scholarly journals Diagnostic search algorithm for IgE-independent allergic rhinitis

2020 ◽  
Vol 19 (2) ◽  
pp. 69-73
Author(s):  
R. A. Trigubenko ◽  
◽  
E. G. Portenko ◽  

Allergic rhinitis is a widespread disease located at the junction of two specialties: otorhinolaryngology and allergology. Currently, it is characterized by an early onset, often continuously recurring course and refractory to traditional methods of treatment. Unstable remissions, a tendency to complications, and the lack of effectiveness of the therapy suggest that allergic rhinitis occurs against the background of secondary immunodeficiency, a favorable factor for the development of bacterial superinfection on the damaged mucous membrane of the nasal cavity. In conditions of impaired immune homeostasis, the microbial landscape of the nasal mucosa is characterized by polymorphism, bacterial agents can act as an infectious antigen. The article is devoted to a current problem – chronic IgE-independent allergic rhinitis due to allergen-specific lymphocytes or IgG antibodies with the formation of immune complexes. The article reveals the content of the concept of “chronic infectious-dependent allergic rhinitis”, its characteristic features are highlighted and described, the key stages of diagnosis are considered. The importance of knowledge about mediators of chronic eosinophilic inflammation for practitioners is reflected. The work is interdisciplinary in nature, written at the intersection of otorhinolaryngology, allergology and immunology and will be interesting to doctors of various specialties.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 814.3-814
Author(s):  
A. Ben Tekaya ◽  
L. Ben Ammar ◽  
M. Ben Hammamia ◽  
O. Saidane ◽  
S. Bouden ◽  
...  

Background:Infectious spondylodiscitis is a therapeutic emergency and is a current problem. It can affect the different levels of the spine. Multifocal forms, touching several floors, however remain rare.Objectives:To compare the clinical, biological, radiological and therapeutic aspects of unifocal versus multifocal spondylodiscitis.Methods:This is a retrospective study of 113 patients admitted to our service over a period of 20 years [1998-2018]. The diagnosis of spondylodiscitis was made on the basis of clinical, biological, radiological and bacteriological data. We have divided our population into two groups: unifocal and multifocal spondylodiscitis.Results:Spondylodiscitis was more frequently unifocal (75.2%) than multifocal (24.8%). The average age of the patients was 55.8 years. There were 62 men and 51 women. There was no difference in age and sex between the two groups (p=0.5 and p=0.8, respectively).Diabetes was more frequent in the group of multifocal spondylodiscitis but with no statistically significant difference (p=0.4). No statistically significant difference between the two groups regarding the start mode (p=0.7), the schedule (p=0.3), the presence of neurological signs (p=0.7), fever (p = 0.2), impaired general condition (p=0.6) and biological inflammatory syndrome (p=0.6).Cervical and dorsal spine involvement was more common in multifocal spondylodiscitis (p = 0.02 and p = 0.01; respectively). There were 11 spondylodiscitis involving 2 floors (cervical and dorsal: 2 cases, cervical and lumbar: 3 cases, dorsal and lumbar: 6 cases) and 3 spondylodiscitis involving 3 floors.Radiologically, the presence of vertebral fracture and involvement of the posterior arch was more frequent during the multifocal form (p=0.03 and p=0.001; respectively). The frequency of para-vertebral abscesses, epiduritis and the presence of spinal cord compression were similar in the two groups (p=0.6; p=0.7 and p=0.2, respectively).Tuberculosis was more frequent during the multifocal form (p = 0.05) and brucellosis during the unifocal form (p = 0.03). Disco-vertebral biopsy was performed in 79 cases. It was more often contributory during multifocal spondylodiscitis (p = 0.03).The occurrence of immediate complications was more frequent in multifocal spondylodiscitis but with no statistically significant difference (p=0.2).Conclusion:Multifocal sppondylodiscitis is seen mainly in immunocompromised subjects. Our study found that diabetes is the most common factor in immunosuppression. Note also the predominance of involvement of the posterior elements, tuberculous origin and immediate complications.Disclosure of Interests:None declared


2020 ◽  
Vol 11 (2) ◽  
pp. 33-40
Author(s):  
I. Kudinova ◽  

The research of the conformation and development of innovative tourist products is a current problem today. The article summarized and systematized the innovative features of the tourist product in order to build the tourist industry and increase the competitiveness of the tourist industry. It stated that innovation is a necessary process in creating a new attractive tourist product, also in creating сonducive conditions for intensifying the activity of investors in the tourist sphere of the country. The following types of innovations in the tourist industry are listed, namely: product, technological, marketing, service, organizational and management innovations and innovations of logistics. The competitive strengths which should be the basis of formation of competitiveness of Ukraine in the field of tourist business, are highlighted, namely: unique healing climate, numerous territories with therapeutic opportunities, considerable historical and cultural potential, attractiveness of our country's tourist industry for foreign investment. Also defined are the problematic directions regarding the tourist attractiveness of Ukraine. Emphasis is placed on the fact that the state should support the development of tourist business in Ukraine in accordance with the following principles: to provide financing in accordance with the needs of the industry, to create favorable conditions for its further development, to determine and maintain priority directions of the development of the industry, to support and protect the Ukrainian and foreign tourists, tour operators and agents and their associations. The popular and new innovative directions of tourist, trends and technologies that are currently in demand with tourists are identified. Each tourist trend direction is described. The main requirements are listed and proposals are made to create an innovative tourist product.


Temida ◽  
2003 ◽  
Vol 6 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Slobodan Savic ◽  
Djordje Alempijevic

Protection of children from abuse and neglect is a current problem in the world. The consequences of violence against children are very important because they can leave behind permanent bodily injuries up to severe invalidity, as well as psychological consequences which very often lead to transmission of violence into next generations. In most extreme cases death occurs as a consequence of abuse and neglect. In this paper authors present legislation which regulate social protection of children and youth in Sweden, with special emphasis on protection from abuse and neglect. Sweden is a country in which social care of most vulnerable groups including children, was always at the top of priorities. Authors made comparative analysis of Swedish and domestic (Serbian) laws regarding protection of children from violence, with particular emphasis on mandatory report of these cases from professionals who are in regular professional contact with children. Authors will also put emphasis on duties of medical doctors in the system of protection of children and youth from abuse and neglect.


2020 ◽  
Vol 25 (3) ◽  
pp. 7-12
Author(s):  
Rud V.V. ◽  

This paper considers the problems of the integration of independent manipulator control systems. Areas of control of the manipulator are: recognition of objects and obstacles, identification of objects to be grasped, determination of reliable positions by the grasping device, planning of movement of the manipulator to certain positions with avoidance of obstacles, and recognition of slipping or determination of reliable grasping. This issue is a current problem primarily in industry, general-purpose robots, and experimental robots. This paper considers current publications that address these issues. Existing algorithms and approaches have been found in the management of both parts of the robot manipulator and solutions that combine several areas, or the integration of several existing approaches. There is a brief review of current literature and publications on the above algorithms and approaches. The advantages and disadvantages of the considered methods and approaches are determined. There are solutions that cover either some areas or only one of them, which does not meet the requirements of the problem. Using existing approaches, integration points of existing implementations are identified to get the best results. In the process, a system was developed that analyzes the environment, finds obstacles, objects for interaction, poses for grasping, plans the movement of the manipulator to a specific position, and ensures reliable grasping of the object. The next step was to test the system, test the performance, and adjust the parameters for the best results. The resulting system was developed by the research team of RT-Lions, Technik University, Reutlingen. The hardware research robot includes an Intel Realsense camera, a Sawyer Arm manipulator from Rethink Robotics, and an internally grabbing device.


2006 ◽  
Vol 90 (519) ◽  
pp. 425-430 ◽  
Author(s):  
A. D. Keedwell

Smallest defining setsA standard Sudoku square is a 9 × 9 latin square in which each of the nine 3 × 3 subsquares into which it can be separated contains each of the integers 1 to 9 exactly once.A current problem is to complete such a square when only some of the cells have been filled. These cells are often called ‘givens’. (Such problems are currently (2005) published daily in British newspapers.) In more mathematical terms, the given filled cells constitute a defining set or uniquely completable set for the square if they lead to a unique completion of the square. If, after deletion of any one of these givens, the square can no longer be completed uniquely, the givens form a critical set. The investigation of critical sets for ‘ordinary’ latin squares is a topic of current mathematical interest. (See [1] for more details.)


2020 ◽  
Vol 29 (12) ◽  
pp. 706-709
Author(s):  
Renee Barrett

The preceptorship period is of great importance in the career of a nurse, as he or she moves from being a student to a competent, accountable professional. Problems with the current preceptorship system for preceptors include not receiving adequate training—particularly in providing constructive feedback to preceptees. In addition, when a small number of nurses are repeatedly assigned preceptees to mentor, this can lead to burnout. Preceptees can feel overwhelmed by their first months as a newly qualified nurse (NQN) and can feel unsupported if a preceptor's teaching style or personality is unsuited to them. This can lead to attrition in the nursing workforce, a current problem. This article suggests a new way of organising preceptorship, by allowing preceptors to opt in to the scheme, providing a pool of energised and enthusiastic preceptors. In turn, NQNs could initially work with the pool of nurses before being given the choice of which preceptor to work with individually.


1992 ◽  
Vol 101 (1_suppl) ◽  
pp. 51-57 ◽  
Author(s):  
Jack L. Paradise

Although viruses are the most common causes of childhood throat infections, interest in the etiology of these infections has primarily focused on whether an individual episode is caused by group A β-hemolytic streptococcus (GABHS), particularly since the recent outbreaks of rheumatic fever in certain areas of the country. Penicillin remains the cornerstone of treatment in GABHS pharyngitis. Early treatment effects prompt clinical improvement and reduces the risk of transmission. Whether early treatment suppresses immunologic response and results in a higher recurrence rate than does delayed treatment is still unknown, but recent evidence suggests that it does not. The causes of persistent GABHS carriage, its clinical importance, and optimal methods of treatment are all still in question. When penicillin treatment does not eradicate carriage, other drugs may be efficacious. In children severely affected with recurrent throat infection, tonsillectomy is generally effective and is sometimes a desirable option.


Sign in / Sign up

Export Citation Format

Share Document