Comparative analysis of the concentration of matrix metalloproteinases in the blood serum before and after surgical treatment of breast cancer

Te article describes clinical and psychological issues of the PTSD development in breast cancer patients afer surgical treatment (mastectomy). Te results of comparative analysis with the use of the psychodiagnostic tests battery of the breast cancer related PTSD symptoms group and the well coped with cancer related distress group are presented. Te regression analysis results allowed to distinguish psycho-social risk factors for breast cancer related PTSD manifestation

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The effect of surgery on the levels of matrix metalloproteinases in patients with inguinal hernia

Physiological Research ◽

10.33549/physiolres.934625 ◽

2021 ◽

Vol 70 (4) ◽

pp. 627-634

Author(s):

Sabina Strohalmová ◽

Kateřina Levová ◽

Aleš Antonín Kuběna ◽

Zdeněk Krška ◽

David Hoskovec ◽

...

Keyword(s):

Extracellular Matrix ◽

Inguinal Hernia ◽

Surgical Treatment ◽

Matrix Metalloproteinases ◽

Healthy Controls ◽

Serum Concentrations ◽

Blood Samples ◽

Metalloproteinase Inhibitors ◽

Before And After ◽

Circulating Levels

Matrix metalloproteinases (MMPs) are associated with the alteration of extracellular matrix. The purpose of this study was to investigate how the levels of matrix metalloproteinases and their inhibitors – TIMPs are influenced by the presence of inguinal hernia as well as by its surgical treatment. The studied group consisted of 25 patients with inguinal hernia and 21 healthy controls for comparison. Two blood samples - before and after the treatment were collected from patients. Serum concentrations of MMPs and TIMPs were analysed by multiplex immunoassays. There was a difference in circulating levels of MMPs in patients before the surgery compared to healthy controls – the concentrations of MMP-2 and MMP-9 were significantly lower (p=0.026, p=0.018, respectively). After the surgery, the levels of MMPs, especially MMP-2 (p<0.0001), were significantly decreased in patients compared to the preoperative values, apart from MMP 9. On the contrary, MMP-9 showed significant increase after the surgery (p<0.0001). Circulation levels of TIMP-2 in patients were significantly decreased in comparison with controls (p=0.004), whereas levels of TIMP-1 were similar to controls. Both tested metalloproteinase inhibitors showed a significant decrease in detected levels (TIMP-1 p=0.0004; TIMP-2 p<0.0001) after the procedure compared to the preoperative values. The levels of MMPs, especially MMP-2 and MMP-9, and their inhibitors TIMP-1 and TIMP-2 are involved by the presence of inguinal hernia as well as are influenced by the surgery.

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Soluble B7-H4 and its association with clinical characteristics and prognosis in patients with early breast cancer

10.21203/rs.3.rs-93991/v1 ◽

2020 ◽

Author(s):

Pawel Mach ◽

Oliver Hoffmann ◽

Sabine Kasimir-Bauer ◽

Rainer Kimmig ◽

Boerge Schmidt ◽

...

Keyword(s):

Breast Cancer ◽

Serum Concentration ◽

Blood Serum ◽

Clinical Characteristics ◽

Checkpoint Inhibitors ◽

Response To Therapy ◽

Adjuvant Setting ◽

Before And After ◽

Novel Target ◽

Concentration Levels

Abstract Background: Immunotherapy is a promising area for treatment of breast cancer (BC) that has transformed patient care. Immune checkpoint inhibitors are only effective in a subset of patients, and the identification of biomarkers that predict response to therapy is crucial to increase the rates of responders. B7-H4 is a potentially novel target for cancer therapy.Methods: We examined the association of sB7-H4 with clinical characteristics and prognosis in patients with early BC. Using ELISA, we analyzed sB7-H4 serum concentrations in a total of 572 early BC patients before the onset of therapy, 109 patients (cohort 1) in the neo-adjuvant setting and 463 patients in the adjuvant setting (cohort 2). In cohort 1, measurements were also performed after neo-adjuvant therapy (NACT).Results: In cohort 1, sB7-H4 blood serum concentration was delectable in 27/109 (26%) patients before and in 50/109 (48%) patients after NACT. In cohort 2, the detection rate was only 4% (18/461 patients). In cohort 1, no significant differences between patients, even when stratifying for particular intrinsic subtypes, before and after NACT were observed. No significant chances in sB7-H4 blood serum concentration levels before and after NACT were associated with clinical parameters, prognosis and the risk of recurrence. The median blood serum concentration levels in cohort 2 were significantly higher than in cohort 1 after NACT (p=0.04) but not before NACT. Conclusions: sB7-H4 concentration levels in serum of non-metastatic BC patients are neither associated with prognosis nor with clinical characteristics in the adjuvant and neo-adjuvant setting.

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Effect of mammography screening on surgical treatment for breast cancer in Norway: comparative analysis of cancer registry data

BMJ ◽

10.1136/bmj.d4692 ◽

2011 ◽

Vol 343 (sep13 1) ◽

pp. d4692-d4692 ◽

Cited By ~ 32

Author(s):

P. Suhrke ◽

J. Maehlen ◽

E. Schlichting ◽

K. J. Jorgensen ◽

P. C. Gotzsche ◽

...

Keyword(s):

Breast Cancer ◽

Comparative Analysis ◽

Surgical Treatment ◽

Cancer Registry ◽

Mammography Screening ◽

Registry Data ◽

Cancer Registry Data

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A comparative analysis of quality of life of women diagnosed with breast and ovarian cancer

10.21203/rs.3.rs-889274/v1 ◽

2021 ◽

Author(s):

Marta Dąbrowska-Bender ◽

Robert Słoniewski ◽

Urszula Religioni ◽

Adam Fronczak ◽

Anna Staniszewska ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Ovarian Cancer ◽

Comparative Analysis ◽

Surgical Treatment ◽

Cancer Therapy ◽

Social Life ◽

Health Assessment ◽

Eortc Qlq

Abstract Background A comparative analysis of changes in quality of life of women diagnosed with ovarian and breast cancer after surgical treatment followed by adjuvant cancer therapy. Methods The study covered 220 women diagnosed with ovarian (n = 89) or breast cancer (n = 131) after surgical treatment followed by adjuvant cancer therapy (chemotherapy, radiotherapy, hormone therapy). The tools used to measure the quality of life were: standardised EORTC QLQ-C30 questionnaire and QLQ-BR23 module for breast cancer and QLQ-OV28 module for ovarian cancer. Results The women with breast cancer rated their health higher than the women with ovarian cancer. The health assessment made by the patients was not related to the type of cancer (P > 0.05). They experienced pain, dyspnea and weakness regardless of the location of cancer. In addition, the health of the women had a significant impact on their family and social life, but nonetheless, no statistically significant differences were found between the two groups (P > 0.05). Whilst the patients with breast cancer rated their quality of life and health higher than the patients with ovarian cancer, the differences were not statistically significant (P > 0.05). Conclusions The results show that there is an urgent need to provide cancer patients with support of psycho-oncologists, medical staff, community (including organisations that help women with a specific type of cancer) and family members at each stage of the disease and therapy to improve the health and quality of life of the population.

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Statistical Analysis of Factors Influencing Survival of Women with Breast Cancer by Treatment Types

Statistics of Ukraine ◽

10.31767/su.1(88)2020.01.13 ◽

2020 ◽

Vol 88 (1) ◽

pp. 108-115

Author(s):

I. M. Motuziuk ◽

O. M. Dumenko

Keyword(s):

Breast Cancer ◽

Comparative Analysis ◽

Statistical Analysis ◽

Surgical Treatment ◽

Cancer Patients ◽

National Cancer Institute ◽

Survival Rates ◽

Breast Cancer Patients ◽

Survival Curves ◽

Treatment Type

This article investigates breast cancer incidence in Ukraine. The research is based on National cancer-registry data. It describes the problem of treatment choice complexity and ambiguity between surgical treatment and combined surgical treatment. The paper examines two types of combined surgical treatment: a combination of surgery with radiotherapy and a combination of surgery with radiotherapy and chemotherapy. In order to determine the positive and negative effects of each type of treatment, we conducted statistical analysis. The analysis was based on female patients’ data from the National Cancer Institute. Based on the results, the study proved the relevance of survival analysis from the perspective of overall survival and progression-free survival by treatment type. The article describes the analysis and its findings on 5-year survival rates. Specifics of research with censored data and methodology of evaluating factor weights in the Kaplan – Meier method are described. It also describes the distribution of patients treated in the National Cancer Institute, which made it possible to build a representative sample. The sample was used to conduct a comparative analysis of survival rates among breast cancer patients by treatment type. We built survival curves for comparative analysis by treatment type. This helped define relevant 5-year survival rates among patients. The study analyzed a number of factors that could be significant and could influence breast cancer patients’ survival. Furthermore, we applied stratified analysis by treatment type and checked the hypothesis that there is no difference between the population survival curves by using Log-rank and Wilcoxon tests. Based on the study results, new possibilities for further analysis were described. The results could be used for patients’ survival modeling and for determining the relationship between risk factors when they are influenced by another one. The results will be helpful in determining recommendations about treatment type.

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