scholarly journals Secondary Syphilis During Pregnancy: The Importance of Screening and Clinical Management

2021 ◽  
Vol 33 (2) ◽  
pp. 145
Author(s):  
Indah Purnamasari ◽  
Jusuf Barakbah ◽  
Sunarko Martodiharjo ◽  
Dwi Murtiastutik ◽  
Maylita Sari ◽  
...  
Keyword(s):  
Congenital Syphilis ◽  
Venereal Disease ◽  
Secondary Syphilis ◽  
Fishy Odor ◽  
Sexually Transmitted ◽  
History Of ◽  
Obstetric Ultrasonography ◽  
Maternal Syphilis ◽  
Sexual Promiscuity

Background: Syphilis is one of the most serious sexually transmitted diseases worldwide, and has tremendous consequences for the mother and her developing fetus if left untreated. The burden of morbidity and mortality due to congenital syphilis is high. Purpose: Screening and prompt to know the importance of treatment of syphilis during pregnancy. Case: A 32-year-old multigravida in 5 months of pregnancy presented with multiple raised lesions over her labia. It was accompanied by fluor and smelly fishy odor. There was no history of genital ulcers in either spouse and no history of sexual promiscuity. History of antenatal care in public health showed non-reactive status of HIV, syphilis and hepatitis B. Clinical examination revealed multiple flat, moist warts over her labia mayora and minora, and multiple roseola syphilitica on the plantar pedis sinistra. Darkfield microscopic examination presence spirochete, venereal disease research laboratory (VDRL) titer was 1:16 and T. pallidum particle agglutination assay (TPHA) titer was 1:2560. Obstetric ultrasonography examination was suggestive no mayor congenital abnormalities. Both of serology VDRL and TPHA were non-reactive in her husband. Significant of lesion improvement and decrease a fourfold titer serologic in VDRL (1:4) and TPHA (1:320) as follow-up 3 months after being treated with single intra-muscular injections of benzathine penicillin 2.4 million units. Discussion: Coordinated prenatal care and treatment are vital. It’s implemented before the fourth month of pregnancy to reduce vertical transmission and all associated side effects of congenital syphilis. Penicillin is highly efficacious in maternal syphilis and prevention of congenital syphilis. Conclusion: Universal screening and adequate pregnancy care must be a priority.

Confirmatory serological testing of blood donors positive on TPHA screening in Singapore

1997 ◽  
Vol 8 (12) ◽  
pp. 760-763 ◽  
Author(s):  
S S Wong ◽  
D L T Teo ◽  
R K W Chan
Keyword(s):  
Blood Donors ◽  
Congenital Syphilis ◽  
Past History ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Serological Testing ◽  
Sexually Transmitted ◽  
Blood Transfusion Service ◽  
History Of ◽  
Latent Syphilis

Summary: Seventy-two blood donors who were tested positive by the Singapore Blood Transfusion Service (SBTS) for Treponema pallidum haemagglutination (TPHA) test, were evaluated at the Department of Sexually Transmitted Diseases Clinic (DSC) between November 1994 to December 1996. All underwent syphilis serological testing, including rapid plasma reagin test (RPR), TPHA test and fluorescent treponemal antibody-absorption (FTA-Abs) test. All except one (98.6%) were confirmed TPHA positive by the DSC. Of the 71 TPHA-confirmed-positive donors, 53 (74.6%) were subsequently tested positive for FTA-Abs and 18 (25.4%) were tested negative for FTA-Abs. Twenty-two (31%) of the 71 TPHA-positive blood donors had reactive RPR and 49 (69%) had non-reactive RPR. Of the 22 TPHA-positive donors who had reactive RPR, 19 (86%) had positive FTA-Abs (13 late latent syphilis, 4 serological scar, one late congenital syphilis, one secondary syphilis), and 3 (14%) had negative FTA-Abs (all late latent syphilis). Of the 49 TPHA-positive donors who had non-reactive RPR, 34 (69%) had positive FTA-Abs (24 late latent syphilis, 9 serological scar, one late congenital syphilis) and 15 (31%) had negative FTA-Abs (12 late latent syphilis, 2 serological scar, one false-positive TPHA). Only one TPHA-positive donor referred by the SBTS subsequently turned out to have negative syphilis serology at the DSC. Overall, 68 (95.8%) TPHApositive donors who had a past history of sexual exposure were managed as treated or untreated syphilis, regardless of their RPR or FTA-Abs results. However, FTAAbs was found to be useful in the management of 3 (4.2%) TPHA-positive blood donors in the absence of a history of sexual exposures.

scholarly journals Manifestações orais da sífilis: revisão sistematizada de literatura

2019 ◽  
Vol 8 (8) ◽  
Author(s):  
Erison Santana Santos ◽  
Jamile de Oliveira Sá ◽  
Rachel Lamarck
Keyword(s):  
Congenital Syphilis ◽  
Health Sector ◽  
Secondary Syphilis ◽  
World Health ◽  
Oral Manifestations ◽  
Oral Diseases ◽  
Probable Case ◽  
Sexually Transmitted ◽  
Global Epidemiology ◽  
Head Neck

A sífilis é uma infecção bacteriana exclusiva de seres humanos que é transmitida principalmente através de relações sexuais sem o uso de preservativos. Embora seja mais comum em regiões genitais, pode manifestar sinais e sintomas na cavidade oral e mimetizar lesões potencialmente malignas e, dependendo do seu estágio, pode levar ao óbito. O objetivo desse estudo foi realizar uma revisão de literatura a fim de conhecer as principais manifestações orais da sífilis. Foi realizado um levantamento bibliográfico na base de dados PubMed e SciELO. A busca foi realizada durante o mês de agosto e setembro de 2018. No PubMed, foram utilizados os termos “syphilis oral”, “manifestations of syphilis”, “syphilis in oral cavity”, “syphilis in buccal cavity”, “syphilis in mouth”. Na SciELO, foram usadas os descritores: “oral manifestations of syphilis”, “manifestações orais AND sífilis”. As manifestações orais da sífilis embora sejam raras, são importantes para o cirurgiã-dentista diagnosticar a infecção em estágios menos agressivos da doença. Pode manifestar-se de diversas formas, dependendo do período de evolução da infecção. Sua incidência vem aumentando devido às mudanças de hábitos na população, principalmente nos grupos de risco. Sendo assim, conhecer as principais manifestações orais da sífilis é importante para intervir em estágios menos avançados, visto que é uma infecção que pode se disseminar rapidamente e levar o paciente a óbito se não tratada.  Descritores: Sífilis; Manifestações Bucais; Cancro; Treponema pallidum.ReferênciasLeuci S, Martina S, Adamo D, Ruoppo E, Santarelli A, Sorrentino R et al. Oral Syphilis: a retrospective analysis of 12 cases and a review of literature. Oral diseases. 2013;19(8):738-46.Leão JC, Gueiros LAM, Porter SR. Oral manifestations of syphilis. Clinics. 2006;61(2):161-66.Bruce AJ, Rogers RS 3rd. Oral manifestations of sexually transmitted diseases. Clin Dermatol. 2004;22(6):520-27.Neville BW, Damm DD, Allan CM, Chi AC. Patologia Oral e Maxilofacial. 4.ed. Elsevier: Rio de Janeiro; 2016.Kojima N, Klausner JD. An update on the global epidemiology of syphilis. Curr  Epidemiol Rep. 2018;5(1):24-38.World Health Organization. Global health sector strategy on sexually transmitted infections 2016-2021. 2016. The WHO's strategy for STI treatment.Carbone PN, Capra GG, Nelson BL. Oral Secondary Syphilis. Head Neck Pathol. 2016; 10(2):206-8.Dickenson AJ, Currie WJ, Avery BS. Screening for syphilis in patients with carcinoma of the tongue. Br J Oral Maxillofac Surg. 1995;33(5):319-20.Ficarra G, Carlos R. Syphilis: the renaissance of a old disease with oral implications. Head Neck Pathol. 2009;3(3):195-206.Gaul JS, Grossschimdt K, Gusenbauer C, Kanz F.  A probable case of congenital syphilis from pre-Columbian Austria. Anthropol Anz. 2015; 72(4):451-72.Jones L, Ong ELC, Okpokman A, Sloan P, Macleod I, Staines KS. Three cases of oral syphilis - an overview. Br Dental J. 2012; 212(10):477-80.Little JW. Syphilis: a update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(1):3-9.Minicucci EM, Vieira RA, Oliveira DT, Marques SA. Oral manifestations of secondary syphilis in the elderly – a timely reminder for dentists. Aust Dent J. 2013;58(3):368-70.Paulo LF, Servato JP, Oliveira MT, Duriguetto AF Jr, Zanetta-Barbosa D. Oral manifestations of oral syphilis. Int J Infect Dis. 2015;35:40-2.Scott CM, Flint SR. Oral syphilis—re-emergence of an old disease with oral manifestations. Int J Oral Maxillofac Surg. 2005;34(1):58-63.Siqueira CS, Saturno JL, Sousa SCO, Silveira FR. Diagnostic approaches in unsuspected oral lesions of syphilis.   Int J Oral Maxillofac Surg. 2014; 43(12):1436-40.Strieder LR, Léon JE, Carvalho YR, Kaminagakura E. Oral syphilis: report of three cases and characterization of the inflammatory cells. Annals of Diagnostic Pathology. 2015;19:76-80.

scholarly journals Men treated for syphilis in Białystok, Poland, 2014-2018

2019 ◽  
pp. 329-335
Author(s):  
Agnieszka Beata Serwin ◽  
Adriana Grochowska ◽  
Iwona Flisiak
Keyword(s):  
Urban Areas ◽  
Partner Notification ◽  
Secondary Syphilis ◽  
Contact Tracing ◽  
Professional Activity ◽  
Symptomatic Infection ◽  
Sexually Transmitted ◽  
Sexual Contacts ◽  
Sex With Men

INTRODUCTION. Incidence of syphilis is increasing in Europe in recent years, mainly due to high incidence in men, especially men who have sex with men (MSM). AIM. To analyse sociodemographic, epidemiological and clinical characteristics of men treated for syphilis in Bialystok in 2014 – 2018, to compare these of MSM and men who have sex with women (MSW). MATERIAL AND METHODS. Analysis of age, residency, professional activity, type of sexual contacts (steady vs. casual), marital status, stage of syphilis diagnosed, concomitant sexually transmitted infections (STIs), treatment, partner notification and follow-up attendance. RESULTS. Of 49 male patients with syphilis 26 (53.06%) were MSM and 23 (46.94%) – MSW. The average age was 33.67 and 35.87 years in MSM and MSW patients, respectively. Majority of patients in both groups were residents of urban areas. Tradesmen and those unemployed constituted the highest proportion in MSM and MSW group, respectively. MSM were in majority single and had only casual contacts while MSW, mostly married or engaged in steady relationship, had also casual contacts. Secondary syphilis was most frequently diagnosed in MSM and late latent syphilis - in MSW. Eight patients (16.32%) had concomitant HIV infection, in all diagnosed before syphilis. Contact tracing was successful in 26.92% of MSM and 39.13% of MSW. Follow-up was not done or not completed in half of MSM and more than half of MSW. CONCLUSIONS. Results confirm that MSM play a crucial role in the current epidemics of syphilis. They have mainly casual sexual contacts and have symptomatic infection. In both MSM and MSW contact tracing and follow-up attendance is suboptimal.

scholarly journals Imunopatogenesis Treponema pallidum dan Pemeriksaan Serologi

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Efrida Efrida ◽  
Elvinawaty Elvinawaty
Keyword(s):  
Clinical Symptoms ◽  
Early Stage ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Major Health Problem ◽  
Sexually Transmitted ◽  
Tertiary Syphilis ◽  
History Of ◽  
Latent Syphilis

AbstrakSifilis adalah penyakit menular seksual yang sangat infeksius, disebabkan oleh bakteri berbentuk spiral, Treponema pallidum subspesies pallidum. Penyebaran sifilis di dunia telah menjadi masalah kesehatan yang besar dengan jumlah kasus 12 juta pertahun. Infeksi sifilis dibagi menjadi sifilis stadium dini dan lanjut. Sifilis stadium dini terbagi menjadi sifilis primer, sekunder, dan laten dini. Sifilis stadium lanjut termasuk sifilis tersier (gumatous, sifilis kardiovaskular dan neurosifilis) serta sifilis laten lanjut. Sifilis primer didiagnosis berdasarkan gejala klinis ditemukannya satu atau lebih chancre (ulser). Sifilis sekunder ditandai dengan ditemukannya lesi mukokutaneus yang terlokalisir atau difus dengan limfadenopati. Sifilis laten tanpa gejala klinis sifilis dengan pemeriksaan nontreponemal dan treponemal reaktif, riwayat terapi sifilis dengan titer uji nontreponemal yang meningkat dibandingkan dengan hasil titer nontreponemal sebelumnya. Sifilis tersier ditemukan guma dengan pemeriksaan treponemal reaktif, sekitar 30% dengan uji nontreponemal yang tidak reaktifKata kunci: sifilis, Treponema pallidum, serologiAbstractSyphilis is a sexually transmitted disease that is highly infectious, caused by a spiral -shaped bacterium, Treponema pallidum subspecies pallidum. The spread of syphilis in the world has become a major health problem and the common, the number of 12 million cases per year. Infectious syphilis is divided into early and late-stage syphilis. Early-stage syphilis is divided into primary, secondary, and early latent. Advanced stage of syphilis include tertiary syphilis (gumatous, cardiovascular syphilis, and neurosyphilis) and late latent syphilis. Primary syphilis is diagnosed by clinical symptoms of the discovery of one or more chancre (ulcer). Secondary syphilis is characterized by the finding of localized mucocutaneous lesions or with diffuse lymphadenopathy. Latent syphilis without clinical symptoms of syphilis with a nontreponemal and treponemal reactive examination, history of syphilis therapy in nontreponemal test titer increased compared with the results of previous nontreponemal titers. Tertiary syphilis is found guma with reactive treponemal examination, approximately 30% of the non- reactive nontreponemal testKeywords: syphilis, Treponema pallidum, serologi

scholarly journals Essential syphilitic alopecia: Non-scarring alopecia in 21-year-old man

2021 ◽  
Vol 12 (e) ◽  
pp. 1-3
Author(s):  
Hafssa Chehab ◽  
Bertrand Richert
Keyword(s):  
Hair Loss ◽  
Previous History ◽  
Treponema Pallidum ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Secondary Syphilis ◽  
Laboratory Evaluation ◽  
History Of ◽  
High Level

ABSTRACT Alopecia syphilitica is a less common clinical manifestations of secondary syphilis. It is uncommon for hair loss to be the sole or predominant manifestation, as hair loss is the chief clinical and histologic differential diagnosis of. The main difference between alopecia areata and Alopecia syphilitica is the detection of Treponema pallidum in syphilis. We present the case of a 21- year-old belgium man with different patches of non-cicatricial alopecia of his scalp. The patient denied previous history of genital or other skin lesions. Laboratory evaluation was positive for syphilis. The diagnosis of alopecia syphilitica was made and he was treated with single intramuscular injections of benzathine penicillin. The lesions improved with treatment in all the patients who attended follow-up. Dermatologists should maintain a high level of clinical suspicion for this uncommon manifestation of syphilis, particularly when it is the only symptom.

scholarly journals Sexual abuse leading to secondary syphilis in an intellectually disabled person: a case report

2021 ◽  
Vol 7 (6) ◽  
pp. 872
Author(s):  
Rajesh Munusamy ◽  
Nithin Nagaraja
Keyword(s):  
Sexual Abuse ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Penicillin G ◽  
Intellectually Disabled ◽  
Transmitted Infection ◽  
Sexual Transmitted Infection ◽  
Benzathine Penicillin G

<p class="abstract">Syphilis is a sexual transmitted infection (STI) caused by a spirochete, <em>Treponema pallidum</em>. Condylomata lata is a characteristic lesion seen in secondary syphilis. Here we reported a case of 24 year old unmarried male with intellectual disability who presented with condyloma lata over the scrotum, prepuce and perianal region and with moth eaten alopecia over scalp since 1 month. Here the patients mother revealed he had promiscuous relationship with multiple friends, which is a sexual abuse since the patient is intellectually disabled. Clinically diagnosed as secondary syphilis. Venereal disease research laboratory (VDRL) test titre was reactive at 1:32 and <em>Treponema pallidum </em>hemagglutination test (TPHA) was positive. Biopsy was also done, which confirmed diagnosis. Single dose of injection benzathine penicillin G, 2.4 million units was administered intramuscularly. Patient did not develop a Jarisch-herxheimer reaction. On follow up his lesions healed and VDRL titres also came down and non-reactive at 3 months. Here in this case sexual abuse lead to secondary syphilis since patient was intellectually disabled so he couldn’t address his complaints clearly. Hence counselling was done to the patient and family members by dermatologist and psychiatrist.</p><p class="abstract"> </p>

Syphilis (Treponema pallidum)

2018 ◽  
Author(s):  
Mark N. Gilroy ◽  
Juan C. Salazar
Keyword(s):  
Congenital Syphilis ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Public Health Problem ◽  
Adverse Outcomes ◽  
Global Public Health ◽  
Serological Screening ◽  
Sexually Transmitted

Syphilis, a chronic, sexually transmitted disease caused by the extracellular spirochete Treponema pallidum, has exhibited a remarkable resurgence in recent years. Despite the existence of inexpensive, easily administered, and highly effective antibiotic treatments, maternal and neonatal syphilis infections continue to be a major global public health problem. In addition to its potential to cause morbidity in the mother, untreated gestational syphilis (GS) can lead to serious adverse outcomes in the offspring, including stillbirth, prematurity, low birth weight, and neonatal death. Congenital syphilis (CS) is regarded as a missed opportunity during the antenatal care of the mother, resulting from socioeconomic, demographic, and behavioral factors that promote mother-to-child transmission (MTCT) of syphilis. This chapter emphasizes emerging concepts about screening aimed at controlling the ongoing epidemic, including serological screening of mother and infant, newer paradigms of “reverse screening,” clinical presentation, therapy, and long-term neurodevelopmental disabilities that must be a component of follow-up care.

scholarly journals Syphilis, Gonorrhoea, Leprosy and Yaws in the Indonesian Archipelago, 1500-1950

MANUSYA ◽  
2007 ◽  
Vol 10 (4) ◽  
pp. 20-41
Author(s):  
Peter Boomgaard
Keyword(s):  
Southeast Asia ◽  
Sexually Transmitted Diseases ◽  
Venereal Disease ◽  
Sexually Transmitted ◽  
Island Southeast Asia ◽  
Indonesian Archipelago ◽  
Mitigating Factors ◽  
History Of ◽  
Islam And Christianity ◽  
The Impact

This paper dexamines the history of sexually transmitted diseases in Southeast Asia and explores the origins of venereal disease, specifically syphilis and gonorrhoea, in the region. The arrival of new diseases that accompanied Europeans from about 1500, is a subject that scholars have largely ignored in favour of the 19th and 20th centuries. While concentrating on the Indonesian archipelago, the paper also considers to other parts of Southeast Asia to investigate the impact of syphilis and gonorrhoea on the rate of population growth in the region. Unlike gonorrhoea, which was present before the arrival of Europeans, syphilis was a new disease whose introduction by the Portuguese had lethal consequences. Possibly, the propagation of Islam and Christianity in island Southeast Asia after 1500 and of Buddhism in mainland Southeast Asia, were important mitigating factors in checking the spread of syphilis.

Kabaka Mutesa and Venereal Disease: An Essay on Medical History and Sources in Precolonial Buganda

2003 ◽  
Vol 30 ◽  
pp. 309-325 ◽  
Author(s):  
Michael W. Tuck
Keyword(s):  
Medical History ◽  
Venereal Disease ◽  
Well Being ◽  
Sexually Transmitted ◽  
History Of ◽  
Positive Attribute ◽  
Medical Histories ◽  
Health And Well Being ◽  
Erratic Behavior ◽  
Foreign Delegation

In an article in History in Africa about the Ganda monarch Mutesa, Richard Reid argued that Mutesa likely suffered from syphilis. In a chapter on Mutesa in a just published volume, John Rowe concluded that the disease from which Mutesa suffered was gonorrhea. While on the surface similar—both sexually transmitted, neither particularly desirable—the diseases are actually quite different. Popular biographies often offer gossip about individuals' medical histories, but there can be legitimate reasons to investigate the medical history of past leaders, two of which are pertinent here. First, the medical conditions from which they suffered may well have affected their lives and their decisions as leaders. Reid addresses this point, speculating that Mutesa's syphilis may have progressed to an extent that it affected him mentally. Reid suggests that this might help explain Mutesa's erratic behavior toward the latter years of his reign, as he shifted his favor from one court group and foreign delegation to another. Rowe raises a similar point about Mutesa's health and competing groups, although in a different way. Rowe shows how Mutesa's illness became a point of competition between foreign missionaries and indigenous religious specialists as each sought to win his favor by curing his lllness. Reid and Rowe also both mention the effect Mutesa's illness had on the perception of him as Kabaka. The Baganda equated the health and well-being of the Kabaka with the health of the kingdom, and Mutesa's extended illness and bedridden state would not have been a positive attribute.

scholarly journals The Prevalence and Incidence of Sexually Transmitted Infections in a Prospective Cohort of Injection Drug Users in Vancouver, British Columbia

2005 ◽  
Vol 16 (4) ◽  
pp. 225-229 ◽  
Author(s):  
Laura M Kuyper ◽  
Courtney LC Collins ◽  
Thomas Kerr ◽  
Robert S Hogg ◽  
Kathy Li ◽  
...  
Keyword(s):  
Prospective Cohort ◽  
Injection Drug Users ◽  
Drug Users ◽  
Unprotected Sex ◽  
Relative Hazard ◽  
Sex Trade ◽  
Sexually Transmitted ◽  
Cumulative Rate ◽  
History Of

BACKGROUND: While several studies have reported on sexual risk behaviours and the prevalence of sexually transmitted infections (STIs) among injection drug users (IDUs), there are fewer prospective studies that have been able to examine populations of IDUs with no history of STIs. Therefore, the authors examined prevalence, correlates and factors associated with time to first STI infection in a prospective cohort of IDUs in Vancouver, British Columbia.METHODS: The authors examined the prevalence and correlates of STIs among IDUs at the time of recruitment into a prospective cohort study. The authors also evaluated the cumulative rate of time to first STI among IDUs with no history of STIs at baseline using the Kaplan-Meier method, and modelled factors independently associated with first STI using Cox regression.RESULTS: Between May 1996 and November 2003, 1560 individuals were recruited into the cohort; of these individuals, 745 reported a history of STI at baseline. Among the 815 who did not report an STI at baseline, 671 (82%) had at least one follow-up visit and were eligible for the analysis of time to first STI. After 36 months of follow-up, the cumulative rate of first STI was 8.2% for men and 15.9% for women (log-rank P<0.001), whereas the cumulative rate of first STI was 8.0% for IDUs who did not report sex trade involvement versus 19.8% for IDUs who reported sex trade involvement (log-rank P<0.001). In multivariate analyses, the risk of first STI remained independently associated with unprotected sex with regular partners (relative hazard=2.04, 95% CI 1.29 to 3.23; P=0.001) and unprotected sex with sex trade clients (relative hazard=2.36, 95% CI 1.46 to 3.82; P=0.005).CONCLUSIONS: In the present study, the authors found that STIs were associated with both regular sex partnerships and sex trade involvement. These findings are of particular concern because both unprotected sex with regular partners and sex trade involvement is common among IDUs. Interventions to encourage condom use among IDUs, particularly those with regular sex partners and those involved in the sex trade, should be further developed.

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