scholarly journals Arterial rigidity is the fail-safe marker of endothelial dysfunction at early stages of arterial hypertension

2008 ◽  
Vol 14 (4) ◽  
pp. 336-340 ◽  
Author(s):  
N. A. Brojaka ◽  
V. N. Senchikhin ◽  
S. V. Lyamina ◽  
E. A. Korostova ◽  
N. P. Lyamina
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Arterial Wall ◽  
Young Patients ◽  
Main Topic ◽  
Arterial Walls ◽  
Early Stages ◽  
Fail Safe ◽  
Large Vessels

The main topic of the article is the assessment of the endothelial dysfunction and the rigidity of arterial wall in the small, medium and large vessels in young patients with short anamnesis of hypertension and with different variability of blood pressure (BP). In young patients even at the beginning of arterial hypertension (AH) the disturbance in rigidity of arterial walls in great and peripheral vessels occurs. The increased variability of BP in young patients with AH is an aggravating factor of the arterial rigidity disturbances. The assessment of arterial rigidity in young patients at the early stages of the disease can elicit the early signs of endothelial dysfunction

scholarly journals INTRAVENOUS LASER THERAPY IN A COMPREHENSIVE APPROACH TO THE CORRECTION OF RISK FACTORS OF ARTERIAL HYPERTENSION

2020 ◽  
Vol 8 (1) ◽  
pp. 49-51
Author(s):  
Ye. L. Kovalenko ◽  
O. K. Melekhovets
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Uric Acid ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Acid Level ◽  
Arterial Wall ◽  
Myocardial Dysfunction ◽  
Wall Stiffness ◽  
Group 3

Introduction. According to Akl C et al. by 2025, the number of people with arterial hypertension (AH) will increase by 15–20% and reach 1.5 billion people. Since hyperuricemia (HU) is closely related to other AH risk factors, there is a need to study the relationship between HU and other AH risk factors. Objective of this work is to develop rational approaches to modifying individual AH risk factor using intravenous laser therapy (IVLT). Materials and methods. The study included 184 people: Group 1 (n = 30) – normotensive individuals without HU; Group 2 (n = 52) – normotensive patients with HU; Group 3 (n = 48) – patients with essential AH (stage I, 1-2 degree) without HU; Group 4 (n = 54) – patients with essential AH (stage I, 1-2 degree) with HU. Patients in Group 3 and 4 were divided into subgroups according to the treatment regimens: 3A (n = 24), 4A (n = 26) (standard antihypertensive therapy (AHT)) and 3B (n = 24), 4B (n = 28) (combination treatment with AHT and IVLT). The IVLT course was performed with a wavelength of 635 nm, a power of 1.5 mW, a radiation power density of 0.2 W/cm2, a fluence of 0.2 J/cm2, an exposure of 900 seconds, the course – daily, with a total of 10 procedures. Study results. The association between the level of uric acid (UA), systolic blood pressure (SBP), diastolic blood pressure (DBP), endothelial dysfunction (ED), left ventricular myocardial dysfunction, excess increase in arterial wall stiffness, and poikilocytosis in the study groups was established. The use of IVLT in combination with AHT allows to achieve a statistically significant (р < 0.05), compared to AHT reduction in SBPd by 4.2%, DBPd by 2.4%, DBPn by 2.5%, time index (TI) SBPd by 5.1%, TI DBPd by 2.7%, TI SBPn by 19%, rate of morning rise (RMR) SBP by 33.8%, RMR DBP by 31%, early morning blood pressure surge (EMBPS) SBP by 17.3%, EMBPS DBP by 12.8%, puilse wave velosity (PWV) by 4.1%, manifestations of endothelial dysfunction by 1.4%, myocardial dysfunction by 4.5%, poikilocytosis by 2.9%, uric acid level by 3.1% in patients with AH. In AH and HU comorbidity, addition of ILT to AHT allows to achieve an additional reduction in SBPd by 9.3%, DBPd by 7.4%, SBPn by 11,5%, DBPn by 2.7%, TI SBPd by 18.8%, TI DBPd by 18.9%, TI SBPn by 1.8%, TI DBPn by 8,7%, RMR SBP by 25.8%, RMR DBP by 28.5%, EMBPS SBP by 8.2%, EMBPS DBP by 6.0%, PWV by 13.4%, endothelial dysfunction by 3.5%, myocardial dysfunction by 18.8%, poikilocytosis by 5.7%, uric acid level by 11.6% compared to AHT. In patients with normal blood pressure and HU values, the use of IVLT can reduce DBPM, EDVD, poikilocytosis, and UA level parameters (p < 0.05). Conclusions. The presence of direct correlations of average strength between HU and endothelial dysfunction, systolic diastolic dysfunction, excessive increase in arterial wall stiffness, and poikilocytosis was found. The use of IVLT in normotensive and hypertensive patients with AH with an effective method of UA level correction, excessive arterial wall stiffness, myocardial dysfunction, ED and poikilocytosis.

scholarly journals Arterial hypertension: Modern problems

2017 ◽  
Vol 95 (7) ◽  
pp. 581-585
Author(s):  
Igor N. Bokarev ◽  
P. A. Dulin ◽  
Yu. V. Ovchinnikov ◽  
V. B. Simonenko
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Blood Pressure Monitoring ◽  
Hypertensive Crisis ◽  
Elevated Blood ◽  
Pressure Monitoring ◽  
Hypertensive Disease ◽  
Early Stages ◽  
Hypertensive Crises

Arterial hypertension (AH) is one of the most common diseases. Despite numerous studies, many problems related to this pathology remain to be elucidated. The modern classifications of AHare contradictory and true causes of elevated blood pressure (BP) are unknown. There are no methods for diagnostics of early stages of AH nor is there adequateunderstanding of what hypertensive crises are, how they are to be classified and why they develop. Pathomorphosis of AH is practically unexplored. There are no efficient medications and therapies for the radical treatment of AH. The authors propose classification of hypertensive crisis, hypertensive disease, and symptomatic AH. It is recommended to use 24-hour blood pressure monitoring in all AH patients. New approaches to diagnostics of early stages of AH are proposed.

Assessment of arterial wall stiffness by 24-hour blood pressure monitoring

2016 ◽  
Vol 88 (9) ◽  
pp. 119-124 ◽  
Author(s):  
V A Korneva ◽  
T Yu Kuznetsova
Keyword(s):  
Blood Pressure ◽  
Arterial Wall ◽  
Pulse Wave ◽  
Blood Pressure Monitoring ◽  
Vascular Wall ◽  
Pressure Monitoring ◽  
Therapeutic Practice ◽  
Wall Stiffness ◽  
The Given ◽  
Large Vessels

Arterial wall stiffness is an early marker of cardiovascular diseases. The gold standard for assessment of the stiffness of large vessels is presently pulse wave velocity (PWV). Work is in progress on the study of the reference values of PWV in people of different genders and ages. 24-hour blood pressure (BP) monitoring is not only a procedure that can estimate diurnal BP variability, but also monitor the indicators of vascular wall stiffness in a number of cases over a 24-hour period. The given review highlights the pathophysiology of arterial stiffness, methods for its assessment, and the aspects of use in therapeutic practice.

Correction of arterial hypertension in the young patients with obesity

2016 ◽  
Vol 15 (3) ◽  
pp. 146-150
Author(s):  
V. F Luk’janov ◽  
Yuri Mikhailovich Raigorodskiy ◽  
N. V Bolotova ◽  
N. V Posokhova
Keyword(s):  
Magnetic Field ◽  
Blood Pressure ◽  
Nervous System ◽  
Arterial Hypertension ◽  
Young Patients ◽  
Reduce Blood Pressure ◽  
Normal Numbers ◽  
Field Exposure ◽  
Treatment And Prevention ◽  
Prevention Of Hypertension

The study included 90 patients with obesity I-III and arterial hypertension (AH) I of 16-30 years. Evaluated lipid and carbohydrate metabolism, the condition of the autonomic nervous system, circadian blood pressure, pulse wave velocity in the aorta (PWV), and the effectiveness of the running magnetic field with the help of apparatus «MAGNETIC SIMPATOKOR» in order to reduce blood pressure (BP). The patients were divided into 2 groups: basic - 50 people who underwent magnetic simpatokorrektsiya and control - 40 people received placebo physiotherapy. According to a survey in the group allocated to two subgroups - 1A and 1B. Subgroup 1A amounted to 26 patients with hypersympathicotonia who at repeated definition SPV after simpatokorrektsii noted its significant reduction. In the subgroup 1B included 24 patients with a normal tone and parasimpatikotoniey who SPV has not changed much. After 6 months in patients subgroups 1A BP was on normal numbers, DBS remained at baseline values. In the subgroup 1B patients remained elevated blood pressure. The risk of developing hypertension in a subgroup 1A was 22% in the subgroup 1B - 80% or more. Sympathy correction using magnetic field exposure on the cervical sympathetic ganglion is an effective treatment and prevention of hypertension associated with increased activity of the sympathetic nervous system.

scholarly journals The effect of antihypertensive therapy and CPAP therapy on inflammatory and endothelial dysfunction markers levels in patients with severe obstructive sleep apnea syndrome in association with arterial hypertension

2017 ◽  
Vol 14 (1) ◽  
pp. 37-40
Author(s):  
E M Elfimova ◽  
A V Rvacheva ◽  
M I Tripoten ◽  
O V Pogorelova ◽  
T V Balakhonova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Adhesion Molecule ◽  
Severe Obstructive Sleep Apnea ◽  
Cpap Therapy ◽  
Obstructive Sleep

Objective. To evaluate the effect of antihypertensive therapy (AHT) and CPAP therapy on inflammatory and endothelial dysfunction markers levels in patients with severe obstructive sleep apnea (OSA) syndrome in association with arterial hypertension (AH). Materials and methods. The study included 43 male patients with severe OSA syndrome (Apnea-Hypopnea Index 52.4 [46.1; 58.6]) and AH (systolic blood pressure 144.0 [142.0; 156.0] mm Hg, diastolic blood pressure 90.9 [88.3; 93.5] mm Hg). Treatment with angiotensin-converting enzyme inhibitors, calcium antagonists, and thiazide-like diuretics was performed till target BP level measured with Korotkoff method was achieved. The patients who had reached target BP level (BP≤140/90 mm Hg) were randomized into two groups: group 1 included 23 patients who continued taking the AHT, group 2 included 22 patients who continued taking the AHT to which CPAP therapy was added. Peripheral blood lymphocyte immunophenotyping, cytokine panel test (IL-1β, IL-6, tumor necrosis factor a, IL-2Ra, sCD40L), adhesion molecule analysis (ICAM-1, VCAM-1), thromboxane B2, 6-keto-prostaglandin F1 alpha (6-keto-PGF1a), and endothelin-1 levels in blood serum were evaluated at admission, after target BP level achievement (2nd visit) and after 3 months of AHT or AHT+CPAP therapy (3rd visit). Flow-mediated dilation of brachial artery was assessed using reactive hyperemia test by D.Celermajer. Results. Against the background of combined AHT the target BP level was achieved by 95% of patients. After target BP level achievement a significant decrease of IL-1β -0.16 [-0.5; 0], p=0.000 level and number of CD50+ cells (lymphocytes with inter-cellular adhesion molecule ICAM-3) from 2158.5 [1884.7; 2432.3] to 1949.6 [1740.9; 2158.3], p=0.050 were observed in patients with severe OSA associated with AH. There were no significant changes in vascular endothelial function observed in patients taking only AHT. Significant decrease of fibrinogen (-0.3 [-0.4; -0.1], p=0.002) and homocystein (-2.03 [-3.8; -0.2], p=0.03) levels was observed in patients taking both AHT and CPAP therapy. Conclusion. The combination of AHT and CPAP therapy in patients with severe OSA and AH not only allows reaching the target BP level but also leads to inflammatory and endothelial dysfunction markers levels decrease.

scholarly journals AORTIC STIFFNESS ASSESSMENT IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY

2013 ◽  
Vol 12 (3) ◽  
pp. 85-88 ◽  
Author(s):  
E. Yu. Shupenina ◽  
E. N. Yushchuk ◽  
A. B. Khadzegova ◽  
S. V. Ivanova ◽  
I. A. Sadulaeva ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Arterial Hypertension ◽  
Functional Status ◽  
Aortic Stiffness ◽  
Pulse Wave ◽  
Young Patients ◽  
Developed Countries ◽  
The Moment

Cardiovascular disease (CVD) remains the leading cause of death in most developed countries. Morphological and functional status of large arteries plays an important role in the pathogenesis of CVD. At the moment, there are two main methods of aortic stiffness assessment: pulse wave velocity (PWV) measurement and central PW analysis. In advanced age, aortic stiffness increases, which manifests in increased PWV, elevated central blood pressure, and increased parameters of reflected PW. Similar changes can be observed in young patients with arterial hypertension. The existing evidence concerning obesity effects on aortic stiffness is contradictory and warrants further clarification. 

scholarly journals Hypertensive retinopathy: clinical aspects

HYPERTENSION ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 17-23
Author(s):  
N.Ya. Dotsenko ◽  
I.A. Shekhunova ◽  
S.S. Boev ◽  
L.V. Нerasуmenko ◽  
A.V. Molodan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Hypertension ◽  
Prognostic Value ◽  
Prognostic Significance ◽  
Young Patients ◽  
Small Diameter ◽  
Scientific Data ◽  
Clinical Aspects ◽  
Hypertensive Retinopathy ◽  
Routine Practice

Funduscopic examination has long been recognized as the most affordable way to assess the condition of small diameter vessels. However, accumulation of new research data, changes in the requirements for the management of patients with various diseases require a return to the clinical, prognostic significance of fundoscopy and the specification of indications for its conduction in certain situations. This article discusses the prevalence of retinopathy depending on the etiological factor, criteria and stages of its development. Until now, a number of issues regarding retinopathy have not been finally resolved, in particular the classification optimal for routine practice, method of its study, etc. It is believed that changes in the fundus blood vessels reflect parallel changes in the vessels of other regions, but this is not always so. A moderate prognostic value of “mild” retinopathy has been established in terms of the risk of cardiovascular diseases, with moderate retinopathy, this relationship reaches a strong level, and with a malignant one, there is a strong correlation with death. The article discusses indications for fundoscopy in routine clinical practice, taking into account the latest scientific data and international recommendations. For the treatment of hypertensive retinopathy, only adequate control of blood pressure is recommended, which can reduce the signs of retinopathy. The authors concluded that the prognostic value of stage 1–2 hypertensive retinopathy is minimal and does not affect patient management. The latter eliminates the need for fundoscopy in patients with mild, controlled arterial hypertension, not suffering from diabetes, with the exception of young patients. Fundoscopy is required in patients with difficult-to-control and resistant arterial hypertension, high variability of blood pressure.

scholarly journals Correction of endothelial function in hypertension associated with tyberculosis by fixed combination of perindopril and indopamide

2007 ◽  
Vol 13 (4) ◽  
pp. 256-261
Author(s):  
N. YU. Klimenko ◽  
N. V. Drobotya ◽  
A. A. Kastanyan ◽  
V. V. Kaltykova ◽  
E. Sh. Guseynova
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Arterial Hypertension ◽  
Von Willebrand Factor ◽  
Fixed Combination ◽  
Factor Level ◽  
Hypertensive Patients ◽  
Von Willebrand ◽  
Willebrand Factor

A study of daily blood pressure (BP) dynamics, functional endothelial condition at hypertensive patients in combination with tuberculosis of various localization and estimation of an opportunity of correction of the revealed disturbances during 12-week therapy by the fixed combination of perindopril and indapamide - noliprel-forte (Servier, France) were performed. During research more expressed endothelial dysfunction at hypertensive patients, proceeding on a background of tubercular process in comparison with patients with isolated arterial hypertension was revealed. Therapy by noliprel-forte provided the reliable 24-hour control of BP level, which was accompanied by endothelial function normalization that was shown by improvement of a endothelium-dependent vasodilatation and decrease of a von Willebrand factor level. .

scholarly journals Effects of Caloric Restriction Diet on Arterial Hypertension and Endothelial Dysfunction

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 274 ◽  
Author(s):  
Nicola Di Daniele ◽  
Giulia Marrone ◽  
Manuela Di Lauro ◽  
Francesca Di Daniele ◽  
Daniela Palazzetti ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Caloric Restriction ◽  
Vegetable Intake ◽  
Sodium Intake ◽  
Saturated Fat ◽  
Ideal Body Weight ◽  
Brain Vessels ◽  
Restriction Diet

The most common manifestation of cardiovascular (CV) diseases is the presence of arterial hypertension (AH), which impacts on endothelial dysfunction. CV risk is associated with high values of systolic and diastolic blood pressure and depends on the presence of risk factors, both modifiable and not modifiable, such as overweight, obesity, physical exercise, smoking, age, family history, and gender. The main target organs affected by AH are the heart, brain, vessels, kidneys, and eye retina. AH onset can be counteracted or delayed by adopting a proper diet, characterized by a low saturated fat and sodium intake, a high fruit and vegetable intake, a moderate alcohol consumption, and achieving and maintaining over time the ideal body weight. In this review, we analyzed how a new nutritional approach, named caloric restriction diet (CRD), can provide a significant reduction in blood pressure values and an improvement of the endothelial dysfunction. In fact, CRD is able to counteract aging and delay the onset of CV and neurodegenerative diseases through the reduction of body fat mass, systolic and diastolic values, free radicals production, and oxidative stress. Currently, there are few studies on CRD effects in the long term, and it would be advisable to perform observational studies with longer follow-up.

Endothelin-1 and nitrogen oxide metabolites in risk diagnostics of arterial hypertension in persons of young and middle ages occupied in harmful working conditions

2021 ◽  
Vol 66 (9) ◽  
pp. 525-532
Author(s):  
I. A. Umnyagina ◽  
T. V. Blinova ◽  
L. A. Strakhova ◽  
Yu. V. Ivanova ◽  
V. V. Troshin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Arterial Hypertension ◽  
Nitrogen Oxide ◽  
Working Conditions ◽  
Vascular Tone ◽  
Public Health Problem ◽  
Global Public Health ◽  
Occupational Factors ◽  
Endothelin 1

Hypertension is a global public health problem. One of the reasons contributing to the development of arterial hypertension is endothelial dysfunction, which is expressed in the imbalance of vasoactive indicators of vascular tone - nitrogen oxide and endothelin-1. Monitoring the indicators of endothelial dysfunction in workers exposed to harmful occupational factors will help to identify a risk group for the development of occupationally caused diseases of the cardiovascular system and, in particular, arterial hypertension, for early implementation of preventive measures. This study aims to identify the relationship between endothelin-1, nitrogen oxide metabolites and blood pressure in young and middle-aged people occupied in harmful working conditions, to evaluate the studied parameters as possible markers for diagnosing the risk of hypertension. Two hundred thirty-six (236) employees of young and middle age were examined of one of the metallurgical plants of the Nizhny Novgorod region. In order to characterize the state of vascular tone, a coefficient was used that represents the ratio of the concentration of nitrogen oxide (μmol/L) to endothelin-1 (pg/ml) (NOx/ET-1). It was revealed that in one-third of people with normal and high normal blood pressure, the NOx/ET-1 value was 2-3 times less than in people with optimal blood pressure, which indicates the occurrence of endothelial dysfunction and the possible development of persistent arterial hypertension. Harmful occupational factors negatively affect vascular tone - the value of NOx/ET-1 in individuals exposed to harmful factors was 3-4 times less than in individuals not subjected to such exposure. The NOx/ET-1 coefficient can be used as an informative indicator when monitoring health conditions with an in-depth examination of working people; it can be a criterion for the risk of developing hypertension.

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