A STUDY ON THE ROLE OF ELEVATED SERUM PROLACTIN IN PRIMARY FEMALE INFERTILITY

The World Health Organization (WHO) describes infertility as a disability for couples in childbirth to attain pregnancy within 12 months of daily sexual intercourse. The reproductive years of women starts when she starts her menstrual cycle during puberty and capacity to have a child typically ends about age (45) years. However, it may be possible for a woman to become pregnant before her cycles end with menopause. Infertility affects 13–20 per cent of couples worldwide, regardless of race or ethnicity. The present study aim was To study the levels of prolactin and beta hCG in female infertility. And To correlate the levels of prolactin and beta hCG in infertile womens and healthy controls. The present study was conducted in the departments of biochemistry and dept. of obstetrics and gynaecology. The study was conducted on two groups of 40 infertile Females and 40 healthy controls. Serum sample used for estimation of prolactin and hCG, assessed by dry chemistry analyzer. Serum prolactin levels in infertile females is 33.96±11.46 and hCG levels was 86.38±12.45, which was higher in infertile female as compared to healthy control with a p-value of<0.05. The present study concludes that Hyperprolactinemia is a major contributing hormonal factor in infertility among infertile women and, as such, prolactin and hCG should be measured in infertile women.

Download Full-text

The Expression of Prolactin Receptors in Benign Breast Tumors Is Not Associated with Serum Prolactin Level

Journal of Clinical Medicine ◽

10.3390/jcm10245866 ◽

2021 ◽

Vol 10 (24) ◽

pp. 5866

Author(s):

Olena Kolomiiets ◽

Oleksandr Yazykov ◽

Artem Piddubnyi ◽

Mykola Lyndin ◽

Ivan Lukavenko ◽

...

Keyword(s):

Breast Tissue ◽

Elevated Serum ◽

Breast Tumors ◽

Serum Prolactin ◽

Ki 67 ◽

Cystic Fluid ◽

Significant Difference ◽

Hormone Homeostasis ◽

Benign Breast Tumors

The role of prolactin (PRL) and its receptors in the initiation and development of benign breast tumors (BBT) has not been sufficiently studied. An imbalance in the system of hormone homeostasis is crucial in the development of BBT. In particular, an association between elevated prolactin levels and the development of BBT has been reported. Our study showed no significant differences between PRL receptor (PRL-R) expression in BBT tissue under normal and elevated serum PRL levels. There was also no significant correlation between age, PRL-R expression in BBT tissue, intact tissue, and PRL level in the serum. There was a strong significant correlation (p < 0.01; r = 0.92) between PRL-R expression in BBT samples and intact breast tissue, which did not depend on the serum PRL level. There was also no significant difference in the expression of the proliferative marker Ki-67 in BBT tissues from women with normal and elevated levels of serum PRL (p > 0.05). No signs of PRL and its receptors were detected in the BBT cystic fluid women with elevated serum PRL levels. In summary, our prospective study showed that the expression of PRL-R in the tissue of BBT and physiological breast tissue does not depend on the level of serum PRL.

Download Full-text

The Role of Vitamin B6 in Reducing Serum Prolactin in Comparison to Cabergoline

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.10.1.17 ◽

2019 ◽

Vol 10 (01) ◽

Author(s):

Suha J. Witwit

Keyword(s):

Prolactin Level ◽

Vitamin B6 ◽

Reproductive Age ◽

Serum Prolactin ◽

Polycystic Ovaries ◽

Endocrine Disorder ◽

Hypothalamic Pituitary Axis

Hyperprolactinemia is a common endocrine disorder of hypothalamic-pituitary axis. It affect about 4-17% of women in reproductive age and about 3-10% of patients with polycystic ovaries. Vitamin B6 is an effective prolactin inhibitor that is extremely cheap and safe.it exerts hypothalamic dopaminergic effect which causes a significant reduction in prolactin level. The aim of the study is To evaluate the effectiveness of vitamin B6 in reducing serum prolactin in Hyperprolactinemic patient. Compare this effect to that of cabergoline.

Download Full-text

Hepatoprotective Role of Berberine on Doxorubicin Induced Hepatotoxicity - Involvement of Cyp

Current Drug Metabolism ◽

10.2174/1389200221666200620203648 ◽

2020 ◽

Vol 21 (7) ◽

pp. 541-547

Author(s):

Bao Sun ◽

Yue Yang ◽

Mengzi He ◽

Yanan Jin ◽

Xiaoyu Cao ◽

...

Keyword(s):

Drug Metabolism ◽

Cardiac Tissue ◽

Liver Toxicity ◽

Elevated Serum ◽

Similar Response ◽

Wide Range ◽

Cytokine Levels ◽

Major Organ ◽

Anti Oxidant

Background: The liver is one of the major organ involved in drug metabolism. Cytochrome P450s are predominantly involved in drug metabolism. A wide range of CYPs have been reported in the liver which have been involved in its normal as well as in diseased conditions. Doxorubicin, one of the most potent chemotherapeutic drugs, although highly efficacious, also has adverse side effects, with its targets being liver and cardiac tissue. Objective: The study aims to evaluate the reversal potentials of berberine on Doxorubicin induced cyp conversion. Methodology: In the present study, the interplay between anti-oxidants, cytochrome and inflammatory markers in DOX induced liver toxicity and its possible reversal by berberine was ascertained. Results: DOX administration significantly elevated serum as well as tissue stress, which was reverted by berberine treatment. A similar response was observed in tissue inflammatory mediators as well as in serum cytokine levels. Most profound reduction in the cytochrome expression was found in Cyp 2B1, 2B2, and 2E1. However, 2C1, 2C6, and 3A1 although showed a decline, but it did not revert the expression back to control levels. Conclusion: It could be concluded that berberine may be an efficient anti-oxidant and immune modulator. It possesses low to moderate cytochrome modulatory potentials.

Download Full-text

A Study on the Role of Estrogen Receptor Gene Polymorphisms in Female Infertility

Genetic Testing and Molecular Biomarkers ◽

10.1089/gtmb.2016.0097 ◽

2016 ◽

Vol 20 (11) ◽

pp. 692-695 ◽

Cited By ~ 2

Author(s):

Monisha Swaminathan ◽

Vijaya Ganesh ◽

Teena Koshy ◽

Priyanka Venugopal ◽

Solomon Paul ◽

...

Keyword(s):

Estrogen Receptor ◽

Gene Polymorphisms ◽

Receptor Gene ◽

Female Infertility ◽

Estrogen Receptor Gene ◽

Receptor Gene Polymorphisms

Download Full-text

Elevated serum prolactin concentrations in phenylketonuric patients on a ‘loose diet’

Clinical Endocrinology ◽

10.1046/j.1365-2265.1998.00358.x ◽

1998 ◽

Vol 48 (1) ◽

pp. 99-101 ◽

Cited By ~ 10

Author(s):

Schulpis ◽

Papakonstantinou ◽

Michelakakis ◽

Theodoridis ◽

Papandreou ◽

...

Keyword(s):

Elevated Serum ◽

Serum Prolactin

Download Full-text

Severe non-exertional rhabdomyolysis from weight loss supplement in sickle cell trait: A perfect storm?

Case Reports in Internal Medicine ◽

10.5430/crim.v5n1p35 ◽

2018 ◽

Vol 5 (1) ◽

pp. 35

Author(s):

Titilope Olanipekun ◽

Valery Effoe ◽

Ganiat Adeogun ◽

Agniezka Gaertig ◽

Myrtle White ◽

...

Keyword(s):

Weight Loss ◽

Sickle Cell ◽

Sickle Cell Trait ◽

Elevated Serum ◽

African American Female ◽

Garcinia Cambogia ◽

Exertional Rhabdomyolysis ◽

Serum Creatine Phosphokinase ◽

History Of

Exertional rhabdomyolysis from sickle cell trait has been documented. Also, cases of rhabdomyolysis from the use of weight loss supplements in the setting of sickle cell trait and exertion have been described. However, the role of sickle cell trait in non-exertional rhabdomyolysis is not clear. We present a case of severe non-exertional rhabdomyolysis from weight loss supplement in a patient with sickle cell trait.A 45-year-old African American female with sickle cell trait presented to the emergency department with two days history of fatigue and mild breathlessness. She also reported diarrhea and vomiting for five days before presentation. She admitted to taking Garcinia cambogia (a dietary supplement) for weight loss one week prior to the onset of symptoms. She denied alcohol or drug use, rigorous physical activity or trauma.She was dehydrated on examination. Laboratory values revealed markedly elevated serum creatine phosphokinase (CPK) and creatinine levels. Garcinia cambogia was discontinued and she was hydrated with intravenous fluids. Her CPK and creatinine levels significantly trended down and she was discharged home with no apparent sequelae.Our patient had multiple episodes of diarrhea and vomiting likely from the use of Garcinia cambogia. We believe she suffered non-exertional rhabdomyolysis from dehydration in the setting of sickle cell trait. Though dietary weight loss supplements are marketed as generally safe, this case suggests otherwise. We emphasize that clinicians routinely inquire about use of these supplements and provide appropriate counseling to patients on the adverse effects, especially among those with sickle cell trait.

Download Full-text