scholarly journals The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action

2018 ◽  
Vol 17 (4) ◽  
pp. 65-71 ◽  
Author(s):  
V. A. Kurkin ◽  
E. N. Zaitceva ◽  
T. V. Morozova ◽  
O. E. Pravdivtseva ◽  
A. V. Dubishchev ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Comparative Study ◽  
Antidepressant Activity ◽  
Complex Treatment ◽  
Diuretic Activity ◽  
Cardiovascular Pathology ◽  
White Rats ◽  
Liquid Extract ◽  
The Comparative Study ◽  
Antidepressant Action

The purposeof the study is to study the urinative and antidepressant activities of liquid extracts based on flowers, shoots, leaves and fruits ofCrataegus sanguineaPall. to substantiate their use in the development and  manufacture of drugs for the complex treatment of cardiovascular diseases.Materials and methods.The comparative study of the diuretic and antidepressant activity of liquid extracts based on leaves, flowers, shoots and fruits Crataegus sanguinea was conducted. The liquid extracts were obtained on the basis of dried leaves, flowers, shoots and fruits of Crataegus sanguinea. All liquid extracts were obtained in the ratio “raw – extractant” 1 : 1, in all cases the extracting agent was ethyl alcohol 70%. The studies were conducted using outbred white rats of both sexes. All preparations were examined in a dose of 100 μl/kg. The diuretic activity of Crataegus sanguineaof liquid extracts in chronic experiments was determined, 4 h and 24 h portions of urine were collected. The antidepressant activity was tested using the “Desperation” testResults.During the experiment, the diuretic activity of the liquid extract Crataegus sanguinea, as well as the antidepressant activity of liquid extracts of Crataegus sanguinea, shoots and fruits were revealed. Conclusion. Crataegus sanguinea preparations have complex nephrotropic and neurotropic action and can be recommended for use in the cardiovascular pathology treatment.

scholarly journals NEUROTROPIC AND DIURETIC ACTIVITY OF THICK EXTRACT OF THE BLOOD-RED HAWTHORN’S FRUITS

2015 ◽  
Vol 14 (3) ◽  
pp. 18-22 ◽  
Author(s):  
V. A. Kurkin ◽  
A. V. Kurkina ◽  
Ye. N. Zaitseva ◽  
A. V. Dubishchev ◽  
O. Ye. Pravdivtseva ◽  
...  
Keyword(s):  
Body Weight ◽  
Herbal Medicines ◽  
Study Drug ◽  
Antidepressant Activity ◽  
Living Organism ◽  
Neurotropic Activity ◽  
Control Group ◽  
Diuretic Activity ◽  
Water Load ◽  
White Rats

Blood-red hawthorn (Crataegi fructus) are a popular cardiotonic herbal materials, which widely used in medical practice in our country and abroad. In order to prevent diseases of the cardiovascular system is appropriate to prescribe herbal medicines, because they combine the breadth and softness of therapeutic action, along with the absence of a significant number of side effects and contraindications.The purpose was to study diuretic and antidepressant activity of thick fruit extract of blood-red hawthorn.Material and methods. Under laboratory conditions we obtained a thick extract of blood-red hawthorn fruits. This phytopharmaceutical was studied by us for any diuretic and antidepressant activity. Investiga- tions were carried out on white rats of both sexes weighing 200–220 g. Each experimental group consist- ed of ten animals. Study drug was administered intragastrically by stomach tube. Control in both cases served as purified water. For determination of diuretic activity, we used a thick extract of hawthorn fruits in a dose of 20 mg/kg against the background of the water load in the amount of 3% of body weight of the animal. Reference preparation was chosen dichlorthiazid 20 mg/kg. It was administered once. After ad- ministration the animals were placed in metabolic cages for urine collection for 24 hours. The study de- termined diuresis, natriuresis, kaliuresis, and kreatininuresis for 4 h and 24 h of the experiment. On the day of the experiment the animals of the control group was administered water load of 3%, and experi- enced – intragastrically drug in an identical amount. Animals were placed in a metabolic cage for a day. Collected 4 h and 24-h urine sample. Determined by renal excretion of water was recorded concentration of sodium and potassium by flame photometry in the fiery liquid analyzer PAG-1, creatinine – colorimet- ric method for photocolorimeter CFC-3. For determining antidepressant activity we used a thick hawthorn extract in a dose of 25 mg/kg of animal body weight. As a synthetic drug comparisons, we used amitriptilin 5 mg/g.Results. It was found that the thick extract of fruits of blood red hawthorn in a dose of 20 mg/kg for 24 hours increases the diuresis experiment, both by increasing the glomerular filtration rate and by lowering tubular reabsorption. For thick extract of fruits of hawthorn blood-red characteristic expression antide- pressant activity.Conclusion. The studied preparation of blood-red hawthorn’s fruits have properties to provide complex nephrotropic and neurotropic activity on the living organism.

scholarly journals Fruits of Crataegus submollis: study of pharmacological activity of the preparations

2019 ◽  
Vol 4 (3) ◽  
pp. 69-72
Author(s):  
V. A Kurkin ◽  
E. N Zaitceva ◽  
O. E Pravdivtseva ◽  
A. V Kurkina ◽  
V. V Stenyaeva
Keyword(s):  
Antidepressant Activity ◽  
Threshold Dose ◽  
Antidepressant Effect ◽  
Control Group ◽  
Diuretic Activity ◽  
Water Control ◽  
Excretory Function ◽  
Motion Activity ◽  
Liquid Extract ◽  
The Impact

Objectives - to perform a comparative study of the antidepressant action and diuretic activity of liquid extract and decoction of the fruits of Crataegus submollis Sarg. Material and methods. The study of the antidepressant activity was performed using the behavioral despair test. The diuretic activity of the liquid extract and decoction from the Crataegus submollis fruits at a dose of 100 pl/kg was evaluated in long-term experiments. Results. The study revealed the impact of the liquid extract of Crataegus submollis fruits, at a dose of 100 pl/kg, on the motion activity of animals: it increased by 45% if compared to the water-alcohol control group, and equivalent to comparator amitriptyline at a threshold dose of 5 mg/kg. While the diuretic activity of the the liquid extract was not registered. At the same time, the decoction of the fruits of Crataegus submollis, at a dose of 100 pl/kg, did not show antidepressant properties, when compared to water control. It was found that animals from the experimental group relative to water control had a statistically significant increase in renal excretion of water, sodium, potassium and creatinine, equivalent to comparators - furosemide at a threshold dose of 1 mg/kg (4 hours experiment), and hydrochlorothiazide at a mean therapeutic dose of 20 mg/kg (24 hours experiment). Conclusion. The liquid extract from fruits of Crataegus submollis at a dose of 100 |rl/kg showed an antidepressant effect, comparable to the effect of amitriptyline at a dose of 5 mg/kg. An expressed stimulating activity on the kidneys excretory function during the 4 and 24 hours of the experiment is characteristic of the decoction from fruits of Crataegus submollis at a dose of 100 |rl/kg. The fruits of Crataegus submollis Sarg. are promising medicinal plant raw materials.

scholarly journals Comparison of pharmacological activity of hawthorn fruits preparations

2020 ◽  
Vol 5 (2) ◽  
pp. 136-139
Author(s):  
Vladimir A. Kurkin ◽  
Elena N. Zaitceva ◽  
Elena V. Avdeeva ◽  
Viktoriya V. Stenyaeva ◽  
Ilnur Kh. Shaikhutdinov ◽  
...  
Keyword(s):  
Comparative Study ◽  
Raw Materials ◽  
Antidepressant Activity ◽  
Diuretic Action ◽  
Plant Raw Materials ◽  
Alcohol Water ◽  
Diuretic Agents ◽  
The Comparative Study ◽  
White Mongrel ◽  
Saluretic Activity

Objectives - a comparative study of antidepressant activity and diuretic action of water and water-alcohol preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. Materials and methods. The study covers the water and alcohol-water extracts from the fruits of hawthorn blood-red (Crataegus sanguinea Pall.) and Quebec hawthorn (Crataegus submollis Sarg.). The comparative study of the antidepressant activity and the diuretic action of the preparations was carried out on white mongrel rats of both sexes. Results. The liquid extracts of fruits Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 μl/kg revealed an antidepressant activity. Decoctions of Crataegus sanguinea Pall. and Crataegus submollis Sarg. at a dose of 100 μl/kg had a pronounced diuretic and saluretic activity. Pharmacotherapeutic effects of the studied preparations can be explained by the presence of flavonoids in them. Conclusion. The preparations of the fruits of Crataegus sanguinea Pall. and Crataegus submollis Sarg. can be recommended as antidepressant and diuretic agents. The fruits of Crataegus submollis Sarg. are the promising medicinal plant raw materials.

Pandhawa Gubah sebagai Representasi Interaksi Metafisik Manusia Jawa dan Perbandingannya dengan Cheritera Pandawa Lima

Manuskripta ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 67
Author(s):  
Novarina Novarina
Keyword(s):  
Comparative Study ◽  
Literary Theory ◽  
Research Method ◽  
Descriptive Analysis ◽  
Literary Study ◽  
Analysis Method ◽  
Research Objects ◽  
Similarities And Differences ◽  
The Difference ◽  
The Comparative Study

Abstract: This research is a comparative literary study that uses Malay and Javanese versions of Mahabarata text sources. The research objects used were the text edition of Pandhawa Gubah (PG) by Sudibjo Z. Hadisutjipto and the text of Cheritera Pandawa Lima (CPL) by Khalid Hussain. The research method used is descriptive-analysis method. In the comparative study used a comparative literary theory proposed by Endraswara (2011). The results of the text comparison reveal the similarities and differences in the image of Bima figures in the Javanese and Malay versions. The equation as a whole is that both texts contain the same heroic storyline and heroic character, Bima. In addition, Indian influence is still evident in the two texts seen from the nuances of Hinduism that exist in both texts. While the difference is seen in the events that accompany Bima's struggle in achieving his victory. Based on these similarities and differences, it can be seen that the authors attempt to represent the concept of metaphysical interactions vertically and horizontally expressed through PG text. --- Abstrak: Penelitian ini adalah satu kajian sastra bandingan yang menggunakan sumber teks Mahabarata versi Melayu dan Jawa. Objek penelitian yang digunakan adalah edisi teks Pandhawa Gubah (PG) karya Sudibjo Z. Hadisutjipto dan teks Cheritera Pandawa Lima (CPL) karya Khalid Hussain. Metode penelitian yang digunakan adalah metode deskriptif-analisis. Dalam telaah perbandingan digunakan teori sastra bandingan yang dikemukakan Endraswara (2011). Hasil perbandingan teks mengungkapkan adanya persamaan dan perbedaan citra tokoh Bima dalam versi Jawa maupun versi Melayu. Persamaan secara keseluruhan adalah kedua teks tersebut mengandung alur cerita kepahlawanan dan tokoh pahlawan yang sama yaitu Bima. Selain itu, pengaruh India masih tampak dalam kedua teks tersebut dilihat dari nuansa Hinduisme yang ada dalam kedua teks. Sementara perbedaannya tampak pada peristiwa-peristiwa yang menyertai perjuangan Bima dalam mencapai kemenangannya. Berdasarkan persamaan dan perbedaan tersebut tampak adanya upaya penulis untuk merepresentasikan konsep interaksi metafisik secara vertikal dan horizontal yang diungkapkan melalui teks PG.

Auslandswissenschaft und kontrastive Kulturkomparatistik

2008 ◽  
Vol 2008 (1) ◽  
pp. 37-44
Author(s):  
Teruaki Takahashi
Keyword(s):  
Comparative Study ◽  
Intercultural Communication ◽  
Cultural Comparison ◽  
Intercultural Understanding ◽  
The Comparative Study

In the context of the controversies surrounding »globalisation« and In the context of the controversies surrounding »globalisation« and »multiculturality« the comparative study of cultures has the task of aiding intercultural communication and of contributing to the success of intercultural understanding. The model of contrastive cultural comparison discussed here is claimed to have applacibility to every possible study of other countries (»Auslandswissenschaft«) and to be able to provide the Geisteswissenschaften with an intercultural orientation.

Sign in / Sign up

Export Citation Format

Share Document