scholarly journals Laporan Kasus: Kegoyangan Gigi Pada Pasien disertai Diabetes Mellitus

2020 ◽  
Vol 17 (2) ◽  
pp. 46
Author(s):  
Pascalis Adhi Kurniawan ◽  
Rinawati Satrio
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Oral Cavity ◽  
Systemic Disease ◽  
Gingival Recession ◽  
The Body ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Close Relationship

Diabetes Mellitus is a metabolic disorder characterized by an increase in blood glucose levels (hyperglycemia) due to disturbances in insulin secretion and insulin action. Diabetes mellitus (DM) is a disease characterized by high blood glucose levels, because the body cannot release or use insulin adequately. There are many factors that trigger or aggravate periodontitis, including plaque accumulation, calculus (tartar), and systemic factors such as diabetes mellitus. Objective: To explain that there is a close relationship between elevated blood glucose levels and periodontitis. Case Description: A 77 year old woman presented with a loose left upper tooth and pain during eating. The patient admitted to having a history of systemic disease, namely diabetes mellitus. Intra oral examination was found on 27th grade 3 luxation, 6 mm gingival recession, 4 mm probing depth, debris around the teeth, oral hygiene tends to be poor. The therapy provided is in the form of education on the effect of diabetes mellitus on teeth and the condition of the oral cavity in general, as well as the importance of maintaining health and food consumption so that blood sugar conditions are controlled. Conclusion: Periodontal disease can be affected by DM. Periodontitis is one of the manifestations of DM in the oral cavity. The severity of periodontitis can result from an increase in blood glucose levels.

Sitagliptin: A DPP-4 Inhibitor for the Treatment of Type 2 Diabetes Mellitus

2011 ◽  
Vol 3 ◽  
pp. CMT.S6227 ◽  
Author(s):  
Kathryn MS Johnson ◽  
Kathleen Schurr
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetes Therapy ◽  
High Blood Glucose ◽  
Adverse Side Effects ◽  
Glucose Levels ◽  
Blood Glucose Levels

Type 2 diabetes mellitus (T2DM) has become an epidemic, with worldwide projections indicating that more than 336 million people will be afflicted with the disease by 2030. T2DM is characterized by inappropriately high blood glucose levels due to a deficiency in insulin secretion, action, or both. Despite the horrific complications that occur with chronic elevations of blood glucose levels, less than half of those with T2DM do not maintain proper glycemic control. Sitagliptin (Januvia, Merck and Co., Whitehouse Station, New Jersey) is a novel diabetes therapy approved for use in the U.S. and Europe. This small molecule inhibits the activity of DPP-4, a peptidase that degrades the glucoregulatory hormone GLP-1. Sitagliptin increases glucoregulation in individuals with T2DM both as a monotherapy and in combination with other antihyperglycemic drugs, with a low risk of adverse side effects.

scholarly journals GIVING RED RICE (ORIZA NIVARA) TO CHANGE GLUCOSE LEVELS IN DIABETES MELLITUS PATIENTS IN KENDARI CITY

2021 ◽  
Vol 3 (1) ◽  
pp. 38-44
Author(s):  
La Ode Ardiansyah ◽  
Nawawi Nawawi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Brown Rice ◽  
Secondary Data ◽  
The Body ◽  
P Value ◽  
Red Rice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Quasi Experimental

Background:Diabetes mellitus (DM) is a phenomenon which the body  cannot  produce insulin supply which is indicated by increasing blood glucose levels. Red Rice (Oriza nivara) contains flavonoid compounds which have antidiabetic abilities. It can  reduce blood glucose by increasing insulin secretion and preventing insulin resistance. This study aims to determine the effect of giving brown rice (Oriza nivara) to change   blood glucose levels in people with diabetes mellitus in Kendari City. Methods: This research method was carried out with a quasi-experimental design with pre-post test design for 1 week with primary and secondary data collection techniques. The respondents  were  determined by proportional random sampling. Respondents in this study were 33 people with DM. Result:The results of the study on checking blood glucose levels before and after giving brown rice (oriza nivara) within 1 week obtained P value = 0.000 <  alpha 0.05. Conclusion: there is a  significant  effect of giving brown rice (oriza nivara) on changes in blood glucose level in diabetes mellitus people  in Kendari City.

scholarly journals SYSTEMATIC REVIEW ON MEDICAMENTS USED IN MANAGEMENT OF DIABETES MELLITUS

2020 ◽  
pp. 21-29
Author(s):  
ANUPAM JAMWAL
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Low Income ◽  
Developed Countries ◽  
World Health ◽  
Low Income Countries ◽  
Limb Amputation ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Diabetes has a global prevalence in developed countries and rapidly flexing its roots in middle-and low-income countries. According to the World Health Organization, it is a major cause of kidney collapse, heart problems, and lower limb amputation. Diabetes mellitus is a metabolic disorder showing an uncontrolled increase in blood glucose levels. To date, no permanent cure has been developed for the complete restoration of impaired glucose haemostasis. With the use of therapeutic agents and nontherapeutic agents, glucose levels can be kept in control for a very long time. The foremost goal of all current ongoing treatments is to control high blood glucose levels, reduction in elevated lipid levels, and delay in the progression of diabetes-related complications. Various therapeutics agents are developed in recent decades, which shown very promising results in the management of diabetes mellitus. These agents prescribed after reviewing the clinical symptoms and situation of an individual patient. This review compiles noteworthy information related to clinically approved medicaments for diabetes mellitus. Review emphasis on categorization, mechanism of action, noted adverse effects along with the physiological responses of used medicines to treat diabetes mellitus.

scholarly journals Hypoglycemic Effects of Plant Flavonoids: A Review

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Foo Sok Yen ◽  
Chan Shu Qin ◽  
Sharryl Tan Shi Xuan ◽  
Puah Jia Ying ◽  
Hong Yi Le ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Antioxidant Activities ◽  
Diabetic Rats ◽  
The Body ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Multiple Organs

Diabetes mellitus is a metabolic disorder with chronic high blood glucose levels, and it is associated with defects in insulin secretion, insulin resistance, or both. It is also a major public issue, affecting the world's population. This disease contributes to long-term health complications such as dysfunction and failure of multiple organs, including nerves, heart, blood vessels, kidneys, and eyes. Flavonoids are phenolic compounds found in nature and usually present as secondary metabolites in plants, vegetables, and fungi. Flavonoids possess many health benefits such as anti-inflammatory and antioxidant activities, and naturally occurring flavonoids contribute to antidiabetic effects.Many studies conducted in vivo and in vitro have proven the hypoglycemic effect of plant flavonoids. A large number of studies showed that flavonoids hold positive results in controlling the blood glucose level in streptozotocin (STZ)-induced diabetic rats and further prevent the complications of diabetes. The future development of flavonoid-based drugs is believed to provide significant effects on diabetes mellitus and diabetes complication diseases. This review aims at summarizing the various types of flavonoids that function as hyperglycemia regulators such as inhibitors of α-glucosidase and glucose cotransporters in the body. This review article discusses the hypoglycemic effects of selected plant flavonoids namely quercetin, kaempferol, rutin, naringenin, fisetin, and morin. Four search engines, PubMed, Google Scholar, Scopus, and SciFinder, are used to collect the data.

scholarly journals Efek Pemberian Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Tipe 2

2021 ◽  
Vol 5 (2) ◽  
pp. 97-103
Author(s):  
Yhurike Diah Pitaloka ◽  
Siti Juwariyah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Communicable Disease ◽  
Public Health Problem ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Reduce Blood Glucose

Diabetes Mellitus is a non-communicable disease and is an important public health problem. Diabetes mellitus is a chronic disease in which the pancreas does not produce enough insulin or when the body is ineffective in using it (WHO, 2016). One of the non-pharmacological management of diabetes mellitus is the administration of red dragon fruit. Dragon fruit is rich in antioxidants and contains many substances such as calcium, beta-carotene, vitamin B1, vitamin B2, vitamin C, phosphorus and flavonoid substances so that it can be used as a therapy to reduce blood glucose levels by preventing apoptosis due to oxidative reactions. The purpose of this case study is to compile a resume of nursing care in giving red dragon fruit to reduce blood glucose levels. This type of research is descriptive with a case study method in the form of a one group pretest posttest design. The subject of this study was 1 patient with diabetes mellitus. The results of the study showed that there was a change in the patient's condition after being given red dragon fruit for 10 days. Conclusion Dragon fruit has the effect of lowering blood glucose levels in people with type 2 diabetes mellitus because it contains fiber that is able to bind water in the intestines, and contains antioxidants and bioactive compounds and is able to inhibit free radical compounds. Keywords: diabetes mellitus, adults, red dragon fruit

scholarly journals Penghambatan Enzim Alpha-Glukosidase oleh Daun Mimba (Azadirachta indica) dan Rimpang Temu Mangga (Curcuma mangga)

2021 ◽  
pp. 56-64
Author(s):  
Nursalinda Kusumawati ◽  
Haryoto Haryoto ◽  
Peni Indrayudha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
High Blood Glucose ◽  
Mango Ginger ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Neem Leaves

Type 2 diabetes mellitus is a chronic disease of the digestive system characterized by high blood glucose levels. The main enzyme in carbohydrate metabolism is α-glucosidase. One of the therapeutic approaches to treat T2DM is to make glucose uptake into the blood delayed through inhibition of the α-glucosidase enzyme activity. Neem leaves and mango ginger are reported to reduce blood glucose levels. This study aims to determine the potential inhibitor of neem leaves extract and mango ginger extract and their respective fractions on α-glucosidase activity. Simplicia of neem leaves and mango ginger were macerated using 96% ethanol for 24 hours. The ethanol extract of neem leaves and mango rhizome were fractionated using silica gel 60 GF254 as adsorbent and a combination of ethyl acetate and n-hexane as eluent. The extracts of neem leaves and mango rhizome and fractions of both plants were tested for α-glucosidase inhibition with acarbose as a comparison. The results showed that both plants provided inhibitory activity on α-glucosidase with the lowest IC50 value from the semi-polar fraction of neem leaves about 24.16±4.58 μg/mL. Neem leaves and mango ginger have potential as α-glucosidase inhibitors to treat type 2 diabetes mellitus.

scholarly journals Blood glucose level of white rats (Rattus norvegicus) after giving catfish biscuit (Pangasius hypothalmus)

2020 ◽  
Vol 20 ◽  
pp. 04005
Author(s):  
Hidayaturrahmah ◽  
Heri Budi Santoso ◽  
Ridha Aulia Rahmi ◽  
Dewi Kartikasari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rattus Norvegicus ◽  
The Body ◽  
Male Rats ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels

Glucose is an important carbohydrate which is more absorbed into the bloodstream as glucose and other sugar is changed into glucose in the liver. Blood glucose level is closely related to diabetes mellitus. Diabetes mellitus is a disease that arises in a person which is indicated by the presence of blood glucose levels exceeding normal (hyperglycemia) due to the deficiency of the insulin hormone in the body. The design of this research was using RAL with 24 male rats that divided into 6 treatments which were normal with the giving of Na-CMC 0.5% 1mL/200 gram BB, negative with the giving of Na-CMC 0.5% 1mL/200 gram BB, positive with the giving of glibenclamide of 0.45 mg/kg BB and 3 other treatments by giving catfish biscuit (Formula A, Formula B, and formula C) with 4 replications. All treatments were injected with monohydrate alloxan at a dose of 150 mg/kg BW, except for the normal treatment. The results showed that the formulation of catfish biscuit can lower the blood glucose level of white rats. The composition of biscuit with formula C has the highest decreasing percentage which was 80.20% to the blood glucose level of white rats.

scholarly journals Profile of Pregnant Women with Gestational Diabetes Mellitus at Increased Risk for Large for Gestational Age Newborns

2019 ◽  
Vol 41 (05) ◽  
pp. 298-305 ◽  
Author(s):  
Maria da Glória Rodrigues Tavares ◽  
Érika Sales Lopes ◽  
Rosy Anne de Jesus Pereira Araújo Barros ◽  
Rossana Santiago de Sousa Azulay ◽  
Manuel dos Santos Faria
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Gestational Age ◽  
Large For Gestational Age ◽  
High Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Objective Gestational diabetes mellitus (GDM) is associated with a higher risk of perinatal morbidity and mortality, and its main complication is the occurrence of large for gestational age (LGA) newborns. The present study aims to characterize pregnant women with GDM and to identify factors associated with the occurrence of LGA newborns in this population. Methods A cross-sectional study was performed based on medical records of women whose prenatal care and delivery were performed at the Maternal and Child Unit of the Hospital Universitário of the Universidade Federal do Maranhão, state of Maranhão, Brazil. A total of 116 pregnant women diagnosed with GDM were included according to the criteria of the International Association of Diabetes and Pregnancy Study Groups (IADPSG). Results The variables associated with LGA newborns after multivariate analysis were: obesity prior to pregnancy (OR = 11.6; 95% CI: 1.40–95.9), previous macrosomia (OR = 34.7; 95% CI: 4.08–295.3), high blood glucose levels in the 3rd trimester (OR = 2,67; 95% CI: 1.01–7.12) and combined change in the oral glucose tolerance test (OGTT) (fasting + postdextrose) (OR = 3.53; 95% CI: 1.25–14.2) = 1.17–10.6). Otherwise, insufficient weight gain during pregnancy reduced the risk for LGA newborns (OR = 0.04; 95% CI: 0.01–0.32). Conclusion Obesity prior to pregnancy, previous macrosomia, high blood glucose levels in the 3rd trimester, and combined change in the OGTT were independent predictive factors for LGA newborns in pregnant women with GDM.

scholarly journals Laporan Kasus: Manajemen Perawatan Gigi pada Pasien dengan Periodontitis Kronis disertai Diabetes Mellitus

2019 ◽  
Vol 16 (1) ◽  
pp. 1
Author(s):  
Agus Surachman ◽  
Marsaa Paramita ◽  
Aris Aji Kurniawan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Stress Reduction ◽  
Treatment Plan ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Patients With Diabetes ◽  
Sugar Levels ◽  
Deficiency Type

Diabetes mellitus is a metabolic disease in which blood sugar levels are abnormally because the body does not produce enough insulin (type 1) and insulin deficiency (type II). The condition of diabetes can worsen the periodontal tissue. Purpose of this case report is to explain the characteristics, oral manifestations and dental management of patients with diabetes. A 53-year-old request to made aartificial denture. Intraoral examination presented loss of teeth 35, 36, 37, 46, 47 and dental roots 23, 24, 27, 38, 48. Patients have a history of diabetes with Metformin 500 mg oral therapy and have consumed it since 2016. The treatment plan is education, plaque control with supragingival scaling then extraction of the roots dental and making of removable partial dentures. Based on the results of lab tests showed blood glucose levels in October 177 mg / dl. Patients were instructed to maintain oral hygiene with mouthwash prescriptions and to continue diabetes treatment. Dental care in patients with diabetes must consider various things such as the patient's condition, stress reduction, dietary modifications, prophylactic medications, and routine monitoring of blood glucose levels

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