Evaluation of relationship between biochemical parameters and osteoporosis in patients with β-thalassemia major

2022 ◽  
Author(s):  
Mohsen Hamidpour ◽  
Fatemeh Jafari ◽  
Mahdieh Mehrpouri ◽  
Azita Azarkyvan ◽  
Davod Bashash ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Bone Development ◽  
Thalassemia Major ◽  
Late Complications ◽  
Mineral Density ◽  
Study Results ◽  
Thalassemia Minor ◽  
The Mean ◽  
Control Study ◽  
Pth Level

Background: Osteoporosis is one of the late complications of β-Thalassemia major. The pathogenesis of osteoporosis depends on different factors. Ineffectiveness of hematopoiesis is the major factor, and the other factors are defected by hormonal functions or biochemical parameters. Osteoclasts hyperactivity in thalassemia increases the serum receptor activator of nuclear factor Kappa B ligand (RANKL), which plays a crucial role in bone development. This study aimed to evaluate the biochemical and hormonal parameters in patients with β-thalassemia major and their association with osteoporosis. Materials and Methods: In this case-control study, 52 patients with β-thalassemia major and 23 with thalassemia minor as controls were enrolled. The patients’ Bone Mineral Density (BMD) was measured using the Dual Energy X-ray absorptiometry (DEXA) method, and 6 mL peripheral blood of the patients and controls was obtained to detect hormonal and biochemical parameters. Data were analyzed using ANOVA, Spearman correlation coefficient, and T-test. Results:  The mean of BMD in patients was 0.59±0.01 and 0.69±0.11 in femur and vertebrae, respectively. The biochemical parameters in the (patients/ controls) including calcium and alkaline phosphatase (ALK) were 9.1/ 10.2 mg/dL and 171.1/310 IU, respectively indicating a significant decrease (P< 0.05) compared to the controls. On the contrary, the mean levels of Ferritin and Zinc were 1914.18 µg/L and 113.92 mg/mL, respectively which were significantly increased (P= 0.015 and P=0.045, respectively). There was a negative correlation between the femurs BMD of patients with the RANKL level (r= - 0.8, p = 0.034) and the vertebrae BMD of patients with a Parathormone (PTH) level (r= - 0.8, P = 0.028).  Conclusion: The study results indicated that the hyperactivity of RANKL and PTH in thalassemia patients might cause osteoporosis; therefore, detecting biomarkers mentioned above could be useful to diagnose osteoporosis.

scholarly journals Clinical and Polysomnographic Characteristics of Patients with Extreme Obstructive Sleep Apnea, AHI > 100: A Case-Control Study

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Forogh Soltaninejad ◽  
Negarsadat Neshat ◽  
Mehrzad Salmasi ◽  
Babak Amra
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Apnea Hypopnea Index ◽  
Obstructive Sleep ◽  
Study Results ◽  
Significant Difference ◽  
Severe Manifestation ◽  
The Mean ◽  
Nocturnal Polysomnography ◽  
Control Study

Background: Severe obstructive sleep apnea (OSA), defined by apnea-hypopnea index (AHI) as more than 30 events per hour, was previously related to more comorbidity. However, limited studies separated the patients with AHI > 100 from those with a less severe manifestation of the disease. Objectives: The current study aimed at describing the characteristics of this subgroup and comparing them with less severe conditions. Methods: A retrospective analysis was conducted on 114 patients with OSA. Nocturnal polysomnography was used to diagnose severe OSA. Patients were categorized into two groups: (1) 60 < AHI < 100 (very severe OSA), (2) AHI ≥ 100 (extreme OSA). Demographic, medical history, and polysomnographic variables were evaluated and compared between the two groups. Results: Extreme OSA was diagnosed in 19 patients, the mean body mass index (BMI) was significantly higher in this group (39.26 ± 5.93 vs. 35.68 ± 6.45 kg/m2, P = 0.025). They also had lower minimal O2 saturation (65.68 ± 10.16 vs. 74.10 ± 8.74, P = 0.003) and more time with < 90% O2 saturation (T < 90%) (81.78 ± 22.57 vs. 58.87 ± 33.14, P = 0.01). OHS prevalence was significantly higher in the group with extreme OSA (P = 0.04). The most frequent comorbidity was hypertension, with an incidence of 60.5%, for the extreme group, although there was no significant difference between the two groups in terms of clinical associations. Conclusions: The current study results suggested that greater BMI and lower minimal O2 saturation, as well as increased T < 90%, were associated with extreme OSA, although no differences were observed in the associated diseases between the compared groups.

Iron Overload Associated Endocrine Dysfunction Leading to Lower Bone Mineral Density in Thalassemia Major

2020 ◽  
Vol 105 (4) ◽  
pp. e1015-e1024
Author(s):  
Wen-Ping Yang ◽  
Hsiu-Hao Chang ◽  
Hung-Yuan Li ◽  
Ying-Chuen Lai ◽  
Tse-Ying Huang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Iron Overload ◽  
Bone Mineral ◽  
Fibroblast Growth Factor 23 ◽  
Body Height ◽  
Thalassemia Major ◽  
Lower Bone Mineral Density ◽  
Mineral Density ◽  
Fracture History ◽  
The Mean

Abstract Context Patients with thalassemia major (TM) have a lower bone mineral density (BMD) and higher risk of fracture than the general population. The possible mechanisms include anemia, iron overload, malnutrition, and hormonal deficiency, but these have not been thoroughly investigated. Objective To identify major mineral and hormonal factors related to BMD in adult TM patients to provide human evidence for the proposed mechanisms. Design Retrospective study. Setting Referral center. Patients Twenty-nine patients with β-TM, aged 23 to 44 years who were followed-up during 2017 to 2018 were enrolled. Outcome measurements Endocrine profiles, including thyroid, parathyroid, and pituitary function, glucose, vitamin D, calcium, phosphate, and fibroblast growth factor 23 (FGF23) were obtained. The relationships among the above parameters, body height, fractures, and BMD were analyzed. Results Abnormal BMD was observed in 42.9% of women and 23.1% of men. The mean final heights of women and men were 3.7 cm and 7.3 cm lower than the mean expected values, respectively. Fracture history was recorded in 26.7% of women and 35.7% of men. BMD was negatively correlated with parathyroid hormone, FGF23, thyrotropin, and glycated hemoglobin (HbA1c) levels, and positively correlated with testosterone, IGF-1, and corticotropin levels (all P &lt; .05). Moreover, hypothyroidism was associated with lower BMD in both the lumbar spine (P = .024) and the femoral neck (P = .004). Patients with hypothyroidism had a higher percentage of abnormal BMD (P = .016). Conclusion Hypothyroidism, higher HbA1c, and lower adrenocorticotropin were predictors of abnormal BMD in patients with β-TM. Whether the correction of these factors improves BMD warrants further research.

scholarly journals Parathyroid hormone in pediatric patients with β-thalassemia major and its relation to bone mineral density; a case control study

2017 ◽  
Vol 18 (1) ◽  
pp. 75-78 ◽  
Author(s):  
Mostafa El-Nashar ◽  
Ahmed Kamel Mortagy ◽  
Nagham M.S. El-Beblawy ◽  
Eman El-Gohary ◽  
Irene Mokhtar Kamel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Parathyroid Hormone ◽  
Bone Mineral ◽  
Pediatric Patients ◽  
Case Control Study ◽  
Thalassemia Major ◽  
Case Control ◽  
Mineral Density ◽  
Control Study

scholarly journals VITAMIN D DEFICIENCY AND PCOS;

2018 ◽  
Vol 26 (01) ◽  
Author(s):  
Maryam Bashir ◽  
Shafqat Mukhtar ◽  
MUHAMMAD - IKRAM ◽  
Amna Javed
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Reproductive Capacity ◽  
Control Group ◽  
Case Group ◽  
Adult Women ◽  
Ovary Syndrome ◽  
Study Results ◽  
The Mean ◽  
Control Study

BackgroundPolycystic ovary syndrome (PCOS) is mainstream gynaecological problems in adult women. Vitamin D has been linked to propensity of developing PCO. As this hormones has certain effects on insulin sensitivity and restoration of reproductive capacity in women with PCOs. So, a study was planned to establish correlation of deficiency of vitamin D and PCOs.ObjectiveTo determine the correlation of deficiency of vitamin D with PCOs in patients reporting to a teaching hospital.Material & MethodsCase control study carried out at institute of Shaikh Zayed Hospital, Lahore, Gynae-Obst Department for six months. If serum level of vitamin D is < 25nmol/L then deficiency was labeled. Odds ratio was calculated between PCOs and vitamin D deficiency, ResultsThe mean age of the patients was 26.91±6.09 years. In this study, 70% females were married. The mean BMI of patients was 22.59±2.48kg/m2, and 76(76%) patients had normal BMI and 24(24%) patients were overweight. Vitamin D deficiency was observed in 47 cases in which 31 were from case group and 16 were from control group with significant association i.e. OR=3.47. ConclusionOur study results concluded that there is more risk of vitamin D deficiency in females with PCOS as compared to females without PCOS.

scholarly journals Relationship Between Osteopontin Biochemical Parameters and BMD Status in Iraqi Postmenopausal Women with Osteoporosis

2020 ◽  
pp. 2494-2503
Author(s):  
Hadeer H. Shamsulddin ◽  
Lina A. Salih ◽  
Samia A. Eleiwe
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Biochemical Parameters ◽  
Serum Levels ◽  
Mean Value ◽  
Extracellular Matrix Protein ◽  
Control Group ◽  
Mineral Density ◽  
The Mean

Osteopontin hormone (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblasts and osteoclasts and associated with bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis.      The aim of the study is to investigate serum levels of circulating OPN and its relationship with biochemical parameters and BMD in postmenopausal women with osteoporosis in Iraq. Serum samples from fifty postmenopausal women were selected from patients attending two educational hospitals in Baghdad, which are AL Wasity Educational Hospital and Baghdad Educational Hospital, during the period from November 2018 to March 2019. Twenty five postmenopausal healthy women were included as a control group. The studied subjects’ ages were in the range of 45-65 years. Dual energy X-ray absorptiometry (DEXA) was the device used to measure bone mineral density and diagnose osteoporosis in both groups. Blood samples were collected from each participant for measuring the serum levels of biochemical parameters (P, Alp, Ca, and OPN)      The results of the demographic parameters showed a significant (P≤0.05) increase in mean values of age, menopause duration, and duration of productive life in the patients as compared to the control group. Also, strong positive correlations between patients and the control were recorded in age and duration of productive age, with a weak inverse correlation in menopause duration. While a significant (P≤0.05) decrease in the mean value of body mass index (BMI), BMD, and T-score as compared to the control. The correlation in BMI was weak significant positive while in the other two parameters it was weak significant inverse.      The results of the present study showed non-significant differences (P ≥0.05) between the patients and control group for serum biochemical parameters. It was also noticed that there was a significant (P≤0.05) increase in the mean value of osteopontin hormone level in the patients as compared to the control, with a weak significant inverse (p≤0.05) correlation.

scholarly journals EVALUATION OF OSTEOPATHY IN PATIENTS WITH BETA-THALASSEMIA MAJOR USING DIFFERENT IRON CHELATION THERAPIES

2018 ◽  
Vol 11 (11) ◽  
pp. 467
Author(s):  
Ali Jalal Shawkat ◽  
Ahmed Hamed Jwaid ◽  
Ghada Marzouq Awad ◽  
Hayder Adnan Fawzi
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Iron Chelation ◽  
Reference Population ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Mineral Density ◽  
Bone Status ◽  
Vitamin D Levels ◽  
Bone Expansion

Objective: We aim to assess the bone mineral density (BMD) and bone biochemical parameters in Iraqi patients with β-thalassemia major (β-TM).Methods: Dual-energy X-ray absorptiometry scan was used to evaluate bone density and interpreted about Z-score which compares to the BMD of age-, sex-, and ethnicity-matched reference population. Biochemical parameters such as calcium, 25-OH Vitamin D, parathyroid hormone, and serum ferritin (SF) evaluated.Results: No statistical difference in SF between pediatrics and adults was determined; however, 66 patients were having their SF between 1000 and 2500 ng/ml and 122 patients with SF ˃2500 ng/ml. Calcium and Vitamin D levels are low in both adults and pediatrics. The bone status shows high percentages of osteoporosis 62% and 54.5% for pediatrics and adults, respectively, as well as osteopenia 27% and 34.3% for both pediatric and adults and to a lesser extent normal bone status 11% for each. Conclusion: Osteopathy has a high prevalence in Iraqi patients with β-TM and should receive an optimal transfusion and chelation therapy to prevent bone expansion. Calcium and Vitamin D should be routinely determined to prevent deficiency.

scholarly journals Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Hiroya Takami ◽  
Kazunori Washio ◽  
Hiromichi Gotoh
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Hemodialysis Patients ◽  
Serum Phosphorus ◽  
Control Group ◽  
Limited Data ◽  
Mineral Density ◽  
The Mean ◽  
Control Study ◽  
Phosphorus Levels

Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy. However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients. We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD. Seventeen patients were treated with denosumab 60 mg every 6 months, and 20 patients were not treated with denosumab (control group). At seven days, the mean corrected calcium level decreased from 9.2±0.5 mg to 8.5±0.5 mg (P<0.01), and mean serum phosphorus decreased from 5.0±1.3 mg/dl to 4.2±0.9 mg/dl (P<0.01). At 1 month, the corrected calcium and serum phosphorus levels were 9.2±0.9 mg/dl and 4.0±1.1 mg/dl, respectively. At 1 year, BMD increased by 2.6%  ± 4.4% in the denosumab group and decreased by 4.5%  ± 7.7% in the control group (P<0.001). In our observational study, denosumab therapy represents an effective treatment for male dialysis patients with low BMD.

Rorschach Characteristics in Adolescents with Systemic Lupus Erythematosus

2006 ◽  
Vol 28 (1) ◽  
pp. 100-118 ◽  
Author(s):  
J. Santoantonio ◽  
L. Yazigi ◽  
E. I. Sato
Keyword(s):  
Lupus Erythematosus ◽  
Case Control Study ◽  
Activity Index ◽  
Disease Activity Index ◽  
Female Adolescents ◽  
Control Group ◽  
Intelligence Scale ◽  
The Mean ◽  
Experimental Group ◽  
Control Study

The purpose of this study was to investigate the personality characteristics in adolescents with SLE. The research design is a case-control study by means of the Rorschach Method and the Wechsler Intelligence Scale. Study group: 30 female adolescents with lupus, 12–17 years of age. The SLE Disease Activity Index was administered during the period of psychological evaluation. Control group: 32 nonpatient adolescents were matched for age, sex, and socioeconomic level. In the Wechsler Intelligence Scale the mean IQ of the experimental group was significantly lower than that of the control group (77 and 98, respectively, p < .001). In the Rorschach, the lupus patients showed greater difficulty in interpersonal interactions, although they displayed the resources to process affect and to cope with stressful situations. A positive moderate correlation (p = .069) between the activity index of the disease and the affect constriction proportion of the Rorschach was observed: the higher the SLEDAI score, the lower the capacity to process affect. There is a negative correlation between the activity index of the disease and the IQ (p = .001): with a higher activity index of the disease, less intellectual resources are available.

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