Relationship between the severity of endothelial dysfunction and metabolic disorders and the severity of climacteric syndrome

2021 ◽  
Vol 8_2021 ◽  
pp. 119-126
Author(s):  
Tolstov S.N. Tolstov ◽  
Salov I.A. Salov ◽  
Rebrov A.P. Rebrov ◽  
◽  
Keyword(s):  
Endothelial Dysfunction ◽  
Metabolic Disorders ◽  
Climacteric Syndrome

The pathogenic variants in the development of endothelial dysfunction of blood vessels among adolescents with obesity

2015 ◽  
Vol 9 (4) ◽  
pp. 0-0
Author(s):  
Черная ◽  
N. Chernaya ◽  
Маскова ◽  
G. Maskova ◽  
Дадаева ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Essential Hypertension ◽  
Endothelial Dysfunction ◽  
Brachial Artery ◽  
Metabolic Disorders ◽  
Reactive Hyperemia ◽  
Diabetes Type 2 ◽  
Systemic Blood Pressure ◽  
The Body ◽  
Moderate Increase

Patients and methods. The authors have conducted clinical, functional and laboratory examination of 104 adolescents aged 11-18 years with a primary abdominal obesity type. It was additionally studied the reaction of the brachial artery in the process of conducting endothelial test with reactive hyperemia and calculated of percentage flow-mediated dilation (%FMD). Results. In 66% (n=67) cases it was identified endothelial dysfunction vessel (EDV) among adolescents on the basis of positive endothelial samples (FMD<10%). A further analysis was performed among children with dysfunction of endothelium of the brachial artery. The children were divided into 2 groups: children with essential hypertension and EDV and children without essential hypertension and EDV. Adolescents with essential hypertension had a moderate increase in the percentage content of fat mass (M=31,4±4,7%) and metabolic disorders in the blood are recorded with a frequency: hyperglycemia – 16,6%, ВЕСТНИК НОВЫХ МЕДИЦИНСКИХ ТЕХНОЛОГИЙ – 2015 – № 4 Электронный журнал Библиографическая ссылка: Маскова Г.С., Черная Н.Л., Дадаева О.Б. Патогенетические варианты развития дисфункции эндотелия сосудов у подростков с ожирением // Вестник новых медицинских технологий. Электронное издание. 2015. №4. Публикация 2-4. URL: http://www.medtsu.tula.ru/VNMT/Bulletin/E2015-4/5216.pdf (дата обращения: 18.11.2015). DOI:12737/14921 hypercholesterolemia – 4%, hyperinsulinemia – 27% and insulin resistance – 17%. Children without essential hypertension were characterized by significantly more pronounced metabolic disorders in the blood. In particular, hyperglycemia was reported among 33% of adolescents (p=0,04), hypercholesterolemia among 33% (p=0,04), hyperinsulinemia- 45% (p=0,041) and insulin resistance among 30% (p=0,042). Metabolic disorders of blood were registered at a higher percentage of body fat in the body (M=39,45±4,4%). Conclusion. The results analysis of the selected groups allows to reveal a predominant factor that causes dysfunction of endothelium among adolescents with obesity (high systemic blood pressure or hyperinsulinemia), as well as to determine the pathogenetic variants of further progress obesity: the development essential hypertension or increase metabolic disorders with the formation of diabetes type 2.

scholarly journals Role of immunological disorders, endothelial dysfunction and hemostatic disorders in the genesis of arterial hypertension in the metabolic syndrome

2020 ◽  
Vol 22 (2) ◽  
pp. 221-230
Author(s):  
E. I. Polozova ◽  
E. V. Puzanova ◽  
A. A. Seskina
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Immune Cells ◽  
Metabolic Disorders ◽  
Vascular Wall ◽  
Immunological Disorders ◽  
Hemostatic Disorders

Mortality from diseases of the circulatory system is a challenge for the modern health care. Arterial hypertension (AH) mostly contributes to development of cardiovascular complications. It often proceeds against the background of metabolic disorders. Pathogenesis of hypertension is currently being considered a multifactorial disease. Pathogenesis of hypertension certainly has distinct features in presence of metabolic disorders,. Therefore, it is relevant to summarize current literature on the role of immunological disorders, endothelial dysfunction and hemostatic disorders in AH genesis during metabolic syndrome (MS). Most authors agree with existence of several mechanisms that determine relationships between AH and insulin resistance. Development of hypertension in MS patients with is a consequence of immunometabolic processes. Abdominal obesity is an important component of MS. It is associated with chronic inflammation of visceral adipose tissue, its excessive infiltration by immune cells, and increased production of adipokines and cytokines (TNFα, IL-6) with hypertension. AH is associated with a significant increase in T cells, that mediate endothelial dysfunction (ED) and provide a link between hypertension and subsequent atherosclerosis. T lymphocytes trigger a cascade of reactions. IL-17 is the end product of these events It is involved not only in increasing blood pressure, but also contributes to the development of vascular wall stiffness in АН patients. Thus, the relationship between several types of immune cells leads to inflammatory reactions, including those of vascular wall, initiating endothelial dysfunction. Chronic non-specific inflammation in MS, supported by the cytokine system, is a triggering mechanism for ED progression. Excessive production of endothelin-1 and inhibition of nitric oxide production are the classic markers of ED. Immune damage leads to imbalance in the production of vasoconstrictor and vasodilating substances, proliferative and antiproliferative factors in endothelium. It was shown that ED is an integral aspect of the insulin resistance syndrome in pathogenesis of arterial hypertension associated with metabolic disorders, and contributes to its worsening, increased vascular reactivity and further AH development. According to modern studies, it has been shown that excessive synthesis of pro-inflammatory cytokines introduces disturbances in the system of vascular hemostasis. When studying the effects of metabolic disorders upon hemostatic system, we may conclude that activation of fibrinolytic and plasma chains occurs in the same way for both men and women, with small gender characteristics of individual components. The rheological properties of the blood are also changed with developing MS. Systematization of the available literature data on the issue under study can serve as a basis for determining prognostic criteria of hypertension progression and risk of thrombotic complications.

scholarly journals The role of endothelial dysfunction in the development of clinical manifestations of climacteric syndrome in premenopausal women

2017 ◽  
Vol 0 (37) ◽  
pp. 58-64
Author(s):  
О. В. Занько ◽  
Л. В. Болгова ◽  
Н. В. Коваленко ◽  
Т. Ф. Татарчук ◽  
Н. В. Яроцька
Keyword(s):  
Endothelial Dysfunction ◽  
Clinical Manifestations ◽  
Premenopausal Women ◽  
Climacteric Syndrome

scholarly journals Adipocytokines in metabolically healthy obesity

2019 ◽  
Vol 13 (3) ◽  
pp. 169-175
Author(s):  
Sofia G. Shulkina ◽  
Elena N. Smirnova ◽  
Maxim I. Yudin ◽  
Mikhail A. Osadchuk ◽  
Maxim V. Trushin
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Metabolic Disorders ◽  
International Diabetes Federation ◽  
Resistance Index ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Subclinical Inflammation ◽  
Tnf Α

The aim of the investigation was to study the relationship among adipokines, markers of subclinical inflammation and endothelial dysfunction in patients with metabolic healthy obesity (MHO). The study included 50 persons aged 25-50 years with obesity in the absence of metabolic disorders (International Diabetes Federation criteria, 2005, marked as MHO), the control group consisted of 50 healthy respondents without obesity. We studied clinical and biochemical parameters, insulin resistance index (HOMA-IR), levels of leptin, soluble leptin receptors (sLR), resistin, adiponectin, C-reactive protein (CRP-hs), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), von Willebrand factor, free leptin index was calculated in a formula (FLI = leptin × 100 / sLR). In MHO patients, independently of HOMA-IR index, there was an increase in leptin, FLI, resistin, VEGF, and IL-6 parameters. The concentration of CRP-hs and TNF-α in MHO group with HOMA-IR ≥2.7 was increased. Systolic blood pressure correlated with leptin level (r=0.43, P<0.05), FLI (r=0.54; P=0.01), TNF-α (r=0.44; P<0.05) and IL-6 (r=0.33; P<0.05); diastolic blood pressure - with leptin level (r=0.35, P<0.05). Links between high density lipoproteins and leptin (r=–0.55 and r=–0.60; P<0.01), resistin (r=0.32; P<0.05 and r=0.60; P<0.01) and VEGF (r=–0.70, P<0.01) were established. The VEGF level correlated with HOMA-IR (r=0.62; P<0.01), leptin (r=0.29; P<0.05), FLI (r=0.50; P<0.05), resistin (r=0.70; P<0.01), IL-6 (r=0.74, P<0.01) and ET-1 (r=0.29; P<0.05). Obese patients without metabolic disorders, having normotension and normal insulin sensitivity, are less influenced to adverse cardiovascular risks due to less expressed hormonal and inflammatory activation of adipose tissue and, as a result, less pronounced endothelial dysfunction. While insulin resistance develops, cardiovascular risk increases due to activation of subclinical inflammation, angiogenic endothelial dysfunction and leptin resistance.

scholarly journals Endothelial dysfunction in pregnancy metabolic disorders

2020 ◽  
Vol 1866 (2) ◽  
pp. 165414 ◽  
Author(s):  
Cesar Echeverria ◽  
Felipe Eltit ◽  
Juan F. Santibanez ◽  
Sebastian Gatica ◽  
Claudio Cabello-Verrugio ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Metabolic Disorders ◽  
In Pregnancy

The cactus cladode (Opuntia ficus indica) modulates uricemia, improves endothelial dysfunction and corrects oxidative damage in rats fed a cafeteria diet

2020 ◽  
Vol 17 (4) ◽  
pp. 355-365
Author(s):  
Hadjera Chekkal ◽  
Nour el Imane Harrat ◽  
Fatima Bensalah ◽  
Fouad Affane ◽  
Sabrine Louala ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Oxidative Damage ◽  
Antioxidant Capacity ◽  
Functional Properties ◽  
Metabolic Disorders ◽  
Cafeteria Diet ◽  
Junk Food ◽  
Opuntia Ficus Indica ◽  
Content Type ◽  
By Products

PurposeThe effects of Opuntia ficus indica (OFI) cladodes on uricemia level, endothelial dysfunction and oxidative damage were studied in young rats fed a cafeteria diet (CD).Design/methodology/approachA total of 16 young male Wistar rats (weighing 110 ± 20 g and four weeks old) were divided into two homogenous groups. The first group received a CD containing 50% of hyperlipidic diet and 50% of junk food mix (processed mix: hyper-fat, hyper-salted and sweetened) (CD group), and the second group (CD + OFI nopalitos) received the same diet supplemented with 50 g of fresh OFI nopalitos (young cladodes) for 30 days.FindingsOFI nopalitos regulate the hyperuricemia, improve the endothelial dysfunction by raising the bioavailability of nitric oxide(NO) and reduce prooxidant markers by reducing lipid peroxidation and protein oxidation (p < 0.05) and boosting antioxidant capacity and enhancing the antioxidant enzymes activities (p < 0.05) in blood and aorta tissues of rats early fed with a high-fat diet /junk food.Social implicationsBy-products of OFI have specific functional properties that may be beneficial in metabolic disorders and offer a better alternative with an economic and sustainable development perspective.Originality/valueBy-products of OFI highlight potential functional properties mainly based on its potent antioxidant capacity. By-products of OFI can be used as a promising nutraceutical resource to prevent various metabolic disorders in relation with cardiovascular diseases or hyperuricemia in subjects consuming junk food and or living in the Western society to reach the objectives of health policy and maintain a sustainable health system development.

scholarly journals Use of Nutraceuticals in Angiogenesis-Dependent Disorders

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2676 ◽  
Author(s):  
Lucia Morbidelli ◽  
Erika Terzuoli ◽  
Sandra Donnini
Keyword(s):  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
Metabolic Disorders ◽  
Therapeutic Option ◽  
Eye Diseases ◽  
Pathological Conditions ◽  
Degenerative Disorders ◽  
Oxidative Condition ◽  
Human Use ◽  
Critical Aspects

The term of angiogenesis refers to the growth of new vessels from pre-existing capillaries. The phenomenon is necessary for physiological growth, repair and functioning of our organs. When occurring in a not regulated manner, it concurs to pathological conditions as tumors, eye diseases, chronic degenerative disorders. On the contrary insufficient neovascularization or endothelial disfunction accompanies ischemic and metabolic disorders. In both the cases an inflammatory and oxidative condition exists in supporting angiogenesis deregulation and endothelial dysfunction. The use of nutraceuticals with antioxidant and anti-inflammatory activities can be a therapeutic option to maintain an adequate vascularization and endothelial cell proper functioning or to blunt aberrant angiogenesis. A revision of the updated literature reports on nutraceuticals to guide endothelial cell wellness and to restore physiological tissue vascularization is the objective of this paper. The critical aspects as well as lacking data for human use will be explored from a pharmacological perspective.

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