Study of serum copper and zinc levels in association with albumin and uric acid as antioxidant markers in type II diabetes mellitus

Background and Aim: Morbidity and mortality from non-communicable diseases, particularly diabetes are increasing rapidly in Pakistan, the prevalence has reached 17.1%. A strong association has been witnessed between type II diabetes mellitus with atherosclerosis and serum uric acid level. The current study aim was to assess the levels of serum uric acid in type II diabetes mellitus. Materials and Methods: This cross-sectional study was carried out on 85 diagnosed patients of type II diabetes mellitus in Diabetes hospital, Peshawar and the Department of General Medicine, Shaikh Zayed Medical Complex, Lahore during the period from March 2020 to August 2020.Type II diabetes mellitus (DM) diagnosed patients 85 and healthy control 30 were evaluated in this study. The level of hyperuricemia was defined for women > 6 mg/dl and men >7 mg/dl in men. Results: In this study, a total of 85 diabetic diagnosed patients and 30 healthy controls were enrolled. No significant differences were there in the baseline characteristics like anthropometric and socio-demographic parameters. The mean age for diagnosed and control cases was 58.6±8.7 and 56.5±7.6 years with an age range of 40 and 80 years. Hyperuricemia proportion among diabetic patients was 12.13% while none of the control cases had hyperuricemia. The uric acid means level increased from 4.29±0.81 mg/dl with a diabetic duration between 3 and 4 years to 4.59±0.99 mg/dl with a diabetic duration of 5 to 7 years. Furthermore, mean serum uric acid level reached 6.50±1.08 in cases with diabetic duration 8 to 12 years. Statistically, a significant association was found between diabetic duration and serum uric acid. Also, a positive correlation was found in hyperlipidemia, serum uric acid levels, and hypertension. Conclusion: In diabetic patients serum uric acid levels were found to be significantly higher. Diabetic patients had hypertension, elevated serum uric acid levels, and high triglycerides with dyslipidemia. The rise in serum uric acid levels is proportional to the duration of diabetes. Keywords: Serum uric acid, Type 2 diabetes mellitus, Hypertension

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Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

Annals of Clinical Chemistry and Laboratory Medicine ◽

10.3126/acclm.v2i2.15590 ◽

2017 ◽

Vol 2 (2) ◽

pp. 26-34

Author(s):

Hridaya Parajuli ◽

Jyotsna Shakya ◽

Bashu Dev Pardhe ◽

Puspa Raj Khanal ◽

Narayan Prasad Parajuli ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Uric Acid ◽

Serum Uric Acid ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Diabetic Patients ◽

Type Ii ◽

Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

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STUDY OF ASSOCIATION OF SERUM URIC ACID WITH ALBUMINURIA IN TYPE II DIABETES MELLITUS

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2016/179 ◽

2016 ◽

Vol 5 (16) ◽

pp. 769-773

Author(s):

Priti Sambhaji Langote ◽

Mallanna Shankreppa Mulimani

Keyword(s):

Diabetes Mellitus ◽

Uric Acid ◽

Serum Uric Acid ◽

Type Ii Diabetes ◽

Type Ii Diabetes Mellitus ◽

Type Ii

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Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus

Journal of Mahatma Gandhi University of Medical Sciences and Technology ◽

10.5005/jp-journals-10057-0021 ◽

2017 ◽

Vol 2 (1) ◽

pp. 1-6

Author(s):

Jai P Yogi ◽

Anita Semar

Keyword(s):

Diabetes Mellitus ◽

Uric Acid ◽

Glycemic Control ◽

Serum Uric Acid ◽

Type Ii Diabetes ◽

Microvascular Complications ◽

Glycosylated Hemoglobin ◽

Positive Association ◽

Type Ii Diabetes Mellitus ◽

Type Ii

ABSTRACT Type II diabetes mellitus (DM) is the most common endocrine disorder and a leading cause of morbidity and mortality across the world. Long-standing diabetes and a poor glycemic control are the major factors which contribute to the development of various microvascular complications of diabetes. Microvascular changes in kidneys lead to microalbuminuria, which may further lead to end-stage renal disease (ESRD) if left untreated. Elevated serum uric acid level has been recognized as a marker of endothelial dysfunction which contributes to the development of microvascular changes in various organs. The main objective of the present study was to assess the association of serum uric acid and urine microalbumin levels with glycosylated hemoglobin (HbA1c) in type II DM patients. One hundred diagnosed cases of type II DM were enrolled for the study. Blood samples were collected and estimated for fasting blood sugar, serum uric acid, and HbA1c. Also, 24-hour urine samples were collected and analyzed for microalbumin. A positive association (r = 0.203) was observed between HbA1c and serum uric acid. The study also suggested a positive association between glycemic control and microalbuminuria (r = 0.237) in diabetic patients. A strong positive association was also observed between uric acid and urine microalbumin levels (r = 0.338). Findings of the study, therefore, recommend that development of microvascular complications in type II DM patients can be averted by adopting dietary control and healthy lifestyle changes. Strict glycemic control and lowering of serum uric acid levels can be helpful in minimizing the risk of developing nephropathy and its progression toward ESRD. How to cite this article Fiza B, Yogi JP, Choudhary J, Semar A, Sinha M. Association of Hyperuricemia and Urinary Albumin Excretion with Glycosylated Hemoglobin in Patients with Type II Diabetes Mellitus. J Mahatma Gandhi Univ Med Sci Tech 2017;2(1):1-6.

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The Effectiveness of Alpha Mangostin on Kidney Physiology and Histopathology in Type II Diabetes Mellitus

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.83358342 ◽

2021 ◽

Vol 12 (6) ◽

pp. 8335-8342

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Uric Acid ◽

Type Ii Diabetes ◽

Kidney Tissue ◽

Type Ii Diabetes Mellitus ◽

Control Group ◽

Type Ii ◽

Garcinia Mangostana ◽

Significant Difference

The compound isolate alpha Mangostin was the most dominant compound found in the rind and trunk of the mangosteen fruit tree (Garcinia mangostana L.). Alpha Mangostin compounds have pharmacological activities, including antibacterial, antifungal, anticancer, antidiabetic, and other bioactivities. This study aims to determine the bioactivity of alpha Mangostin on kidney function and histopathology in type II diabetes mellitus. This study used an experimental research design with posttest only control group; this study used 36 rats consisting of 6 groups, namely negative control group, positive control group, standard medicine, and the treatment of lecturers alpha Mangostin 10 mg/kg body weight, 30 mg/kg body weight, and 50 mg/kg BW. Parameters measured in this study were uric acid, BUN, creatinine, and renal histopathological evaluation. The results showed that there was a significant difference (p < 0.05) in the examination of creatinine levels, but the BUN and uric acid did not show significant results (p > 0.05) in each group. Observations on renal histopathology showed that alpha Mangostin could normalize damaged kidney tissue compared to positive controls. So it can be concluded that alpha Mangostin isolates in mangosteen has the potential as kidney bioactivity in type II diabetes.

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