PROGNOSTIC SIGNIFICANCE OF SPECIFIC PROTEINS OF PREGNANCY IN WOMEN WITH A UTERINE AT SCAR AND PLACENTA ACCRETA

2020 ◽  
Vol 65 (6) ◽  
pp. 353-357
Author(s):  
Vladimir Anatolyevich Borovkov ◽  
M. B. Igitova ◽  
Y. V. Korenovskiy ◽  
Yu. A. Dudareva
Keyword(s):  
Pregnant Women ◽  
Placenta Accreta ◽  
Screening Program ◽  
Protein A ◽  
Prognostic Significance ◽  
Pregnancy Proteins ◽  
Diagnostic Thresholds ◽  
Diagnostic Threshold ◽  
Specific Proteins

Comparative analysis of serum concentrations of chorionic gonadotropin (hCG) associated with the pregnancy of plasma protein A (PAPP-A) and alpha-fetoprotein (AFP), based on the results of a survey of women as part of a standard screening program (the results were expressed as a MoM - multiply of the median), found a significant increase in the performance of all the studied specific pregnancy proteins in women with a scar on the uterus and placenta acctera (75 patients) compared with the data of the group of pregnant women without scar on the uterus and without abnormalities of attachment of the placenta (150 women). AFP indices were 1.68 ± 0.76 and 1.19 ± 0.43 MoM (p = 0.0018), hCG - 1.62 ± 1.48 and 1.23 ± 0.76 MoM (p = 0, 0112), PAPP-A - 1.93 ± 1.24 and 1.23 ± 0.67 MoM (p <0.0001). Using the ROC analysis, the diagnostic thresholds for the concentrations of AFP, hCG and PAPP-A were calculated. The risk of placenta accreta in women with a scar on the uterus in cases of exceeding the diagnostic threshold of AFP concentration (1.64 MoM) increased 2.5 times (RR = 2.5; 95% CI 1.17-5.36, p = 0, 0185), hCG (1.41 MoM) - 1.6 times (RR = 1.59; 95% CI 1.09-2.32, p = 0.0147), PAPP-A (1.41 MoM) - 2.65 times (RR = 2.65; 95% CI 1.76-3.99, p <0.0001). Determination of the level of specific pregnancy proteins can be used in the system of complex prediction of placental growth in pregnant women with a scar on the uterus as an addition to the assessment of clinical and anamnestic risk factors.

scholarly journals Evaluation of diagnostic thresholds dependability for tribologic signals received in the environment disturbed by vibroacoustic and functional signals

2015 ◽  
Vol 36 (1) ◽  
pp. 17-32
Author(s):  
Paweł Lindstedt ◽  
Marek Zboiński ◽  
Maciej Deliś ◽  
Jerzy Manerowski
Keyword(s):  
Working Conditions ◽  
Operation Time ◽  
Working Environment ◽  
Cauchy Product ◽  
Diagnostic Thresholds ◽  
Diagnostic Threshold ◽  
Complete Set ◽  
The Relationship ◽  
Insufficient Number

Abstract Determination of dependable diagnostic thresholds for tribologic signals received e.g. from antifriction bearings (in particular for insufficient number of measurements, only 4÷5) is a really difficult task due to complexity of working environment where such bearings are operated. Typical working environment for such objects must take account for operation time under various working conditions and accompanying (and disturbing) signals, e.g. vibroacoustic ones. The sought assessment of the relationship between diagnostic signals and environmental noise can be determined from convolution of both diagnostic and environments signals that make up the complete set of received information. The convolution of these two series of signals can be obtained from an algorithm based on the Cauchy product. Then one has to find the coherence factor and the square of amplitude gain for the set of diagnostic signals with reference to various sets of signals received from environment, which makes it possible to evaluate cohesion of the investigated series of signals, thus their suitability to determine diagnostic threshold for tribologic signals intended for the analysis.

A SENSITIVE TIME-RESOLVED FLUOROIMMUNOASSAY FOR DETERMINATION OF MEDIAN LEVELS OF PREGNANCY-ASSOCIATED PLASMA PROTEIN A IN PREGNANT WOMEN IN CHINA

2013 ◽  
Vol 34 (4) ◽  
pp. 365-375 ◽  
Author(s):  
Ting Yu ◽  
Shangxian Gao ◽  
Aihua Yin ◽  
Yongping Tang ◽  
Yingsong Wu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Plasma Protein ◽  
Protein A ◽  
Time Resolved

scholarly journals RADIOLOGICAL DIAGNOSTIC OF PLACENTA ACCRETE IN PREGNANT WOMEN WITH CESAREAN SCAR

2018 ◽  
Vol 25 (3) ◽  
pp. 97-106 ◽  
Author(s):  
A. V. POMORTSEV ◽  
E. D. KHUDOROZHKOVA ◽  
M. A. MATOSYAN ◽  
V. V. MAKUKHINA ◽  
I. G. NOSULYA
Keyword(s):  
Pregnant Women ◽  
Placenta Accreta ◽  
Bladder Wall ◽  
Group Iv ◽  
Front Wall ◽  
Group Iii ◽  
Group I ◽  
Ultrasound Assessment ◽  
Imaging Markers

Aim. To define significant ultrasound and magnetic resonance imaging markers in diagnostics of the depth of chorion invasion in myometrium in pregnant women after Cesarean section was carried out.Materials and methods. 68 pregnant women from 28 to 32 gestation weeks with Caesarian scar and placenta on the front wall of uterus were retrospectively studied. Pregnant women were divided into 4 groups depending on histologic verification of placenta invasion depth. MRI and ultrasound assessment of the lower uterine segment was carried out and the most significant US and MRI markers of placenta accreta were distinguished. Subsequently, the received results of the research were processed by algorithms of factor analysis with calculation of informativeness of each marker and with determination of the forecast of placenta accreta.Results. As a result, group I of pregnant women scored within 0-0.9 conventional units, in group II – 1-3 conventional units, in group III – the score was 3.1-5.0 conventional units, in group IV – 5.1-7.0 conventional units. In groups III and IV are characterized by the fact of signs combination. In group III the combination of 2 signs was detected in 65% of cases, of 3 signs – in 25% of pregnant women.Conclusion. The most informative marker of ultrasound diagnostic of placenta accreta was determination of venous lacunas in its suprabasal part (0.42), in case of MRI it was the assessment of the bladder wall (0.45). The sensitivity and specificity of ultrasonography were 86.2% and 84.8%, in MRI they were 96% and 94.4% respectively.

Significance of the routine first-trimester antenatal screening program for aneuploidy in the assessment of the risk of placenta accreta spectrum disorders

2019 ◽  
Vol 48 (1) ◽  
pp. 21-26
Author(s):  
Grigory A. Penzhoyan ◽  
Tatiana B. Makukhina
Keyword(s):  
High Risk ◽  
Blood Loss ◽  
Pregnant Women ◽  
Placenta Accreta ◽  
Screening Program ◽  
First Trimester ◽  
Significant Difference ◽  
Placenta Accreta Spectrum ◽  
Spectrum Disorders ◽  
Β Hcg

AbstractObjectiveTo select a group at high risk of placenta accreta spectrum disorders (PAS) based on the data of serum screening in the first trimester.MethodsA retrospective analysis of 48 patients with abnormal placental location (AP), including placenta previa (PP) only (n = 23) and PP and PAS (n = 25), was performed. Additionally, the AP group was divided depending on the blood loss volume: not higher than 1000 mL (LBL) (n = 29) and higher than 1000 mL (HBL) (n = 19); diagnostic term of PAS by ultrasound, data pregnancy-associated plasma protein-A (РAРР-A) and free β subunit of human chorionic gonadotropin (free β-hCG) multiple of median (MоM) at 11+0–13+6 weeks of gestation were evaluated. Serological markers were compared with the data of 39 healthy pregnant women with scar after previous cesarean section and normal placental location (control).ResultsThe mean gestation at diagnostic term of PAS was 29 weeks. PAPP-Р MоM [mean (M) ± standard deviation (SD)] was: in controls, 1.07 ± 0.47; in the AP group, 1.59 ± 0.24; in PP, 1.91 ± 1.52; in PAS, 1.30 ± 0.85; in LBL, 1.37 ± 1.20; in HBL, 1.91 ± 1.24. The difference between control/AP, control/PP, control/PAS, PP/PAS, control/LBL, control/HBL and LBL/HBL was Р = 0.256, 0.145, 0.640, 0.311, 0.954, 0.025 and 0.09, respectively. Free β-hCG MoM (M ± SD) was: in controls, 1.08 ± 0.69, in AP, 1.31 ± 0.96; in PP, 1.46 ± 0.19; in PAS, 1.16 ± 0.65; in LBL, 1.30 ± 0.06; in HBL, 1.32 ± 0.78. Comparison of free β-hCG AP with controls and between subgroups did not reveal a significant difference.ConclusionUnderestimation of PAS risk factors in pregnant women with AP leads to late diagnostics of pathology only in the third trimester. The assessment of the РAРР-A level in the first trimester may be helpful for the early prognosis of pathological blood loss at delivery for pregnant women with AP and for forming the high-risk group for PAS.

INDIREKTE PAPIERCHROMATOGRAPHISCHE METHODE ZUR BESTIMMUNG DER HARNOESTROGENE

1961 ◽  
Vol 38 (4) ◽  
pp. 545-562 ◽  
Author(s):  
L. Kecskés ◽  
F. Mutschler ◽  
I. Glós ◽  
E. Thán ◽  
I. Farkas ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Granulosa Cell ◽  
Iron Content ◽  
List Type ◽  
Granulosa Cell Tumour ◽  
Hydrolysis Of ◽  
Phenol Fraction ◽  
Qualitative Determination

ABSTRACT 1. An indirect paperchromatographic method is described for separating urinary oestrogens; this consists of the following steps: acidic hydrolysis, extraction with ether, dissociation of phenol-fractions with partition between the solvents. Previous purification of phenol fraction with the aid of paperchromatography. The elution of oestrogen containing fractions is followed by acetylation. Oestrogen acetate is isolated by re-chromatography. The chromatogram was developed after hydrolysis of the oestrogens 'in situ' on the paper. The quantity of oestrogens was determined indirectly, by means of an iron-reaction, after the elution of the iron content of the oestrogen spot, which was developed by the Jellinek-reaction. 2. The method described above is satisfactory for determining urinary oestrogen, 17β-oestradiol and oestriol, but could include 16-epioestriol and other oestrogenic metabolites. 3. The sensitivity of the method is 1.3–1.6 μg/24 hours. 4. The quantitative and qualitative determination of urinary oestrogens with the above mentioned method was performed in 50 pregnant and 9 non pregnant women, and also in 2 patients with granulosa cell tumour.

Polarographic study of hydrolysis of [8-lysine]vasopressin and its derivatives with blood serum of pregnant women

1980 ◽  
Vol 45 (4) ◽  
pp. 1099-1108 ◽  
Author(s):  
Mikuláš Chavko ◽  
Michal Bartík ◽  
Evžen Kasafírek
Keyword(s):  
Blood Serum ◽  
Pregnant Women ◽  
Degree Of Hydrolysis ◽  
Polarographic Study ◽  
Ph Optimum ◽  
Lysine Vasopressin ◽  
Rate Of Hydrolysis ◽  
Hydrolysis Of ◽  
Vasopressin Analogues

A polarographic study of the hydrolysis of [8-lysine]vasopressin and some hormonogens of the vasopressin series with the blood serum of women in the last week of pregnancy was studied. The dependence of hydrolysis on pH (pH optimum: 7.4-7.50, substrate concentration (Km 1.2 . 10-5M), pH stability and thermal stability were determined. The rate of hydrolysis of individual vasopressin analogues decreases in the order: [8-lysine]vasopressin > Nα-glycyl-prolyl[8-lysine]-vasopressin > Nα-leucyl-[8-lysine]vasopressin > Nα-alanyl-[8-lysine]vasopressin > Nα-phenyl alanyl-[8-lysine]vasopressin > Nα-diglycyl-[8-lysine]vasopressin > Nα-prolyl-[8-lysine]vasopressin > Nα-triglycyl-[8-lysine]vasopressin > Nα-sarcosyl-glycyl-[8-lysine]vasopressin. The degree of hydrolysis gradually increases to a multiple with the length of the pregnancy in consequence of the presence of oxytocine. However, vasopressin is also hydrolysed to a small extent with the enzymes from the blood sera of non-pregnant women. Under similar analytical conditions oxytocin was not hydrolysed with the sera of non-pregnant women and therefore oxytocin is a more suitable substrate than vasopressin for polarographic determination of serum oxytocinase.

scholarly journals The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hong Hong ◽  
Chao Guo ◽  
Zhi-Hua Liu ◽  
Bo-Jie Wang ◽  
Shu-Zhe Zhou ◽  
...  
Keyword(s):  
Pediatric Patients ◽  
Assessment Instrument ◽  
Surgical Patients ◽  
Reference Standard ◽  
Diagnostic And Statistical Manual ◽  
Diagnostic Thresholds ◽  
Diagnostic Threshold ◽  
Effective Instrument ◽  
Sensitivity Specificity ◽  
Selective Surgery

Abstract Background Cornell assessment of pediatric delirium (CAPD) showed advantage in diagnosis of pediatric delirium in Chinese critically ill patients. But its performance in surgical patients is still unclear. The present study was designed to validate the diagnostic performance of CAPD in surgical pediatric patients. Methods This is a prospective validation study. Pediatric patients who underwent selective surgery and general anesthesia were enrolled. Primary outcome was the incidence of delirium within postoperative three days. CAPD Chinese version was used to evaluate if the patient had delirium one time per day. At the meantime, a psychiatrist employed Diagnostic and Statistical Manual of Mental Disorders fifth edition to diagnose delirium, which was the “gold standard”, and the result was considered as reference standard. Sensitivity, specificity and area under receiver operating characteristic (ROC) curve were calculated to investigate the performance of CAPD. Results A total of 170 patients were enrolled. Median age was 4 years old. As diagnosed by psychiatrist, 23 (13.5 %) patients experienced at least one episode of delirium during the follow-up period. When diagnostic threshold was set at 9, CAPD showed the optimal sensitivity (87.0 %, 95 %CI 65.3 %-96.6 %) and specificity (98.0 %, 95 %CI 93.7 %-99.5 %) in comparison with other diagnostic thresholds. ROC analysis showed that CAPD was a good delirium assessment instrument with area under curve of 0.911 (95 % CI 0.812 to 1.000, P < 0.001). Agreement between CAPD and reference standard was 0.849 (Kappa coefficient, P < 0.001). Conclusions This study found that Cornell assessment of pediatric delirium could be used as an effective instrument in diagnosis of delirium in pediatric surgical patients. Trial registration www.chictr.org.cn Identifier: ChiCTR-DDD-17,012,231, August 3, 2017.

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