and segmented cells, increased IL-8, IL-10, fibrinogen, NT-proBNP, CRP, and troponin levels in both groups. IL-8 and IL-10 levels remained normal before and after surgery. Preoperative IL-6 level in group 1 was significantly higher than in group 2 (21,7±13,0 vs 2.5±2,2 pg/ml, р<0,001). Postoperatively, the difference was absent. The CRP level before surgery was high in both groups (3122.7±2175.8 vs 3670.8±2490.0 U/g) but decreased after CBS although remained higher in group 1 (1957.6±1660.3 vs 1069.8±630.2 U/g, р<0,001). Myeloperoxidase level increased postoperatively in both groups but the difference was insignificant. Fibrinogen and CRP in the postoperative period increased more significantly in group 2 than in group 1 (4,9±1,4 vs 4,4±1,1 g/l, р=0,02 and 8,6±2,2 vs 5,4±2,3 mg/l respectively, р<0,001). Conclusion. The study revealed an insignificant decrease in the number of AF episodes in the early post-CDS period in patients treated with omega-3 polyunsaturated fatty acids and atorvastatin compared with those given the latter medication alone. Also, fibrinogen and CRP levels as markers of inflammation increased while SOD antioxidative activity decreased.

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