scholarly journals Complementary effects of coenzyme Q10 and Lepidium sativum supplementation on the reproductive function of mice: An experimental study

2021 ◽  
Author(s):  
Fatemeh Rahimi Asl ◽  
Maryam Khosravi ◽  
Ramin Hajikhani ◽  
Jalal Solati ◽  
Hossein Fahimi
Keyword(s):  
Body Weight ◽  
Luteinizing Hormone ◽  
Coenzyme Q10 ◽  
Follicle Stimulating Hormone ◽  
Reproductive Function ◽  
Serum Testosterone ◽  
Lepidium Sativum ◽  
Control Group ◽  
Male Mice ◽  
Weight Groups

Background: Coenzyme Q10 (CoQ10) and Lepidium sativum (LS) have therapeutic effects on infertility. Objective: To evaluate the combined effects of LS and CoQ10 on reproductive function in adult male NMRI mice. Materials and Methods: Eighty three-months-old male mice (35–40 gr) were divided into four groups (n = 10/each): control (treated with water), CoQ10-treated (200, 300, and 400 mg/kg/body weight), LS-treated (200, 400, 600 mg/kg/body weight), and co-treated (LS [600 mg/kg/body weight] + CoQ10 [200 mg/kg/body weight]) groups. Serum testosterone, luteinizing hormone, follicle-stimulating hormone, and gonadotropin realizing hormone (GnRH) levels were measured using ELISA method. The sperm quality was assessed using Sperm Class Analyzer® (SCA) CASA system and GnRH mRNA expression levels were evaluated by real-time polymerase chain reaction. Results: The number of sniffing and following behavior was significantly higher in LStreated (400 and 600 mg/ml/body weight) groups than the control group (p = 0.0007 and p = 0.0010, respectively). The number of mounting and coupling behaviors was significantly higher in the CoQ10 (300 and 400 mg/ml/body weight)-treated animals than the control group (p = 0.0170 and p = 0.0006, respectively). Co-treatment of CoQ10 (200 mg/ml/body weight) and LS (600 mg/ml/body weight) significantly increased all aspects of sexual behaviors as well as the levels of serum testosterone (p = 0.0011), luteinizing hormone (p = 0.0062), and follicle-stimulating hormone (p = 0.0001); sperm viability (p = 0.0300) and motility (p = 0.0010); and GnRH mRNA levels (p = 0.0016) compared to the control group. Conclusion: The coadministration of CoQ10 and LS significantly improves the activity of the hypothalamic-pituitary-gonadal axis and enhances the reproductive parameters in adult male mice. Key words: Lepidium sativum, Coenzyme Q10, Infertility, Male reproductive function.

Study the effect of alcoholic extractrawsalvia officnalis on some sex hormonesin female mice white

2018 ◽  
Vol 9 (SPL1) ◽  
Author(s):  
Frah razzaq Kbyeh
Keyword(s):  
Body Weight ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Physiological Solution ◽  
Control Group ◽  
Alcoholic Extract ◽  
Female Mice ◽  
Group B ◽  
The Impact ◽  
Stimulating Hormone

 Thirty female mice white used in the experiment for the purpose of knowing the effect of alcoholic extract raw salvia officnalisleaves on the level of sex hormones which were divided animals into three groups experimental rate of ten mice per group dosage group B and C oral daily dose of the extract amount 500 mg / kg of body weight the first group, respectively,in the1000 mg/ Kg of body weight,respectively,either the first set group A treated the same way time and himself as 0.1 ml / g body weight of physiological solution compared to the mind set lasted 30 days dosing was weight when you stop recording the dosage and then kill her blood was collected through a stab heart for the purpose of studies of hormonal (estrogen,progesterone,luteinizing hormone,follicle stimulating hormone and prolactin)extract reflected the impact of the variables studied and related to fertility in the following results compared with the control group. Low body weight was in the doses and the effect of the dose of 1000 mg / kg of body weight was significantly larger dose of 500 mg / kg of body weight at a level significantly 5% P0≤0.05. Significant increase in the level of hormones (progesterone,estrogen,luteinizing hormone,follicle-stimulating hormone) in the doses and the effect of the dose of1000 mg / kg of body weight was significantly larger dose of 500 mg / kg of body weight at a level significantly 5% P0≤0.05. Significant decrease in the level of the hormone prolactin in the doses and the effect of the dose of 1000 mg / kg of body weight was significantly larger dose of 500 mg / kg of body weight at a level significantly 5% P0≤0.05

Effects of alarin on food intake, body weight and luteinizing hormone secretion in male mice

Neuropeptides ◽  
2012 ◽  
Vol 46 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Gregory S. Fraley ◽  
Emily Leathley ◽  
Nicole Lundy ◽  
Emily Chheng ◽  
Issurah King ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Male Mice ◽  
Luteinizing Hormone Secretion

scholarly journals NIFEDIPINEON;

2019 ◽  
Vol 26 (02) ◽  
Author(s):  
Sidra Hamid ◽  
Qaiser Aziz ◽  
Aneela Jamil ◽  
Lubna Meraj ◽  
Shazia Muazam ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Luteinizing Hormone ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Channel Blockers ◽  
Sprague Dawley ◽  
Study Objective ◽  
Serum Luteinizing Hormone ◽  
Sprague Dawley Rats

Background: The most potent and effective drugs used for the management of blood pressure in hypertensive patients are Calcium channel blockers (CCBs). Nifedipine, a CCB, acts by blocking entry of calcium ions all the way through the voltage gated calcium channels (VGCCs) of L-type present in the smooth muscle cells of blood vesselsand reducing the blood pressure by decreasing the peripheral vascular resistance. Objectives: The study objective was to determine the effect of nifedipine on serum luteinizing hormone (LH) and serum testosterone in male Sprague Dawley rats. Study Design: Animal experimental study. Setting: All experiments were conducted at the Research laboratory of Shifa College of Medicine, Islamabad along with National Institute of Health (NIH), Islamabad. Period: October, 2012 to April, 2014. Methods: The study was done on adult male Sprague-Dawley rats (N= 60) aged 90-120 days old and their body weights varied between 200 + 50 grams. Rats were divided intotwo groups (n=30). Group A was administered0.5 ml distilled water/rat daily orally, group B was administered orally with nifedipine 50 mg/kg/rat dissolved in 1ml of DMSO. All the doses were given to rats for 8 weeks. After 8 weeks, serum luteinizing hormone and serum testosterone were measured in both groups. Results: In Nifedipine treated group, serum testosterone was significantly decreasedand serum LH was unaffected as compared to the control group. Conclusion: Nifedipine has adverse effects on male fertility as it decreases serum testosterone level.

scholarly journals Effects of l-Carnitine on the Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Testicular Tissue Oxidative Stress Levels in Streptozotocin-Induced Diabetic Rats

2018 ◽  
Vol 23 ◽  
pp. 2515690X1879605 ◽  
Author(s):  
Nourollah Rezaei ◽  
Tahereh Mardanshahi ◽  
Majid Malekzadeh Shafaroudi ◽  
Saeed Abedian ◽  
Hamid Mohammadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Serum Levels ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Group Vi ◽  
Group I ◽  
Stimulating Hormone

The present study was designed to investigate the antioxidant property of l-carnitine (LC) on serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TH) and testis oxidative stress in streptozotocin (STZ)-induced diabetic rats. The rats were divided into the following groups: group I, control; group II, LC 100 mg/kg/d; group III, diabetic; and groups IV to VI, diabetic rats treated with 50, 100, and 200 mg/kg/d of LC, respectively. Daily injections were given intraperitoneally for 7 weeks. At the end of experimental period, after sacrificing the rats, FSH, LH, TH, total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), mitochondrial function (MTT), protein carbonyl (PC), and reactive oxygen species (ROS) levels were measured. STZ caused an elevation of MDA, ROS, and PC ( P < .001) with reduction of GSH, CAT, TAC, and MTT ( P < .001) in the serum levels. Group VI had significantly increased FSH, LH, and TH levels versus the untreated diabetic group ( P < .001). Although groups V and VI significantly decreased MDA ( P < .001), PC ( P < .01), and ROS ( P < .01) compared with the untreated diabetic group; only in group VI, the activity of GSH ( P < .001), CAT ( P < .01), TAC ( P < .001), and MTT ( P < .001) significantly increased. The results of the present study suggest that LC decreased diabetes-induced oxidative stress complications and also improved serum level of FSH, LH, and TH by reducing levels of lipid peroxidation and increasing antioxidant enzymes.

scholarly journals Decreased luteinizing hormone pulse frequency is associated with elevated 24-hour ghrelin after calorie restriction and exercise in premenopausal women

2013 ◽  
Vol 304 (1) ◽  
pp. E109-E116 ◽  
Author(s):  
Jennifer L. Scheid ◽  
Mary Jane De Souza ◽  
Brenna R. Hill ◽  
Heather J. Leidy ◽  
Nancy I. Williams
Keyword(s):  
Weight Loss ◽  
Luteinizing Hormone ◽  
Premenopausal Women ◽  
Reproductive Function ◽  
Pulse Frequency ◽  
Energy Deficit ◽  
Control Group ◽  
Supervised Exercise ◽  
Lh Pulsatility ◽  
Change In Mean

Elevated ghrelin has been shown to be associated with reduced luteinizing hormone (LH) pulsatility in Rhesus monkeys, rats, men, and recently women. We previously reported that 24-h ghrelin concentrations are elevated in women following a 3-mo exercise and diet program leading to weight loss. We investigated whether the elevations in ghrelin following an ∼3-mo exercise and diet program leading to weight loss are associated with a decrease in LH pulsatility. The nonexercising control group (Control, n = 5) consumed a controlled diet that matched energy needs, whereas energy intake in the exercise group (Energy Deficit, n = 16) was reduced from baseline energy requirements and supervised exercise training occurred five times per a week. Significant decreases in body weight (−3.0 ± 0.6 kg), body fat (−2.9 ± 0.4 kg) and 24-h LH pulse frequency (−0.18 ± 0.08 pulses/h), and a significant increase in 24-h mean ghrelin were observed in only the Energy Deficit group. The pre-post change in LH pulse frequency was negatively correlated with the change in mean 24-h ghrelin ( R = −0.485, P = 0.030) and the change in peak ghrelin at lunch ( R = −0.518, P = 0.019). Interestingly, pre-post change in night LH pulse frequency was negatively correlated with the change in mean day ghrelin ( R = −0.704, P = 0.001). Elevated total ghrelin concentrations are associated with the suppression of LH pulsatility in premenopausal women and may play a role in the suppression of reproductive function following weight loss.

ENHANCED TESTOSTERONE IN FEMALE PATIENTS WITH ANOREXIA NERVOSA: ITS NORMALIZATION AFTER WEIGHT GAIN

1979 ◽  
Vol 90 (2) ◽  
pp. 328-335 ◽  
Author(s):  
B. Baranowska ◽  
S. Zgliczyński
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Weight Gain ◽  
Serum Testosterone ◽  
Gonadal Hormones ◽  
High Serum ◽  
Control Group ◽  
Testosterone Concentration ◽  
Female Patients ◽  
Serum Lh

ABSTRACT In order to elucidate the mechanism of disturbances of gonadal hormones secretion in anorexia nervosa 14 female patients were investigated. A control group also consisted of 14 women of the same age. The serum LH, progesterone, oestrogens: oestrone + oestradiol (Oe1 + Oe2), oestriol (Oe3) and testosterone were determined by radioimmunological methods. In patients with anorexia nervosa the serum testosterone and Oe3 concentrations were dramatically elevated, whereas LH, progesterone and Oe1 + Oe2 were decreased as compared with the control group. Considerable weight gain induced by cyproheptadine treatment caused a normalization of the serum testosterone and Oe3 concentrations in all the patients. A negative correlation between the testosterone level and the deficit in body weight was observed. The mechanism causing the dramatically high serum testosterone concentration in the female patients with anorexia nervosa is discussed.

scholarly journals Influence of Different Feeding Ratio of Pomegranate Peels Powder on Testicular Dimensions, Body Weight and Testosterone Concentration in Karadi Male Lambs

2019 ◽  
Vol 12 (2) ◽  
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Average Daily Gain ◽  
Serum Testosterone ◽  
Control Group ◽  
Final Body Weight ◽  
Testosterone Concentration ◽  
Scrotal Circumference ◽  
Total Body ◽  
Daily Gain

The current study was presented to conclude the influence of different ratio of pomegranate peel powder (PP) in feed of Karadi male lambs, they divided to 4 groups (0% as a control, 1% treatment 1, 2% treatment 2 and 4% as treatment 3), on scrotal circumference (SC), scrotum height (SH), body weight (BW) and blood serum testosterone concentration (T). In this study, sixteen (16) of Karadi male lambs used with 24.30 ± 0.40 kg weight and with 4-5 months old, all lambs have been randomly divided equally into four (4) groups and individually penned in a box for during 63 days. Results in our study showed that SC was significantly different and recorded higher 17.875±0.54 cm in group that fed on 1% PP, also SH recorded higher and significant different in group fed on 1% PP compared with other groups 10.000±0.32 cm. Average blood serum testosterone reduces in all groups compared to control group that fed on 0% of PP (11.418±0.15 n.mol/L). Final body weight in our study had significantly different (P < 0.05) between groups, 1% PP recorded higher weight (34.9 ± 0.58) kg. Each average daily gain, total body gain and initial body weight had not significant different in all groups. Correlation coefficient between SC, SH, blood serum testosterone concentration and final BW computed and ranged between (-0.397 to + 0.914).

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