scholarly journals STUDY OF NEPETAE CATARIAE HERBA FRUITS AS PROMISING MEDICINAL PLANT RAW MATERIAL

2019 ◽  
Vol 7 (3) ◽  
pp. 120-128
Author(s):  
A. G. Devyatov ◽  
G. S. Lapshin ◽  
E. Yu. Babaeva ◽  
E. A. Motina ◽  
E. V. Zvezdina ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Russian Federation ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Lipid Complex ◽  
Wide Range ◽  
The Russian Federation ◽  
Plant Raw Material ◽  
Active Substances

Nepetae catariae herba is used in the Russian Federation as spice. The chemical compounds of herb have been studied. This plant has been introduced into the culture. There are its domestic varieties. The fruits of the plant accumulate up to 25% of fatty oil and contain specific laballenic acid, which has a wide range of antimicrobial and fungicidal actions. The yield of fruit crops is 5–6 c/ha.The aim is to study some criteria for the standardization of the quality of Nepetae catariae herb as a new medicinal plant raw material.Materials and methods. The studied fruits are from the biological collection of Federal State Budgetary Institution of All – Russia Research Institute of Medicinal and Aromatic Plants. Binocular magnifier brand MBS-10 and Axioplan 2 imaging microscope by Carl Zeiss were used. The sample preparation was carried out according to the State Pharmacopoeia of the Russian Federation (XIV edition). Anatomical diagnostic features were studied in powder and cross section with staining reagents for the presence of some biologically active substances. Qualitative reactions were carried out with water and alcohol-water extracts from the fruits. The content of the lipid complex according to pharmacopoeia monograph 2.5.0035.15 has been determined.Results. A description of the external and diagnostic anatomical features is given. The main groups of biologically active substances and the content of the lipid complex in a possible new material – the fruits of Nepeta cataria – have been identified.Conclusion. The description of the external features of the fruit has been specified. For the first time, crushed fruits have been characterized. It has been established that the morphology of endocarp cells and seed embryo cells are best preserved in a mellow fruit. Physico-optical properties of cellular structures and the ability for basic microchemical reactions are preserved in all zones of pericarp and seeds. Qualitative reactions showed the presence of the following components in the fruits: saponins, flavonoids and a lipid complex. A dispersion composition has been studied. The yield of the lipid complex and its appearance have been determined. Fruits can be used as promising fat-oil raw materials. The results of the study can be used in drafting Pharmacovigilance Reference Document considering a promising type of medicinal plant raw material on the basis of Nepetae catariae herba fruits. 

scholarly journals Comparative study of phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine

2021 ◽  
pp. 66-75
Author(s):  
Iryna Sas ◽  
Andrii Hrytsyk ◽  
Taras Koliadzhyn ◽  
Oleh Koshovyi
Keyword(s):  
Phenolic Compounds ◽  
Comparative Study ◽  
Hydroxycinnamic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Wide Range ◽  
Nitrogen Containing Compounds ◽  
Active Substances

Species of Betonica L. genus are widespread in Ukraine and contain different groups of biologically active substances: hydroxycinnamic acids, flavonoids, tannins, iridoids, terpenoids, steroids, essential oil, organic acids, vitamin K, nitrogen-containing compounds, phenylethanoid glycosides. Species of Betonica L. genus show a wide range of pharmacological activity (anti-inflammatory, antioxidant, choleretic, diuretic, sedative, antitumor, antihypertensive, etc.) and phenolic compounds are one of the most important and promising groups of biologically active substances of these plants. The aim. The aim of the work was to conduct a comparative study of the phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine. Materials and methods. The object of the study was the herb of Betonica peraucta and Betonica brachydonta harvested in the phase of mass flowering of the plant in Ivano-Frankivsk region. The study of phenolic compounds was carried out by paper chromatography, HPLC and spectrophotometry. Results. 7 components of tannins, 4 flavonoids, 5 hydroxycinnamic acids, 2 coumarins were identified and quantified by HPLC in the studied raw material. The quantitative content of the main groups of phenolic compounds in the herb of Betonica peraucta and Betonica brachydonta was determined by the method of absorption spectrophotometry: polyphenols – 5.96 % and 4.82 %, tannins – 1.62 % and 0.68 %, flavonoids – 2.07 % and 1.13 %, hydroxycinnamic acids – 7.01 % and 3.58 %, respectively. Conclusions. As a result of the conducted studies it was found that the content of phenolic compounds in the herb of Betonica peraucta is significantly higher than in the herb of Betonica brachydonta. Therefore, this species is promising for further research and creation of new drugs

scholarly journals WILLOW TRIANDRA (SALIX TRIANDRA L.): PROSPECTS AND OPPORTUNITIES FOR USE IN MEDICINE AND PHARMACY

2018 ◽  
Vol 6 (4) ◽  
pp. 318-339
Author(s):  
E. G. Sannikova ◽  
O. I. Popova ◽  
E. V. Kompantseva
Keyword(s):  
Medicinal Plant ◽  
Russian Federation ◽  
Biologically Active ◽  
Raw Material ◽  
Forest Steppe ◽  
The North ◽  
Willow Species ◽  
The Russian Federation ◽  
Anti Inflammatory ◽  
Salix Triandra

One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.

scholarly journals Investigation of Walnut Herbal Drug Raw Material

2019 ◽  
Vol 8 (4) ◽  
pp. 38-46
Author(s):  
N. V. Chebyshev ◽  
A. V. Strelyaeva ◽  
D. I. Lezhava ◽  
A. N. Luferov ◽  
N. V. Bobkova ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Medicinal Plant ◽  
Raw Materials ◽  
Juglans Regia ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Alcohol Extract ◽  
Plant Raw Materials ◽  
Active Substances

Introduction. Walnut (Juglans regia L.) is a medicinal plant containing a large number of biologically active substances. A number of authors propose to use walnut leaves as medicinal raw materials, in which juglone, flavonoids, tannins, ascorbic acid and other substances are identified. Currently, a standardization technique for this type of raw material has been developed and proposed. However, the medicinal plant walnut can be a source of other types of raw materials, such as milky-waxed walnuts, walnut bark, and walnut partitions. These types of medicinal raw materials contain a large number of biologically active substances and have a great potential for pharmacological activity. Therefore, the study with the subsequent standardization of medicinal plant material of walnut fruits in the stage of milk-wax ripeness and walnut bark is relevant.Aim. The aim of the study is to study the external signs, microscopy of raw walnut bark and walnut fruit in the stage of milky-wax ripeness and chemical composition of alcohol extract from these types of raw materials.Materials and methods. Chromato-mass spectrometry and TLC were used in the work.Results and discussion. When describing external signs and microscopy, diagnostic signs of both whole and crushed raw materials, and powder of walnut bark, and fruits of walnut in the stage of milky-wax ripeness were revealed. Alcohol extract obtained from medicinal plant raw materials walnut bark is a clear brown liquid. Alcohol extract obtained from medicinal plant raw materials of walnut fruit at the stage of milky-wax ripeness is a transparent, green-brown liquid with a fragrant odor.Conclusion. Gallic acid was identified by TLC in walnut bark. Chromato-mass spectrometry in alcohol extraction from the fruit of walnut in the stage of milky-wax maturity was able to identify 17 compounds belonging to different classes of biologically active substances. Sugars, flavonoids, coumarin phenolic compounds, organic acids were identified. In alcoholic extraction from the bark of a walnut, marker compounds have been determined, the combination of which makes it possible to quickly identify this type of raw material using chromatography-mass spectrometry. 

DEVELOPMENT OF THE COMPOSITION AND TECHNOLOGY OF SEDATIVE FILMS

2021 ◽  
pp. 162-168
Author(s):  
Zamakhaeva E.A. ◽  
Oleshko O.A. ◽  
Yaborova O.V. ◽  
Smirnova M.M. ◽  
Kuritsyn A.V.
Keyword(s):  
Medicinal Plant ◽  
Raw Materials ◽  
Biological Fluid ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Plant Raw Materials ◽  
Number Of Patients ◽  
Wide Range ◽  
Active Substances

Herbal sedatives have been popular for several centuries, and the accumulated knowledge that has been passed down from generation to generation laid the foundation for the development of traditional medicine, and over time for such a science as herbal medicine. Herbal sedatives have a wide range of therapeutic effects, are well tolerated and have no serious adverse reactions, and are not addictive. According to statistical data on the incidence of the population by main classes and individual diseases for 2010-2018, the number of patients with diseases of the nervous system is growing annually, along with this, the need for sedative drugs is increasing. In this regard, the search and development of effective and safe medicines based on medicinal plant raw materials is an urgent area [1, 2]. Pharmaceutical infusions and decoctions, according to the order of the Ministry of Health of the Russian Federation No. 751n dated October 26, 2015, have a shelf life of 2 days, which significantly limits the possibility of their use. The production of films based on aqueous extracts from medicinal plant raw materials will make it possible to obtain more stable drugs, in addition, films have a number of advantages over other dosage forms. Films containing biologically active substances of plant origin have received the unofficial name phytofilms, which are a type of transdermal therapeutic systems. Phytofilms are hydrophilic systems that swell when in contact with water (or biological fluid), absorbing it in a certain amount, which leads to the dissolution of biologically active substances. They differ from synthetic polymeric therapeutic systems in that phytofilms are made in the form of matrix transdermal therapeutic systems on carriers of natural origin (gelatin, collagen, sodium alginate, agar-agar, etc.), which makes them safer [3, 4].

Чабер садовый – перспективное сырье

2018 ◽  
Author(s):  
E.L. Malankina ◽  
N.G. Romanova ◽  
S.G. Solopov ◽  
T.N. Tkacheva
Keyword(s):  
Phenolic Compounds ◽  
Essential Oil ◽  
Russian Federation ◽  
Raw Materials ◽  
Biologically Active ◽  
Raw Material ◽  
Satureja Hortensis ◽  
Study Results ◽  
The Russian Federation ◽  
Active Substances

Представлены результаты испытания отечественных и зарубежных сортов чабера садового (Satureja hortensis L.) в условиях Нечерноземной зоны РФ. Определено содержание основных биологически активных веществ (эфирного масла, флавоноидов, суммы фенольных соединений) в сырье семи сортов. Показано, что низкорослые сорта характеризовались наибольшим накоплением эфирного масла, в то время как накопление фенольных соединений не зависело от высоты растений.In this article are presented the study results of Russian and European varieties of the garden savory (Satureja hortensis L.) in conditions of the Non-сhernozem zone of the Russian Federation. It was determined the content of the main biologically active substances (essential oil, flavonoids, the sum of phenolic compounds) in raw materials of 7 varieties. The content of essential oil in raw material was between 0,18–1,06%. It was shown that the low-growing varieties were characterized by the greatest accumulation of essential oil. The content on phenolic compounds did not depended on the height of the plants and was from 5,12 to 14,1%.

scholarly journals Phytochemical composition of Thymus Serpyllum L. plants and study of antibacterial activity

2020 ◽  
Vol 130 (1) ◽  
pp. 68-75
Author(s):  
N.A. Duzbayeva ◽  
◽  
Sh.K. Sanyazova ◽  
K. Kabdysalym ◽  
M.M. Nykmukanovа ◽  
...  
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Mass Spectrometry Analysis ◽  
Pure Substance ◽  
Individual Compound ◽  
Spectrometry Analysis ◽  
Wide Range ◽  
Thymus Serpyllum ◽  
Active Substances

The results of phytochemical studies of plants are presented of the genus Thymus Serpyllum L. growing in East Kazakhstan. The quantitative characteristics of macro- and micronutrients are determined. In plants, the maximum calcium content is 654.25 µ g / ml, magnesium 235.34 µ g / ml. From thyme (Thymus serpyllum L.), a pure substance of the class of flavonoids, campferid, was isolated. The structure of the compound was proved by spectral (IR, UV, 13C NMR, 1H -, mass spectrometry) analysis methods. The biological activity of phytopreparations and the obtained individual compound was studied. This article presents the results of chemical composition study of the aboveground part of Thymus Serpyllum L. and the number of biologically active substances widely used in folk medicine, distributed in the Eastern territory of Kazakhstan. Thymus Serpyllum L. is a valuable medicinal plant raw material and a source of a number of biologically active substances (flavonoids, phenolycosides, phenolic acids, tannins, essential oils), which is characterized by a wide range of pharmacological activity that can resist inflammation, viruses, anti-rheumatic and other diseases.

EVALUATION OF SOME QUALITY INDICATORS AND PROSPECTS FOR USING DIFFERENT VARIETIES OF PEAR FRUIT IN MEDICINE

2021 ◽  
pp. 5-10
Author(s):  
Dosayeva A.N. ◽  
Nesterova N.V.
Keyword(s):  
Organic Acids ◽  
Quality Indicators ◽  
Russian Federation ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Extractive Substances ◽  
The Russian Federation ◽  
Active Substances ◽  
Pectin Substances

In this article, the authors studied the macrodiagnostic characteristics of pear fruits of three varieties that are most common in the food markets of the Russian Federation. To date, the standardization of such promising and rich in the composition of biologically active substances (BAS) raw materials is carried out only in accordance with the state Standards of the food industry. The research was aimed at developing quality indicators necessary for identifying raw materials that could be considered as a source for obtaining medicinal substances. For all the studied fruits, the total content of extractive substances, organic acids in terms of malic acid and pectin substances was determined. The content of extractive substances was from 15.8% to 17.6%, organic acids - from 0.34% to 1.09%, pectin substances - from 1.15% to 1.87%. As a result of the qualitative reactions, the data of TLC-spectrophotometric method pear fruits, the varieties which are most widely cultivated on the territory of the Russian Federation, was identified as arbutin, which allows to consider the material as a promising source of valuable biologically-active substances and actualizes the further research aimed at developing modern methods of standardization for inclusion in the proposed regulatory documentation.

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

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