scholarly journals Analysis of the results of combined treatment of cervix precancerous pathology in reproductive aged women

2021 ◽  
pp. 83-88
Author(s):  
I.Z. Gladchuk ◽  
I.Z. Gladchuk ◽  
N.M. Kashtalian
Keyword(s):  
Cold Plasma ◽  
Medical Center ◽  
Combined Treatment ◽  
Cervical Dysplasia ◽  
Functional Results ◽  
Hpv Infection ◽  
Reproductive Age ◽  
Immunomodulatory Therapy ◽  
Plasma Ablation ◽  
Oncogenic Hpv

Aim of the study. Comparative analysis of the results of cervical epithelial neoplasia (CIN) I and II levels (p16ink4a-negative) (LSIL in LAST terminology) treatment against the background of highly oncogenic HPV infection using cold plasma ablation and immunomodulatory therapy with Аllokin-alpha.Materials and methods. We examined 60 women who received treatment for CIN I and CIN II (p16ink 4A negative) at the Multidisciplinary Medical Center of Odessa National Medical University. All women were of reproductive age, had mild dysplasia, high-risk HPV infection (HPV 16, 18, 31, 45) and histological confirmation of CIN I and CIN II (p16ink 4A negative). The patients were divided into 2 groups: 1 (main) group consisted of 30 women who received cold plasma ablation of cervical dysplasia in combination with immunomodulatory therapy with Аllokin-alpha (1 mg subcutaneously every other day, 3 injections before surgery and 3 injections after ablation), Group 2 (control) consisted of 30 patients who received standard cold plasma ablative treatment without prescribing immunomodulators. All women underwent cytomorphological examination of the cervical epithelium, HPV testing by RealTime PCR and colposcopy with mandatory targeted biopsy at the preoperative stage.Results. The use of combined cold plasma ablative treatment of CIN I and CIN II (p16ink 4A negative) in combination with the administration of the immunomodulator Аllokin-alpha significantly reduced the duration of discharge after ablation to 5.44 ± 1.03 days (95% CI: 4.96–6.05), the timing of epithelialization is up to 29.31 ± 1.12 days (95% CI: 26.81–32.32), and to exclude cases of recurrence of genital warts and cervical keratosis. Chances of HPV elimination 6 months after treatment (OR – 5.48; 95% CI: 1.56–29.03; p = 0.0075) and 12 months after treatment (OR – 15.48; 95% CI : 2.05–136.45; p = 0.0094), significantly higher with the combined with immunomodulation method of treatment, in contrast to only cold plasma ablation.Conclusion. Combined, with the use of cold plasma ablation and immunomodulation by perioperative management of Аllokin-alpha, LSIL treatment against the background of highly oncogenic HPV infection in women of reproductive age is accompanied by better functional results, compared with the use of cold plasma ablation alone: reduction in the duration of discharge, acceleration of epithelialization, normalization of the colposcopic and cytologic picture, decrease in the frequency of relapses, a significant increase in the frequency of HPV elimination.

scholarly journals EXPERIENCE OF IMMUNOCORRECTIVE TREATMENT IN THE MANAGEMENT OF PATIENTS WITH CERVICAL INTRAEPITHELIAL NEOPLASIA ON THE BACKGROUND OF GENITAL PAPILLOMAVIRUS INFECTION

2021 ◽  
pp. 48-53
Author(s):  
N. M. ROZHKOVSKA ◽  
I. Z. GLADCHUK ◽  
N. M. KASHTALYAN ◽  
Ia. V. ROZHKOVSKYI
Keyword(s):  
Cervical Cancer ◽  
Cervical Intraepithelial Neoplasia ◽  
Cold Plasma ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Immunomodulatory Therapy ◽  
Complex Treatment ◽  
Papillomavirus Infection ◽  
Plasma Ablation ◽  
Interferon Status

Introduction. Human papillomavirus (HPV), its highly oncogenic types, is considered to be the initiating factor in the development of dysplasia and cervical cancer The role of immunomodulatory therapy in reducing the risk of cervical cancer in women with cervical intraepithelial neoplasia (CIN) associated with HPV infection remains in the focus of researchers. Aim of the study: to evaluate the effectiveness of the use of the immunomodulator Allokin-alfa in the complex treatment of cervical intraepithelial neoplasia against the background of genital papillomavirus infection. Materials and methods. We examined 60 women who received CIN1- 2 treatment on the background of HPV infection of high oncogenic risk in the multidisciplinary medical center of the Odessa National Medical University. The patients were divided into 2 groups: 1 (main) group consisted of 30 women who received cold plasma ablation of cervical dysplasia in combination with immunomodulatory therapy with alloferon, group 2 (comparison) consisted of 30 patients who received standard cold plasma ablative treatment without immunomodulators. The control group consisted of 30 healthy women. All women underwent cytomorphological examination of the cervical epithelium, HPV testing, colposcopy, and targeted biopsy. Immunological status was assessed by indicators of cellular and humoral immunity, the content of α- and γ-interferon. Results. In patients with CIN1-2 against the background of HPV, an increase in the level of serum Ig A, CD8 level, a decrease in the CD4 content and immunoregulatory index, CD19 content were revealed, which indicated immunosuppression. Immunocorrective therapy witn alloferon (Allokin-alfa) in complex, with cold plasma ablation, treatment of CIN1-2 promoted the normalization of the parameters of immunity and interferon status, which contributed to the acceleration of epithelialization, (OR — 15,48; 95% CІ: 2,05-136,45; р=0,0094). a decrease in the frequency of residual lesions, and a HPV elimination. Conclusions. Complex treatment of CIN1-2 using cold plasma ablation and immunocorrection by perioperative administration of alloferon (Allokin-alfa) is accompanied by better functional results, compared only with the use of cold plasma ablation: accelerated epithelialization, improved colposcopic picture, decreased frequency of relapses, elimination of HPV, normalization of immunе and interferon status.

Association of detection of aflatoxin in plasma of Kenyan women with increased detection of oncogenic HPV.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 5530-5530
Author(s):  
Jianjun Zhiang ◽  
Elkanah Omenge ◽  
Titus Maina ◽  
Kapten Muthoka ◽  
Stephen Kiptoo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cervical Dysplasia ◽  
Hpv Infection ◽  
Immunosuppressive Agent ◽  
Sub Saharan Africa ◽  
Hpv Testing ◽  
Hpv 16 ◽  
Kenyan Women ◽  
Hpv Types ◽  
Oncogenic Hpv

5530 Background: Cervical cancer is the leading cause of cancer-related deaths among women living in Africa. Only a small proportion of HPV-infected women develop cervical cancer and other cofactors may increase a woman’s risk of developing cervical cancer. Aflatoxin, a potent carcinogen and immunosuppressive agent, is produced by fungi that contaminate corn and other staple foods in sub-Saharan Africa. Women who ingest aflatoxin may be more likely to have persistent infections with oncogenic HPV type. Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from HIV-uninfected women 18 and 45 years of age who presented for cervical cancer screening at Moi Referral and Teaching Hospital (Eldoret, Kenya) and had normal VIA examination. HPV testing was performed on cervical swabs using the Roche Linear Array Assay. Aflatoxin-albumin adduct (AFB1-lys) was detected and quantified in plasma. The association of plasma AFB1-lys detection and concentration and the detection of HPV was examined. Results: Sufficient plasma was available from 88 HIV-uninfected women and was transported to the U.S. for aflatoxin testing. Valid HPV testing results were available for 86 of these women (mean age 34.0 years); 49 women (57.0%) had detectable AFB1-lys and 37 (43.0%) had no detection. Substantial variation existed in plasma AFB1-lys concentrations among the 49 women (range 0.02 to 0.21 pg/µL). Detection of AFB1-lys was not associated with age, and other behavioral factors such as number of lifetime partners, marital status and age at first sex. AFB1-lys detection was associated with detection of A9 HPV types (HPV 16, 31, 33, 35, 52, and 58) as a group in cervical swabs (p = 0.029) as well as A9 types excluding HPV 16 (p = 0.020), but not with individual A9 types, A7 HPV types (such as HPV 18), or low-risk HPV types. A concentration dependent association of AFB1-lys was seen with detection of A9 HPV types as a group (p = 0.009), non-HPV 16 A9 types (p = 0.005), and HPV 52 (p = 0.042), but not with the A7 HPV types. Conclusions: AFB1-lys was detected in 57% of HIV-uninfected Kenyan women without cervical dysplasia. AFB1-lys-positive women were more likely than AFB1-lys-negative women to have oncogenic HPV A9 types detected. Higher plasma AFB1-lys concentrations were associated with increased likelihood of oncogenic HPV A9 type detection. Further studies are needed to determine if chronic exposure to aflatoxin interacts with HPV infection (and possibly HIV co-infection) to modulate the risk of cervical cancer in women in Kenya and other developing countries.

Endonasal dacryocystorhinostomy in the treatment of acute abscessed dacryocystitis

Reflection ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 47-51
Author(s):  
M.I. Shlyakhtov ◽  
◽  
K.G. Naumov ◽  
A.V. Krushinin ◽  
◽  
...  
Keyword(s):  
Cold Plasma ◽  
Lateral Wall ◽  
Functional Results ◽  
Long Term Results ◽  
Lacrimal Sac ◽  
Plasma Ablation ◽  
Primary Procedure ◽  
Membranous Obstruction

Aim. Estimation of acute abscessed dacryocystitis endosurgery treatment long term results. Methods. A retrospective analysis of a group including 16 patients with acute dacryocystitis and lacrimal sac abscess in whom endonasal dacryocystorhinostomy was performed as a primary procedure. Mean age was 57 years. All operations were performed under general anesthesia. To remove the mucous membrane of the lateral wall of the nose and the medial wall of the lacrimal sac, we used the Coblator® II radio wave cold plasma ablator (RF8000E) (USA). The bone window was formed using a SONOCA 185 ultrasonic bone dissector from Soring (Germany) with an oscillation frequency of 35 kHz. The operation was completed by bicanalicular intubation with FCI’s Bika silicone system. Results. Mean post-op follow-up period was 6 months. Lacrimal ducts passability was achieved in 13 of 16 patients (81,25 %). Three patients (18,75 %) had recurrent epiphora after surgery and underwent reoperations. In one of them (6,25 %) granuloma formation around the dacryostoma was found and in two (12,5 %) membranous obstruction of the anastomosis occurred. In all the patients pain has ceased within 3 days post-oр. Medial eyelids edema and erythema have gradually ceased in 2 days and completely resolved in 7–10 days. Conclusions. Success rate (81,25 %) in long-term functional results of endonasal dacryocystorhinostomy operations shows high efficacy of our methods of nasolacrimal anastomosis formation in the treatment of patients with acute dacryocystitis and lacrimal sac abscess. Key words: endonasal dacryocystorhinostomy; lacrimal sac abscess; ultrasound bone dissection; cold plasma ablation.

Clinical management of patients with diseases of the cervix with persistent HPV infection: the possibility of combined treatment

GYNECOLOGY ◽  
2014 ◽  
Vol 16 (6) ◽  
pp. 12-15
Author(s):  
V.E. Radzinsky ◽  
◽  
I.M. Ordiyants ◽  
N.V. Buyanova ◽  
O.S. Pobedinskaya ◽  
...  
Keyword(s):  
Clinical Management ◽  
Combined Treatment ◽  
Hpv Infection

scholarly journals PENYULUHAN PENTINGNYA PEMERIKSAAN IVA PADA WUS (Wanita Usia Subur) DI DESA SUKAMAJU KABUPATEN MUARO JAMBI TAHUN 2018

2020 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Lia Artika Sari ◽  
Enny Susilawati
Keyword(s):  
Cervical Cancer ◽  
Community Service ◽  
Causes Of Death ◽  
Hpv Infection ◽  
Reproductive Age ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Women Of Reproductive Age ◽  
Common Causes ◽  
Post Test

ABSTRAK Latar Belakang: Kanker merupakan salah satu penyebab kematian yang paling utama di dunia, sekitar 40 wanita tiap harinya terdiagnosa kanker leher rahim. Kanker leher rahim disebabkan oleh virus HPV, infeksi HPV sendiri sering kali tidak menimbulkan gejala. Desa Suka Maju merupakan salah satu desa yang terdapat di Kabupaten Muaro Jambi dan mempunyai jumlah wanita usia subur berjumlah 820 orang, namun hanya 17,11% wanita usia subur yang baru memanfaatkan pelayanan IVA.Metode: Dengan memberikan penyuluhan kepada wanita usia subur dengan (WUS) sebanyak 40 orang, dan diberikan pre dan post test untuk mengevaluasi pengetahuan wanita usia subur mengenai pemeriksaan IVA Hasil: terjadi kenaikan pengetahuan wanita usia subur di Desa Sukamaju sebesar 87,5%.Kesimpulan: Penyuluhan dapat meningkatkan pengetahuan wanita usia subur terhadap pentingnya pemeriksaan IVA. ABSTRACT Background: Cancer is one of the most common causes of death in the world. About 40 women are diagnosed with cervical cancer every day. Cervical cancer is caused by the HPV virus, HPV infection itself often causes no symptoms. Suka Maju Village is one of the villages in Muaro Jambi Regency that has 820 women of childbearing age, but only 17.11% of women of childbearing age have just used IVA services.Methods: employed in community service was to provide counseling to women of reproductive age with (WUS) as 40 women, and then given pre and posttests to evaluate the knowledge of women of childbearing age After being given counseling on IVA examinations. In brief,Result: There was an increase in the knowledge of women of childbearing age in Sukamaju Village by 87.5 %. Conclusion: Health education can increasedthe knowledge of women of childbearing age on the importance of IVA Chencking

scholarly journals Prevalence of High Risk HPV in HIV-Infected Women From Belém, Pará, Amazon Region of Brazil: A Cross-Sectional Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Jacqueline Cortinhas Monteiro ◽  
Ricardo Roberto de Souza Fonseca ◽  
Tuane Carolina de Sousa Ferreira ◽  
Luana Lorena Silva Rodrigues ◽  
Andreza Reis Brasil da Silva ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Multiple Sexual Partners ◽  
Sexually Transmitted ◽  
High Risk Hpv

Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. Several studies have shown a higher prevalence of HPV infection in HIV-infected women. The aim of this study was to determine the prevalence and the genotype diversity of HPV infection in HIV-infected women. From April 2010 to December 2012 cervical specimens were collected from 169 HIV-infected women who screening for cervical cancer at Reference Unit in Belém. The detection of HPV infection was performed by nested PCR and HPV type was performed using a commercial system. The prevalence of HPV infection was 63.3%. Of the 47 genotyped samples, 40.4% was found positive for high risk-HPV 16 and 12.8% for high risk-HPV 52. HPV infection was predominant in the group of women with no incidence of cytological abnormalities and more prevalent in women of reproductive age, unmarried, low education level, and who reported use condoms during sexual intercourse. It was observed an association between HPV infection and independent variables, such as condom use, multiple sexual partners, and history of sexually transmitted diseases. High-risk types of HPV infection were prevalent in our study. Infection with multiple high-risk HPV genotypes may potentiate the development of cervical cancer in HIV-infected women.

scholarly journals RESULTADOS CLINICOS Y RADIOLOGICOS POSTERIORES AL TRATAMIENTO QUIRURGICO DE FRACTURA DE MESETA TIBIAL EN PACIENTES MILITARES EN ACTIVO DEL CENTRO MEDICO NAVAL DE MEXICO

2021 ◽  
Vol 9 (11) ◽  
pp. 1089-1094
Author(s):  
Camargo-Garcia R. ◽  
◽  
Diaz-De Jesus B. ◽  
Keyword(s):  
Surgical Approach ◽  
Tibial Plateau ◽  
Tibial Plateau Fracture ◽  
Medical Center ◽  
Functional Results ◽  
Daily Activities ◽  
Joint Fractures ◽  
Plateau Fracture ◽  
Military Patients ◽  
The Military

Objective: To lay foundations in the population of theNavy Secretary from Mexico on the frequency, surgical approach, and recovery time of tibial plateau fractures, which would help in the future to develop more efficient protocols for the treatment of these patients and achieve their faster recovery, incorporating into their daily activities of high impact without complications. Materials and methods: We evaluated the functional and radiographic recovery of 20 active military patients with tibial plateau fracture undergoing surgical treatment at the Naval Medical Center of Mexico (CEMENAV) during the period from 2018 to 2021. Results: Of the patients evaluated in this study, it was found that 70% were men, in addition, it was observed that the most frequent tibial plateau fracture was type III, based on the Schatzker scale. Highlighting that the surgical approach most frequently was the previous one >80% of patients. In addition, 45% of patients showed excellent functional recovery, but 15% were poor. However, 90% of the patients had a very good radiographic recovery. Conclusion: The management of proximal tibial joint fractures that occur in the military, which are treated surgically at the Naval Medical Center of Mexico, show favorable functional results accompanied by an adequate radiological evaluation.

Self-sampling versus physician-sampling for human papillomavirus testing

2005 ◽  
Vol 16 (11) ◽  
pp. 727-729 ◽  
Author(s):  
T Agorastos ◽  
K Dinas ◽  
B Lloveras ◽  
R Font ◽  
JR Kornegay ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Sampling Methods ◽  
Cervical Dysplasia ◽  
Kappa Statistic ◽  
Hpv Infection ◽  
Outpatient Clinics ◽  
Sampling Techniques ◽  
Northern Greece ◽  
Hpv Dna ◽  
Exfoliated Cells

We evaluated the detection of human papillomavirus (HPV) infection using two sampling methods of cervical exfoliated cells, consisting of self-sampling of vaginal cells and cervical sampling performed by the physician. Women included were 379 patients of the general population attending outpatient clinics in Northern Greece for routine cytological cervical dysplasia screening. HPV DNA detection was similar with both sampling techniques. The HPV prevalences in self-collected samples were 4.7% and 3.7% in the physician-collected samples ( P>0.05). The Kappa statistic for HPV DNA agreement between the two methods was 0.54 (95% Confidence interval = 0.33–0.75). Self-sampling of cervico-vaginal exfoliated cells could be used as an alternative option to test for HPV infection.

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