scholarly journals BLOOD VELOCITY IN FUNCTION OF ARTERIOLES IN HYPERTENSIVE PATIENTS

2013 ◽  
Vol 19 (1) ◽  
pp. 38-43
Author(s):  
O. B. Poselyugina ◽  
V. S. Volkov ◽  
E. V. Rudenko ◽  
N. Al Ghalban
Keyword(s):  
Blood Flow ◽  
Disease Duration ◽  
Blood Velocity ◽  
Healthy People ◽  
Hypertensive Patients ◽  
Essential Arterial Hypertension ◽  
Flow Cycle ◽  
The Mean ◽  
Design And Methods

Objective. To study blood velocity in arterioles in hypertensive patients by doppler. Design and methods. We assessed blood velocity in 90 patients with essential arterial hypertension (AH) and in 83 patients with type 2 diabetes mellitus (DM2) with AH («Minimax-Doppler-K»), and in 102 control subjects: during systole (Vs, cm/s), diastole (Vd, cm/s) and during the mean blood flow cycle (Vm, cm/s). Then spontaneous changes of blood velocity were recorded during 1 minute. In patients with DM2 association between blood velocity and disease duration was studied. In 43 hypertensive patients Vsand Vdwere defined after treatment. Results. Hypertensive patients had the highest blood velocity, lower values were defined in healthy people, and hypertensive subjects with DM2demonstrated the lowest blood velocity. Fluctuations in blood velocity during systole were the highest in healthy people, less in hypertensives and the smallest in subjects with DM2 and AH. Variations of blood velocity during diastole were the highest in AH patients, less in patients with DM2 with AH and the least in healthy subjects. Blood velocity in arterioles is lower in patients with the longer duration of DM2. In treated hypertensive patients blood velocity in arterioles reduces. Conclusion. By assessment of blood flow velocity in arterioles we can evaluate the functional state of these vessels in hypertensive patients.

1715-P: Impaired Postprandial Adipose Tissue Microvascular Blood Flow in Healthy People with a Family History of Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
KATHERINE ROBERTS-THOMSON ◽  
RYAN D. RUSSELL ◽  
DONGHUA HU ◽  
TIMOTHY M. GREENAWAY ◽  
ANDREW C. BETIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Flow ◽  
Adipose Tissue ◽  
Family History ◽  
Healthy People ◽  
Microvascular Blood Flow ◽  
History Of

scholarly journals Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves’ ophthalmopathy patients

2006 ◽  
Vol 155 (5) ◽  
pp. 681-685 ◽  
Author(s):  
E Berrin Yuksel Konuk ◽  
Onur Konuk ◽  
Muge Misirlioglu ◽  
Adnan Menevse ◽  
Mehmet Unal
Keyword(s):  
Disease Duration ◽  
Clinical Activity ◽  
Connective Tissues ◽  
Positive Correlation ◽  
Graves Ophthalmopathy ◽  
Compressive Neuropathy ◽  
The Mean ◽  
Cox 2

Objective: The aim of this study is to evaluate the expression of cycloocygenase-2 (COX-2) in orbital fibroadipose connective tissue in Graves’ ophthalmopathy (GO) patients, and investigate the associations between COX-2 expression and GO characteristics. Methods: The orbital fibroadipose connective tissues of 23 cases demonstrating moderate or severe GO, and eight control subjects without any history of thyroid or autoimmune disease were analyzed for COX-2 mRNA expression. Real-time relative quantitative PCR was performed to assess transcripts of COX-2 using the LightCycler. The disease activity was evaluated by the clinical activity score (CAS). The clinical features of GO were evaluated by total eye score (TES) and the cases were divided into two groups; type 1 cases included higher degrees of proptosis with orbital fat volume increase, and type 2 cases included cases with compressive neuropathy and limited extraocular muscle functions. Results: The mean ± s.d. disease duration was 5.7 ± 7.1 years. The mean ± s.d. CAS and TES of cases were 1.60 ± 1.04 and 7.5 ± 1.8 respectively. The mean ± s.d. expression of COX-2 was 0.023 ± 0.013 and 0.010 ± 0.002 in GO cases and controls (P = 0.008), and 0.015 ± 0.073 and 0.029 ± 0.135 in type 1 and type 2 cases respectively (P = 0.007). COX-2 expression showed a statistically significant positive correlation with TES (r = 0.634, P = 0.001), and a negative correlation with the disease duration (r = −0.621, P = 0.002). Conclusions: COX-2 is expressed at higher levels in orbital fibroadipose tissues of GO cases. This showed a positive correlation with increasing severity of orbital disease suggesting possible relation with COX-2 expression and orbital inflammation in GO.

Permanent Hypertension after Renal Homotransplantation in Man

1975 ◽  
Vol 48 (5) ◽  
pp. 391-403 ◽  
Author(s):  
J. P. Grünfeld ◽  
D. Kleinknecht ◽  
J. F. Moreau ◽  
P. Kamoun ◽  
J. Sabto ◽  
...  
Keyword(s):  
Experimental Data ◽  
Blood Flow ◽  
Left Kidney ◽  
Plasma Renin ◽  
Artery Stenosis ◽  
Renin Release ◽  
Normal Range ◽  
Hypertensive Patients ◽  
The Mean ◽  
Arteriovenous Difference

1. In forty-one patients who underwent renal homotransplantation the following measurements were made: (a) blood flow and its distribution in the transplanted kidney as measured by the 85Kr washout method; (b) renin release in the renal vein of the transplant; (c) arteriovenous difference in plasma renin activity (PRA) of the recipient's remaining left kidney. 2. Eleven transplanted patients were normotensive. Renal haemodynamic data were comparable with those obtained in potential kidney donors. 3. Three hypertensive patients had chronic rejection. The mean renal blood flow and the percentage of flow in the first component of the washout curve were reduced. Renin release from the transplant, however, was normal. 4. Ten hypertensive patients had transplant artery stenosis. In eight of them renin release from the graft as well as peripheral PRA were within normal range. This result is similar to experimental data obtained in Goldblatt renovascular hypertension. The two patients with the tightest artery stenosis had an elevated renin release from the transplant. 5. Thirteen hypertensive patients had elevated arteriovenous difference in PRA of the recipient's own left kidney. Peripheral PRA was significantly higher than in normotensive patients. Left nephrectomy relieved hypertension in ten of them; three have not so far undergone nephrectomy. 6. In four other cases hypertension was also relieved by removal of the patient's own kidney; however, the arteriovenous difference in PRA of that kidney fell within normal range.

scholarly journals The effectiveness of the replacement of the generic blockers of the renin-angiotensin-aldosterone system by perindopril arginine in patients with uncontrolled blood pressure: the results of the regional program “DIFFERENCE”

2018 ◽  
Vol 24 (3) ◽  
pp. 359-368
Author(s):  
N. N. Nikulina
Keyword(s):  
Blood Pressure ◽  
Calcium Antagonist ◽  
Angiotensin Ii ◽  
Generic Drugs ◽  
Uncontrolled Blood Pressure ◽  
Hypertensive Patients ◽  
Receptor Blockers ◽  
The Mean ◽  
Study Completion ◽  
Design And Methods

Taking into account the widespread use of generic drugs and insufficient rate of achieving the target blood pressure (BP), a regional program “DIFFERENCE” was initiated. The purpose of this study was to assess the chance of increasing the effectiveness of antihypertensive therapy (AHT) by replacing generic perindopril and receptor blockers to angiotensin II (BRA) by the original perindopril and generic indapamide by the original one.Design and methods. The study included 330 hypertensive patients (47,3% males; the average age of men is 53,5 ± 8,5 years, women — 54,2 ± 10,2 years, p > 0,05). The mean systolic BP was 149,5 ± 5,3 mm Hg, average diastolic BP — 96,4 ± 4,9 mm Hg; 1st HTN degree was achieved in 49,1% patients, 2nd — in 41,2%; 3rd degree remained in 9,7%. Monotherapy of HTN was prescribed in 79,4% patients.Results. After the transfer from the generic perindopril to the original drug (± transfer from the generic indapamide to the original one) within 4 weeks no other changes of AHT were introduced. During these 4 weeks, the average systolic BP decreased to 139,1 ± 5,1 mm Hg, diastolic blood pressure declined to 88,2 ± 5,8 mm Hg, which allowed to achieve the target BP in 37,0% patients (p < 0,01). On the Month 1 visit, taking into account indications, the frequency of combined AHT increased to 76,4%, on the Month 3 visit — to 88,2%, exceeding the original one by 4,3 times (p < 0,01). On the Month 3 visit the average systolic BP was 136,5 mm Hg, diastolic BP — 85,9 mm Hg, the target BP level was achieved in 53,9% cases (p < 0,01). By the study completion, the most often combination included perindopril with diuretic or calcium antagonist.Conclusions. The study “DIFFERENCE” demonstrated the effectiveness of the replacement of generic perindopril and BRA by the original perindopril combined, if necessary, with the replacement of generic indapamide by the original one in patients wth uncontrolled HTN. To date, the combined AHT has not been assigned frequently enough, which is also the reason for the insufficient efficiency. The most common were the combinations of perindopril with diuretic or calcium antagonist. 

scholarly journals Relationship between blood velocity and conduit artery diameter and the effects of smoking on vascular responsiveness

2004 ◽  
Vol 96 (6) ◽  
pp. 2139-2145 ◽  
Author(s):  
Lee Stoner ◽  
Manning Sabatier ◽  
Kristy Edge ◽  
Kevin McCully
Keyword(s):  
Blood Flow ◽  
Brachial Artery ◽  
Local Heating ◽  
Blood Velocity ◽  
Vascular Health ◽  
Arterial Diameter ◽  
Arterial Blood ◽  
Vascular Responsiveness ◽  
The Mean ◽  
The Relationship

Transient changes in arterial diameter in response to transient ischemia-induced changes in arterial blood velocity have been used as an index of vascular health. The purpose of this study was to determine the relationship between blood velocity and diameter in the brachial artery by different methods of increasing blood velocity. Acute cigarette smoking was used with otherwise healthy young occasional smokers to determine the influence of endothelial-nitric oxide pathways on the arterial diameter-blood velocity relationship. Nine nonsmokers and 12 occasional smokers (<1 pack/wk) were tested. Blood flow to the forearm was manipulated to indirectly investigate the relationship between blood velocity and diameter in the brachial artery. Blood flow to forearm was manipulated through the use of 1) 5-min ischemia; 2) handgrip exercise; 3) indirect local heating; and 4) 5-min ischemia plus indirect local heating. A strong relationship was observed between blood velocity and diameter independent of the method used to increase blood velocity ( R2 = 0.89). The mean slope of the velocity-diameter relationship was not different between nonsmokers and occasional smokers who abstained from smoking at least 2 days. Acute smoking did not alter the slope of the velocity-diameter relationship although the mean intercept was decreased as a result of consistent vasoconstriction (7–10%). The mechanisms by which smoking impairs vascular health are largely unknown. These findings differ from previous smoking studies that used chronic and/or heavier smokers. The velocity-diameter relationship appears independent of the method for increasing velocity. Acute smoking in occasional smokers results in vasoconstriction without altering vascular responsiveness. The velocity-diameter relationship may be a useful measure of the progression of vascular disease.

scholarly journals A randomized, prospective, open label comparative study of the efficacy of azilsartan and ramipril in the management of hypertension in patients with type-2 diabetes mellitus

2021 ◽  
Author(s):  
Husna Siddiqua ◽  
Ghulam Subhani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Open Label ◽  
Once Daily ◽  
Hypertensive Patients ◽  
The Mean

Background: Patients with diabetes are prone to have hypertension. Hypertension is risk factors for complications of the vascular system, cardiovascular diseases and leads to atherosclerosis. It has been estimated that the diabetics tend to have about two times more risk of having hypertension than the general population. Objective of current study is to study and compare the efficacy of azilsartan and ramipril in the management of Hypertensive patients with type 2 diabetes mellitusMethods: randomized, prospective, open label comparative study was carried out among 60 known cases of diabetes mellitus type-2 with hypertension. Patients were randomly allocated into two groups: group-A (N=30) taking ACE Inhibitor tablet ramipril 5 mg Once daily orally. Group-B (N=30) taking angiotensin II receptor antagonist tablet azilsartan 40 mg once daily orally. At the commencement of the trial, patients were subjected to thorough clinical examination with necessary investigations and base line values were recorded.Results: Both the groups were comparable for age, sex and treatment taken. There was a significant reduction in the mean arterial pressure (17.43 for azilsartan group vs. 14.5 for ramipril group) (mmHg), creatinine clearance (mean reduction of 18.8 for azilsartan group vs. 13.94 for ramipril group), and urinary albumin excretion (mean reduction of 29.74 in azilsartan group vs. 17.25 for ramipril group). In azilsartan group the reduction was more in all parameters compared to ramipril group without effecting renal parameters.Conclusions: Azilsartan was more effective in reducing the mean arterial pressure (mmHg), creatinine clearance as well as urinary albumin excretion in Hypertensive patients with Type 2 diabetes mellitus without effecting renal parameters.

scholarly journals Comparative analysis of arteriolar Doppler ultrasound parameters in hypertensive patients with or without Type 2 diabetes mellitus

2012 ◽  
Vol 11 (5) ◽  
pp. 18-21 ◽  
Author(s):  
V. S. Volkov ◽  
E. V. Rudenko ◽  
O. B. Poselyugina
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Flow ◽  
Type 2 Diabetes Mellitus ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Blood Flow Velocity ◽  
Healthy Controls ◽  
Essential Arterial Hypertension

Aim.Using the Doppler ultrasound method, to describe functional status of arterioles in patients with essential arterial hypertension (AH) and individuals with Type 2 diabetes mellitus (DM-2) and concomitant AH.Material and methods.The study included 90 AH patients and 83 patients with DM-2 and AH. Systolic (Vs, cm/s), diastolic (Vd, cm/s), and mean (Vm, cm/s) arteriolar blood flow velocity was measured using the Miniplex Doppler device. The subsequent spontaneous changes in blood flow velocity were registered for one minute and presented as percentages.Results.The maximal blood flow velocity was observed in AH patients, followed by healthy controls and patients with DM-2 and AH. The Vs variation was the largest in healthy people, smaller in AH patients, and the smallest in participants with AH and DM-2. The maximal Vd variation was observed in AH patients, followed by patients with AH and DM-2 and healthy controls.Conclusion.The assessment of arteriolar blood flow velocity provides information about arteriolar tonus and its dynamics over time.

scholarly journals Comparison of Salivary Cortisol Level in Type 2 Diabetic Patients and Pre-Diabetics with Healthy People

2019 ◽  
Vol 7 (14) ◽  
pp. 2321-2327 ◽  
Author(s):  
Maedeh Salehi ◽  
Abbas Mesgarani ◽  
Soosan Karimipour ◽  
Shaghayegh Zahed Pasha ◽  
Zahra Kashi ◽  
...  
Keyword(s):  
Cortisol Level ◽  
Salivary Cortisol ◽  
Healthy People ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Type 2 Diabetic Patients ◽  
Salivary Cortisol Level ◽  
The Mean ◽  
Type 2 Diabetic

BACKGROUND: Cortisol is one of the important enzymes of saliva. Control of this hormone is an effective way to adjust the glucose level in diabetic patients. AIM: The aim of this research is to compare the salivary cortisol level in type 2 diabetic patients and pre-diabetics with healthy people. METHODS: In this case-control study (2018), the unstimulated salivary samples were collected from 44 patients with type 2 diabetes, 44 pre-diabetic people (case group), and 44 healthy subjects (control group), matched for age and gender. The samples were transferred to the laboratory, and salivary cortisol level was measured using ELISA. Data were analysed using SPSS 22 and Chi 2 tests. RESULTS: The mean salivary cortisol level in type 2 diabetic patients was 3.14 ± 1.17, in pre-diabetic cases was 1.83 ± 0.68, and in healthy controls was 0.86 ± 0.43 (P < 0.001). The mean DMFT in type 2 diabetic patients was 19.6 ± 6.5, in the pre-diabetic group was 13.43 ± 4.5, and in healthy controls was 9.38 ± 3.72 (P < 0.001). CONCLUSION: With regards to the results, salivary cortisol level in type 2 diabetic patients is more than pre-diabetic people, and in pre-diabetic people is more than healthy people. Also, there was a significant relation between salivary cortisol level and DMFT index.

Impact of COVID 19 Lockdown on Glycemic Control in Patients with Type 2 Diabetes Mellitus in Dubai

2021 ◽  
Vol 18 ◽  
Author(s):  
Ibtehal Makki ◽  
Nouf Alnoon ◽  
Najma Rahmani ◽  
Jawaher Almulla ◽  
Asma Alamiri ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
P Value ◽  
Before And After ◽  
The Mean ◽  
Design And Methods ◽  
The Impact

Objective: The objective of this study is to evaluate the impact of the COVID-19 lockdown on glycemic control and accompanying laboratory parameters in patients with type 2 Diabetes Mellitus. Research design and methods: This study is a retrospective cohort study that was done on a multicenter level. It was conducted during the lockdown in 341 individuals. HbA1c was tested to measure glycemic control immediately before and after the lockdown period that lasted for 13 weeks. Results: The primary outcome was the improvement of mean HbA1C after 13 weeks of lockdown compared to the pre-lockdown HbA1C. It was found that the mean HbA1C improved from 7.5±1.5 to 7.3±1.5 with a p-value of 0.001. Conclusion: Our study showed that patients with type 2 diabetes mellitus exhibited an improvement in their glycemic control after the period of lockdown.

scholarly journals Assessment of Thyroid Profile of Type 1 and Type 2 Diabetes Mellitus Patients and Patients with Diabetic Complications

2020 ◽  
Vol 6 ◽  
pp. 1
Author(s):  
Friday K Iweka ◽  
Godwin RA Okogun ◽  
Ebenezer O Dic-Ijiewere ◽  
Lawrence F Dada ◽  
Iredia K Akhuemokhan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Diabetic Patients ◽  
Hypertensive Patients ◽  
Control Subjects ◽  
The Mean ◽  
Thyroid Profile

This study was undertaken to assess the thyroid profile of diabetes mellitus (DM) patients and patients with some associated complications in the Edo state, Nigeria. Blood samples from 267 subjects, consisting of 164 diabetic patients (24 type 1 DM and 140 type 2 DM) and 103 nondiabetic apparently healthy individuals (as controls), were analyzed. The thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) levels were determined using the enzyme linked immunosorbent assay (ELISA). From the result obtained, the T3 level was found significantly (p < 0.05) higher in diabetic-nephropathy (D-NEPHR) patients than the control subjects, while the TSH and T4 levels of D-NEPHR were insignificantly (p > 0.05) higher than those of the control group. The mean TSH level was significantly (p < 0.05) lower in diabetic hypertensive patients when compared with the control group, while the plasma T3 level was significantly (p < 0.05) higher in diabetic hypertensive patients when compared with the control group. There was no significant difference (p > 0.05) in the mean value of T4 of diabetic hypertensive patients when compared with the control subjects. The mean plasma T3 and T4 were significantly (p < 0.05) higher in diabetic neuropathy (D-NEUR) patients than those of control subjects. There were no significant (p > 0.05) differences in the mean plasma TSH level of D-NEUR patients when compared with those of control subjects. The mean plasma T3and T4 levels of diabetic patients with coronary heart disease (DM-CHD) were significantly (p < 0.05) higher than those of control subjects while the mean plasma TSH level of DM-CHD was significantly (p < 0.05) lower than that of control subjects. No significant (p > 0.05) difference in the mean plasma TSH, T4, and T3 levels of diabetic retinopathy subjects when compared with those of control subjects was obtained.

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