scholarly journals Biological Effects Due to Hypomagnetic Field and Its Research Progress

2017 ◽  
Vol 4 (2) ◽  
pp. 14-19 ◽  
Author(s):  
Jin-hua Ouyang ◽  
Hong-zhen Li
Keyword(s):  
Biological Effects ◽  
Research Progress ◽  
Hypomagnetic Field

scholarly journals Ultrasound microbubble contrast agent – carried chemotherapeutic drug microbubbles

2019 ◽  
Vol 131 ◽  
pp. 01015
Author(s):  
Junyang Song
Keyword(s):  
Contrast Agent ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Development Prospect ◽  
Research Progress ◽  
Chemotherapeutic Drug ◽  
Invasive Treatment ◽  
Microbubble Contrast Agent ◽  
Chemotherapy Drugs ◽  
Non Invasive

With the continuous research and development of ultrasound microbubble contrast agent-carried chemotherapeutic drug microbubbles, ultrasound microbubble contrast agent not only facilitates the early detection and early diagnosis of tumors but also provides a new direction and development prospect for the drug delivery route. With a broad development prospect, it is expected to become a new safe, effective and non-invasive treatment. This paper reviews the biological effects and research progress of contrast-enhanced microbubble-loaded chemotherapy drugs in tumor therapy.

scholarly journals Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Shengjie Yang ◽  
Dan Li ◽  
Zongliang Yu ◽  
Yujuan Li ◽  
Min Wu
Keyword(s):  
Gut Microbiota ◽  
Energy Homeostasis ◽  
Metabolic Diseases ◽  
Biological Effects ◽  
Intestinal Barrier ◽  
Isoquinoline Alkaloid ◽  
Research Progress ◽  
Intestinal Barrier Function ◽  
Potential Contribution ◽  
Nonalcoholic Fatty Liver

Atherosclerosis (AS), especially atherosclerotic cardiovascular diseases (ASCVDs), and metabolic diseases (such as diabetes, obesity, dyslipidemia, and nonalcoholic fatty liver disease) are major public health issues worldwide that seriously threaten human health. Exploring effective natural product-based drugs is a promising strategy for the treatment of AS and metabolic diseases. Berberine (BBR), an important isoquinoline alkaloid found in various medicinal plants, has been shown to have multiple pharmacological effects and therapeutic applications. In view of its low bioavailability, increasing evidence indicates that the gut microbiota may serve as a target for the multifunctional effects of BBR. Under the pathological conditions of AS and metabolic diseases, BBR improves intestinal barrier function and reduces inflammation induced by gut microbiota-derived lipopolysaccharide (LPS). Moreover, BBR reverses or induces structural and compositional alterations in the gut microbiota and regulates gut microbe-dependent metabolites as well as related downstream pathways; this improves glucose and lipid metabolism and energy homeostasis. These findings at least partly explain the effect of BBR on AS and metabolic diseases. In this review, we elaborate on the research progress of BBR and its mechanisms of action in the treatment of AS and metabolic diseases from the perspective of gut microbiota, to reveal the potential contribution of gut microbiota to the multifunctional biological effects of BBR.

scholarly journals Research progress of biological effects of cell membrane under infrared and terahertz irradiation

2021 ◽  
Vol 70 (24) ◽  
pp. 248707-248707
Author(s):  
Bo Wen-Fei ◽  
◽  
Che Rong ◽  
Kong Lei ◽  
Zhang Ming-Jie ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Biological Effects ◽  
Research Progress ◽  
Terahertz Irradiation

scholarly journals Research Progress on the Biological Effects of Low-Dose Radiation in China

Dose-Response ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 155932581983348 ◽  
Author(s):  
Kaihua Ji ◽  
Yan Wang ◽  
Liqing Du ◽  
Chang Xu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Low Dose ◽  
Biological Effects ◽  
Research Progress ◽  
Low Dose Radiation ◽  
Dose Radiation

scholarly journals Biological Effects of Space Hypomagnetic Environment on Circadian Rhythm

2021 ◽  
Vol 12 ◽  
Author(s):  
Xunwen Xue ◽  
Yasser F. Ali ◽  
Wanrong Luo ◽  
Caorui Liu ◽  
Guangming Zhou ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Neurological Diseases ◽  
Biological Effects ◽  
Outer Space ◽  
Interdisciplinary Cooperation ◽  
Hypomagnetic Field ◽  
Earth Magnetic Field ◽  
Living Organisms ◽  
Interplanetary Missions

The intrinsic earth magnetic field (geomagnetic field, GMF) provides an essential environmental condition for most living organisms to adapt the solar cycle by rhythmically synchronizing physiological and behavioral processes. However, hypomagnetic field (HMF) of outer space, the Moon, and the Mars differs much from GMF, which poses a critical problem to astronauts during long-term interplanetary missions. Multiple experimental works have been devoted to the HMF effects on circadian rhythm and found that HMF perturbs circadian rhythms and profoundly contributes to health problems such as sleep disorders, altered metabolic as well as neurological diseases. By systemizing the latest progress on interdisciplinary cooperation between magnetobiology and chronobiology, this review sheds light on the health effects of HMF on circadian rhythms by elaborating the underlying circadian clock machinery and molecular processes.

scholarly journals Research Progress of the Role of Anthocyanins on Bone Regeneration

2021 ◽  
Vol 12 ◽  
Author(s):  
Wei Mao ◽  
Guowei Huang ◽  
Huan Chen ◽  
Liangliang Xu ◽  
Shengnan Qin ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Molecular Mechanisms ◽  
Biological Effects ◽  
Continuous Process ◽  
Osteoclast Differentiation ◽  
Fragility Fractures ◽  
Osteoclast Formation ◽  
Research Progress ◽  
Treatment Of Osteoporosis

Bone regeneration in osteoporosis and fragility fractures which are highly associated with age remains a great challenge in the orthopedic field, even though the bone is subjected to a continuous process of remodeling which persists throughout lifelong. Regulation of osteoblast and osteoclast differentiation is recognized as effective therapeutic targets to accelerate bone regeneration in osteopenic conditions. Anthocyanins (ACNs), a class of naturally occurring compounds obtained from colored plants, have received increasing attention recently because of their well-documented biological effects, such as antioxidant, anti-inflammation, and anti-apoptosis in chronic diseases, like osteoporosis. Here, we summarized the detailed research progress on ACNs on bone regeneration and their molecular mechanisms on promoting osteoblast differentiation as well as inhibiting osteoclast formation and differentiation to explore their promising therapeutic application in repressing bone loss and helping fragility fracture healing. Better understanding the role and mechanisms of ACNs on bone regeneration is helpful for the prevention or treatment of osteoporosis and also for the exploration of new bone regenerative medicine.

Anti-Tumor Effects of Melittin and Its Potential Applications in Clinic

2019 ◽  
Vol 20 (3) ◽  
pp. 240-250 ◽  
Author(s):  
Can Lyu ◽  
Fanfu Fang ◽  
Bai Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Clinical Applications ◽  
Water Soluble ◽  
Research Progress ◽  
Severe Side Effect ◽  
Potential Applications ◽  
Future Potential

Melittin, a major component of bee venom, is a water-soluble toxic peptide of which a various biological effects have been identified to be useful in anti-tumor therapy. In addition, Melittin also has anti-parasitic, anti-bacterial, anti-viral, and anti-inflammatory activities. Therefore, it is a very attractive therapeutic candidate for human diseases. However, melittin induces extensive hemolysis, a severe side effect that dampens its future development and clinical application. Thus, studies of melittin derivatives and new drug delivery systems have been conducted to explore approaches for optimizing the efficacy of this compound, while reducing its toxicity. A number of reviews have focused on each side, respectively. In this review, we summarize the research progress on the anti-tumor effects of melittin and its derivatives, and discuss its future potential clinical applications.

Biological Effects of Hypomagnetic Field: Ground‐Based Data for Space Exploration

2021 ◽  
Author(s):  
Zheyuan Zhang ◽  
Yanru Xue ◽  
Jiancheng Yang ◽  
Peng Shang ◽  
Xichen Yuan
Keyword(s):  
Biological Effects ◽  
Space Exploration ◽  
Hypomagnetic Field
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