Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis.

2011 ◽  
Vol 58 (1) ◽  
Author(s):  
Jolanta Zuwała-Jagiełło ◽  
Monika Pazgan-Simon ◽  
Krzysztof Simon ◽  
Maria Warwas
Keyword(s):  
Oxidative Stress ◽  
Liver Cirrhosis ◽  
Inflammatory Response ◽  
Chronic Inflammation ◽  
Inflammatory Markers ◽  
Antioxidant Defense ◽  
Early Stage ◽  
Plasma Concentrations ◽  
Advanced Oxidation ◽  
Advanced Oxidation Protein Products

Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis. In the present study, we investigated the association between chronic inflammatory response triggered by AOPPs and the severity of liver disease as assessed by the Child-Pugh score. Plasma concentrations of AOPPs and inflammatory markers such as C-reactive protein, tumor necrosis factor-α, and interleukin-6 were measured in 41 patients with HCV-related cirrhosis, 43 patients with alcohol-related liver cirrhosis (ALC), and in 30 age and sex matched controls. In comparison with controls, AOPPs were increased in HCV-related compensated (Child-Pugh A) and decompensated (Child-Pugh B-C) cirrhosis and in alcohol-related compensated cirrhosis. AOPPs level positively correlated with Child-Pugh score in alcohol-related cirrhosis but not in HCV-related cirrhosis and the correlation with the indices of chronic inflammation was stronger in ALC. In turn, AOPPs in HCV-related cirrhosis was related to inflammation to a lesser extent, but a significant correlation with antioxidant defense could be noted. In summary, liver cirrhosis was associated with increased formation of AOPPs, which differed between alcohol-related and HCV-related cirrhosis with respect to the relationship between AOPPs and antioxidant defense, stage of liver cirrhosis, and inflammatory response. The significant correlation between AOPPs accumulation and indices of chronic inflammation, more specifically TNF-α, suggests that oxidative stress may be a mediator of chronic inflammatory state in the early stage of alcohol-related cirrhosis.

scholarly journals Elevated advanced oxidation protein products levels in patients with liver cirrhosis.

2009 ◽  
Vol 56 (4) ◽  
Author(s):  
Jolanta Zuwała-Jagiełło ◽  
Monika Pazgan-Simon ◽  
Krzysztof Simon ◽  
Maria Warwas
Keyword(s):  
Oxidative Stress ◽  
Liver Cirrhosis ◽  
Advanced Oxidation ◽  
Total Antioxidant Status ◽  
Meld Score ◽  
Stress Index ◽  
Serum Concentrations ◽  
Advanced Oxidation Protein Products ◽  
Decompensated Liver Cirrhosis ◽  
Total Antioxidant

Serum concentrations of advanced oxidation protein products (AOPPs) and glycation end products (AGEs) were assessed with respect to functional compromise of liver, as determined by the Child-Pugh and MELD scores. Patients with decompensated liver cirrhosis (Child-Pugh B and C) exhibited significantly higher serum concentrations of AOPPs than both patients with compensated liver cirrhosis (Child-Pugh A) and controls. The levels of plasma AGEs in all liver cirrhotic patients were higher when compared with those with the controls and this difference was statistically significant. Plasma total antioxidant status of the patients was significantly lower than that of controls. Significant positive correlations between AOPPs level and the MELD score and between the oxidative stress index and the MELD score were found in all patients with liver cirrhosis. Altered AOPPs levels in decompensated patients may influence the potency of oxidative stress and the progression of liver disease.

Advanced oxidation protein products in serum of patients with myotonic disease type I: association with serum γ-glutamyltransferase and disease severity

2005 ◽  
Vol 43 (7) ◽  
Author(s):  
Gabriele Siciliano ◽  
Livia Pasquali ◽  
Anna Rocchi ◽  
Michela Falorni ◽  
Fabio Galluzzi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Characteristic Curve ◽  
Advanced Oxidation ◽  
Clinical Severity ◽  
Total Serum ◽  
Type I ◽  
Advanced Oxidation Protein Products ◽  
Severity Scores

AbstractSteinert's disease (myotonic dystrophy type 1; MD) is caused by a CTG trinucleotide expansion on 19q13.3. Although the pathogenic mechanism underlying multisystem involvement in MD is still unclear, a role of oxidative stress in this disease has been suggested. We investigated 39 MD patients to assess the plasma concentration of advanced oxidation protein products (AOPPs) and γ-glutamyltransferase (GGT) and related them to clinical severity scores. Plasma AOPP levels (p=0.021), total serum GGT activity (p=0.0005) and GGT activity associated with low-density lipoprotein (p=0.0021) were significantly higher in patients than in controls. There was significant correlation between serum GGT levels and AOPPs (r=0.5831; p=0.0022). A statistically significant increase in serum GGT with age was found in MD patients (p=0.0193). Receiver operating characteristic curve analysis showed that higher AOPP levels were significantly associated with extra-muscular signs of the disease, i.e., cataracts and heart involvement (area under the curve±SE=0.908±0.083), but not with muscular involvement. The concomitant increment in GGT and AOPPs indicates a possible role of oxidative stress in the pathogenesis of MD type 1, while the association of increased AOPP levels with extra-muscular signs of the disease suggests that individual susceptibility to oxidative stress can modulate the extra-muscular phenotype of the disease.

scholarly journals Level of advanced oxidation protein products is associated with subclinical atherosclerosis

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Zsolt Bagyura ◽  
Angéla Takács ◽  
Loretta Kiss ◽  
Edit Dósa ◽  
Réka Vadas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Subclinical Atherosclerosis ◽  
Advanced Oxidation ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Advanced Oxidation Protein Products ◽  
Male Population

Abstract Background Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers of oxidative stress. Thickening of the carotid intima-media layers indicates subclinical atherosclerosis and can be detected by carotid ultrasound. Objective Our aim was to examine the association between carotid intima-media thickness (CIMT) and the level of AOPPs. Methods Carotid duplex scans and measurements of AOPPs were performed on 476 participants of a cardiovascular population study. The presence of conventional cardiovascular risk factors was investigated with a questionnaire, physical examination, and laboratory tests. Results There was a positive correlation between maximum CIMT and the level of AOPPs only in the male population (r = 0.219, p = 0.033). Multivariate analysis has revealed that the association between AOPPs and mean or maximum CIMT was independent of cardiovascular risk factors (OR = 1.458, p = 0.004, and OR = 2.038, p < 0.001). Conclusions Among males, the elevated level of AOPPs as a marker of oxidative stress may signal the existence of early atherosclerotic alterations.

scholarly journals Effects of EPA and DHA Supplementation on Plasma Specialized Pro-resolving Lipid Mediators and Blood Monocyte Inflammatory Response in Subjects with Chronic Inflammation (OR29-01-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jisun So ◽  
Nirupa Matthan ◽  
Krishna Maddipati ◽  
Alice Lichtenstein ◽  
Dayong Wu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Inflammatory Response ◽  
Chronic Inflammation ◽  
Plasma Concentrations ◽  
Plasma Phospholipid ◽  
Docosapentaenoic Acid ◽  
Blood Monocytes ◽  
High Oleic Sunflower Oil ◽  
Epa And Dha

Abstract Objectives The role of n-3 fatty acid-derived specialized pro-resolving mediators (SPMs), including the novel docosapentaenoic acid (DPA) products, in reducing inflammation in humans has not been determined. We evaluated the differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on plasma SPMs and the resulting impact on the inflammatory response of peripheral blood monocytes. Methods In a randomized, controlled, crossover trial, 21 subjects (9 men and 12 women, 50–75 y) with chronic inflammation (C-reactive protein > 2 µg/mL) entered a 4-week lead-in control phase (high oleic sunflower oil, 3 g/d) and then two sequential 10-week supplementation phases with pure EPA or DHA (3 g/d each), separated by a 10-week washout phase. Plasma phospholipid (PL) fatty acid composition and SPMs, including their precursors, were measured at the end of each phase. Following lipopolysaccharides (LPS) stimulation, the inflammatory response of blood monocytes was assessed by inflammatory gene expression. Results EPA increased PL EPA (P < 0.001) and plasma concentrations of 18-HEPE, the precursor of the E-series resolvins (RvEs) (P < 0.001). The increase in plasma 18-HEPE concentrations, was associated with the increase in PL EPA (β = 14.9 pg/ml, P < 0.01). However, RvEs were undetectable. EPA increased PL DPA (P < 0.001) but not DPA-derived SPMs. DHA increased PL DHA and plasma concentrations of 17-HDHA and 14-HDHA, the precursors of DHA-derived SPMs (P < 0.001). DHA also significantly increased PL EPA and 18-HEPE (P < 0.001), suggesting some DHA retroconversion to EPA. Interestingly, DHA lowered PL DPA (P < 0.001) but increased the DPA-derived SPMs RvD5n-3 DPA and MaR1n-3 DPA (P < 0.001). In monocytes, while both EPA and DHA lowered the LPS-induced expression of TNFA(P < 0.03 and P < 0.001, respectively), TNFA expression was inversely correlated with plasma concentrations of MaR1n-3 DPA (ρ = −0.32, P < 0.04). Conclusions Relative to EPA, DHA supplementation increases a broader range of SPMs, with EPA and DHA differentially affecting PL DPA and DPA-derived SPMs. Plasma concentrations of MaR1n-3 DPA following EPA and DHA supplementation are associated with an attenuated inflammatory response in blood monocytes, suggesting a potential role of this SPM in reducing inflammation in humans. Funding Sources Funded by USDA/NIFA and Cohn Student Award. Supporting Tables, Images and/or Graphs

Oxidative Stress in the Early Stage of Psychosis

2021 ◽  
Vol 21 ◽  
Author(s):  
Ventriglio Antonio ◽  
Bellomo Antonello ◽  
Favale Donato ◽  
Bonfitto Iris ◽  
Vitrani Giovanna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Negative Symptoms ◽  
Antioxidant Defense ◽  
Psychotic Disorders ◽  
Early Stage ◽  
Antioxidant Defense System ◽  
Cochrane Library ◽  
First Episode ◽  
Enzymatic Antioxidants ◽  
Defense System

Background: In the past few decades, increasing evidence in the literature has appeared describing the role of the antioxidant defense system and redox signaling in the multifactorial pathophysiology of psychosis. It is of interest to clinicians and researchers alike that abnormalities of the antioxidant defense system are associated with alterations of cellular membranes, immune functions and neurotransmission, all of which have some clinical implications. Methods: This narrative review summarizes the evidence regarding oxidative stress in the early stages of psychosis. We included 136 peer-reviewed articles published from 2007 to 2020 on PubMed EMBASE, The Cochrane Library and Google Scholar. Results: Patients affected by psychotic disorders show a decreased level of non-enzymatic antioxidants, an increased level of lipid peroxides, nitric oxides, and a homeostatic imbalance of purine catabolism. In particular, a significantly reduced antioxidant defense has been described in the early onset first episode of psychosis, including reduced levels of glutathione. Also, it has been shown that a decreased basal low -antioxidant capacity correlates with cognitive deficits and negative symptoms, mostly related to glutamate-receptor hypofunction. In addition, atypical antipsychotic drugs seem to show significant antioxidant activity. These factors are critical in order to treat cases of first-onset psychosis effectively. Conclusion: This systematic review indicates the importance that must be given to anti-oxidant defense systems.

Monitoring oxidative stress in acute-on-chronic liver failure by advanced oxidation protein products

2011 ◽  
Vol 42 (2) ◽  
pp. 171-180 ◽  
Author(s):  
Hua Liu ◽  
Tao Han ◽  
Jie Tian ◽  
Zheng-Yan Zhu ◽  
Ying Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Failure ◽  
Advanced Oxidation ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Advanced Oxidation Protein Products
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