Assessment of Blood Antioxidant Defense and Oxidative Stress in Colorectal Carcinoma Patients Undergoing Capecitabine and Oxaliplatin Combined with Bevacizumab Treatment

Iron (Fe) deficiency impairs photosynthetic efficiency, plant growth and biomass yield. This study aimed to reveal the role of nitric oxide (NO) in restoring Fe-homeostasis and oxidative status in Fe-deficient alfalfa. In alfalfa, a shortage of Fe negatively affected the efficiency of root andshoot length, leaf greenness, maximum quantum yield PSII (Fv/Fm), Fe, S, and Zn accumulation, as well as an increase in H2O2 accumulation. In contrast, in the presence of sodium nitroprusside (SNP), a NO donor, these negative effects of Fe deficiency were largely reversed. In response to the SNP, the expression of Fe transporters (IRT1, NRAMP1) and S transporter (SULTR1;2) genes increased in alfalfa. Additionally, the detection of NO generation using fluorescence microscope revealed that SNP treatment increased the level of NO signal, indicating that NO may act as regulatory signal in response to SNP in plants. Interestingly, the increase of antioxidant genes and their related enzymes (Fe-SOD, APX) in response to SNP treatment suggests that Fe-SOD and APX are key contributors to reducing ROS (H2O2) accumulation and oxidative stress in alfalfa. Furthermore, the elevation of Ascorbate-glutathione (AsA-GSH) pathway-related genes (GR and MDAR) Fe-deficiency with SNP implies that the presence of NO relates to enhanced antioxidant defense against Fe-deficiency stress.

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Changes in Bone Metabolism and Antioxidant Defense Systems in Menopause-Induced Rats fed Bran Extract from Dark Purple Rice (Oryza sativa L. Cv. Superjami)

Nutrients ◽

10.3390/nu13092926 ◽

2021 ◽

Vol 13 (9) ◽

pp. 2926

Author(s):

Soo Im Chung ◽

Su Noh Ryu ◽

Mi Young Kang

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Bone Loss ◽

Bone Metabolism ◽

Rice Bran ◽

Antioxidant Defense ◽

Control Group ◽

Defense Systems ◽

Antioxidant Defense Systems ◽

And Oxidative Stress

Menopause is a matter of concern for women’s health due to a deficiency of female hormones; additionally, reactive oxygen species and aging can cause osteoporosis. Food becomes increasingly interesting as a menopausal woman’s alternative to hormone therapy. The effects of ethanol extracts from dark purple Superjami rice bran on bone metabolism and antioxidant defense systems in menopause-induced animal models were evaluated. Female rats underwent sham surgery or were ovariectomized to induce a menopause-like state. Rats were divided into a sham control group (SHAM), an ovariectomized control group (OVX), and an ovariectomized grou supplemented with Superjami rice bran extract group (OVX-S) and fed for 8 weeks. The OVX groups exhibited significantly more weight gain, amounts of bone turnover biochemical markers (alkaline phosphatase, osteocalcin, and C-terminal telopeptide), bone loss, lipid-peroxidation and oxidative stress than the SHAM group. However, Superjami bran extract added to the diet resulted in a significant reduction in body weight and lipid peroxidation, as well as enhanced bone metabolism and antioxidant enzyme activities, in ovariectomized rats. These results propound that extracts from Superjami rice bran have therapeutic potentiality against bone loss and oxidative stress in menopause-induced states and will be useful in preventing postmenopausal osteoporosis and oxidative damage.

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Salivary Antioxidant and Oxidative Stress Marker Levels in HIV-Positive Individuals

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207322666190306144629 ◽

2019 ◽

Vol 22 (1) ◽

pp. 59-64

Author(s):

Samaneh Vaziri Amjad ◽

Poorandokht Davoodi ◽

Mohammad Taghi Goodarzi ◽

Hamidreza Abdolsamadi ◽

Jalal Poorolajal ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Defense ◽

Antioxidant Defense System ◽

Oxidative Stress Marker ◽

Hiv Positive ◽

Control Group ◽

Defense System ◽

Positive Group ◽

Total Antioxidant ◽

And Oxidative Stress

Background:HIV infections are a worldwide health problem. HIV infection reduces CD4+ cell counts. Oxidative stress might play an important role in the stimulation of virus replication and immunodeficiency. Saliva might be the first line of defense against oxidative stress.Objective:The aim of this study was to evaluate the oxidative stress marker and antioxidant levels of saliva in HIV-infected patients by measuring total antioxidant capacity and malondialdehyde level.Methods:A total of 49 HIV-positive patients and 49 healthy HIV-negative individuals were randomly selected. All the patients were clinically examined. Five mL of unstimulated whole saliva was collected and evaluated by spectrophotometric assay. Data were analyzed with STATA 11.Results:Mean ages of the case and control groups were 28 and 33 years, respectively. Salivary malondialdehyde levels were significantly higher in the HIV-positive group (3.68±2.26) compared to the healthy control group (2.79±1.91). Levels of salivary total antioxidant capacity were significantly lower in the HIV-positive group (0.20± 0.09) compared to the control group (0.27±0.10).Conclusion:The antioxidant defense system in HIV-positive individuals was low and oxidative stress was high in this population. Saliva might be used as a diagnostic tool for antioxidant changes in HIV-positive patients in the future. There were changes in salivary antioxidant defense system and oxidative stress in HIV-positive individuals. Antioxidant supplements might help local salivary and general health statuses.

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Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice

Food & Function ◽

10.1039/d1fo01693h ◽

2021 ◽

Author(s):

Wen Nie ◽

Ye-ye Du ◽

Fei-ran Xu ◽

Kai Zhou ◽

Zhao-ming Wang ◽

...

Keyword(s):

Oxidative Stress ◽

Gut Microbiota ◽

Liver Damage ◽

Antioxidant Defense ◽

Antioxidant Defense System ◽

Bioactive Peptide ◽

Defense System ◽

Stress Injury ◽

Jinhua Ham ◽

And Oxidative Stress

Lys-Arg-Gln-Lys-Tyr-Asp bioactive peptide in JHP prevent ALD by regulating gut microbiota, upregulating the expression of the NRF2/HO-1 antioxidant defense system and reducing oxidative stress injury in liver cells.

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Effect of peritoneal dialysis on antioxidant defense system and oxidative stress

Hong Kong Journal of Nephrology ◽

10.1016/j.hkjn.2012.09.004 ◽

2012 ◽

Vol 14 (2) ◽

pp. 33-37 ◽

Cited By ~ 2

Author(s):

Farzaneh Montazerifar ◽

Mansour Karajibani ◽

Houshang Sanadgol ◽

Mohammad Hashemi

Keyword(s):

Oxidative Stress ◽

Peritoneal Dialysis ◽

Antioxidant Defense ◽

Antioxidant Defense System ◽

Defense System ◽

And Oxidative Stress

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Impact of multigenerational exposure to AgNO3 or NM300K Ag NPs on antioxidant defense and oxidative stress in Caenorhabditis elegans

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2021.112178 ◽

2021 ◽

Vol 216 ◽

pp. 112178

Author(s):

Lisa M. Rossbach ◽

Deborah H. Oughton ◽

Erica Maremonti ◽

Dag M. Eide ◽

Dag A. Brede

Keyword(s):

Oxidative Stress ◽

Caenorhabditis Elegans ◽

Antioxidant Defense ◽

Ag Nps ◽

And Oxidative Stress

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Swimming Prevents Memory Impairment by Increasing the Antioxidant Defense in an Animal Model of Duchenne Muscular Dystrophy

10.1101/751461 ◽

2019 ◽

Author(s):

Priscila Mantovani Nocetti Ribeiro ◽

Adriano Alberti ◽

Viviane Freiberger ◽

Letícia Ventura ◽

Leoberto Ricardo Grigollo ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Animal Model ◽

Duchenne Muscular Dystrophy ◽

Muscular Dystrophy ◽

Antioxidant Defense ◽

Antioxidant Defenses ◽

Mdx Mice ◽

Encephalic Structures ◽

And Oxidative Stress

Duchenne muscular dystrophy (DMD) is a genetic disease which is associated to a progressive skeletical muscle degeneration. Swimming is usually indicated for avoiding impact and facilitating adherence because of a better adaptation to a warm water invironment and also for its benefits on cognition, and modulating memory and learning processes and for increasing antioxidant defenses in oxidative stress. The objective of this study was to evaluate the effects of a swimming protocol on memory and oxidative stress in an animal model of Duchenne muscular dystrophy. Methods: male mdx and wild type mice within 28 days were used in this study. The animals were trained in an stepped swimming protocol for four consecutive weeks. Twenty four hours after the last exercise day, aversive memory and habituation memory tests were performed and removed the encephalic structures of striatus, pre frontal cortex, hippocampus, and cortex and gastrocnemius and diafragma muscles to evaluate protein carbonilation and lipid peroxidation and free thiols. Results: it was verified that swimming was able to reduce significantly the levels of lipid peroxidation and protein carbonilation in gastrocnemius and hippocampus and striatus in exercised animals. Swimming has also prevented lipid peroxidation in diafragma. Besides, this swimming protocol was able to increase free thiols in gastrocnemius, diafragma and in analysed SNC structures. These results showed that swimming prevented aversive and habituation memory in mdx mice.

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