scholarly journals Changes in cardiac structure and function with aging

2022 ◽  
Author(s):  
Tanushree Agrawal ◽  
Sherif F. Nagueh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiac Remodeling ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Physiological Changes ◽  
Age Related ◽  
Cardiac Structure And Function ◽  
And Function

Aging is associated with progressive changes in cardiac structure and function. The prevalence of cardiovascular risk factors and disease also increases profoundly with advancing age. Therefore, understanding the spectrum of physiological changes in the aging heart is crucial for the identification and risk stratification of cardiovascular disease. In this review, we discuss echocardiographic features of age-related cardiac remodeling.

scholarly journals The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185114 ◽  
Author(s):  
Steffen E. Petersen ◽  
Mihir M. Sanghvi ◽  
Nay Aung ◽  
Jackie A. Cooper ◽  
José Miguel Paiva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Uk Biobank ◽  
Cardiac Structure And Function ◽  
The Uk ◽  
And Function ◽  
The Impact

scholarly journals Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk

2020 ◽  
Vol 7 (3) ◽  
pp. 1344-1361
Author(s):  
Fei Fei Gong ◽  
Jennifer M. Coller ◽  
Michele McGrady ◽  
Umberto Boffa ◽  
Louise Shiel ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Structure And Function ◽  
Longitudinal Change ◽  
Cardiac Structure ◽  
Age Related ◽  
Cardiac Structure And Function ◽  
And Function

scholarly journals Kashmiri Wazwan: Are We Listening to Our Endothelium?

JMS SKIMS ◽  
2013 ◽  
Vol 16 (2) ◽  
pp. 72-74
Author(s):  
M Fuad Jan ◽  
Suhail Allaqband
Keyword(s):  
Insulin Resistance ◽  
Cardiac Remodeling ◽  
Experimental Models ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Unsaturated Lipid ◽  
Diet Induced Obesity ◽  
Blood Pressure Homeostasis ◽  
Cardiac Structure And Function ◽  
And Function

In animal models of diet-induced obesity, hypercaloric (4.6 Kcal/g) diets have been shown to have metabolic hormonal effects, including hyperglycemia, insulin resistance and changes in leptin profiles 1, as well as undesirable effects on blood pressure homeostasis and even cardiac remodeling. Such effects have been directly and inversely correlated with saturated and unsaturated lipid consumption, respectively. In these experimental models, it also has been elegantly demonstrated that a variety of alterations in cardiac structure and function occur due to reduced myofilament Ca2+ sensitivity, alterations in Ca2+ handling proteins and beta-adrenergic receptors2-5. JMS 2013;16(2):72-74

Abstract P138: Alterations in Cardiac Structure and Function in Young Adults Born Extremely Preterm: Impact of Neonatal Bronchopulmonary Dysplasia

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Muhammad Oneeb Rehman Mian ◽  
Jean-Luc Bigras ◽  
Rafael Fernandes ◽  
Mariane Bertagnolli ◽  
Li Feng Xie ◽  
...  
Keyword(s):  
Young Adults ◽  
Preterm Birth ◽  
Cardiac Remodeling ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Lv Mass ◽  
Extremely Preterm ◽  
Cardiac Structure And Function ◽  
And Function

Objective: Studies support a causal association between preterm birth and increased risk of cardiovascular diseases. Increased left and right ventricular mass and impaired systolic and diastolic function has been reported in young adults born preterm. However, the impact of extreme preterm birth and prematurity-specific complications on adult cardiac structure and function has not been evaluated. We assessed cardiac structure and function in young adults born extremely preterm (EPT) versus term, and correlated long term cardiac remodeling with neonatal bronchopulmonary dysplasia (BPD). Methods: Eighty five EPT (gest. age = 27.1±1.4 weeks) were recruited along with term-born controls matched for age, sex and socioeconomic status. Birth and neonatal data (gestational age, birth weight, BPD indicated by O 2 requirements at 36 weeks postmenstrual age) was collected. Ambulatory blood pressure (Spacelabs) and echocardiographic measurements (Phillips) were taken. Comparisons were performed using ANOVA or T-test. Results: EPT presented with increased systolic (119±9 vs 116±8 mmHg, P<0.05) and diastolic (68±5 vs 66±6 mmHg, P<0.05) blood pressures. EPT exhibited reduced septal thickness (IVS, 6.8±0.8 vs 7.1±1.1 mm, P<0.05), left ventricular internal dimension (LVID, 46±4 vs 48±5 mm, P<0.05), LV end-diastolic (98±20 vs 106±24 ml, P<0.05) and end-systolic (36±9 vs 40±11 ml, P<0.01) volumes, right ventricular internal dimension (RVID, 22±3 vs 24±4 mm, P<0.05), and LV mass (104±27 vs 115±30 g, P<0.05), but similar LV mass and volume indexes. EPT exhibited increased LV myocardial performance index (0.41±0.04 vs 0.39±0.04, P<0.01), reduced mitral lateral e’ (17.6±2.8 vs 19.1±2.6 cm/s, P<0.01), mitral s’ (10.7±2.3 vs 11.6±2.3 cm/s, P<0.01), tricuspid E’ (15.8±2.7 vs 16.8±2.1 cm/s, P<0.05), and tricuspid S’ (13.1±2.0 vs 14.0±2.0 cm/s, P<0.01) waves, and a trend in reduced mitral E wave (81±14 vs 85±15 cm/s, P=0.09). EPT with neonatal BPD exhibited greater reduction in IVS (6.5±0.8 mm, P<0.05 vs terms), LVID (45±4 mm, P<0.05), LV Mass (98±22 g, P<0.05), and RVID (20±3 mm, P<0.01). Conclusions: EPT exhibit cardiac structural and functional alterations compared to term-born individuals. Neonatal BPD in EPT is a key contributor to long term cardiac remodeling.

Abstract 193: Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure in Women

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Amy Sarma ◽  
Samantha Paniagua ◽  
Elizabeth Liu ◽  
Emily Lau ◽  
Martin Larson ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Remodeling ◽  
Structure And Function ◽  
Cardiovascular Health Study ◽  
Cardiac Structure ◽  
Live Births ◽  
Nulliparous Women ◽  
Increased Risk ◽  
Cardiac Structure And Function ◽  
And Function

Introduction: Greater parity has been associated with increased risk of cardiovascular disease, though effects on cardiac remodeling and heart failure risk remain unclear. Hypothesis: We hypothesized that multiple prior live births are associated with (1) structural and functional cardiac remodeling and (2) risk of future heart failure. Methods: We examined the association of number of live births and echocardiographic measures of cardiac structure and function in women participants of the Framingham Heart Study (FHS) using multivariable linear regression. We next examined the association of parity with incident heart failure (HFpEF, HFrEF) using Cox models in a pooled analysis of n=10,431 participants of FHS, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Results: Among n=3931 FHS participants (mean age 48 ± 13 years), higher number of live births was associated with worse LV fractional shortening (multivariable β -1.11 (0.31), p= 0.0005 in ≥ 5 live births vs nulliparous women, p trend= 0.02, Figure ). In addition, greater parity was associated with worse cardiac mechanics including global circumferential strain and longitudinal and radial dyssynchrony (p< 0.01 for all comparing ≥ 5 live births vs nulliparity). Over a mean follow-up of 11.7 ± 3.2 years, 298 HFpEF and 225 HFrEF events occurred. Women with ≥5 live births were at higher risk of developing future HFrEF compared with nulliparous women (HR 1.93, 95% CI 1.19-3.12, p=0.008); by contrast, a lower risk of HFpEF was observed (HR 0.58, 95% CI 0.37-0.91, p=0.02, p trend= 0.04). Conclusions: Greater number of live births are associated with worse cardiac structure and function, as well as increased risk of incident HFrEF. Further studies are needed to better understand mechanisms by which repeated pregnancies portend adverse cardiovascular risk.

scholarly journals HEART AND AGE (PART II): CLINICAL MANIFESTATIONS OF AGEING

2013 ◽  
Vol 12 (4) ◽  
pp. 86-90 ◽  
Author(s):  
D. U. Akasheva ◽  
E. V. Plokhova ◽  
I. D. Strazhesko ◽  
E. N. Dudinskaya ◽  
O. N. Tkacheva
Keyword(s):  
Clinical Manifestations ◽  
The Elderly ◽  
Structure And Function ◽  
Disease Development ◽  
Cardiac Structure ◽  
Age Related ◽  
High Prevalence ◽  
Cardiac Structure And Function ◽  
And Function

Ageing is an inevitable process which affects quality of life and reduces life expectancy. Age-related cardiac changes reduce compensatory reserves of the heart and accelerate the disease development. Such changes in cardiac structure and function, observed in the absence of cardiovascular disease (CVD), are considered age-related. However, taking into account the high prevalence of CVD in the elderly, it is problematic to define the genuine cardiac ageing. This review discusses a range of subclinical cardiac conditions which are common in older people. 

Cardioprotective potential of lithium and role of fractalkine in euthymic patients with bipolar disorder

2021 ◽  
pp. 000486742110625
Author(s):  
Pao-Huan Chen ◽  
Cheng-Yi Hsiao ◽  
Shuo-Ju Chiang ◽  
Ruei-Siang Shen ◽  
Yen-Kuang Lin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Lithium Treatment ◽  
Structure And Function ◽  
Cardiac Structure ◽  
High Cardiovascular Risk ◽  
Cohen’S D ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Cohen's D

Objective: Over a half century, lithium has been used as the first-line medication to treat bipolar disorder. Emerging clinical and laboratory studies suggest that lithium may exhibit cardioprotective effects in addition to neuroprotective actions. Fractalkine (CX3CL1) is a unique chemokine associated with the pathogenesis of mood disorders and cardiovascular diseases. Herein we aimed to ascertain whether lithium treatment is associated with favorable cardiac structure and function in relation to the reduced CX3CL1 among patients with bipolar disorder. Methods: We recruited 100 euthymic patients with bipolar I disorder aged over 20 years to undergo echocardiographic study and measurement of plasma CX3CL1. Associations between lithium treatment, cardiac structure and function and peripheral CX3CL1 were analyzed according to the cardiovascular risk. The high cardiovascular risk was defined as (1) age ⩾ 45 years in men or ⩾ 55 years in women or (2) presence of concurrent cardiometabolic diseases. Results: In the high cardiovascular risk group ( n = 61), patients who received lithium as the maintenance treatment had significantly lower mean values of left ventricular internal diameters at end-diastole (Cohen’s d = 0.65, p = 0.001) and end-systole (Cohen’s d = 0.60, p = 0.004), higher mean values of mitral valve E/A ratio (Cohen’s d = 0.51, p = 0.019) and superior performance of global longitudinal strain (Cohen’s d = 0.51, p = 0.037) than those without lithium treatment. In addition, mean plasma levels of CX3CL1 in the high cardiovascular risk group were significantly lower among patients with lithium therapy compared with those without lithium treatment ( p = 0.029). Multiple regression models showed that the association between lithium treatment and mitral value E/A ratio was contributed by CX3CL1. Conclusion: Data from this largest sample size study of the association between lithium treatment and echocardiographic measures suggest that lithium may protect cardiac structure and function in patients with bipolar disorder. Reduction of CX3CL1 may mediate the cardioprotective effects of lithium.

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