High Calorie Diet with a Combination of Intermittent Restriction Affects the Reproductive Cycle and The Weight of Mice (Mus Musculus)

Highlight:High-calorie diet influence with interval restrictions combination on the reproductive cycle and weight of the uterus in mice were analyzed.Calories balance impact for female reproductive health. Abstract :Balanced calories affected for body health and daily activities. Lose of energy can disturb the health and daily activities, while over calorie for diets also causes disorders such as metabolic. When there are excess calories in the body will be involved. It can be an obesity risk, diabetes mellitus, fertility disorder, cancer, and cardiovascular disease. Furthermore, in women there can be an increase in menstrual disorders and fertility disorderrisk (Silvestris et al., 2018). This study aims to analyze high-calorie diet influence with interval restrictions combination on the reproductive cycle and weight of the uterus in mice. Experimental laboratory is a mouse (mus musculus) female’s balb/c as object population. Sampling techniques using probability sampling with simple random sampling type. The study results on fisher's exact test gave a result of p > 0.05 so there was no significant difference between control group, high calorie diet group, and high calorie diet with interval restrictions group on the results of vaginal swabs /post-treatment reproductive cycle. The study outcome on robust tests between control, high calorie diet, and high calorie diet with interval restrictions groups. Obtained results (p < 0.05) that mean there are some significant discrepancies in the weight of uterine organ between groups. Calories balance in the body can impact female reproductive health.

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Experimental evaluation of the impact of low doses of the herbicide 2,4-D in drinking water on some indices of lipid and immune status

Hygiene and Sanitation ◽

10.18821/0016-9900-2016-95-5-450-454 ◽

2019 ◽

Vol 95 (5) ◽

pp. 450-454

Author(s):

Larisa A. Chesnokova ◽

I. V. Mikhaylova ◽

I. P. Voronkova ◽

D. S. Karmanova

Keyword(s):

Potable Water ◽

Ldl Cholesterol ◽

Immune Status ◽

The Body ◽

Low Doses ◽

Different Types ◽

Calorie Diet ◽

The Impact ◽

High Calorie Diet ◽

High Calorie

There were studied features of the manifestation of incoming with potable water nontoxic doses of the herbicide 2,4-D on the body mass index, some indices of lipid metabolism and immune system in different types of diets in the experiment in rats. There was shown a significant gain in body weight of animals, and MDA and leptin level in the serum under the action of a herbicide in conjunction with a high-calorie diet. In all experimental groups there was noted the increased level of total cholesterol, tendency to the increase of LDL cholesterol. Under the action of the herbicide there was noted an increase of IL-6, TNF-a and the numbers of leukocytes and, on the contrary, the reduction of the number of thymocytes and kariocytes in thymus and spleen.

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The effects of melatonin administration in determined times of day on the kidney in rats with high-calorie diet-induced obesity

Bulletin of Taras Shevchenko National University of Kyiv Series Problems of Physiological Functions Regulation ◽

10.17721/1728_2624.2019.26.35-41 ◽

2019 ◽

Vol 26 (1) ◽

pp. 35-41

Author(s):

O. Kalmukova ◽

T. Kushmyruk ◽

M. Dzerzhynsky

Keyword(s):

Functional State ◽

Antioxidant Properties ◽

The Body ◽

Correction Function ◽

Diet Induced Obesity ◽

Melatonin Administration ◽

Kidney Morphology ◽

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

Kidneys, like the cardiovascular system, are one of the main target organs, the most vulnerable to obesity, because the first take on the metabolism correction function at an increasing excess of fat tissue in the body. Kidney affection under obesity is a multifactorial thing that is caused by a number of processes, including inflammation, oxidative stress, lipid metabolism disorders, renin-angiotensin-aldosterone system activation, insulin resistance and other factors. An optimal candidate for reducing the harmful effects of kidneys obesity should be a compound that simultaneously exhibits anti-inflammatory and antioxidant properties, controls the circadian rhythm, and also affects on the adipokines secretion. The molecule that meets these conditions is melatonin.The aim of our study was to determine morpho-functional state (morphology characteristic of kidney glomeruli and tubules; morphometric parameters: area and density of glomeruli) of kidney in rats with high-calorie (high fat) diet-induced obesity after melatonin administration in determined time of the day. Melatonin was administered daily by gavage for 7 weeks in dose 30 mg/kg 1 h before lights-off (ZT11) rats with high-calorie diet (HCD). Rats with HCD had huge changes in kidney morphology, which manifested in presence of numerous mesangial cells outside glomeruli and lipid droplets in tubules epithelial cells, while area and density of glomeruli in cm2 decrease. In general kidney with above mentioned characteristic from HCD rats lose their ability to conduct strongly renal function. After melatonin used in rats with HCD arise leveling of pathological changes, which associated with consumption of HCD. Namely, in rats with development obesity melatonin administrations led to increase area and density in comparison to HCD group, moreover glomeruli density reach control values. This is suggest that melatonin have protecting effect against glomerular degeneration. In conclusions, melatonin influence on kidney morpho-functional state in rats with HCD and turn back pathological its changes, moreover evening administration can use for obesity therapy via its strong action on conservation glomerular morphology.

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Research on mechanism of the effect of charred hawthorn on digestive by SCF /c-kit pathway

10.21203/rs.3.rs-138593/v1 ◽

2021 ◽

Author(s):

Qian He ◽

Cui Liu ◽

Ting Wang ◽

Jingying Sun ◽

Xia Zhou ◽

...

Keyword(s):

Gastric Fluid ◽

The Body ◽

Flow Index ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Group Model ◽

Calorie Diet ◽

The Brain ◽

High Calorie Diet ◽

High Calorie

Abstract Background Hawthorn is the dry ripe fruit of Crataegus pinnatifida Bge in rose family which is a traditional Chinese medicine(TCM) for High-calorie-diet-induced dyspepsia (HC-DID). This study aimed to investigate whether the charred hawthorn coupled with its odor could alleviate HC-DID by brain-gut interaction and stem cell factor(SCF) /c-kit pathway. Methods Rats were randomly divided into 7 groups: control group, model group, cisapride group, hawthorn group (HT), charred hawthorn group (CHT), odor of charred hawthorn (OCHT), CHT + OCHT group. HC-DID rat model was established by high calorie diet for 10 days, hawthorn decoction was administered by gavage, and the self-developed solid drug odor delivery device was used for odor administration. The body weight, food intake, gastrointestinal motility, gastric fluid and gastric acid flow index were determined. HE staining was used to observe the pathological changes of rats. Electrophysiology was used to evaluate the effect of hawthorn combined with its charred odor therapy on electroencephalogram and Electrogastrogram. The SCF and c-kit levels or expressions by immunohistochemistry(IHC), enzyme linked immunosorbent assay (ELISA). Results We found that the odor of charred hawthorn (OCHT) affects the brain (central nervous system) of rats, and hawthorn decoction (raw hawthorn and charred hawthorn) coupled with the odor of charred hawthorn alleviated the symptoms of diet-induced dyspepsia in rats by modulating SCF/c-Kit pathway. Conclusion Thus, we concluded that odor of charred hawthorn has therapeutic effect on dyspepsia and hawthorn may alleviate dyspepsia related symptoms by affecting SCF/c-Kit signal pathway.

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Treat CF-Related Diabetes With Insulin, High-Calorie Diet

Pediatric News ◽

10.1016/s0031-398x(06)71279-6 ◽

2006 ◽

Vol 40 (9) ◽

pp. 9

Author(s):

BRUCE JANCIN

Keyword(s):

Calorie Diet ◽

High Calorie Diet ◽

High Calorie

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The evaluation of lipid peroxidation and oxidative modification of proteins in blood serum under obesity development and the consumption of aqueous kidney beans Phaseolus vulgaris pods extract

Current Issues in Pharmacy and Medical Sciences ◽

10.2478/cipms-2020-0008 ◽

2020 ◽

Vol 33 (1) ◽

pp. 38-44

Author(s):

Alona Yurchenko ◽

Daryna Krenytska ◽

Olexii Savchuk ◽

Tetiana Halenova ◽

Natalia Raksha ◽

...

Keyword(s):

Lipid Peroxidation ◽

Oxidative Modification ◽

Resistance Development ◽

Oxidative Modification Of Proteins ◽

Kidney Beans ◽

Calorie Diet ◽

Diet Control ◽

High Calorie Diet ◽

High Calorie

AbstractOur interest has focused on the investigation of the anti-obese potential of kidney beans (P. vulgaris) pods extract. In the course of the study, obesity development in rats was induced with high-calorie diet. Control and obese rats then have consumed with aqueous kidney beans (P. vulgaris) pods extract during 6 weeks (200 mg/kg). Results show that the long-term consumption of P. vulgaris pods extract can lead to the reduction of hyperglycemia and insulin resistance development. Furthermore, we saw a normalization of lipid peroxidation parameters and oxidative modification of protein due to the consumption of the kidney beans (P. vulgaris) pods extract. Our experimental data demonstrate the ability of the kidney beans (P. vulgaris) pod extracts to mitigate obesity development but the details of this mechanism remains to be not fully understood.

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