Science often advances upon willful transgression of a seeming interdiction. Examples which leap to a chemist’s mind are noble gas compounds, strained hydrocarbons such as tetrahedranes, activation (by organometallics) of even methane, and, to mention just one brilliant, more recent achievement, inclusion of an allene within the confines of a six-membered ring while preventing its conversion into a benzenoid. Such feats put all the cunning of a scientist into coaxing and, yes, coercing the system at hand to obey instructions from one’s daring imagination. As always, it is hard. Not for nothing is our playroom called a laboratory. And when the task is done and the time arrives to convey to others (who might not be privy to the anguish of the work) all that struggle and the majesty of the achievement, the scientist quite naturally lapses into metaphor. One such, founded in male 19th century language as much as in history, is some more or less prurient variant of “Unveiling the Secrets of Nature.” Another, evoking the thorny, twisted path to understanding and the long hours of toil in the laboratory, is “Wrestling with Nature.” The latter metaphor has been central to experimental science at least since the Elizabethan Age, and is the subject of this small essay. While the roots of the metaphor lie in Greek myth, it makes a striking debut in a seminal brief for experiment in science. This arresting phrase also marks a bifurcation in the way science is viewed by nonscientists, even—and especially so—in our day. The proof text here is that of Francis Bacon (1561–1626), in his 1605 Of the Advancement of Learning. Bacon writes: . . . For like a man’s disposition is never well known till he be crossed, nor Proteus ever changed shapes till he was straitened and held fast; so the passages and variations of nature cannot appear so fully in the liberty of nature, as in the trials and vexations of art. . . . He repeats the imagery in his remarkable 1620 Novum Organum. Bacon’s 1620 book was a clarion call to replace what passed as Aristotelian reasoning about the world with experiment.