scholarly journals Therapeutic approaches to tackle COVID-19: An overview

2021 ◽  
Vol 8 (2) ◽  
pp. 121-135
Author(s):  
Princy Louis Palatty ◽  
Rosme David ◽  
Belinda Mangalath Philip ◽  
Clint Sunny ◽  
Mamatha J ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Guidelines ◽  
World Health Organisation ◽  
Current Medical ◽  
World Health ◽  
Director General ◽  
The Novel ◽  
Therapeutic Approaches ◽  
Literature Searches ◽  
Novel Coronavirus

: A series of an acute atypical respiratory disease occurred during December 2019 in Wuhan, China, that quickly metamorphosed as a pandemic, spreading across the globe, leaving more than 104,911,186 infected and more than 2,278,579 dead, in its wake within a year. This Novel Coronavirus, was also called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and the disease was called Coronavirus Disease 19 (COVID-19). On 30 January 2020, The World Health Organisation (WHO) Director-General, declared the novel coronavirus outbreak, a public health emergency of international concern and flagged off WHO's highest level of alarm.: To elaborate the various drug therapies used in trials and vaccines available for COVID-19 across the globe.: We compiled the literature searches under a single heading and scrutinized over 154 articles, for extracting data on the various pharmacotherapeutic approaches available to treat COVID-19.: Despite wide and varied treatment guidelines being available, the cure or prevention is still elusive for COVID-19. The categoric efficacy of vaccines must be proved to tackle the fast-mutating coronavirus.: Current medical management is largely supportive with no targeted therapy available. Several drugs including lopinavir-ritonavir, remdesivir, antibiotics, hydroxychloroquine, steroids, anticoagulants, and antidiabetic drugs like metformin have been tried in clinical trials. Vaccines targeting the three different components of SARS-CoV-2 viruses, in different phases of clinical trials world-wide, have been made available.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

A Qualitative Comparison of the Covex Respirator with Face Shield Versus the N95 Respirator

2020 ◽  
Author(s):  
Reid Mimmack ◽  
Elijah Germo ◽  
Garrett Augustine ◽  
Kumar Belani
Keyword(s):  
Filtration Efficiency ◽  
Current Medical ◽  
Pass Rate ◽  
World Health ◽  
Protective Equipment ◽  
The Novel ◽  
Qualitative Comparison ◽  
Medical Standard ◽  
Novel Coronavirus ◽  
Health Organization

Abstract In March 2020, the World Health Organization declared the novel coronavirus (COVID-19) outbreak a worldwide pandemic. The pandemic led to concerns of shortages regarding healthcare-related resources, including personal protective equipment (PPE), ventilators, and more. The uniquely designed COVEX respirator with face shield was engineered and manufactured by Augustine Surgical, Inc. to combat the PPE shortage. The novel COVEX mask is an “all-in-one” face shield and filter with a Viral Filtration Efficiency (VFE) greater than 99%. A standard respirator qualitative fit test was completed on the COVEX respirator as well as the current medical standard 3M N95 respirator. Fit test studies comparing the two masks yielded similar outcomes. The COVEX respirator had a qualitative fit test pass rate of 96.6% and the 3M N95 respirator had a pass rate of 93.3% (n=30). Participants also reported other variables comparing the comfort and fit of each mask, which is described further in the discussion. The COVEX respirator with face shield passed a standardized qualitative fit test at a rate similar to the current medical standard N95 respirator. Our results suggest that the COVEX mask may be a viable PPE option in the future.

scholarly journals Year of the Mask; COVID-19 Challenges for Orthopaedic Surgery

2020 ◽  
Vol 10 ◽  
Author(s):  
Evert Smith
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Orthopaedic Surgery ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Virus Spread ◽  
Central Hospital ◽  
The World ◽  
Respiratory Physician ◽  
Novel Coronavirus

As a response to the viral pneumonias and severe illnesses that were emerging in patients, an ophthalmologist November 2019 a novel coronavirus emerged in Wuhan, Hubei, China Dr Li Wenliang, working at Wuhan Central Hospital, voiced his concerns only to be severely admonished by the authorities. The accelerated spread of the Severe Acute Respiratory Syndrome (SARS) in Wuhan, and then globally, as a result of the novel coronavirus was acute and pronounced. China alerted the World Health Organisation to several pneumonia cases at the end of December 2019 and the first death was recorded in early January 2020. The respiratory physician Dr Nanshan Zhong, announced human-to-human spread and a few days later on the 23 January 2020, Wuhan was placed under quarantine. The virus spread outside China and the WHO declared the outbreak a global health emergency on 30 January 2020. Tragically Dr Li Wenliang died on 7 February 2020 as a result of exposure to the virus, leaving a five-year-old son and a pregnant wife.

scholarly journals The potential impact of COVID 19 on poor and conflict-ridden communities in Sub-Sahara Africa (SSA): A conceptual paper

2020 ◽  
Vol 1 (2) ◽  
pp. 125-132
Author(s):  
Mathew Nyashanu ◽  
Tistsi Tsopotsa ◽  
Scovia Nalugo Mbalinda ◽  
Gemma North ◽  
Maureen Mguni ◽  
...  
Keyword(s):  
Policy Development ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Public Health Professionals ◽  
Global Pandemic ◽  
Potential Impact ◽  
Wu Zhao ◽  
Future Policy ◽  
Novel Coronavirus

The first cases of the novel coronavirus disease (COVID-19), previously known as 2019-nCoV, were reported in late December 2019 in Wuhan, China (Wu, Zhao, Yu B, et al 2020). The virus then spread to Malaysia and Thailand and eventually to the Americas, Europe, Australia and Africa. On the 11thof March 2020 the World Health Organisation (WHO) declared the COVID-19 a global pandemic. This concept paper  explores the potential impact of COVID-19 on poverty stricken and conflict-ridden communities in Sub-Sahara Africa. In doing so, the paper also explored the implications for public health professionals working with these communities, including recommendation for future policy development.

scholarly journals The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

2021 ◽  
Author(s):  
Richmond Sam Quarm ◽  
Rosemond Sam-Quarm ◽  
Richmond Sam-Quarm
Keyword(s):  
Rational Choice Theory ◽  
Choice Theory ◽  
Respiratory Illness ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Cross Sectional ◽  
The World ◽  
The Government ◽  
Novel Coronavirus

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

scholarly journals A cross-sectional study for determining the perception and preferences of immunity boosters for protection against COVID-19

2020 ◽  
Vol 7 (10) ◽  
pp. 1498
Author(s):  
Dhairya P. Nanavaty ◽  
Ankushi A. Sanghvi ◽  
Manav S. Mehta ◽  
Sarbari Gupta ◽  
Gurusharan Dumra
Keyword(s):  
Family Doctor ◽  
Drug Market ◽  
World Health Organisation ◽  
Cross Sectional Study ◽  
World Health ◽  
The Novel ◽  
Cross Sectional ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Source Of Information

Background: The World Health Organisation declared the novel coronavirus (COVID-19) outbreak as a global pandemic on March 11, 2020.  The consumption of vitamins, especially C, D, and zinc, hydroxychloroquine, and Arsenicum album 30 (homeopathy), has increased tremendously. However, the clinical trial showing the benefits of these agents is still underway though there have been a lot of discussion about these in print, electronic, and social media.Method: A questionnaire-based observational study was conducted. The participants were inquired about the use of any type of immunity booster by them and the source of information regarding the same. The data was analysed using Excel and Python.Results: Our study included 1147 participants. A dramatic increase of 21.97% in the consumption of immunity-boosting agents after the COVID-19 outbreak was observed, maximally in Ayurveda. The major source of information for immunity-boosters was provided by friends/family/relatives (50.4%). 52.7% of the respondents selected Ayurveda as their preferred choice of immunity booster (prophylaxis). If the respondents were to develop any of the COVID-19 symptoms, the majority (45.1%) decided to contact their family doctor, and 53.7% chose Allopathy as their preferred system for treatment. 91.5% of the respondents agreed to take a vaccine if it develops.Conclusion: There has been a boom in the immunity booster drug market because people are selecting immunity boosters despite no scientific background. It is imperative to educate people regarding the same and also conduct research studies to find benefits, if any.

scholarly journals The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

2021 ◽  
Author(s):  
Richmond Sam Quarm ◽  
Rosemond Sam-Quarm ◽  
Richmond Sam-Quarm
Keyword(s):  
Rational Choice Theory ◽  
Choice Theory ◽  
Respiratory Illness ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Cross Sectional ◽  
The World ◽  
The Government ◽  
Novel Coronavirus

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

The Novel Coronavirus SARS Cov-2 and its evolving impact on Ophthalmic Practice

2020 ◽  
Vol 5 (Special) ◽  
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Movement Restriction ◽  
Mortality And Morbidity ◽  
Risk Of Mortality ◽  
Difficulty Breathing ◽  
Containment Measures ◽  
Novel Coronavirus ◽  
And Control

SARS-Cov-2 is a novel coronavirus that is believed to have emerged from the wet markets in Wuhan, Hubei Province in China late in December 2019. The spread of this virus was soon declared to be a pandemic by the World Health Organisation, with nearly 1 million cases reported worldwide by 31st March 2020 [1]. Those who contract the virus can go on to develop coronavirus disease 2019 (COVID-19) – with symptoms commonly presenting as fever, dry cough and associated fatigue [2]. These symptoms can progress to difficulty breathing or shortness of breath, chest pain or pressure, loss of speech or movement [3]. The high risk of mortality and morbidity of this illness has resulted in worldwide awareness and control campaigns, resulting in varying levels of movement restriction and containment measures implemented to reduce the rate of transmission of SARS-Cov-2.

scholarly journals The Socio-Economic Ramifications of the Covid-19 Pandemic: The Case of Ghana

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Richmond Sam Quarm ◽  
◽  
Rosemond Sam-Quarm ◽  
Richmond Sam-Quarm ◽  
◽  
...  
Keyword(s):  
Rational Choice Theory ◽  
Choice Theory ◽  
Respiratory Illness ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Cross Sectional ◽  
The World ◽  
The Government ◽  
Novel Coronavirus

The novel, dreaded, disruptive, and disastrous Covid-19 pandemic took the world by storm in January, 2020. The Covid-19 pandemic in Ghana is part of the worldwide coronavirus disease caused by “severe acute respiratory syndrome (SARS-CoV-2)”. On 12th January, 2020 the World Health Organisation (WHO) confirmed that the novel coronavirus was the cause of a respiratory illness that affected a cluster of people in Wuhan City, Hubei Province, China. This was reported to the WHO on 31st December, 2019. On 11th March, 2020, WHO declared the novel Covid-19 a global pandemic (Graphic Online, 2020a). It is worthy to note how the Government of Ghana, political parties, citizens, scientists and academia, corporate entities, faith based organisations, traditional rulers, have offered varied forms of interventions to combat the scourge. The Theoretical Framework of this research was underpinned by the Theory of Epidemics, the Agency Theory, the Rational Choice Theory, and the Stakeholder Theory. We conducted a cross-sectional research through non-probability and purposive sampling with 250 respondents. We also employed face-to-face interviews, structured closed-ended and open-ended Questionnaires (Braun and Clarke, 2012; Denzin, 2017), which were administered online through email application via Google Forms. One of our major findings was that with the approval of Pfizer/BioNTech Covid-19 vaccine by the UK’s MHRA on 1st December, 2020 (Graphic Online, 2020b); and subsequently by the US FDA a week later on 8th December, 2020 (Graphic Online, 2020c), all governments around the globe in general, but Africa in particular, must make conscious efforts backed by adequate budgetary allocations to secure maximum quantities of the vaccines for their vulnerable teeming population.

scholarly journals Pneumomediastinum in a child with severe COVID-19

2020 ◽  
pp. 20200062
Author(s):  
Anne G Carroll ◽  
Nuala Quinn ◽  
Carl Byrne ◽  
Ghadir Kassab ◽  
Siobhan Whelan ◽  
...  
Keyword(s):  
Health Care Providers ◽  
Clinical Course ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Care Providers ◽  
Radiological Findings ◽  
Global Pandemic ◽  
International Data ◽  
Novel Coronavirus

The current global pandemic of the novel coronavirus SARS-CoV2 is a threat to the health and lives of millions of people worldwide. The latest statistics from the World Health Organisation show that there have been 6,515,796 confirmed cases worldwide with 387,298 confirmed deaths (last update 5 June 2020, 10:41 CEST). The majority of critically unwell patients with SARS-CoV2 are adults and the radiological findings associated with them are consistent throughout the literature. However, the reported paediatric cases are few, and as such, there is a limited body of evidence available. More international data is needed, not only on the clinical presentation, but also the radiological findings, so that health-care providers are better able to understand and diagnose this pandemic disease. We describe a case of a previously healthy 9-year-old female who presented to the Emergency Department with symptoms suggestive of raised intracranial pressure. Her CT revealed a medulloblastoma and post-operatively she tested positive for SARS-CoV2. She had a rapid deterioration in her clinical condition and required admission to the intensive care unit (ICU). We provide the supporting radiology along her clinical course in order to demonstrate important insights into this disease in children, including the unusual pnemomediastinum complications which occurred as part of her clinical course. This case is the first reported of its kind.

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