STUDY OF CLINICAL AND PATHOGENETIC EFFECTS OF ANTI-VIRAL DRUG BASED ON FAVIPIRAVIR IN COMORBID PATIENTS WITH COVID-19 AT THE OUTPATIENT STAGE OF TREATMENT

In many ways, arterial hypertension and obesity determine the likelihood of a severe course and lethal outcomes in COVID-19. This fact justifies the expediency of an early use of drugs with a direct antiviral action, the analysis of their efficacy not only in the acute, but also in the postcovid period.The aim of the research was to analyze the outpatient cards and case histories of the COVID-19 patients to study the effect of the early (up to the 5th day after the onset of the first symptoms of the disease) use of the drug based on favipiravir, on the frequency of patients’ hospitalizations with arterial hypertension and obesity, as well as to determine the cytokine status characteristics of this patient category in the postcovid period.Materials and methods. “An open prospective comparative study of the “Areplivir®” (favipiravir) efficacy in the debut of COVID-19 in comorbid patients” was carried out in the Republic of Mordovia (the analysis of the hospitalizations frequency and blood levels of M-CSF, EPO in 218 patients, in terms of the use of the antiviral preparation).Results. According to the results of the analysis, it was found out that, despite the presence of comorbid conditions that increase the risk of developing a severe course of COVID-19, i.e. obesity and essential arterial hypertension, in the group of patients taking favipiravir, the need for hospitalization was twice as low (p < 0.05), in relation to the comparison group. The analysis of the cytokine status revealed that in the postcovid period, in the group that took the drug based on favipiravir at the outpatient stage, the average level of M-CSF was significantly lower (p> 0.05), and EPO was higher (p> 0.05) than in the patients from the group “without antiviral drugs at the outpatient stage”. Indirectly, according to the previously obtained data, that acts as a potential marker for reducing the risk of long-term cardiovascular complications of COVID-19.Conclusion. This study showed that an early prescription of favipiravir contributes to a decrease in the rate of COVID-19 patients’ hospitalization even against the background of concomitant hypertension and obesity, due to a decrease in the likelihood of moderate and severe courses of the disease, and also leads to an earlier objective and subjective recovery. The results demonstrated a high potential benefit of an early favipiravir use in the novel coronavirus infection and in the prevention of postcovid complications.

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Vascular endothelial growth factor as a potential marker of subclinical organ damage mediated by arterial hypertension

Siberian Medical Journal ◽

10.29001/2073-8552-2019-34-3-40-44 ◽

2019 ◽

Vol 34 (3) ◽

pp. 40-44

Author(s):

E. Yu. Gubareva ◽

I. V. Gubareva

Keyword(s):

Vascular Endothelial Growth Factor ◽

Essential Hypertension ◽

Growth Factor ◽

Arterial Hypertension ◽

Organ Damage ◽

Cardiovascular Complications ◽

Vascular Endothelial ◽

Potential Marker ◽

Endothelial Growth Factor

The authors’ report presents a brief review of the key studies, providing the reason for the use of vascular endothelial growth factor as a marker for stratification of the risk of cardiovascular complications in patients with essential hypertension.

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PREVALENCE OF ESSENTIAL ARTERIAL HYPERTENSION IN CHILDREN AND ADOLESCENTS OF DAGESTAN AND THE CONTENT OF Mg, K, Ca, Zn, Pb IN SOILS AND NATURAL WATERS OF THE TERRITORY

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-5-203-208 ◽

2021 ◽

Vol 100 (5) ◽

pp. 203-208

Author(s):

Sh.K. Salikhov ◽

◽

D.Z. Alieva ◽

U.A. Magomedova ◽

S.О. Abdulkadyrova ◽

...

Keyword(s):

Arterial Hypertension ◽

Natural Waters ◽

Chemical Elements ◽

The Body ◽

Cross Sectional ◽

Number Of Patients ◽

Significant Difference ◽

Geochemical Factors ◽

Essential Arterial Hypertension ◽

The Republic

The aim of the study is to determine the role of geochemical factors (the content of Mg, K, Ca, Zn, Pb in soils and natural waters of the plain zone of Dagestan) in the prevalence of essential arterial hypertension (EAH) among the population of children. Materials and methods of research: an observational cross-sectional (one-step) study of the prevalence of EAH in the child population was carried out. The prevalence rates of EAH among children in the plain zone of the Republic of Dagestan are calculated for 100,000 children 0–17 years old, without taking into account gender differences. The content of elements (Mg, K, Ca, Zn, Pb) in the environment (soil, natural waters) was determined by atomic absorption spectroscopy. Results: one-way analysis of variance (One-Way ANOVA) of indicators of the content of metals (Mg, K, Ca, Zn, Pb) in the regions and objects (soils, natural waters) of the study revealed a statistically significant difference in the data (for soils: F=81,06772, p<0,0002; for natural waters: F=58,86451, p<0,00001). The dependence of children's EAH on the content of chemical elements in the objects of the biosphere of Dagestan was determined, which was expressed in an increase in the number of patients with EAH when Pb content exceeded (r=+ 0,576, r=+ 0,759) and with the decrease of Mg (r=–0,668, r=–0,173), K (r=–0,440, r=–0,636), Ca (r=–0,693, r=–0,533), Zn (r=–0,051, r=–0,827) in soils and natural waters. Conclusion: when assessing the pathogenesis of EAH in the population of children, the content of Mg, K, Ca, Zn, Pb in soil and water should be taken into account, since these microelements, entering the body with water and food, affect the elemental status of child's body.

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SARS-CoV-2 Isolation and Propagation from Turkish COVID-19 patients

10.1101/2020.04.23.056309 ◽

2020 ◽

Cited By ~ 2

Author(s):

Cihan Tastan ◽

Bulut Yurtsever ◽

Gozde Sir ◽

Derya Dilek Kancagi ◽

Sevda Demir ◽

...

Keyword(s):

Rna Virus ◽

The Novel ◽

Isolation And Characterization ◽

Characterization Studies ◽

Positive Strand Rna Virus ◽

The Republic ◽

Novel Coronavirus ◽

Positive Strand Rna ◽

Vaccine Testing ◽

Republic Of Turkey

AbstractThe novel coronavirus pneumonia, which was named later as Coronavirus Disease 2019 (COVID-19), is caused by the Severe Acute Respiratory Syndrome Coronavirus 2, namely SARS-CoV-2. It is a positive-strand RNA virus that is the seventh coronavirus known to infect humans. The COVID-19 outbreak presents enormous challenges for global health behind the pandemic outbreak. The first diagnosed patient in Turkey has been reported by the Republic of Turkey Ministry of Health on March 11, 2020. Today, over ninety thousand cases in Turkey, and two million cases around the world have been declared. Due to the urgent need for vaccine and anti-viral drug, isolation of the virus is crucial. Here, we report one of the first isolation and characterization studies of SARS-CoV-2 from nasopharyngeal and oropharyngeal specimens of diagnosed patients in Turkey. This study provides an isolation and replication methodology, and cell culture tropism of the virus that will be available to the research communities.Article SummaryScientists have isolated virus from Turkish COVID-19 patients. The isolation, propagation, and plaque and immune response assays of the virus described here will serve in following drug discovery and vaccine testing.

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Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology

International Journal of Hypertension ◽

10.1155/2020/8019360 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Alexander Kamyshnyi ◽

Inna Krynytska ◽

Victoriya Matskevych ◽

Mariya Marushchak ◽

Oleh Lushchak

Keyword(s):

Arterial Hypertension ◽

Pressure Control ◽

The Novel ◽

Global Public Health ◽

Angiotensin Converting Enzyme 2 ◽

Cardiovascular Comorbidities ◽

Public Health Challenge ◽

Novel Coronavirus ◽

Ace2 Gene

Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is an ongoing global public health challenge. Current clinical data suggest that, in COVID-19 patients, arterial hypertension (AH) is one of the most common cardiovascular comorbidities; it can worsen outcomes and increase the risk of admission to intensive care unit (ICU). The exact mechanisms through which AH contributes to the poor prognosis in COVID-19 are not yet clear. The putative relationship between AH and COVID-19 may be linked to the role of angiotensin-converting enzyme 2 (ACE2), a key element of the AH pathophysiology. Another mechanism connecting AH and COVID-19 is the dysregulation of the immune system resulting in a cytokine storm, mediated by an imbalanced response of T helper cells subtypes. Therefore, it is essential to optimize blood pressure control in hypertensive patients and monitor them carefully for cardiovascular and other complications for the duration of COVID-19 infection. The question whether AH-linked ACE2 gene polymorphisms increase the risk and/or worsen the course of SARS-CoV-2 infection should also receive further consideration.

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Management of Patients with Left Ventricular Assist Device during the COVID-19 Pandemic

Medicina ◽

10.3390/medicina58010116 ◽

2022 ◽

Vol 58 (1) ◽

pp. 116

Author(s):

Gassan Moady ◽

Tuvia Ben Gal ◽

Shaul Atar

Keyword(s):

Left Ventricular Assist Device ◽

Ventricular Assist Device ◽

Cardiovascular Complications ◽

Left Ventricular ◽

The Novel ◽

Assist Device ◽

Ventricular Assist ◽

Management Of Complications ◽

Left Ventricular Assist ◽

Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) is an infectious disease with multi-organ involvement, including the cardiovascular system. The disease may cause several cardiovascular complications, and may increase morbidity and mortality among patients with background cardiovascular disease. Patients with advanced heart failure are often treated with left ventricular assist device (LVAD), and represent a unique population mandating multi-disciplinary approach. Several aspects of COVID-19 should be taken into account in LVAD implants, including right ventricular involvement, hemodynamic alterations, thromboembolic and haemorrhagic complications, and the psychological effects of social isolation. Patients with VAD and suspected COVID-19 should be transferred to specialized centers for better management of complications. Here, we review the implications of COVID-19 pandemic on LVAD patients with our recommendations for appropriate management.

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Experience of international cooperation in developing epidemic control measures during COVID-19 spread in the Republic of Moldova

Journal of microbiology epidemiology immunobiology ◽

10.36233/0372-9311-125 ◽

2021 ◽

Vol 98 (4) ◽

pp. 373-382

Author(s):

A. Yu. Popova ◽

T. A. Ruzhentsova ◽

T. Yu. Krasovskaya ◽

K. V. Аlbul ◽

N. V. Beril ◽

...

Keyword(s):

Lung Ventilation ◽

Control Measures ◽

Laboratory Diagnostics ◽

The Novel ◽

Healthcare Organizations ◽

Epidemic Control ◽

Republic Of Moldova ◽

Coronavirus Infection ◽

The Republic ◽

Novel Coronavirus

The purpose of the study — to identify the factors contributing to the spread of the novel coronavirus infection within the territory of the Republic of Moldova and to develop measures aimed at their elimination.Materials and methods. In May 2020, experts of Rospotrebnadzor (the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing), together with leading employees of institutions participating in planning and implementing measures aimed at prevention of COVID-19 spread, conducted a detailed analysis of epidemic control and curative measures in 10 healthcare organizations in the Republic of Moldova. They assessed the effectiveness of the undertaken actions in in-patient facilities, in laboratories, and in the country in general.Results. The existing approaches to treatment of patients with COVID-19 and to laboratory diagnostics were in line with the common practices; the adequacy of measures was evidenced by the hospital bed capacity and the stock of artificial lung ventilation machines. In the meantime, the experts came across the factors that obviously contributed to the infection spread. Their elimination could intercept some paths of infection and improve the situation.Conclusion. The analysis of the current measures and their results is important for planning and implementing actions aimed at improvement of the epidemic situation in different regions. The collaborative efforts helped slow down the outbreak in the Bender psychoneurological residential facility; outbreaks were prevented in other limited-access institutions; the incidence among healthcare workers decreased; the daily number of new COVID-19 cases decreased to 0–5 during the summer months in the Dniestrian Moldovan Republic. Presently, there is a clear picture of approaches that should be taken to decrease the incidence. Most likely, the experience obtained in the fight against the novel coronavirus infection will be of great use in future if any new variants of viruses emerge.

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Novel coronavirus infection COVID-19: extrapulmonary manifestations

Terapevticheskii arkhiv ◽

10.26442/00403660.2020.08.000767 ◽

2020 ◽

Vol 92 (8) ◽

pp. 4-11 ◽

Cited By ~ 1

Author(s):

I. V. Maev ◽

A. V. Shpektor ◽

E. Yu. Vasilyeva ◽

V. N. Manchurov ◽

D. N. Andreev

Keyword(s):

Arterial Thrombosis ◽

Respiratory Symptoms ◽

Myocardial Damage ◽

Cardiovascular Complications ◽

Clinical Syndrome ◽

The Novel ◽

Wide Range ◽

Serum Transaminases ◽

Coronavirus Infection ◽

Novel Coronavirus

The novel coronavirus infection COVID-19 in most cases manifests with respiratory symptoms and fever, however, some patients may have cardiovascular and gastroenterological manifestations. A feature of the clinical syndrome of COVID-19 is the development of pronounced immunopathological reactions and disorders of hemostasis, leading to the development of a wide range of cardiovascular complications. The course of COVID-19 may be complicated by the development of acute myocardial infarction, venous and arterial thrombosis and thromboembolism in various vascular pools, the development of acute myocardial damage and myocarditis. Among the gastroenterological manifestations, diarrhea, nausea or vomiting, as well as abdominal pain, are most often detected. These symptoms may precede the appearance of respiratory signs of the disease, and in some cases come to the fore in the clinical picture of the disease. In addition, in some patients there are laboratory signs of liver injury (increased serum transaminases). The exact pathogenesis of the above disorders continues to be studied.

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Russian Medical Society for Arterial Hypertension Expert Consensus: Hypertension and COVID-19

Systemic Hypertension ◽

10.26442/2075082x.2020.3.200362 ◽

2020 ◽

Vol 17 (3) ◽

pp. 35-41

Author(s):

Irina E. Chazova ◽

Natalia V. Blinova ◽

Vera A. Nevzorova ◽

Juliya V. Zhernakova ◽

Mikhail P. Savenkov ◽

...

Keyword(s):

Arterial Hypertension ◽

Medical Society ◽

Target Cells ◽

The Novel ◽

Angiotensin Converting Enzyme 2 ◽

High Prevalence ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

The Relationship ◽

Russian Medical

The novel coronavirus infection (COVID-19) caused by the b-coronavirus SARS-CoV-2, and leads to acute respiratory distress-syndrome, has affected more than nineteen million people worldwide, resulting in 0.7 million deaths as of August 2020. The fact that the virus uses angiotensin-converting enzyme 2 as a receptor for entering the target cell, and the high prevalence of hypertension and other cardiovascular diseases among patients with COVID-19, have caused serious discussions on the management of such patients. This consensus of experts from the Russian Medical Society for Arterial Hypertension analyzed the existing data on the relationship between COVID-19 and hypertension, the pathophysiological aspects of the penetration of the virus into target cells and the use of renin-angiotensin-aldosterone system inhibitors in patients with hypertension and COVID-19.

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A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome—A Pilot Study

Journal of Clinical Medicine ◽

10.3390/jcm10112507 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2507

Author(s):

Felix Bende ◽

Cristina Tudoran ◽

Ioan Sporea ◽

Renata Fofiu ◽

Victor Bâldea ◽

...

Keyword(s):

Multidisciplinary Approach ◽

Systolic Function ◽

Liver Stiffness ◽

Cardiovascular Complications ◽

Acute Illness ◽

The Novel ◽

Pulmonary Injury ◽

Liver Elastography ◽

Hepatic Lesions ◽

Novel Coronavirus

(1) Background: Patients suffering from the novel coronavirus 2019 (COVID-19) disease could experience several extra-pulmonary involvements, including cardiovascular complications and liver injury. This study aims to evaluate the presence of cardiac and liver alterations in patients with post-acute COVID-19 syndrome using transthoracic echocardiography (TTE) and liver elastography (LE). (2) Methods: A total of 97 subjects recovering from COVID-19, attending the hospital’s specialized outpatient clinic for persisting symptoms at 3 to 11 weeks after the acute illness, were included in this study. They all had a basal COVID-19 assessment, and subsequently, a clinical evaluation, laboratory tests, TTE, and LE. (3) Results: considering the presence of pulmonary injury during COVID-19, patients were divided into two groups. Although none of them had altered systolic function, we evidenced pulmonary hypertension, diastolic dysfunction, increased liver stiffness, viscosity, and steatosis in around one-third of the patients, with significantly higher values in subjects with pulmonary injury compared to those without. (4) Conclusion: persisting symptoms characterizing the post-acute COVID-19 syndrome could be explained by residual cardiac and hepatic lesions, which were worse in more severe COVID-19 forms. These patients may be at risk of developing liver fibrosis and cardiac alterations and should be investigated in the first 12 weeks after the onset of the infection.

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The Characteristics, Manifestations and Cardiopulmonary Imaging (CT/MRI) of COVID-19 in SARS-CoV-2 Infection

Journal of Interdisciplinary Medicine ◽

10.2478/jim-2020-0035 ◽

2021 ◽

Vol 6 (2) ◽

pp. 48-52

Author(s):

Abigaela Rus ◽

Nora Rat ◽

Monica Chitu ◽

Imre Benedek

Keyword(s):

Cardiovascular Complications ◽

Public Health Emergency ◽

World Health ◽

Imaging Features ◽

The Novel ◽

The World ◽

Novel Coronavirus ◽

Health Organization ◽

Cardiac Manifestations ◽

Expert Recommendations

Abstract The World Health Organization (WHO) declared the transmission of SARS-CoV-2 a Public Health Emergency of International Concern. The novel coronavirus has diverse manifestations, usually similar to a common cold or influenza. The majority of patients with coronavirus disease have typical imaging features. The typical CT characteristics of patients with COVID-19 pneumonia are ground-glass opacities and consolidative lesions with a peripheral and posterior distribution. Noninvasive imaging methods are precise and rapid means of diagnosing pneumonia and cardiovascular complications caused by COVID-19 infection. Therefore, it is important for clinicians to understand the implications of this pandemic and to be familiar with the different imaging aspects of the novel coronavirus disease. This review focuses on the most commonly reported imaging findings of COVID-19 infection in different patients from different countries, the expert recommendations, and the cardiac manifestations of SARS-CoV-2 infection.

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