scholarly journals Dynamics of the painful syndrome, cardial dysfunction and cerebral disorders at patients suffering vertebral cardialgies while treatment of intraosteal blockades

2009 ◽  
Vol 8 (1(2)) ◽  
pp. 125-128
Author(s):  
V. A. Filimonov ◽  
Ye. L. Sokov ◽  
L. Ye. Kornilova
Keyword(s):  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Ischemic Disease ◽  
Painful Syndrome ◽  
The Given ◽  
Universal Mechanism

177 patients with clinical manifestations of thoracocervical osteochondrosis with vertebro-cardial syndrome and ischemic disease of heart were inspected. 94 patients (main group) underwent a course of intraosteal blockades, while 83 patients (control group) underwent a course of paravertebral blocades. Higher therapeutical effectiveness of intraosteal blockades in treatment of the given patients compared to paravertebral blockades was revealed. Osteogenetic factor can be considered a universal mechanism of forming spondilogenic cardio-cerebral disorders.

scholarly journals Clinical evaluation of the effectiveness of treatment of the hand-foot syndrome – skin toxicity of antitumor target therapy with multi-kinase inhibitors

2018 ◽  
Vol 12 (3) ◽  
pp. 140-149 ◽  
Author(s):  
Evgeniya A. Shatokhina ◽  
Larisa S. Kruglova ◽  
Oleg A. Shukhov
Keyword(s):  
Lipoic Acid ◽  
Kinase Inhibitors ◽  
Clinical Manifestations ◽  
Main Group ◽  
Betamethasone Dipropionate ◽  
Control Group ◽  
Positive Trend ◽  
Alpha Lipoic Acid ◽  
Significant Difference ◽  
Hand Foot Syndrome

Background. The effective treatment of the hand-foot syndrome is a necessary component of the complex treatment of patients receiving antitumor therapy with multikinase inhibitors. Aims. The assessment of a new effective method for the treatment of palm-plantar syndrome in patients receiving multi-kinase inhibitors. Materials and methods. There are 27 patients received antitumor treatment with multi-kinase inhibitors and had clinical manifestations of the hand-foot syndrome (HFS) for observation. The main group (14 patients) used a combination of an alpha-lipoic acid at a dose of 600 mg per day per os and an ointment containing 0.005% calcipotriol and 0.05% betamethasone dipropionate 2 times a day. The control group, included 13 patients, used a combination with a cream containing 10% urea and ointment containing 0.05% betamethasone dipropionate. Results. After a week of treatment, the regression of the skin process was observed in both groups, but it was more evident in the main group: significant differences in severity of erythema, paresthesia, pain and burning sensation, the Dermatological Life Quality Index (DLQI) were observed at this stage of therapy (p < 0.05). After 2 weeks of therapy: a more positive trend in the main group in terms of erythema, paresthesia and burning, but the most significant difference is DLQI – 17.4 in the main group and 22.8 in the control group (p < 0.0001). At the end of the 3rd week of therapy: differences with the main characteristics of erythema, desquamation, paresthesia (p < 0.0008), pain (p < 0.0001), DLQI (p < 0.0001). At the end point of the study (after 4 weeks of therapy), significant differences were found in reducing the symptoms and the main parameters for evaluating the effectiveness of DLQI in patients of the main group with a reliability of p < 0.0001. The high correlation of DLQI was found with erythema, pain, burning, paresthesia and desquamation. Conclusions. The treatment of the hand-foot plantar syndrome combined using alpha-lipoic acid inside and topical therapy in the form of an ointment containing calcipotriol and betamethasone dipropionate, can be recommended for patients receiving targeted therapy with multi-kinaseinhibitors.

scholarly journals FEATURES OF CLINICAL MANIFESTATIONS, CELLULAR AND HUMORAL IMMUNITY OF NEWBORNS WITH INTRAUTERINE MIXED INFECTIONS

2020 ◽  
pp. 427-433
Author(s):  
M.A. YUSUPOVA ◽  
◽  
K.I. ISMOILOV ◽  
Keyword(s):  
Humoral Immunity ◽  
Phagocytic Activity ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phagocytic Index ◽  
Control Group ◽  
Mixed Infections ◽  
Secondary Immunodeficiency ◽  
Group I ◽  
Cellular And Humoral Immunity

Objective: To study the features of clinical manifestations, cellular and humoral immunity of newborns with intrauterine mixed infections (IUMI). Methods: A comprehensive survey of 45 infants with IUMI was carried out. Depending on the classification of IUMI they were divided into 3 main groups: group I – 24 patients (53%) with the viral-bacterial association, group II – 12 patients (27%) with the viral-viral association, and group III – 9 patients (20%) with the viral-parasitic association. The control group consisted of 10 newborns born from uninfected, somatically healthy mothers. Diagnosis of IUMI was based on the detection of specific antibodies of the IgA, IgG and IgM classes, as well as phagocytic activity and phagocytic index of leukocytes. In addition, general clinical, biochemical, bacteriological and instrumental research methods have been conducted. Results: The blood serum IgA and IgM indices in patients of the main group were significantly higher, and the mean IgG values were lower compared to the control group. Analysis of cellular immunity parameters in the main group showed a decrease in the number of mature T-lymphocytes (CD3), B-lymphocytes (CD20), the number of T-helpers and cells that produce IL-2 in the peripheral blood, compared with the control group. In the main group, there was also an increase in the number of apoptosis cells (CD95), cells with high cytotoxic activity (CD25, CD71) and the percentage of natural killer cells (CD16). A decrease in the phagocytic activity and phagocytic index of neutrophils was recorded, which indicates the insufficiency of the nonspecific component of immunity. Conclusions: In newborns, various changes were found both on the part of specific and nonspecific components of immunity. This indicates the development of secondary immunodeficiency in this category of patients and makes it necessary to add to the main treatment of immune corrective therapy. Keywords: Congenital infections, mixed intrauterine infections, TORCH syndrome, opportunistic infections, secondary immunodeficiency.

Results of the inclusion of osteopathic correction in the complex therapy of patients with chronic gastritis

2021 ◽  
pp. 80-89
Author(s):  
R. T. Fazlyakhmetov ◽  
R. R. Safiullin ◽  
A. V. Ustinov
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Eradication Therapy ◽  
Clinical Manifestations ◽  
Integrated Approach ◽  
Main Group ◽  
Control Group ◽  
Study Results ◽  
Complex Therapy

Introduction. Many key questions regarding the etiology, pathogenesis, clinical manifestations and treatment of chronic gastritis remain open. So, despite the success of chronic gastritis pharmacotherapy, much attention is paid to non-drug methods of therapy, in particular, osteopathy. However, evidences of the osteopathic methods effectiveness for the chronic gastritis treatment, obtained by objective instrumental methods, are insufficiently presented in the modern literature.The goal of research — to study the results of osteopathic correction inclusion in the complex therapy of patients with chronic gastritis.Materials and methods. The study involved 50 patients with chronic gastritis, divided by simple randomization into a control group (25 people) and a main group (25 people). The participants in the control group received standard eradication therapy according to a three-component scheme. The participants of the main group additionally received osteopathic correction. In both groups, at the beginning and at the end of the study, there were performed fibroesophagogastroduodenoscopy with targeted biopsy to assess the gastric mucosa state, Helicobacter pylori identification, and intragastric pH-metry to assess gastric juice acidity.Results. According to the study results, a statistically significant (p<0,05) decrease in edema and hyperemia of gastric mucosa was found in the control and main groups. There was a statistically significant (p<0,001) decrease in gastric aciditywith osteopathic accompaniment, compared with unaccompanied drug treatment. In both groups, there was a statistically significant (p<0,05) decrease in the incidence of Helicobacter pylori carriage. Conclusion. Based on the obtained results, it can be assumed that an integrated approach using osteopathic correction in the treatment of chronic gastritis may be more effective than the standard course of treatment.

Hepatoprotective therapy with low molecular weight sugar drug for pregnant women with liver dysfunction amid early toxicosis and hepatotoxicity

2021 ◽  
Vol 20 (2) ◽  
pp. 19-28
Author(s):  
E.V. Mozgovaya ◽  
◽  
M.A. Kryshnya ◽  
E.V. Shelaeva ◽  
S.V. Nagorneva ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pregnant Women ◽  
Bile Acids ◽  
Alanine Aminotransferase ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Low Molecular Weight ◽  
Sugar Solution ◽  
Drug Induced

Objective. To assess the efficacy and safety of low molecular weight sugar solution as a hepatoprotector in the first trimester of pregnancy in patients with liver functional disorders against the background of early toxicosis and / or hepatotoxicity. Patients and methods. The study included 70 patients: the main group (n = 30) – pregnant women with functional hepatopathies who received therapy with drug Heptrong; the control group (n = 30) – pregnant women who received standard treatment, of which 15 patients had hepatotoxicity (essential phospholipid therapy) and 15 patients with early toxicosis (intravenous saline fluid therapy, Cerucal), as well as 10 pregnant women with early toxicosis who were treated without drugs (the placebo group). Results. Pregnant women with early toxicosis noted a decrease in its clinical manifestations against the use of the drug Heptrong after 2.3 ± 0.8 days from the onset of therapy; by the end of therapy, all patients had no vomiting, and nausea stopped in 80%, which was not observed in comparison groups. The normalization of alanine aminotransferase (≤40 U/L) occurred in 80% of pregnant women in the main group (p < 0.01) and in 66% (p < 0.01) when treating with essential phospholipids. The normalization of alanine aminotransferase (≤40 U/L) occurred in 90% (p < 0.01) and 33.3% (p = 0.03), respectively. A significant decrease in the level of bile acids (from 8.49 ± 2.1 μmol/L to 2.74 ± 1.1 μmol/L; p < 0.05) and improvement in the indicators of the antioxidant system – an increase in total antiradical activity (from 804.0.0 ± 10.5 μmol/L to 839.0 ± 11.0 μmol/L; p < 0.05) and a decrease in the level of conjugated dienes (from 3.77 ± 0.2 μmol/L to 3.26 ± ± 0.1 μmol/L; p < 0.05) – were observed only in the main group. A number of other indicators of the “liver panel” tended to improve only in the main group. Conclusion. Heptrong is an effective hepatoprotective drug, which considerably improves the state of pregnant women during early toxicosis and helps to reduce liver transaminases and bile acids in pregnant women with hepatotoxicity. Due to the antiinflammatory and pronounced antioxidant effect, which is not observed in standard pharmacological treatment, Heptrong can be used to prevent late obstetric complications. Key words: Heptrong, drug-induced hepatopathies, “liver panel” indicators, early toxicosis

scholarly journals STUDY OF RIVAROXABAN FOR VENOUS THROMBOEMBOLISM PROPHYLAXIS AFTER LOWER EXTREMITY FRACTURES IN RUSSIAN CLINICAL PRACTICE

2018 ◽  
pp. 47-51
Author(s):  
M. V. Belov
Keyword(s):  
Lower Extremity ◽  
Dabigatran Etexilate ◽  
Clinical Manifestations ◽  
Bleeding Risk ◽  
Recurrent Dislocation ◽  
Main Group ◽  
Control Group ◽  
Thromboembolism Prophylaxis ◽  
Vein Thrombosis ◽  
Femur Fractures

Thepurposeof the study was to evaluate the efficacy and safety of rivaroxaban in patients after surgical treatment for the lower extremity fractures.Patients and methods. Retrospective multicenter study included 663 patients with femur fractures, 43 patients with complications after total hip arthroplasty (periprosthetic femur fractures, recurrent dislocation) and 10 patients with shinbone fractures. The majority (81.99%) of patients were elderly or senile. In postoperative period all patients received a standard prophylactic dose of anticoagulants. Out of them 75 (main group) – rivaroxaban (10 mg/day), 241 (control group) – other drugs (enoxaparin – 40 mg/day and dabigatran etexilate 150 or 220 mg/day). The efficacy of prophylaxis was assessed by clinical picture and Doppler ultrasound scans.Results.Average bed day made up 9.28. During hospitalization no cases of PE were recorded. In the main and control groups the rate of deep vein thrombosis with clinical manifestations made up 1.89 and 3.31%, respectively. No cases of fatal bleeding occurred. Signs of continuous bleeding in the area of surgical intervention (soaking dressings or recurring wound hematomas) in the main group was recorded rarely (3.15%) than in the control one (8.29%).Conclusion.Reduction of VTE rate with no increase in bleeding risk indicates the feasibility of rivaroxaban use for postoperative PE prophylaxis in patients with lower extremity fractures.

scholarly journals Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

2021 ◽  
pp. 27-32
Author(s):  
A. S. Klimova ◽  
E. V. Shrayner ◽  
A. I. Khavkin ◽  
N. V. Kokh ◽  
G. I. Lifshits ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Polymorphic Locus ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Significant Difference ◽  
Taqman Pcr ◽  
Pcr Method ◽  
H Pylori ◽  
Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

scholarly journals Fluid resuscitation patients with burn sepsis

2020 ◽  
pp. 42-43
Author(s):  
O.M. Kovalenko ◽  
O.I. Osadcha ◽  
A.A. Kovalenko ◽  
A.S. Grisha ◽  
O.M. Lynnyk ◽  
...  
Keyword(s):  
Comparison Group ◽  
Total Body Surface Area ◽  
Clinical Manifestations ◽  
Main Group ◽  
Oxidation Products ◽  
Control Group ◽  
Carbonyl Groups ◽  
Septic Complications ◽  
Endogenous Intoxication ◽  
Lipid Oxidation Products

Objective. The purpose the of the study is to improve the fluid therapy regimens for burn sepsis patient. Materials and methods. The study is based on the observation 52 patients with burn sepsis aged 23 to 65 years, with a total body surface area more than 35 % at the Kyiv City Clinical Hospital № 2 during 2016-2019. Patients were divided into two groups: the main group – 30 patients were treated with crystalloids, plasma, albumin and Rheosorbilact (RSL); control group – 16 patients received treatment without using of RSL. Clinical and biochemical parameters of endogenous intoxication (tissue destruction products, medium weight molecules (MWM), concentrations of lipid oxidation products (LOP) – by diene conjugate content and oxidatively modified proteins (OMP) – by carbonyl groups) were studied. Results and discussion. Syndrome of endogenous intoxication was an increase in burn sepsis patients, which correlated with an increase in the number of LOP, OMP, MWM, namely an increase in the hydrophobic (most toxic) fraction of MWM, which is 2-3 times higher than in healthy, sick and both groups. MWM and hydrophobic fraction remained high during the observation period in patients of the comparison group. MWM decreased by 1.35 times in patients of the main group relative to the group of crystalloids. The level of carbonyl groups of serum OMP in patients of the comparison group was 50 % higher than in the main group. The indicators of LOP exceeded 1.45 times in the comparison group, which testified to the continuation of oxidative stress and the continuation of systemic inflammation. Acute respiratory distress syndrome (ARDS) was characterized by the appearance of bilateral infiltrates in the lungs, according to radiography. This common organ dysfunction was detected in 75 % of patients in the comparison group and in 63 % of patients in the RSL-group. The duration of mechanical ventilation in the main group decreased by 1,6 days. Conclusions. The use of Rheosorbylact for patients with burn sepsis at a dose of 15 ml/kg has led to a decrease in the manifestations of intoxication syndrome, reduction of MWM, LOP, OMP, clinical manifestations of systemic inflammatory response, septic complications by 1.3 times, septic shock from 16 to 12 %, and the incidence of ARDS from 75 to 63 %.

scholarly journals Nеw tесhniquеs for physiсal rеhabilitation of powеr sports athlеtеs with artеrial hypеrtеnsion: a randomizеd сontrollеd trial

2020 ◽  
Vol 97 (3) ◽  
pp. 76-82
Author(s):  
A.B. Miroshnikov ◽  
A.V. Smolеnskiy ◽  
A.D. Formеnov
Keyword(s):  
Blood Pressure ◽  
High Intensity ◽  
Blood Pressure Measurement ◽  
Clinical Manifestations ◽  
Oxidative Capacity ◽  
Main Group ◽  
Physical Rehabilitation ◽  
Control Group ◽  
Heavy Weight ◽  
The Impact

Essential hypertension is a frequent diagnosis in power sports athletes, heavy weight categories. The aim of the study: To evaluate the impact of high-intensity aerobic work on blood pressure and oxidative abilities of hypertensive athletes of power sports, heavy weight categories. Rеsеarсh mеthods: Examination and physical rehabilitation were conducted in 55 hypertensive representatives of power sports, heavy weight categories comparable in age, sex and main clinical manifestations. Athletes were randomized into two groups: the main group (n=35) and the control group (n=20). Athletes of the main group were trained for 180 days (3 times a week) on an ergometer using a high-intensity interval protocol, while the control group participants were trained for 180 days (3 times a week) using their traditional power protocol. The tasks were performed using the following methods: examination, polling, gasometric analysis, triple blood pressure measurement, muscle tissue oxygenation level measurement and mathematical statistics methods. Rеsults: After 180 days of physical rehabilitation, the participants in the main group had a 148% reduction in oxygen oxygenation, an increase in capacity and working time at maximum oxygen consumption, and a reliable decrease in blood pressure: systolic blood pressure by 8.0%, diastolic blood pressure by 10.8%. Сonсlusion: Our protocol for physical rehabilitation of power sports athletes allows us to effectively and safely influence the oxidative capacity of working muscles and blood pressure.

scholarly journals Biliary reflux after laparoscopic modified antireflux monoanastomotic gastric bypass surgery

Pathologia ◽  
2021 ◽  
Vol 18 (3) ◽  
pp. 311-320
Author(s):  
M. V. Nikolaiev
Keyword(s):  
Morbid Obesity ◽  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Clinical Manifestations ◽  
Main Group ◽  
Mini Gastric Bypass ◽  
Control Group ◽  
Biliary Reflux ◽  
Gastric Bypass Operation

Aim. Determination of biliary reflux in patients with morbid obesity after a single-anastomotic gastric bypass operation performed in the clinic's modification and according to the classical Roux-en-Y gastric bypass technique. Development of diagnostic criteria for biliary reflux Materials and methods. The results of treatment of 36 patients with morbid obesity who underwent bypass surgery were studied. The patients are divided into two groups. Clinically modified laparoscopic monoanastomotic gastric bypass surgery was performed in 25 patients (main group). The control group included 11 patients after the standard technique of Roux-en-Y laparoscopic gastric bypass. Inclusion criteria were: persons of both sexes aged 18-60 years with morbid obesity and a body mass index of 40 or more, as well as 35 or more in the presence of comorbid diseases (type 2 diabetes mellitus, arterial hypertension, dyslipidemia, sleep apnea syndrome). In both groups, impedance pH measurements were performed in the postoperative period. Statistical processing was performed using the Statistica 13.0 software package using parametric and nonparametric statistical methods.  Results: Clinical manifestations of the enterogastric biliary reflex were found in both groups; in addition, clinical manifestations of the corresponding symptoms were noted by patients of both groups. The analysis of daily pH-metry in the studied groups showed that in the esophagus the time with pH <4 in the main group 2.83 (1.55; 3.95)% 3.00 (2.30; 3.50)% in the control group, time with pH 4-6.9 (physiological for the esophagus) 92.40 (90.65; 94.20)% and 94.10 (89.80; 95.50)%, respectively, time with pH> 7 (weak alkaline) was 4.80 (3.45; 5.85)% and in the control group 2.90 (1.20; 7.20)%. There was no statistically significant difference in these indicators (p> 0.05). Conclusions. Monoanastomotic gastric bypass surgery in the modification of the clinic has the same positive properties as the Rouen-Wye technique, allowing you to avoid the risks associated with possible pathological reflux of bile into the esophagus. Patients who have undergone mini-gastric bypass surgery require a thorough examination with fibrogastroscopy in combination with pH impedance measurement at least 1 time per year in order to determine biliary reflux and morphological changes both in the lumen of the esophagus and in the stomach stump. The level of quality of life of patients after surgery in the control group and the main group does not significantly differ, as evidenced by the results of the questionnaire survey using the GERG Q questionnaire, which indicates the effectiveness of the methodology of laparoscopic monoanastomotic gastric bypass surgery modified in the clinic. Key words: morbid obesity, gastric bypass surgery, surgical treatment, mini-gastric bypass, biliary reflux.

scholarly journals Selection of a topical preparation in the basic treatment of chronic hemorrhoids

2021 ◽  
pp. 80-88
Author(s):  
A. Ya. Ilkanich ◽  
K. Z. Zubailov ◽  
S. S. Kurbanov ◽  
A. A. Aysanov ◽  
Yu. S. Voronin ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Pain Syndrome ◽  
Main Group ◽  
Control Group ◽  
Topical Drugs ◽  
Comparison Groups ◽  
Group A ◽  
Prevalence Of Pain ◽  
Main Components ◽  
Rectal Suppositories

Introduction. The vast majority of recommendations for conservative treatment of patients with chronic hemorrhoids contain recommendations for the use of systemic drugs with venotonic and angioprotective properties and the use of topical drugs to treat and prevent exacerbation of the disease. The action of the main components of the topical drugs used is aimed at controlling local inflammation, implemented through various mechanisms. The choice of a drug is mainly subjective.Aim of the study. Comparative clinical evaluation of the effectiveness of topical drugs for the treatment of chronic hemorrhoids.Materials and methods. There are two treatment schemes that are distinguished by the type of the drug that is used. The main group includes patients in treatment of whom a combined preparation based on lidocaine and fluocortolone in the form of rectal suppositories manufactured by Bayer (221 (50.6%) patients) was used. In the control group – a combined preparation on the basis of tribenoside and lidocaine in the form of rectal suppositories by Recordati company (216 (49,4%) people). The rate of suppositories administration and duration of their use was 21 days. Clinical efficacy was estimated by the rate of regression of the main clinical manifestations of the disease: bleeding, pain syndrome, discomfort.Results and discussion. By the 14th day of treatment with Bayer preparation, bleeding as the main sign of disease exacerbation persisted in 15.2% (5) of the main patients against 26.7% (8) of the control group patients. Positive effect was obtained in the majority of patients with the initial prevalence of pain syndrome. On the 14th day the pain remained in 17.0% (8) patients of the main group against 27.9% (12) of the control group. Sense of discomfort was preserved in 10% (4) of the main group patients against 15.8% (6) of the control group patients. Regression of combined clinical manifestations of the disease in the comparison groups showed the fastest elimination of inflammation in the main group in 79.4% of patients against 73.0% in the control group on the 14th day of treatment.Conclusions. Thus, the use of Bayer preparation allowed ensuring the regression of the main clinical manifestations of the disease in a shorter time. This drug can be recommended for use in complex treatment of chronic hemorrhoids in everyday clinical practice.

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