scholarly journals Tuberculous Lymphadenitis coexists with Non-Hodgkin Lymphoma

2020 ◽  
Vol 1 (2) ◽  
pp. 52
Author(s):  
Nenci Siagian ◽  
Bramantono Bramantono ◽  
Usman Hadi
Keyword(s):  
Septic Shock ◽  
Febrile Neutropenia ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Common Symptom ◽  
Tuberculous Lymphadenitis ◽  
Non Hodgkin Lymphoma ◽  
Night Sweats ◽  
History Of ◽  
The Common

Tuberculous Lymphadenitis (TBLN) is most common extrapulmonary tuberculosis. The common symptom of TBLN is cervical lymphadenopathy which is known to mimic numerous pathological conditions like NHL. Coexistency TBLN and lymphoma is  a rare. A woman, 56 years old, had chief complaint of cervical masses since 2 months ago. She had history of weight loss, fever and night sweats but no history of chronic cough. From physical examination and supporting examination, the patient was diagnosed with TBLN coexists with NHL. She got antituberculosis drug (ATD) for 2 weeks before chemotherapy. The patient died of septic shock 9 days later after chemotherapy. From HPE examination, TBLN and NHL may show simillar feature so Zhiel-Neelsen staining and Immunohistochemical are important to confirm each disease. ATD was given to supress the mycobacterium activity before chemotherapy. However the patient had febrile neutropenia after chemotherapy and died of septic shock. Both TBLN and NHL may occur with simillar sign and symptom and HPE. Further examinations have to be done to confirm the diagnosis of both disesases. Although ATD had given to prevent Tb infection progresivity. On 7 days after chemotherapy she had febrile neutropenia and lead to death due to septic shock.

Disease Spectrum of Cervical Lymphadenopathy in adults

2021 ◽  
Vol 15 (11) ◽  
pp. 2853-2855
Author(s):  
Rabia Amin Butt ◽  
Zonaira Rathore ◽  
Afia Sarwar ◽  
Faiza Azam ◽  
Faria Waqar Khan ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Tertiary Care ◽  
Cervical Lymphadenopathy ◽  
Diagnostic Tools ◽  
Tuberculous Lymphadenitis ◽  
Care Hospital ◽  
Inclusion Criteria ◽  
Non Hodgkin Lymphoma ◽  
Malignant Lesions ◽  
Age Range

Aim: To determine the frequency of different diseases resulting in cervical lymphadenopathy in specimens of patients presenting in tertiary care hospital. Methodology: It was a cross sectional study conducted at the histopathology section of the pathology department of Services Institute of Medical Sciences/Services Hospital Lahore. The study was approved by the ethical committee of the institution. The study was completed in six months.100 cases fulfilling the inclusion criteria were registered. Inclusion criteria included patients above 16 years of age, patients from both sexes, unilateral or bilateral irrespective of duration. Lymph nodes less than 1cm were not included in the study. Informed consent was taken. Both FNAC and Biopsy were used as diagnostic tools. All the data was analysed with SPSS version 11. Results: During a period of six months, a total of 100 cases of cervical lymphadenopathy were studied. These included 75 benign and 25 malignant cases. Out of benign cases 53% were diagnosed as tuberculous lymphadenitis. About 81.3% were in the age range of 16-25 years and 18.7% were in the age range of 26-35 years. 22% cases were diagnosed as reactive lymphadenitis. About 54.54% of these patients were in the age range of 16-25 years and 45.46% were in the age range of 26-35 years. The highest frequency among malignant lesions consisted of Non-Hodgkin lymphoma 16% followed by Hodgkin lymphoma 5% and metastatic disease 4%.The age range of malignant lesions was in the range of 36-78 years. Conclusion: Our study concludes that cervical lymphadenopathy is the common clinical presentation in our setup and tuberculosis is the commonest cause. Keywords: Hodgkin lymphoma, Non-Hodgkin lymphoma, Fine needle aspiration cytology

scholarly journals Left Lateral Cervical Mass with Draining Sinuses

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Stylianos A. Michaelides ◽  
George D. Bablekos ◽  
Avgerinos-Romanos Michailidis ◽  
Efthalia Gkioxari ◽  
Stephanie Vgenopoulou ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Complete Recovery ◽  
Tuberculous Lymphadenitis ◽  
Male Smoker ◽  
Oral Steroids ◽  
Cervical Swelling ◽  
Uncommon Case ◽  
Physical Findings

The aim of the present study is to describe an uncommon case of tuberculous lymphadenitis (TL) in a symptomless 89-year-old male smoker patient, who presented at the emergency department of our hospital with left lateral cervical swelling with draining sinuses. No other clinical symptoms or physical findings were observed at admission. An elevated erythrocyte sedimentation rate (ESR) and a small calcified nodule in chest CT were the only abnormal findings. Pus samples from sinuses were examined and confirmed tuberculosis which was in agreement with surgical pathology of lymph nodes. A four- (4-) drug antituberculous regimen was administered. After an initial remission of his symptoms, the patient presented an exacerbation of the cervical swelling with draining sinuses necessitating addition of oral steroids. TL can be symptomless presenting a paradoxical reaction during treatment. The uniqueness of our case lies in the patient’s advanced age, which is uncommon with cervical lymphadenopathy as a form of extrapulmonary tuberculosis, as well as in the administration of oral steroids to resolve the neck’s clinical deterioration. The patient had a complete recovery and was free of disease after completion of his six-month antituberculous chemotherapy.

scholarly journals INCIDENCE OF ORONASOPHARYNGEAL & LARYNGEAL TUBERCULOSIS CASES IN PULMONARY TUBERCULOSIS CASES

2020 ◽  
Vol VOLUME 8 (ISSUE 2) ◽  
pp. 28-32
Author(s):  
Mohd Aftab
Keyword(s):  
Hearing Loss ◽  
Global Health ◽  
Pulmonary Tuberculosis ◽  
Health Problem ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Neck Mass ◽  
Common Symptom ◽  
Global Health Problem ◽  
Laryngeal Tuberculosis

ABSTRACT Background: Tuberculosis is a major global health problem. Tuberculosis may be Pulmonary or Extrapulmonary. Oro-nasopharyngeal and L a r yngea l tuberculosis a re a form of Extrapulmonary Tuberculosis. Nasopharyngeal tuberculosis presents with neck mass, nasal obstruction, rhinorrhoea, epistaxis, Otalgia, hearing loss and cervical Lymphadenopathy. Common symptom of Laryngeal tuberculosis is hoarseness of voice. This study will increase awareness regarding Oro-nasopharyngeal / Laryngeal tuberculosis and will help in differentiating it from Oro-nasopharyngeal / Laryngeal carcinoma.

scholarly journals Diagnostic dilemmas of head and neck tuberculosis: our experience and review of literature

2020 ◽  
Vol 6 (5) ◽  
pp. 934
Author(s):  
Pallavi Pavithran ◽  
Mahesh S. G.
Keyword(s):  
Head And Neck ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Review Of Literature ◽  
Nodal Disease ◽  
Head And Neck Region ◽  
History Of ◽  
Tuberculous Otitis Media ◽  
High Index Of Suspicion

<p class="abstract"><strong>Background:</strong> The aim of the study was to highlight the varied and changing presentations of head and neck tuberculosis, discuss the difficulties in diagnosis and treatment.</p><p class="abstract"><strong>Methods:</strong> This was a 5 years retrospective analysis of patients with extrapulmonary tuberculosis (EPTB) of the head and neck region.  </p><p class="abstract"><strong>Results:</strong> 43 patients with EPTB were studied. Most had cervical lymphadenopathy (35), 9 had laryngeal, 7 tuberculous otitis media, and one patient each of PNS, oropharyngeal and retropharyngeal involvement. 8 patients had pulmonary TB, 2 had Potts spine, and 5 gave history of previous TB. FNAC was effective in nodal disease, PPD test positive in 20% and HPE was used to make the diagnosis in other types.</p><p class="abstract"><strong>Conclusions:</strong> TB is re-emerging as a significant cause of morbidity. Diagnosing EPTB requires high index of suspicion. Cervical lymphadenopathy is the commonest presentation, followed by larynx, and then ear. FNAC is a reliable and convenient way to diagnose lymphadenopathy. Hitopathological examination needed for confirmation, and for other sites. Further investigations are needed to exclude pulmonary or systemic TB. All patients should be categorised into proper category of anti-tuberculous treatment (ATT) and treated according to ATT regimen.</p>

scholarly journals Cervical Lymphadenopathy in a Nonagenarian Woman: What to Think?

2019 ◽  
Author(s):  
Vanessa Meireles Chaves ◽  
Fernando Nogueira ◽  
Gilberto Pires da Rosa ◽  
Sofia Tavares ◽  
Inês Ferreira ◽  
...  
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Public Health Problem ◽  
Excisional Biopsy ◽  
The Elderly ◽  
Extensive Study ◽  
Tuberculous Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Presumptive Treatment ◽  
Cervical Lymph Nodes

Tuberculosis remains a worldwide public health problem. Cervical tuberculous lymphadenitis (TBL) or scrofula is the most common form of extrapulmonary tuberculosis, affecting the cervical lymph nodes. We report the case of a 93-year-old woman presenting with cervical adenopathies with 3 months duration. Fine needle aspiration (FNA) biopsy yielded a noncaseous granulomatous process, but was negative for Mycobacterium tuberculosis (MT). As the adenopathies had grown, an excisional biopsy was performed. An extensive study of infectious aetiologies was performed, including for MT, with a negative outcome. Owing to the persistence of cervical lymphadenitis with caseous granulomas, a diagnosis of TBL was strongly suspected and presumptive treatment was initiated. Afterwards, diagnostic confirmation was obtained by isolation of MT in the lymph node culture. The patient presented a favourable clinical outcome. This case highlights that a high index of suspicion is essential for the diagnosis of TBL, especially in the elderly, and emphasizes the importance of pursuing diagnostic confirmation, in which FNA and excisional biopsy plays a key role.

scholarly journals Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Eamon Shamil ◽  
David Cunningham ◽  
Billy L. K. Wong ◽  
Piyush Jani
Keyword(s):  
Clinical Manifestations ◽  
Miliary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Selective Inhibition ◽  
Antituberculosis Therapy ◽  
Night Sweats ◽  
History Of ◽  
Neck Lump ◽  
One Year

Tuberculosis is an opportunistic infection with protean clinical manifestations. We describe a case of Ruxolitinib induced miliary tuberculosis presenting as a neck lump. A 78-year-old female presented with a two-month history of right-sided neck lump associated with fever, night sweats, and significant weight loss. She had a past medical history that included myelofibrosis, being treated with Ruxolitinib. Examination demonstrated 4 × 4 cm right-sided cervical lymphadenopathy. A chest radiograph showed extensive shadowing in both lungs. CT scan demonstrated perilymphatic nodes in addition to the cervical mass. An ultrasound-guided biopsy of a cervical lymph node demonstrated confirmedMycobacterium tuberculosisinfection. It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient. The medication was stopped and a 12-month regime of antituberculosis therapy commenced. She remained well at one-year follow-up with resolution of lung involvement. Clinicians should consider tuberculosis as a differential diagnosis for patients presenting with a neck lump, particularly in those taking immunosuppressant medication such as Ruxolitinib. A multidisciplinary approach is needed to promptly treat the tuberculosis and consider discontinuation of Ruxolitinib.

scholarly journals Scabies in Children: A Retrospective Study

2020 ◽  
Vol 32 (1) ◽  
pp. 55
Author(s):  
Retha Retha ◽  
Sawitri Sawitri
Keyword(s):  
Family Members ◽  
Sarcoptes Scabiei ◽  
Clinic Visit ◽  
Physical Contact ◽  
Common Symptom ◽  
Academic Hospital ◽  
Outpatient Clinic Visit ◽  
History Of ◽  
The Common ◽  
Almost All

Background: Scabies is a skin disease in humans and is caused by Sarcoptes scabiei mite. It burrows into the skin and is transmitted through close physical contact. The common symptom is itchiness, mainly occur at night, along with a history of itch from family members or friends with whom the patients might have close physical contact before. Scabies is still a concerning health problem for the majority of poor and developing countries. Purpose: To evaluate the profile of newly-admitted children scabies patients. Methods: This study retrospectively evaluated the medical records of subjects with scabies in the Children Dermatology Division, Dermatology and Venereology Department of Dr. Soetomo General Academic Hospital, Surabaya, between January 2012 and December 2014. Results: There were 545 patients with scabies (33.6% from Children Dermatology Division visit and 3.2% from overall outpatient clinic visit), mainly consisted of children aged 5-14 years old (69%), and mostly males (62.6%). The most common symptom was itchiness (70.28%), most patient sought treatment after the complaint have been persisted for more than 30 days (51.7%), and 66.4% patients have family members with similar complaint. Most of the lesions were found on the hands (60.37%), mostly as papules (73.2%). Almost all of them did not undergo a skin scraping examination (99.1%). The most common therapy combination was permethrin 5% and oral antihistamine (49.7%). Conclusions: This profile on scabies patients was expected to aid in improving scabies treatment in the future.

Sinus Histiocytosis with Massive Cervical Lymphadenopathy

1986 ◽  
Vol 95 (4) ◽  
pp. 331-335 ◽  
Author(s):  
Vanessa G. Schweitzer ◽  
Gregg D. Bobier
Keyword(s):  
Lymph Node ◽  
Fatal Outcome ◽  
Cervical Lymphadenopathy ◽  
Metastatic Carcinoma ◽  
Lymph Node Biopsy ◽  
Sinus Histiocytosis ◽  
Tuberculous Lymphadenitis ◽  
Massive Lymphadenopathy ◽  
Polyclonal Hypergammaglobulinemia ◽  
History Of

Sinus histiocytosis with massive cervical lymphadenopathy (SHML) was originally described in 1969 as a benign clinicopathologic entity characterized by massive bilateral cervical lymphadenopathy, fever, leukocytosis, elevated ESR, and hypergammaglobulinemia, usually occurring within the first two decades of life. We present an illustrated case of an elderly patient with polyclonal hypergammaglobulinemia and a 2-year history of multilobulated cervical and submandibular lymphadenopathy. The etiology and pathogenesis of SHML are not known. Diagnosis requires lymph node biopsy to exclude other causes of cervical lymphadenopathy such as malignant lymphoma, malignant histiocytosis, metastatic carcinoma, and tuberculous lymphadenitis. Histologic examination shows marked dilatation of subcapsular and medullary lymph node sinuses containing large, foamy or vacuolated histiocytes. Although no curative treatment is known, corticosteroids, radiation therapy, vinblastine and oral cyclophosphamide, and surgery have been used to palliate constitutional symptoms and mechanical obstruction from massive lymphadenopathy. Since one third of SHML patients have evidence of disease for 5 years, and a mortality rate of 7% exists with benign histologic disease, all patients with SHML should be carefully screened for evidence of immunodeficiencies that may precipitate a fatal outcome.

scholarly journals Comparison of FNAC vs Excision Biopsy for suspected Tuberculous Cervical Lymphadenopathy

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Ajmal Farooq ◽  
Imran Ameen
Keyword(s):  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Tuberculous Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Aspiration Cytology ◽  
Safe Alternative ◽  
Associated Symptoms ◽  
History Of ◽  
Needle Aspiration Cytology

Although Excision Biopsy has traditionally been required to diagnose cervical tuberculous lymphadenitis tine needle aspiration cytology (FNAC) has also been found to be useful. This prospective study presents the comparison of FNAC vs Excision Biopsy for suspected tuberculous cervical lymphadenitis in 100 consecutive. The aim and objective of the study was to determine whether FNAC is helpful in diagnosing tuberculous cervical lymphadenopathy thus avoiding Excision Biopsy. Patients between 5-70 years of age with suspected tuberculous lymphadenitis were included. Among these 62% were female and 38% were male 74% belong to poor class and 26% to middle class. 86%, were having history of immunization again tuberculosis with BCG. While 14% had no such history. The neck swelling was present in all 100 patients with some percentage of associated symptoms. The FNAC was positive for tuberculosis in 80 (80%) patients and Excision Biopsy in 94(94%) patients. Excision Biopsy was more sensitive than FNAC (94% vs 80%) in diagnosing tuberculous cervical lymphadenopathy. So it was concluded that FNAC is a safe alternative to Excision Biopsy and it should be recommended as first line and Excision Biopsy as second line investigation only if results of FNAC are negative.

scholarly journals A rare and interesting case report of Kikuchi-Fujimoto disease masquerading as tuberculosis

2020 ◽  
Vol 7 (10) ◽  
pp. 3508
Author(s):  
Joel Danie Mathew ◽  
Ajithakumari K. ◽  
Jiby Soosen Ninan ◽  
Juby Sunny
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Interesting Case ◽  
Excision Biopsy ◽  
Post Operative Period ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
High Index Of Suspicion ◽  
Very High

Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limited condition, probably genetic, that mainly affects young women which often presents with localised lymphadenopathy and fever. Reporting the case of a 17-year-old girl, with a strong family history of tuberculosis, who presented to the surgery OPD with cervical lymphadenopathy and a history of anti-tubercular treatment for the same complaints two years back. An excision biopsy revealed necrotizing histiocytic lymphadenitis suggestive of KFD. Post-operative period was uneventful and patient had spontaneous resolution of her complaints upon follow up. It is quite difficult to make a pre-operative diagnosis of this disease, until the clinician has got a very high index of suspicion especially because of the more common differential diagnoses including extrapulmonary tuberculosis. 

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