Antifungal activity of crude extracts of stem-bark of Acacia ampliceps Maslin. (Family Leguminosae)

In the Southern Pantanal, the hyacinth macaw (Anodorhynchus hyacinthinus), an endangered species, often chooses the manduvi tree (Sterculia apetala) as a nesting site, because of its physical properties. In addition, the chemical composition of the wood may also contribute to a nesting selection by the hyacinth macaws. The objective of this study was to determine the main chemical components of S. apetala bark for two seasons, and evaluate its fungicidal potential. Bark samples from S. apetala trees with and without nests of A. hyacinthinus were collected in January (wet season) and August (dry season) of 2012. The inhibition of mycelium growth (MGI) from tree samples with and without nests were assessed using a phytochemical analysis to evaluate their antifungal activity against Trichoderma sp. Phytochemical analysis confirmed the presence of phenolic compounds and flavonoids. In both seasons, samples obtained from nested trees had higher content of total phenols than those collected from non-nested trees. The average content of total flavonoids was higher in January for samples with nest and in August for samples without nest. All selected samples showed antifungal activity, and those with nest collected in August (peak of hyacinth macaw breeding) resulted in an MGI of 51.3%. Therefore, this percentage, related to the content of flavonoids and the presence of coumarins, may influence the reproductive success of hyacinth macaws and other species of birds, in this region. This is the first chemical study report with the stem bark of S. apetala.

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Phytochemical, cytotoxicity and antioxidant studies on the stem bark of Piper arborescens

Malaysian Journal of Fundamental and Applied Sciences ◽

10.11113/mjfas.v13n4.706 ◽

2017 ◽

Vol 13 (4) ◽

pp. 840-845 ◽

Cited By ~ 1

Author(s):

Nicholas Anak Daniel ◽

Fasihuddin Badruddin Ahmad ◽

Zaini Assim ◽

Chua Hun Pin

Keyword(s):

Brine Shrimp ◽

Antioxidant Activities ◽

Stem Bark ◽

Artemia Salina ◽

Methyl Eugenol ◽

Gas Chromatography Mass Spectrometry ◽

Caryophyllene Oxide ◽

Phytochemical Study ◽

Crude Extracts ◽

High Cytotoxicity

Phytochemical study on the stem bark of P. arborescens has isolated six secondary metabolites from the crude extracts by using column chromatography, while identification was performed by using Gas Chromatography - Mass Spectrometry (GC-MS), Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared (FTIR). The isolated metabolites were identified as caryophyllene oxide (1), α-bisabolol (2), benzamide 2-(methylamino) (3), 2-ethylpiperidine (4), piperine (5) and methyl eugenol (6). Toxicity test on the four crude extracts of P. arborescens shows a high cytotoxicity against Artemia salina brine shrimp with LC50 values ranging from 13.12 to 58.70 µg/mL. Greater cytotoxicity of the crude extracts of P. arborescens indicated the presence of potent cytotoxic components in this Piper spp. Antioxidant assay of P. arborescens against 2-diphenyl-1-picrylhydrazyl (DPPH) indicated moderate antioxidant activities of methanol, dichloromethane, chloroform and hexane crude extracts with EC50 values of 21.68, 23.82, 32.88 and 36.88 µg/mL, respectively.

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In-vitro Antimicrobial Activities and Phytochemical Screening of Selected Plant Extracts against Some Medically and Agriculturally Important Pathogens

European Journal of Medicinal Plants ◽

10.9734/ejmp/2020/v31i1030293 ◽

2020 ◽

pp. 167-189

Author(s):

Yirgashewa Asfere ◽

Ameha Kebede ◽

Dejene Zinabu

Keyword(s):

Stem Bark ◽

Antibacterial Activities ◽

Antimicrobial Activities ◽

Plant Parts ◽

Antibacterial And Antifungal Activities ◽

Ruta Chalepensis ◽

Crude Extracts ◽

Growth Inhibitory ◽

Scientific Justification

In Ethiopia, many plants are used for medicinal drive-by old-style naturopaths without any scientific justification for their therapeutic values. The principal aim of this study were to evaluate the in vitro antibacterial and antifungal activities of the leaf, root and stem bark extracts of Rhamnus prinioides (gesho), Justicia schimperiana (sensel) and Ruta chalepensis (Tena adam) against some common pathogenic species of bacteria and fungi. The results of this study shown that the crude extracts of ethanol, methanol, hexane and water crude extracts had antimicrobial activities on most bacterial and fungi species of some solvent extracts. Ethanol and methanol crude extracts had the highest growth inhibitory effects as compared with those of the aqueous and hexane crude extracts. But, the four solvent crude extracts had fewer antimicrobial activities than commercially available drug(chloramphenicol and clotrimazole). Campylobacter jejuni and Staphylococcus aureus were found to be the most vulnerable microbes to the crude ethanol (99.5%). The growth-inhibitory events of the crude extracts were found to be significantly dissimilar for both concentrations (30 and 60 mg/ml) in all plant parts (p < 0.05). In general, this study did not only indicate that the antibacterial activities of R. prinioides (gesho), J. schimperiana (sensel) and R. chalepensis (Tena adam). It also accesses a scientific justification for its old-style use against some diseases.

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Pentacyclic Triterpenes and Other Constituents from Ficus cordata (Moraceae)

Zeitschrift für Naturforschung B ◽

10.1515/znb-2008-1113 ◽

2008 ◽

Vol 63 (11) ◽

pp. 1335-1338 ◽

Cited By ~ 9

Author(s):

Herve M. P. Poumale ◽

Rodrigue T. Kengap ◽

Jean Claude Tchouankeu ◽

Felix Keumedjio ◽

Hartmut Laatsch ◽

...

Keyword(s):

Antifungal Activity ◽

Secondary Metabolites ◽

Betulinic Acid ◽

Nmr Spectra ◽

2D Nmr ◽

Stem Bark ◽

Published Data ◽

Pentacyclic Triterpenes ◽

2D Nmr Spectra ◽

Lupeol Acetate

Abstract Two new pentacyclic triterpenes 8,26-cyclo-urs-21-en-3β, 20β-diol (1) and 3β-acetoxy-8.26- cyclo-ursan-20β-ol (2) together with 3-friedelanone, oleanolic acid, betulinic acid, lupeol acetate, α- and β-amyrine, S.SJ^'-tetrahydroxyflavane, and 3,5,7,3',4'-pentahydroxyflavane were isolated from the stem bark of Ficus cordata (Moraceae). The structures of these secondary metabolites were established using ID and 2D NMR spectra and by comparison with published data or with authentic samples. Compounds 1 and 2 exhibited weak antibacterial and no antifungal activity.

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Antifungal Activity and Phytochemical Analysis of Column Chromatographic Fractions of Stem Bark Extracts of Ficus sycomorus L. (Moraceae)

Journal of Plant Sciences ◽

10.3923/jps.2007.209.215 ◽

2007 ◽

Vol 2 (2) ◽

pp. 209-215 ◽

Cited By ~ 4

Author(s):

S.W. Hassan ◽

M. Lawal ◽

B.Y. Muhammad ◽

R.A. Umar ◽

L.S. Bilbis ◽

...

Keyword(s):

Antifungal Activity ◽

Stem Bark ◽

Phytochemical Analysis ◽

Ficus Sycomorus ◽

Column Chromatographic

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A New Benzophenanthridine Alkaloid from Caloncoba Glauca

Natural Product Communications ◽

10.1177/1934578x1701200314 ◽

2017 ◽

Vol 12 (3) ◽

pp. 1934578X1701200

Author(s):

Jabar B.P.A.A. Agbo ◽

James D.S. Mpetga ◽

Raphael Bikanga ◽

Roland T. Tchuenguem ◽

Rolande B.N. Tsafack ◽

...

Keyword(s):

Candida Albicans ◽

Antifungal Activity ◽

Stem Bark ◽

Mass Spectrometric ◽

First Report ◽

Mass Spectrometric Evidence ◽

Benzophenanthridine Alkaloid

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL ( Candida albicans) and dihydrochelerythrine (2) [MIC = 32 ( C. albicans and C. parapsilosis), and 128 μg/mL ( C. krusei)] had moderate to weak antifungal activity.

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