Giant Cell Variant of Glioblastoma Multiforme: Report of a Rare Variant in a Child

Basic & Clinical Cancer Research ◽

10.18502/bccr.v12i3.5771 ◽

2021 ◽

Author(s):

Zahra Aminparast ◽

Mazaher Ramezani

Keyword(s):

Glioblastoma Multiforme ◽

Giant Cell ◽

Parietal Lobe ◽

Female Child ◽

Cell Variant ◽

The Right ◽

Persistent Headache ◽

Low Prevalence ◽

Available Information ◽

Giant Cell Glioblastoma

Malignant glial tumors are rare in children. Giant cell variant is a rare subtype of glioblastoma, accounting for about 0.8% of brain tumors and 5% of glioblastoma tumors. Giant cell glioblastoma is a male predominant tumor in children and adults. Due to the low prevalence of this variant, available information is limited. An 11-year-old female child was referred with a chief complaint of a progressive persistent headache. MRI showed a well-defined cystic lesion with a solid mural component in the right parietal lobe with a compression effect on the ipsilateral ventricular system. Surgery was done. After the pathologist reported glioblastoma multiforme, a giant cell variant, the patient received 30 sessions of radiation therapy. The patient was readmitted 18 months later with a headache, and the pathologist confirmed the recurrence of the tumor. Based on radiology, the giant cell glioblastoma cannot be distinguished from the common subtype glioblastoma. The pathologists must be aware of this entity, and histologic differential diagnoses are warranted for diagnostic, prognostic, and therapeutic purposes.

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Association between giant cell glioblastoma and glioblastoma multiforme in the United States: A retrospective cohort study

Brain and Behavior ◽

10.1002/brb3.1402 ◽

2019 ◽

Vol 9 (10) ◽

Author(s):

Amro K. Bin Abdulrahman ◽

Khalid A. Bin Abdulrahman ◽

Yousef R. Bukhari ◽

Abdulaziz M. Faqihi ◽

Juan Gabriel Ruiz

Keyword(s):

United States ◽

Cohort Study ◽

Glioblastoma Multiforme ◽

Giant Cell ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

The United States ◽

Giant Cell Glioblastoma

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Cerebral Glioblastomas Can Be Cured!

Neurosurgery ◽

10.1227/00006123-198505000-00027 ◽

1985 ◽

Vol 16 (5) ◽

pp. 714-717 ◽

Cited By ~ 24

Author(s):

Paul C. Bucy ◽

H.R. Oberhill ◽

Edir B. Siqueira ◽

H.M. Zimmerman ◽

Richard K. Jelsma

Keyword(s):

Glioblastoma Multiforme ◽

Parietal Lobe ◽

Complete Recovery ◽

Full Time ◽

X Ray ◽

Cerebral Gliomas ◽

The Right

Abstract In 1959, a 30-year-old man underwent the removal of a glioblastoma multiforme from the right parietal lobe of his brain. After the operation, he received x-ray therapy. He made a complete recovery. Today, over 25 years later, he is alive and well and is regularly employed full-time. If glioblastomas and other cerebral gliomas are removed completely, the patients can be cured of their tumors.

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Giant cell glioblastoma in childhood-Pathohistological and immunohistochemical analysis, forecast and complex treatment

Medical & Clinical Research ◽

10.33140/mcr.06.07.06 ◽

2021 ◽

Vol 6 (7) ◽

Keyword(s):

Glioblastoma Multiforme ◽

Giant Cell ◽

Magnetic Resonance Image ◽

Clinical Case ◽

Immunohistochemical Analysis ◽

Cell Resistance ◽

Complex Treatment ◽

Early Diagnostics ◽

Image Characteristics ◽

Giant Cell Glioblastoma

A six year old child is presented with giant cell glioblastoma multiforme. The importance of pathohistological and immunohistochemical analysis is discussed for the diagnosis of this rare pathohistological subtype glioblastoma in childhood. The Magnetic Resonance Image Characteristics, unfavorable prognosis and high cancer cell resistance to radiotherapy (RT) and chemotherapy (Ch) are also highlighted. The risk of local recurrences and tumor progression is high, despite the complex treatment, including visibly total tumor surgery, postoperative RT and adjuvant Ch. By this pediatric clinical case of childhood giant cell glioblastoma multiforme, we emphasize the emerging need to optimize early diagnostics and the multidisciplinary healing approach.

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#648 Multifocal giant cell glioblastoma multiforme in a twin with multifocal bilateral retinoblastoma

Journal of Pediatric Hematology/Oncology ◽

10.1097/00043426-199707000-00096 ◽

1997 ◽

Vol 19 (4) ◽

pp. 385

Author(s):

P. C. Davis ◽

D. E. McDonnell ◽

F. Yaghami ◽

K. L. Satya-Prakash ◽

A. L. Lightsey ◽

...

Keyword(s):

Glioblastoma Multiforme ◽

Giant Cell ◽

Bilateral Retinoblastoma ◽

Giant Cell Glioblastoma

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Cerebellar giant cell glioblastoma multiforme in an adult

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.133615 ◽

2014 ◽

Vol 5 (3) ◽

pp. 295 ◽

Cited By ~ 2

Author(s):

SatyaBhusan Senapati ◽

SudhansuSekhar Mishra ◽

SanjayKumar Behera ◽

ManmathKumar Dhir

Keyword(s):

Glioblastoma Multiforme ◽

Giant Cell ◽

Giant Cell Glioblastoma

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Anaplastic astrocytoma and anaplastic oligodendroglioma occurring 6 years after subtotal resection of a central neurocytoma

Journal of Neurosurgery ◽

10.3171/jns-07/07/0185 ◽

2007 ◽

Vol 107 (1) ◽

pp. 185-189 ◽

Cited By ~ 8

Author(s):

Masayuki Kanamori ◽

Toshihiro Kumabe ◽

Mika Watanabe ◽

Teiji Tominaga

Keyword(s):

Glioblastoma Multiforme ◽

Anaplastic Astrocytoma ◽

Lateral Ventricle ◽

Parietal Lobe ◽

Central Neurocytoma ◽

Nuclear Accumulation ◽

Anaplastic Oligodendroglioma ◽

Subtotal Resection ◽

One Year ◽

The Right

✓The authors present the case of a 51-year-old man who presented with an anaplastic astrocytoma and anaplastic oligo-dendroglioma that developed 6 years after subtotal resection of a central neurocytoma in his right lateral ventricle. He had received neither radiation therapy nor chemotherapy after the original resection. On readmission, neuroimaging revealed a mass in the right parietal lobe and a diffuse lesion in the right temporal lobe, insula, and corona radiata. Because both lesions extended to the right lateral ventricle wall, they were regarded as recurrent rather than metachronous tumors. Histological examination revealed anaplastic oligodendroglioma in the parietal lobe and anaplastic astrocytoma in the insula. One year later, the anaplastic astrocytoma was found to have transformed into a glioblastoma multiforme. Fluorescence in situ hybridization analysis and immunohistochemical examinations detected deletions of the 1p36 and 19q13 loci, and nuclear accumulation of TP53 protein in the anaplastic oligodendroglioma but not in the glioblastoma multiforme. These findings suggest that central neurocytoma or progenitor cells have the potential for oligodendrocytic and astrocytic transformation with different genetic aberrations.

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Subgaleal and brain abscesses due to Salmonella enteritidis following craniotomy for giant cell glioblastoma multiforme: A case report and literature review

Surgical Neurology International ◽

10.25259/sni-31-2019 ◽

2019 ◽

Vol 10 ◽

pp. 37 ◽

Cited By ~ 6

Author(s):

Ali Akhaddar ◽

Walter Hall ◽

Mohammed Boucetta

Keyword(s):

Glioblastoma Multiforme ◽

Literature Review ◽

Antibiotic Therapy ◽

Giant Cell ◽

Salmonella Enteritidis ◽

Tumor Resection ◽

Surgical Site Infections ◽

Intracranial Surgery ◽

Brain Abscesses ◽

Giant Cell Glioblastoma

Background: Cranial surgical site infections due to Salmonella species are rarely reported. Only eight cases of Salmonella enteritidis infection following intracranial surgery for brain tumor have been reported to date. We describe a unique case of both subgaleal and brain abscesses caused by S. enteritidis following craniotomy for a parafalcine giant cell glioblastoma multiforme. A literature review of the previously published cases is also provided. Case Description: A 36-year-old previously healthy man presented with a posterior parietal parafalcine giant cell glioblastoma multiforme. 5 weeks after craniotomy for tumor resection, the patient presented with worsening headache and painful swelling at the cranial operative site. Head computed tomography and magnetic resonance imaging scans revealed both scalp and brain abscesses in the previous surgical site. He was treated with aspiration of the subgaleal abscess and ciprofloxacin antibiotic therapy; he made a full recovery. Cultures of the aspirate identified S. enteritidis, although the primary site of infection was not detected. Conclusions: Although postoperative S. enteritidis infections are rare, the large numbers of patients with malignant brain tumors who require tumor resections and receive corticosteroids are at great risk. Adequate drainage (if possible), early isolation of the pathogens, and control of the infection by antibiotic therapy guided by antimicrobial susceptibility testing are vital components to prevent this potentially fatal condition.

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Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

10.20944/preprints201905.0221.v1 ◽

2019 ◽

Author(s):

Amro K. Bin Abdulrahman ◽

Yousef R. Bukhari ◽

Abdulaziz M. Faqihi ◽

Khalid A. Bin Abdulrahman ◽

Juan Gabriel Ruiz

Keyword(s):

Glioblastoma Multiforme ◽

Mortality Rate ◽

Giant Cell ◽

Treatment Modalities ◽

Central Nervous System Tumor ◽

Seer Database ◽

Historical Cohort ◽

Hispanic Ethnicity ◽

The U.S ◽

Giant Cell Glioblastoma

Brain cancer is the tenth leading cause of death in the U.S. Glioblastoma multiforme (GBM) is the most lethal primary malignant central nervous system tumor in adults. The present study employed samples from 1985-2014 to discover the difference in prognosis among glioblastoma subtypes after the evolution of treatment modalities over the past few years. The current study aims to find the differences between Glioblastoma multiforme (GBM) and giant cell glioblastoma (GCG) in terms of prognosis among adults and elderly patients in the U.S. This study is a historical cohort type of study and is conducted on adults and elderly individuals with GBM or GCG from the years 1985-2014 in the U.S. Data were collected from the Surveillance, Epidemiology, and End Results Program (SEER) database. The study exposure was GBM or GCG and the outcome was mortality. The potential confounders were age, sex, race, ethnicity, year of diagnosis, primary site, and surgery. A chi-square test was used for categorical data. A univariate analysis was used for variables having a p-value < 0.05. Potential confounders were selected and evaluated using multivariate logistic regression models to calculate the odds ratio with stepwise selection. The study sample was 25,117. The incidences of GBM and GCG were not similar in relation to age group. Also, Spanish-Hispanic ethnicity was independently protective of GBM and GCG as compared to Non-Spanish-Hispanic ethnicity patients with GBM have a higher mortality rate than do GCG patients. The mortality rate was higher among patients diagnosed before 2010. In conclusion, GCG was not statistically significant in association to reduced mortality. Non-Spanish-Hispanics with GBM or GCG had a higher mortality rate than did Spanish-Hispanics. Factors such as being female, being age >59, and having a year of diagnosis before 2010 were independently associated with increased mortality.

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Cerebellar giant cell glioblastoma multiforme in an adult

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0039-1700339 ◽

2014 ◽

Vol 05 (03) ◽

pp. 295-297 ◽

Cited By ~ 1

Author(s):

Sudhansu Sekhar Mishra ◽

Sanjay Kumar Behera ◽

Manmath Kumar Dhir ◽

Satya Bhusan Senapati

Keyword(s):

Glioblastoma Multiforme ◽

Giant Cell ◽

Clinical Presentation ◽

Treatment Options ◽

Treatment Modalities ◽

Imaging Studies ◽

Pathological Characteristics ◽

Cerebellar Glioblastoma ◽

Cell Variant ◽

Cerebellar Infarct

ABSTRACTCerebellar glioblastoma multiforme (GBM) is a rare tumor that accounts for only 1% of all cases of GBM and its giant cell variant is even much rarely encountered in adults. A case of cerebellar giant cell GBM managed at our institution reporting its clinical presentation, radiological and histological findings, and treatment instituted is described. In conjunction, a literature review, including particular issues, clinical data, advances in imaging studies, pathological characteristics, treatment options, and the behavior of such malignant tumor is presented. It is very important for the neurosurgeon to make the differential diagnosis between the cerebellar GBM, and other diseases such as metastasis, anaplastic astrocytomas, and cerebellar infarct because their treatment modalities, prognosis, and outcome are different.

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