scholarly journals The Epidemiological and Clinical Characteristics of Celiac Disease among Patientswith Irritable Bowel Syndrome in Zanjan Province, Iran

2021 ◽  
Author(s):  
Hassan Neishaboori ◽  
Somaye Abdollahi Sabet ◽  
Pegah Moharrami Yeganeh ◽  
Seyede Vanoushe Azimi Pirsaraei
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Clinical Characteristics ◽  
Delayed Diagnosis ◽  
Cross Sectional Study ◽  
Endoscopic Biopsy ◽  
Cross Sectional ◽  
Diagnostic Approaches ◽  
Spss Software ◽  
Irritable Bowel

Background: There are some overlaps between celiac disease and irritable bowel syndrome symptoms (IBS). It can lead to misdiagnosis or delayed diagnosis of celiac disease. In some guidelines, it is recommended to screen for celiac in IBS cases. For assessment of the necessity for such diagnostic approaches in patients, this study was done to evaluate the epidemiological and clinical characteristics of celiac disease among IBS cases in Zanjan, Iran. Methods: In this descriptive cross-sectional study, 121 cases with IBS attending to gastroenterology clinics since 2015 to 2018 were enrolled. The laboratory tests and upper digestive endoscopy were performed for all patients. Endoscopic biopsy specimens were taken from the duodenum, and the samples were examined to confirm diagnosis of celiac disease. Data analysis was done by SPSS software. Results: Of 121 studied patients, 51.2% were male. The mean age of the patients was 36.65 ± 10.09 years old. The most common IBS subtype was mixed (80.2%). According to the serology results and Marsh grading, 4.1% and 1.6% had celiac disease and potential celiac disease, respectively. There were statistically significant differences among celiac disease in gastroesophageal reflux disease and abdominal discomfort/cramping. Conclusion: The incidence of celiac disease was evaluated 4.1 cases per each 100 patients with IBS, which was higher than recent similar studies, and screening for celiac disease in these patients is advisable. However, further studies with larger sample size are required to attain more definite results.

scholarly journals Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

2020 ◽  
Author(s):  
Adam Miraj Gembe
Keyword(s):  
Health Care ◽  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Medical Students ◽  
Health Care Professionals ◽  
Tissue Transglutaminase ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Irritable Bowel

Abstract Background: Global prevalence of irritable bowel syndrome is high among medical students and health care professionals with significant morbidity. Similarly, the prevalence of celiac disease in irritable bowel syndrome is higher than the general population. These conditions impair quality of life and contribute to social-economic burden. In Tanzania, little is known about irritable bowel syndrome and celiac disease among medical students and health care professionals. Methods: A cross sectional study was conducted to MUHAS and Mloganzila Academic Medical Center (MAMC) staff and students who fulfilled the online shared Rome IV criteria of irritable bowel syndrome from August to November 2018. A structured questionnaire was used to collect socio-demographic data, anthropometric measurements and clinical manifestations. Blood samples for full blood picture, liver enzymes and Erythrocyte Sedimentation Rate were taken. Celiac disease was tested using anti-tissue transglutaminase antibody test. Qualitative and quantitative data were summarized using frequency distribution tables. Chi-square and fishers exact test were used to study comparison between groups. Logistic regression was used to study associations. Data was analyzed using SPSS version 20.0 and a P value of ≤0.05 was considered significant.Results: Out of 1,321 participants, 192 (14.5%) had irritable bowel syndrome in which 77 (40.1%) were males and 115 (59.9%) were females. Among the 192 participants with irritable bowel syndrome, 3 (1.6%) were positive for celiac disease, 2 (66.7%) were females and 1 (33.3%) was a male. Of the 3 patients with CD, 2 had elevated ALAT and 1 had anaemia. Age (AOR 2.53, 95% C.I 1.57-4.09), sex (AOR 1.67, 95% C.I 1.16-2.41), marital status (AOR 4.95 C.I 2.07-11.82), alcohol intake (AOR 2.47, 95% C.I 1.16-5.23), year of study (AOR 8.49, 95% C.I 5.71-12.64) and sleep duration (AOR 2.24, 95% C.I 1.23-4.06) were found to be independently associated with IBS. Conclusion: Prevalence of IBS and its associated factors in our study population was similar to findings from studies done elsewhere. Also, our study revealed a low prevalence of celiac disease among IBS participants.

Prevalence of celiac disease in Iranian patients with irritable bowel syndrome: A cross-sectional study

2013 ◽  
Vol 15 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Ali Akbar Shayesteh ◽  
Eskandar Hajiani ◽  
Seyed Jalal Hashemi ◽  
Abdolrahim Masjedizadeh ◽  
Seyed Mahmod Latifi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Irritable Bowel ◽  
Iranian Patients

scholarly journals Prevalence of celiac disease in irritable bowel syndrome patients: A single centre experience from a large teaching hospital of Lahore, Pakistan

2021 ◽  
Vol 14 (4) ◽  
pp. 176-179
Author(s):  
Mohammad Ahmed Saifullah ◽  
Amer Ahmad Khan ◽  
Sarmad Zahoor ◽  
Sidra Saif ◽  
Javed Sajjad Hashmi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Demographic Data ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Military Hospital ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Irritable Bowel

Background: Many studies have been conducted worldwide to evaluate the proportion of patients with Celiac disease (CD) in persons presenting with Irritable Bowel Syndrome (IBS), showing a positive association between the two diseases. However, reports from Pakistan remain scanty. This study aims to find out the prevalence of CD in patients presenting with IBS and to establish the correlation of both diseases. Patients and methods: It was a descriptive cross-sectional study conducted at Combined Military Hospital, Lahore (CMHL) from January 2018 till March 2019. Consecutive, nonprobability sampling was used to include 210 patients of both genders with the age range of 15-65 years fulfilling ROME IV criteria and were not previously diagnosed as CD or CKD or CLD. Demographic data was noted. Serum Anti tTG levels and Duodenal Biopsy from the second part was assessed to diagnose CD. CD was labeled if the disease was present on both serological and Histopathological reports. Data were analyzed by using SPSS version 20. Descriptive statistics were calculated and a Chi-square test was used to compare the outcome variables with P-value < 0.05 as significant. Results: Of 210 enrolled patients, 113 (53, 8%) were male and 97 (46.2%) were female. The mean age of the patients was 28.40 ± 5.06 years. Eight patients (3.8%) were positive for Anti tTg and on histopathological findings suggestive of CD. Seven of 8 were less than 35 years old. Out of 8 positive patients, 6 (75%) were females. However, the p-value was found to be insignificant for age (0.549) and gender (0.096). On stratification with respect to duration of IBS, all 8 patients diagnosed with celiac disease were having symptoms of IBS for less than 12 months (100%) which was significant statistically (7.1% vs 0.0%; p=0.007). Conclusion: The frequency of CD was 3.8% among IBS patients. Considering this percentage of CD in IBS patients s, a high index of suspicion for CD in IBS patients is required,

scholarly journals Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

2021 ◽  
Author(s):  
Khaldoon Thanoon Al-Abachi
Keyword(s):  
Irritable Bowel Syndrome ◽  
Celiac Disease ◽  
Gastrointestinal Disorder ◽  
Cross Sectional Study ◽  
Rome Iii Criteria ◽  
Positive Serology ◽  
Cross Sectional ◽  
Rome Iii ◽  
The Mean ◽  
Irritable Bowel

Abstract Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria. Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD. Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation. Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.

scholarly journals Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

2021 ◽  
Vol 11 (1) ◽  
pp. 35
Author(s):  
Zahra A. Barandouzi ◽  
Joochul Lee ◽  
Kendra Maas ◽  
Angela R. Starkweather ◽  
Xiaomei S. Cong
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Alpha Diversity ◽  
Diversity Indices ◽  
Cross Sectional Study ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Food Components ◽  
Irritable Bowel

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

scholarly journals Irritable Bowel Syndrome Among University Students in Jordan

2019 ◽  
Author(s):  
Amjad Al-Shdaifat ◽  
Anwar Al-Kassar ◽  
Asgeir Johannessen ◽  
Zaid Al-Dabbagh ◽  
Mohamed Al-Ethawi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
University Students ◽  
Multivariable Analysis ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Rome Iii Criteria ◽  
Cross Sectional ◽  
Rome Iii ◽  
Irritable Bowel ◽  
Hashemite University

Abstract Background Irritable bowel syndrome (IBS) is one of the commonest diagnosed gastrointestinal disorders (GI) in primary care and gastroenterology practices. This study aimed to explore the prevalence of IBS, and identify associated factors, among university students in Jordan. Methods A cross-sectional study was conducted among students at the Hashemite University in Jordan. A validated, confidential, self-administered data collection questionnaire was used for the collection of personal and sociodemographic data, and the Rome III criteria were used to define IBS. Logistic regression analysis was done to identify factors associated with IBS. Results A total of 198 students participated in the study, of whom 163 had complete data and could be assessed by the Rome III criteria. The age range of the students was 18 to 35 years, and 91 (55.8%) were women. Overall, 26 (16.0%) of the respondents were diagnosed with IBS. Poor sleep (Adjusted Odds Ratio [AOR] 3.9; 95% confidence interval [CI] 1.5-10.4; p<0.01), being married (AOR 7.6; 95% CI 2.0-28.8; p<0.01) and a family history of IBS (AOR 2.9; 95% CI 1.1-7.7; p=0.03) were independently associated with IBS in multivariable analysis. Conclusion IBS was common among otherwise healthy university student in Jordan. Lifestyle factors such as poor sleep appeared to be associated with IBS symptoms.

scholarly journals Predictive value of alarm symptoms in Rome IV irritable bowel syndrome: A multicenter cross-sectional study

2022 ◽  
Vol 10 (2) ◽  
pp. 563-575
Author(s):  
Qian Yang ◽  
Zhong-Cao Wei ◽  
Na Liu ◽  
Yang-Lin Pan ◽  
Xiao-Sa Jiang ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Predictive Value ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Irritable Bowel ◽  
Rome Iv
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