Exceptional case of disseminated necrobiosis lipoidica similar to a sarcoidosis form at the child affected by diabetes type I

2016 ◽  
Vol 19 (4) ◽  
pp. 227-230
Author(s):  
V. T Bazaev ◽  
M. B Tseboeva ◽  
M. S Tsarueva
Keyword(s):  
Diabetes Mellitus ◽  
Short Review ◽  
Exceptional Case ◽  
Diabetes Type ◽  
Type I ◽  
Necrobiosis Lipoidica ◽  
Modern Methods ◽  
Diabetes Type I ◽  
Methods Of Treatment

The article describes the infrequent disseminated necrobiosis lipoidica similar to a sarcoidosis form which developed at the five-year-old child affected by type 1 diabetes mellitus. The short review concerns the questions of an etiology, pathogenesis, clinical forms, diagnostics and the modern methods of treatment of the described pathology. In the review 26 sources of literature are used. The case is of interest to dermatovenereologists, endocrinologists, pediatricians.

Fasa Registry on Diabetes mellitus (FaRD): Feasibility Study and Pilot Phase Results

2020 ◽  
Author(s):  
Babak Pezeshki ◽  
Aliasghar Karimi ◽  
Amir Ansari ◽  
Mohammad Hosein yazdanpanah ◽  
Mitra Elmi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Population Based ◽  
Type I ◽  
Pilot Phase ◽  
Medication History ◽  
Laboratory Findings ◽  
Diabetes Type I ◽  
Population Based Registry ◽  
Dm Type 2

Abstract BackgroundDiabetes mellitus (DM) is the most common chronic diseases. This disease is the main risk factor of fetal diseases such as myocardial infarction and stroke. There is no cure for DM, and an effective strategy must control it. Every attempt to control DM and patient outcomes require a surveillance system to consider the efficacy and safety measures. Fasa Registry on Diabetes mellitus (FaRD) is the first population-based registry for DM in Iran targeted to provide a meticulous description of social, mental health, clinical, and laboratory values of patients, to consider the management patterns of these patients, to discover the degree of adherence to the recommendations.Methodsthe diagnosis of diabetes (Type I and II) characterized by the level of plasma glucose. The pregnant women were excluded. Three registrar nurses collected data on demographics, physical exams, past medical history, medication history, and laboratory findings. Resultsthe pilot phase included the first 381 patients, 257 (67.5%) were women, and 124 (32.5%) were men. With a mean age of 57.54 ± 12.12years among subjects, the 347 (94.5%) of them had DM type 2, and 20 (5.4%) of them had type 1. ConclusionBased on our results, the characteristics of patients suffering DM do not afford their medical cost, so the majority of them were not adherence to the practice guidelines.The achievement of FaRD helps physicians and patients to better controlling the DM.The finding of this pilot study shows the FaRD is feasible, and it will make a comprehensive population-based registry for DM in the region.

Multi-collector ICP-mass spectrometry reveals changes in the serum Mg isotopic composition in diabetes type I patients

2019 ◽  
Vol 34 (7) ◽  
pp. 1514-1521 ◽  
Author(s):  
Rosa Grigoryan ◽  
Marta Costas-Rodríguez ◽  
Steven Van Laecke ◽  
Marijn Speeckaert ◽  
Bruno Lapauw ◽  
...  
Keyword(s):  
Isotopic Composition ◽  
Reference Population ◽  
Diabetes Type ◽  
Type I ◽  
Diabetes Type 1 ◽  
Age And Gender ◽  
Diabetes Type I ◽  
And Gender ◽  
Icp Mass Spectrometry

Serum Mg shows a lighter isotopic composition in diabetes type-1 patients than in an age- and gender-matched reference population.

INFLUENCE OF PINEALON ON EXPRESSION OF GENES OF PRO- AND ANTIOXIDANT ENZYMES AND FREE RADICAL PROCESSES IN RATS IN THE MODEL OF SUGAR DIABETES

2020 ◽  
Author(s):  
M.P. Fomenko ◽  
◽  
A.M. Menzheritsky ◽  
G.V. Karantysh ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Type I Diabetes ◽  
Diabetes Type ◽  
Type I ◽  
Antioxidant Genes ◽  
Free Radical Processes ◽  
Expression Of Genes ◽  
Diabetes Type I ◽  
Radical Processes

The article presents an analysis of the effect of pinealon on free radical processes and the level of expression of the SOD1, GPX4 and GSR genes in the rat hippocampus in a model of streptozotocininduced diabetes (type I diabetes mellitus). It has been established that when modeling diabetes in the hippocampus, intensification of radically radical processes is observed: the level of prooxidants increases, the level of antioxidants decreases, as well as the level of expression of antioxidant genes. With the introduction of pinealone in dosages of 50 or 100 ng/kg in the model of diabetes mellitus, the pro-antioxidant balance shifts towards a decrease in the production of free radicals and an increase in antioxidant protection. Pinealon at a dosage of 100 ng/kg is more effective.

scholarly journals THE Assesssment of PARAMETERS OF LONG-TERM METABOLIC control in children WITH DIABETES TYPE I using UNDERGOING different types of insulin THerapy and using different means of its introduction

2015 ◽  
pp. 41-45
Author(s):  
N. V. Volkova ◽  
H. G. Mikhno ◽  
A. V. Solntseva
Keyword(s):  
Glycosylated Hemoglobin ◽  
Diabetes Type ◽  
Type I ◽  
Diabetes Type 1 ◽  
Complications Of Diabetes ◽  
Acute Complications ◽  
Different Types ◽  
Diabetes Type I

Objective: to carry out comparative analysis of long-term compensation of carbohydrate metabolism in children with diabetes type 1 undergoing different types of insulin therapy and using different means of its introduction. Material and methods . We analyzed data of 77 medical histories of children with diabetes type 1. The patients were divided into 3 groups depending on the type of insulin and the way of its introduction. We analyzed both initial and current for the moment of the experiment parameters of glycosylated hemoglobin levels, frequency of blood glucose self-testing, presence of acute complications of diabetes mellitus. Results . The children undergoing continuous subcutaneous insulin introduction revealed significant decrease of glycosylated hemoglobin levels and absence of acute complications of diabetes. The group of children using insulin analogues for a long time had significantly lower glycemia variability and revealed no acute complications of diabetes. Conclusions . We revealed long-term compensation of carbohydrate metabolism in the children with diabetes type I who used insulin pump therapy.

scholarly journals Challenge of diabetes mellitus and researchers’ contributions to its control

2021 ◽  
Vol 19 (1) ◽  
pp. 614-634
Author(s):  
Ayodele T. Odularu ◽  
Peter A. Ajibade
Keyword(s):  
Diabetes Mellitus ◽  
Medical Records ◽  
Diabetes Type ◽  
Future Studies ◽  
The Past ◽  
Significant Events ◽  
Review Study ◽  
Type 3

Abstract The aim of this review study was to assess the past significant events on diabetes mellitus, transformations that took place over the years in the medical records of treatment, countries involved, and the researchers who brought about the revolutions. This study used the content analysis to report the existence of diabetes mellitus and the treatments provided by researchers to control it. The focus was mainly on three main types of diabetes (type 1, type 2, and type 3 diabetes). Ethical consideration has also helped to boost diabetic studies globally. The research has a history path from pharmaceuticals of organic-based drugs to metal-based drugs with their nanoparticles in addition to the impacts of nanomedicine, biosensors, and telemedicine. Ongoing and future studies in alternative medicine such as vanadium nanoparticles (metal nanoparticles) are promising.

scholarly journals The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
David P. McBey ◽  
Michelle Dotzert ◽  
C. W. J. Melling
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Type 1 Diabetes ◽  
Exercise Training ◽  
Muscle Fibre ◽  
Lipid Content ◽  
Fibre Type ◽  
Insulin Treatment ◽  
Type I

Abstract Background Intensive-insulin treatment (IIT) strategy for patients with type 1 diabetes mellitus (T1DM) has been associated with sedentary behaviour and the development of insulin resistance. Exercising patients with T1DM often utilize a conventional insulin treatment (CIT) strategy leading to increased insulin sensitivity through improved intramyocellular lipid (IMCL) content. It is unclear how these exercise-related metabolic adaptations in response to exercise training relate to individual fibre-type transitions, and whether these alterations are evident between different insulin strategies (CIT vs. IIT). Purpose: This study examined glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise-training. Methods Male Sprague-Dawley rats were divided into four groups: Control-Sedentary, CIT- and IIT-treated diabetic sedentary, and CIT-exercised trained (aerobic/resistance; DARE). After 12 weeks, muscle-fibre lipids and glycogen were compared through immunohistochemical analysis. Results The primary findings were that both IIT and DARE led to significant increases in type I fibres when compared to CIT, while DARE led to significantly increased lipid content in type I fibres compared to IIT. Conclusions These findings indicate that alterations in lipid content with insulin treatment and DARE are primarily evident in type I fibres, suggesting that muscle lipotoxicity in type 1 diabetes is muscle fibre-type dependant.

Type I Diabetes Mellitus

2019 ◽  
Author(s):  
Joseph I. Wolfsdorf ◽  
Katharine Garvey
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Autoimmune Diabetes ◽  
Type I ◽  
Insulin Deficiency ◽  
Glucose Levels

Type 1 diabetes mellitus is characterized by severe insulin deficiency, making patients dependent on exogenous insulin replacement for survival. These patients can experience life-threatening events when their glucose levels are significantly abnormal. Type 1 diabetes accounts for 5 to 10% of all diabetes cases, with type 2 accounting for most of the remainder. This review details the pathophysiology, stabilization and assessment, diagnosis and treatment, disposition and outcomes of patients with Type 1 diabetes mellitus. Figures show the opposing actions of insulin and glucagon on substrate flow and plasma levels; plasma glucose, insulin and C-peptide levels throughout the day; the structure of human proinsulin; current view of the pathogenesis of Type 1 autoimmune diabetes mellitus; pathways that lead from insulin deficiency to the major clinical manifestations of Type 1 diabetes mellitus; relationship between hemoglobin A1c values at the end of a 3-month period and calculated average glucose levels during the 3-month period; different combinations of various insulin preparations used to establish glycemic control; and basal-bolus and insulin pump regimens. Tables list the etiologic classification of Type 1 diabetes mellitus, typical laboratory findings and monitoring in diabetic ketoacidosis, criteria for the diagnosis of Type 1 diabetes, clinical goals of Type 1 diabetes treatment, and insulin preparations. This review contains 10 figures, 9 tables, and 40 references. Keywords: Type 1 diabetes mellitus, optimal glycemic control, hypoglycemia, hyperglycemia, polyuria, polydipsia, polyphagia, HbA1c, medical nutrition therapy, Diabetic Ketoacidosis

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