scholarly journals Impact of Metabolic Syndrome Risk Factors in First-Degree Relatives of Type 2 Diabetic Patients

2007 ◽  
Vol 4 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Susana Siewert ◽  
Sergio Filipuzzi ◽  
Leticia Codazzi ◽  
Irma Gonzalez ◽  
Marta S. Ojeda
2016 ◽  
Vol 54 (4) ◽  
pp. 211-216 ◽  
Author(s):  
Azam Shafaei ◽  
Abdoljalal Marjani ◽  
Masoud Khoshnia

Abstract Introduction. The role of progranulin in individuals with metabolic syndrome is not exactly clear.We aimed to assess the serum level of progranulin in type 2 diabetic patients with and without metabolic syndrome and compare them with healthy controls. Methods. The study included 60 patients with type 2 diabetes and 30 healthy individuals as control groups. Biochemical parameters and progranulin levels were determined. Results. Subjects with metabolic syndrome showed significantly higher levels of triglyceride, waist circumference, BMI, systolic and diastolic blood pressure than subjects without metabolic syndrome and the control groups, while HDL-cholesterol level was significantly lower in subjects with metabolic syndrome. Fasting blood sugar was significantly higher in type 2 diabetic patients than in the control groups. Serum level of progranulin was slightly increased in subjects with metabolic syndrome. Serum progranulin level had no significant relationship with metabolic syndrome components. Conclusions. Serum progranulin was also not dependent on cardiometabolic risk factors for subjects with metabolic syndrome, but it could be considered for the management of type 2 diabetes mellitus. Further studies are recommended to explain the effect of progranulin on the pathogenesis of metabolic risk factors.


2020 ◽  
Author(s):  
Tina Uprety ◽  
Saroj Kunwar ◽  
Soumya Harsha Gurung ◽  
Shraddha Thapa ◽  
Sanjita Shrestha ◽  
...  

Abstract ObjectiveMetabolic syndrome and diabetes mellitus concurrently potentiates a number of risk factors, significantly higher prevalence of cardiovascular diseases. Numerous risk factors associated with diabetes gets intensified by the presence of metabolic syndrome. Diabetes and metabolic syndrome together can increase the risk of cardiovascular disease by 2 to 4 folds. The main objective of this study was to determine the prevalence of MetS in Type 2 Diabetic patients. Components of metabolic syndrome were measured and compared to determine the prevalence. Hospital based cross-sectional study was conducted from September 2019 to December 2019 at Star hospital and Modern Technical College, Sanepa, Nepal. A total number of 353 patients with type 2 diabetes visiting Star Hospital were included in the study. ResultsAmong 353 participants, metabolic syndrome was diagnosed in 242 (68.5%) participants using NCEP-ATPIII criteria. The prevalence of MetS was 68.5% among which male were 123 (76.3%) and female were 119 (61.9%). MetS was found to be highest in age group of 50-59 years with 34.2% (83) participants. Dyslipidemia with raised TG 71.4% and reduced HDL 76% was found to be most prevalent component in our study followed by hypertension 73.1%.


Author(s):  
Tina Uprety ◽  
Saroj Kunwar ◽  
Ashim Rai ◽  
Avaya Khanal ◽  
Shraddha Thapa ◽  
...  

<p class="abstract"><strong>Background:</strong> Metabolic syndrome (MetS) and diabetes mellitus concurrently potentiates a number of risk factors, significantly higher prevalence of cardiovascular diseases. Numerous risk factors associated with diabetes gets intensified by the presence of metabolic syndrome. Diabetes and metabolic syndrome together can increase the risk of cardiovascular disease by 2 to 4 folds. The main objective of this study was to determine the prevalence of MetS in type 2 diabetic mellitus (T2DM) patients. Components of metabolic syndrome were measured and compared to determine the prevalence.</p><p class="abstract"><strong>Methods:</strong> Hospital based cross-sectional study was conducted from September 2019 to December 2019 at star hospital and modern technical college, Sanepa, Nepal. A total number of 353 patients with T2DM visiting star hospital were included in the study.</p><p class="abstract"><strong>Results:</strong> Among 353 participants, MetS was diagnosed in 242 (68.5%) participants using NCEP-ATP III criteria. The prevalence of MetS was 68.5% among which male were 123 (76.3%) and female were 119 (61.9%). MetS was found to be highest in age group of 50-59 years with 34.2% (83) participants. Dyslipidemia with raised TG (triglyceride) 71.4% and reduced HDL 76% was found to be most prevalent component in our study followed by hypertension 73.1%.</p><p class="abstract"><strong>Conclusions:</strong> 68.5% prevalence of MetS in T2DM with 76.3% male and 61.9% female according to NCEP-ATP III was found with anthropometric indices significantly higher in the male population compared to female population.</p>


Sign in / Sign up

Export Citation Format

Share Document