scholarly journals Review of Insulin-Like Growth Factor 1 Signaling Pathway and Its Role in Protection against Brain Diseases

2017 ◽  
Vol 3 (4) ◽  
pp. 237-245
Author(s):  
Min Wei ◽  
Lun Dong ◽  
Hengzhu Zhang ◽  
Zhenfei Teng ◽  
Xiaodong Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Axon Growth ◽  
Brain Diseases ◽  
Therapeutic Effects ◽  
Insulin Like Growth Factor ◽  
Cellular Interactions ◽  
Cellular Mechanisms ◽  
Central Nervous Systems ◽  
The Central Nervous System

Insulin-like growth factor 1 (IGF-1) is a pluripotent growth factor, with multiple functions in the peripheral and central nervous systems. Increasing evidence suggests that IGF-1 fine-tunes the development of the central nervous system, ensuring proper neuronal differentiation, maturation, and connectivity. It supports neuronal survival and axon growth, and acts on myelinating Schwann cells and oligodendroglia. The biological functions of IGF-1 are modulated by the IGF-1 signaling pathway. Recent studies have proposed the modulation of the members of the IGF-1/IGF-1 signaling pathway as treatment for neuropathologies. In this study, we introduce the structure of IGF-1/2 and its receptors, with the intra-cellular interactions. Further, we review the therapeutic effects of IGF-1 in different models of brain diseases, via activation of different cellular mechanisms.

Review of insulin-like growth factor 1 signaling pathway and its role in protection against brain diseases

2017 ◽  
Vol 3 (4) ◽  
pp. 237-245
Author(s):  
Min Wei ◽  
Min Wei ◽  
Lun Dong ◽  
Hengzhu Zhang ◽  
Zhenfei Teng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Brain Diseases ◽  
Insulin Like Growth Factor

scholarly journals Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

Biomedicines ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 261
Author(s):  
Milad Ashrafizadeh ◽  
Masoud Najafi ◽  
Sima Orouei ◽  
Amirhossein Zabolian ◽  
Hossein Saleki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Bioactive Compound ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Cellular Mechanisms ◽  
Pharmacological Activities ◽  
Growth Factor Beta

Resveratrol (Res) is a well-known natural product that can exhibit important pharmacological activities such as antioxidant, anti-diabetes, anti-tumor, and anti-inflammatory. An evaluation of its therapeutic effects demonstrates that this naturally occurring bioactive compound can target different molecular pathways to exert its pharmacological actions. Transforming growth factor-beta (TGF-β) is an important molecular pathway that is capable of regulating different cellular mechanisms such as proliferation, migration, and angiogenesis. TGF-β has been reported to be involved in the development of disorders such as diabetes, cancer, inflammatory disorders, fibrosis, cardiovascular disorders, etc. In the present review, the relationship between Res and TGF-β has been investigated. It was noticed that Res can inhibit TGF-β to suppress the proliferation and migration of cancer cells. In addition, Res can improve fibrosis by reducing inflammation via promoting TGF-β down-regulation. Res has been reported to be also beneficial in the amelioration of diabetic complications via targeting the TGF-β signaling pathway. These topics are discussed in detail in this review to shed light on the protective effects of Res mediated via the modulation of TGF-β signaling.

scholarly journals Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction

2017 ◽  
Vol 114 (36) ◽  
pp. 9731-9736 ◽  
Author(s):  
Rigo Cintron-Colon ◽  
Manuel Sanchez-Alavez ◽  
William Nguyen ◽  
Simone Mori ◽  
Ruben Gonzalez-Rivera ◽  
...  
Keyword(s):  
Growth Factor ◽  
Body Temperature ◽  
Calorie Restriction ◽  
Core Body Temperature ◽  
Insulin Like Growth Factor ◽  
Hypothalamic Nuclei ◽  
The Central Nervous System ◽  
Temperature Homeostasis ◽  
Core Body ◽  
The Brain

When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive mechanism that may have evolved to conserve energy until more food becomes available. Here, we found in the mouse that the insulin-like growth factor 1 receptor (IGF-1R) controls this response in the central nervous system. Pharmacological or genetic inhibition of IGF-1R enhanced the reduction of temperature and of energy expenditure during calorie restriction. Full blockade of IGF-1R affected female and male mice similarly. In contrast, genetic IGF-1R dosage was effective only in females, where it also induced transient and estrus-specific hypothermia in animals fed ad libitum. These effects were regulated in the brain, as only central, not peripheral, pharmacological activation of IGF-1R prevented hypothermia during calorie restriction. Targeted IGF-1R knockout selectively in forebrain neurons revealed that IGF signaling also modulates calorie restriction-dependent Tbregulation in regions rostral of the canonical hypothalamic nuclei involved in controlling body temperature. In aggregate, these data identify central IGF-1R as a mediator of the integration of nutrient and temperature homeostasis. They also show that calorie restriction, IGF-1R signaling, and body temperature, three of the main regulators of metabolism, aging, and longevity, are components of the same pathway.

scholarly journals Activation of the Insulin-Like Growth Factor 1 Signaling Pathway by the Antiapoptotic Agents Aurintricarboxylic Acid and Evans Blue1

Endocrinology ◽  
2001 ◽  
Vol 142 (7) ◽  
pp. 3098-3107 ◽  
Author(s):  
Rachel Beery ◽  
Michal Haimsohn ◽  
Nadin Wertheim ◽  
Rina Hemi ◽  
Uri Nir ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Insulin Like Growth Factor ◽  
Aurintricarboxylic Acid
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