Review of insulin-like growth factor 1 signaling pathway and its role in protection against brain diseases

2017 ◽  
Vol 3 (4) ◽  
pp. 237-245
Author(s):  
Min Wei ◽  
Min Wei ◽  
Lun Dong ◽  
Hengzhu Zhang ◽  
Zhenfei Teng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Brain Diseases ◽  
Insulin Like Growth Factor

scholarly journals Review of Insulin-Like Growth Factor 1 Signaling Pathway and Its Role in Protection against Brain Diseases

2017 ◽  
Vol 3 (4) ◽  
pp. 237-245
Author(s):  
Min Wei ◽  
Lun Dong ◽  
Hengzhu Zhang ◽  
Zhenfei Teng ◽  
Xiaodong Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Axon Growth ◽  
Brain Diseases ◽  
Therapeutic Effects ◽  
Insulin Like Growth Factor ◽  
Cellular Interactions ◽  
Cellular Mechanisms ◽  
Central Nervous Systems ◽  
The Central Nervous System

Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor, with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system, ensuring proper neuronal differentiation, maturation, and connectivity. It supports neuronal survival and axon growth, and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study, we introduce the structure of IGF-1/2 and its receptors, with the intra-cellular interactions. Further, we review the therapeutic effects of IGF-1 in different models of brain diseases, via activation of different cellular mechanisms.

scholarly journals Activation of the Insulin-Like Growth Factor 1 Signaling Pathway by the Antiapoptotic Agents Aurintricarboxylic Acid and Evans Blue1

Endocrinology ◽  
2001 ◽  
Vol 142 (7) ◽  
pp. 3098-3107 ◽  
Author(s):  
Rachel Beery ◽  
Michal Haimsohn ◽  
Nadin Wertheim ◽  
Rina Hemi ◽  
Uri Nir ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Insulin Like Growth Factor ◽  
Aurintricarboxylic Acid
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