scholarly journals Pan-cancer analysis identifies ITIH1 as a novel prognostic indicator for hepatocellular carcinoma

Aging ◽  
2021 ◽  
Author(s):  
Qing-hua Chang ◽  
Ting Mao ◽  
Yan Tao ◽  
Tao Dong ◽  
Xuan-xuan Tang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Indicator ◽  
Pan Cancer

scholarly journals Perioperative Geriatric Assessment as A Predictor of Long-Term Hepatectomy Outcomes in Elderly Patients with Hepatocellular Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 842
Author(s):  
Masaki Kaibori ◽  
Hideyuki Matsushima ◽  
Morihiko Ishizaki ◽  
Hisashi Kosaka ◽  
Kosuke Matsui ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Geriatric Assessment ◽  
Proportional Hazards ◽  
Prognostic Indicator ◽  
Cox Proportional Hazards ◽  
Rate Of Change ◽  
Score Change ◽  
Comorbidity Burden ◽  
Reduction Group

This retrospective study recorded pertinent baseline geriatric assessment variables to identify risk factors for recurrence-free survival (RFS) and overall survival (OS) after hepatectomy in 100 consecutive patients aged ≥70 years with hepatocellular carcinoma. Patients had geriatric assessments of cognition, nutritional and functional statuses, and comorbidity burden, both preoperatively and at six months postoperatively. The rate of change in each score between preoperative and postoperative assessments was calculated by subtracting the preoperative score from the score at six months postoperatively, then dividing by the score at six months postoperatively. Patients with score change ≥0 comprised the maintenance group, while patients with score change <0 comprised the reduction group. The change in Geriatric 8 (G8) score at six months postoperatively was the most significant predictive factor for RFS and OS among the tested geriatric assessments. Five-year RFS rates were 43.4% vs. 6.7% (maintenance vs. reduction group; HR, 0.19; 95%CI, 0.11–0.31; p < 0.001). Five-year OS rates were 73.8% vs. 17.8% (HR, 0.12; 95%CI, 0.06–0.25; p < 0.001). Multivariate Cox proportional hazards analysis showed that perioperative maintenance of G8 score was an independent prognostic indicator for both RFS and OS. Perioperative changes in G8 scores can help forecast postoperative long-term outcomes in these patients.

Plasma Level of Interleukin-35 as an Independent Prognostic Indicator in Hepatocellular Carcinoma

2016 ◽  
Vol 61 (12) ◽  
pp. 3513-3521 ◽  
Author(s):  
Xiangting Qiu ◽  
Xinhua Wang ◽  
Yucui Song ◽  
Lingling Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Plasma Level ◽  
Prognostic Indicator

scholarly journals NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Ji-sheng Jing ◽  
Hongbo Li ◽  
Shun-cai Wang ◽  
Jiu-ming Ma ◽  
La-qing Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cox Regression ◽  
Survival Curve ◽  
Disease Free Survival ◽  
Prognostic Indicator ◽  
Clinicopathological Characteristics ◽  
Pcr Analysis ◽  
Kaplan Meier ◽  
Tumor Tissues ◽  
The Relationship

N-myc downstream-regulated gene 3 (NDRG3), an important member of the NDRG family, is involved in cell proliferation, differentiation, and other biological processes. The present study analyzed NDRG3 expression in hepatocellular carcinoma (HCC) and explored the relationship between expression of NDRG3 in HCC patients and their clinicopathological characteristics. We performed quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) analysis and immunohistochemistry (IHC) analyses on HCC tissues to elucidate NDRG3 expression characteristics in HCC patients. Kaplan–Meier survival curve and Cox regression analyses were used to evaluate the prognoses of 102 patients with HCC. The results revealed that compared with non-tumor tissues, HCC tissues showed significantly higher NDRG3 expression. In addition, our analyses showed that NDRG3 expression was statistically associated with tumor size (P=0.048) and pathological grade (P=0.001). Survival analysis and Kaplan–Meier curves revealed that NDRG3 expression is an independent prognostic indicator for disease-free survival (P=0.002) and overall survival (P=0.005) in HCC patients. The data indicate that NDRG3 expression may be considered as a oncogenic biomarker and a novel predictor for HCC prognosis.

Serum interleukin-6 and C-reactive protein as a prognostic indicator in hepatocellular carcinoma

Cytokine ◽  
2012 ◽  
Vol 60 (3) ◽  
pp. 686-693 ◽  
Author(s):  
Jeong Won Jang ◽  
Byong Sun Oh ◽  
Jung Hyun Kwon ◽  
Chan Ran You ◽  
Kyu Won Chung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Interleukin 6 ◽  
Prognostic Indicator ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals DUXAP8 a Pan-Cancer Prognostic Marker Involved in the Molecular Regulatory Mechanism in Hepatocellular Carcinoma: A Comprehensive Study Based on Data Mining, Bioinformatics, and in vitro Validation

2019 ◽  
Vol Volume 12 ◽  
pp. 11637-11650 ◽  
Author(s):  
Chaosen Yue ◽  
Chaojie Liang ◽  
Pengyang Li ◽  
Lijun Yan ◽  
Dongxin Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Data Mining ◽  
Prognostic Marker ◽  
Regulatory Mechanism ◽  
Pan Cancer ◽  
Comprehensive Study

Transferrin receptor 1 overexpression is associated with tumour de‐differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma

2019 ◽  
Vol 75 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Makiko Adachi ◽  
Keita Kai ◽  
Koutaro Yamaji ◽  
Takao Ide ◽  
Hirokazu Noshiro ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transferrin Receptor ◽  
Prognostic Indicator ◽  
Transferrin Receptor 1

scholarly journals Cyclin-Dependent Kinase and Antioxidant Gene Expression in Cancers with Poor Therapeutic Response

2020 ◽  
Vol 13 (2) ◽  
pp. 26
Author(s):  
George S. Scaria ◽  
Betsy T. Kren ◽  
Mark A. Klein
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pancreatic Cancer ◽  
Antioxidant Defense ◽  
Treatment Strategies ◽  
The Cancer Genome Atlas ◽  
Cyclin Dependent Kinase ◽  
Critical Pathways ◽  
Cancer Genome Atlas ◽  
Antioxidant Gene Expression ◽  
Pan Cancer

Pancreatic cancer, hepatocellular carcinoma (HCC), and mesothelioma are treatment-refractory cancers, and patients afflicted with these cancers generally have a very poor prognosis. The genomics of these tumors were analyzed as part of The Cancer Genome Atlas (TCGA) project. However, these analyses are an overview and may miss pathway interactions that could be exploited for therapeutic targeting. In this study, the TCGA Pan-Cancer datasets were queried via cBioPortal for correlations among mRNA expression of key genes in the cell cycle and mitochondrial (mt) antioxidant defense pathways. Here we describe these correlations. The results support further evaluation to develop combination treatment strategies that target these two critical pathways in pancreatic cancer, hepatocellular carcinoma, and mesothelioma.

Elevated Lung Shunt Fraction as a Prognostic Indicator for Disease Progression and Metastasis in Hepatocellular Carcinoma

2016 ◽  
Vol 27 (6) ◽  
pp. 804-811 ◽  
Author(s):  
Tyler Sandow ◽  
Daniel DeVun ◽  
Paul Gulotta ◽  
Humberto Bohorquez ◽  
David Kirsch
Keyword(s):  
Hepatocellular Carcinoma ◽  
Disease Progression ◽  
Prognostic Indicator ◽  
Shunt Fraction ◽  
Lung Shunt

scholarly journals Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma

Theranostics ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 2814-2829 ◽  
Author(s):  
Hui Wang ◽  
Linhui Liang ◽  
Qiongzhu Dong ◽  
Lin Huan ◽  
Jia He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Tumor Metastasis ◽  
Prognostic Indicator

Interleukin-22 serum levels are a negative prognostic indicator in patients with hepatocellular carcinoma

Hepatology ◽  
2013 ◽  
Vol 59 (3) ◽  
pp. 1207-1207 ◽  
Author(s):  
Oliver Waidmann ◽  
Bernd Kronenberger ◽  
Patrick Scheiermann ◽  
Verena Köberle ◽  
Heiko Mühl ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Levels ◽  
Prognostic Indicator ◽  
Interleukin 22
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