Hematology parameters aid to differentiate Indian SARS-CoV-2 positive patients from suspected cases

2021 ◽  
Author(s):  
Shanaz Khodaiji ◽  
Binu Jacob ◽  
Dia Mansukhani
Keyword(s):  
Hematology Parameters

Complex biological patterns of hematology parameters in childhood necessitating age‐ and sex‐specific reference intervals for evidence‐based clinical interpretation

2020 ◽  
Vol 42 (6) ◽  
pp. 750-760
Author(s):  
Mary Kathryn Bohn ◽  
Victoria Higgins ◽  
Houman Tahmasebi ◽  
Alexandra Hall ◽  
En Liu ◽  
...  
Keyword(s):  
Reference Intervals ◽  
Specific Reference ◽  
Evidence Based ◽  
Clinical Interpretation ◽  
Hematology Parameters ◽  
Biological Patterns ◽  
Age And Sex

A Micro-Fabricated Electrical-Impedance-Based In-Flight Hematology Analyzer

2005 ◽  
Author(s):  
Bradley E. Layton ◽  
Brian G. Jamieson ◽  
Stephanie M. Sullivan
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Electrical Impedance ◽  
Cell Distribution ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Red Blood Cell Count ◽  
Hematology Parameters ◽  
Microchannel Device ◽  
Red Blood Cell Distribution

We present a proposed method to obtain three hematology parameters: red blood cell count, mean red blood cell volume and red blood cell distribution width on a microfabricated microchannel device. Detection will be conducted with an impedance device, in a series of three or more filter beds with channel dimensions on the order of 2–7 μm wide × 5 μm high × 5–15 μm long, and a total device volume on the order of 1 μl.

scholarly journals Preliminary study to identify severe from moderate cases of COVID-19 using combined hematology parameters

2020 ◽  
Vol 8 (9) ◽  
pp. 593-593 ◽  
Author(s):  
Changzheng Wang ◽  
Rongrong Deng ◽  
Liyao Gou ◽  
Zhongxiao Fu ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Preliminary Study ◽  
Hematology Parameters

scholarly journals Historical control data for hematology parameters obtained from toxicity studies performed on different Wistar rat strains: Acceptable value ranges, definition of severity degrees, and vehicle effects

2020 ◽  
Vol 4 ◽  
pp. 239784732093148
Author(s):  
Marlies de Kort ◽  
Klaus Weber ◽  
Björn Wimmer ◽  
Katharina Wilutzky ◽  
Patricia Neuenhahn ◽  
...  
Keyword(s):  
Health Status ◽  
Strain Differences ◽  
Wistar Rat ◽  
Historical Control ◽  
Data Sets ◽  
Rat Strains ◽  
Control Data ◽  
Data Set ◽  
Hematology Parameters ◽  
Historical Control Data

The physiological and health status of control animals may vary. Due to this variation, it is important to define acceptable ranges of control hematology parameters to gain a better understanding of adverse and non-adverse effects of test substances. After generating historical control data for two Wistar rat strains (RccHan™:WIST and Crl:WI(Han)) from different breeders, the data sets were statistically analyzed using Minitab®. After noticing that single outliers can affect the study control data set, the respective outliers were verified relative to the available histopathology findings, for example, inflammatory pulmonary lesions following vehicle aspiration or spontaneous sperm granuloma affecting the health status and hematology data of the respective animals. Such data points were excluded from the control data set. Comparing both data sets, it was obvious that different blood sampling and anesthesia methods as well as strain differences may result in slightly different values. After excluding the outliers, a data set from animals with presumably good health status was generated to define acceptable ranges and severity degrees. To evaluate effects, possibly influencing hematology parameters and defined acceptable ranges, selected vehicles and different study types were observed.

Thirteen-Week Oral Toxicity Study of l-Glutamine in Rats

2004 ◽  
Vol 23 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Shoji Tsubuku ◽  
Kazuhisa Hatayama ◽  
Kazunori Mawatari ◽  
Miro Smriga ◽  
Takeshi Kimura
Keyword(s):  
Ketone Bodies ◽  
Recovery Period ◽  
Control Group ◽  
Standard Diet ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Urine Ph ◽  
Toxicological Effects ◽  
Adverse Effect Level ◽  
Hematology Parameters

l-Glutamine (Gln) is a semiessential amino acid used in enteral feeding in critically ill patients, and is contained in numerous dietary supplements available to the general public. This study evaluated toxicological effects of Gln in male and female Sprague-Dawley rats. Gln produced by Ajinomoto Co. (Tokyo, Japan) was incorporated into a standard diet at doses equal to 1.25%, 2.5%, and 5.0% ( w/ w), respectivelly. A control group of rats received only a standard diet. All diets were administered ad libitum for 13 consecutive weeks. To examine recoverability of any potential effects, the administration period was followed by a 5-week recovery period, during which only the standard diet was provided to all animals. Throughout the administration and recovery periods, no deaths were observed, and no changes in diet consumption, ophthalmologic findings, gross pathology, and histopathology were detected. Several changes in urine parameters (total protein, urine pH, and a positive incidence (±) of ketone bodies) were observed in the 2.5% and 5.0% groups at the end of the administration period. Minor increases were found in hematology parameters for the 5.0% group (platelet count, γ-globulin, lactate dehydrogenase [LDH]), but all changes were within physiological range. No effects of administration were observed in the 1.25% group. The no-observed-adverse-effect level (NOAEL) for Gln was estimated at 1.25% for both genders (males 0.83 ± 0.01 g/kg/day; females, 0.96 ± 0.06 g/kg/day).

Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys

2005 ◽  
Vol 12 (1) ◽  
pp. 72-75 ◽  
Author(s):  
Henk-Jan Schuurman ◽  
Harold T Smith
Keyword(s):  
Reference Values ◽  
Clinical Chemistry ◽  
Cynomolgus Monkeys ◽  
Hematology Parameters

Intravenous Safety Study in Rats Given Paramagnetic, Polystyrene Beads with Covalently Bound Sheep Anti-Mouse Immunoglobulin G (IgG)

1995 ◽  
Vol 14 (4) ◽  
pp. 251-265 ◽  
Author(s):  
R. D. White ◽  
J. A. Glosson ◽  
D. E. Gordon ◽  
S. J. Northup
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
Clinical Chemistry ◽  
Reticuloendothelial System ◽  
Female Rats ◽  
Significant Group ◽  
Treatment Groups ◽  
Male And Female Rats ◽  
Body Weight Data ◽  
Hematology Parameters

The potential for acute toxicity from Dynabeads1 M-450 Sheep Anti-Mouse IgG ST (SAM-Beads) administered once intravenously to male and female rats was assessed. SAM-Beads in saline containing 0.5% plasma protein fraction (PPF) was intravenously administered at dosages of 9.6 times 104 or 8.3 times 108 beads/kg at a rate of ≥2.5 ml/min/kg. Rats administered 9.6 times 104 beads/kg were killed 14 days posttreatment. Rats administered 8.3 times 108 beads/kg were killed either 14 or 42 days posttreatment. Saline containing 0.5% PPF served as the control article. Treatment groups were statistically compared with respect to clinical chemistry, hematology parameters, and body weight data. No significant group differences were detected (α = 0.01) with respect to any statistically analyzed data. No SAM-Beads were detected in urine samples collected overnight posttreatment. No test beads were found in any of the tissues from animals administered 9.6 times 104 beads/kg. The SAM-Beads were evident in the lung, liver, spleen, lymph nodes, kidney, and sternal bone marrow of rats administered 8.3 times 108 beads/kg and killed 14 or 42 days posttreatment. The SAM-Beads observed were recognized as a foreign body and were phagocy-tized by cells of the reticuloendothelial system. The majority of the SAM-Beads were found in the lung, liver, and spleen and were slightly more numerous among animals who were killed at 14 days. There was also a trend toward an increased incidence and/or distribution of phagocytized beads in the bone marrow of animals killed 42 days posttreatment when compared with the 14-day killed animals. A few extracellular beads were present in the lymph nodes, kidneys, and sternal bone marrow. Under the conditions of this study, intravenous administration of Dynabeads M-450 Sheep Anti-Mouse IgG ST did not result in any adverse test-article-related macroscopic, clinical pathologic, or histopathologic changes.

scholarly journals The Utility of a Three Part Differential Hematology Analyzer with CRP for Assessing Malaria

2020 ◽  
Author(s):  
Jun Ivan Nishimura ◽  
Parag Dharap ◽  
Sebastien Raimbault
Keyword(s):  
Malaria Infection ◽  
Statistical Difference ◽  
Monsoon Season ◽  
Statistical Significance ◽  
Malaria Diagnosis ◽  
Hematology Analyzer ◽  
Hematology Parameters ◽  
Microscopic Findings ◽  
Different Levels ◽  
Differential Part

Abstract BackgroundHematology analyzers display abnormal hematology parameters during malaria infection providing insightful information for suspecting and assessing malaria infection. The goal of this study is to demonstrate the potential of a three part differential hematology analyzer to assess malaria, provide information about the parasitemia, and discuss the importance of combining CRP with hematology parameters to obtain further information about the malaria infection.MethodsThe present study shows the results of a retrospective study involving comparison of raw instrument data from a three part differential hematology analyzer with CRP measurement and corresponding microscopic findings of samples obtained during the monsoon season of years 2018 and 2019 in Mumbai, India. Mann-Whitney U and Krustal-Wallis tests were applied for obtaining statistical significance of hematology parameters and CRP among P. vivax, P. falciparum, dengue and negative samples. ResultsThe study considers 1008 non-malaria febrile cases, 209 P. vivax, 31 P. falciparum positive malaria samples, five cases of mixed species malaria infection, and three co-infection of malaria and dengue. Median values of WBCs, PLTs, PCT and %LYM were lower in malaria and dengue samples compared to negative ones with statistical difference (p < 0.05). Contrary, medians of MCHC, MPV, PDW, and %MON were higher than negative samples. The greatest difference in the analyzer results of malaria and dengue cases was observed in between their medians of CRP levels, which is evidenced by the values of the first quartiles of P. vivax and P. falciparum cases, and the third quartile of dengue cases being 8.6 and 10.4 mg/L, respectively.The parameters with a statistical difference for different levels of parasitemia were WBC, PLT, %MON and CRP. An interfering abnormal peak was observed in the white blood cell histogram, below 37 fl, in malaria infected samples, especially in P. vivax cases, where the height of that peak showed a strong correlation with red blood cells infected predominantly with larger parasitic forms.ConclusionsA three differential part hematology analyzer has the potential to not only trigger malaria diagnosis confirmation but also assess the severity of the infection when CRP is considered.

scholarly journals Exploring the value of routinely measured hematology parameters for identification of elderly patients at high risk of death at the Emergency Department

2018 ◽  
Vol 17 (4) ◽  
pp. 188-202
Author(s):  
Renuka S Bindraban ◽  
◽  
Maarten J ten Berg ◽  
Saskia Haitjema ◽  
Imo E Hoefer ◽  
...  
Keyword(s):  
Emergency Department ◽  
High Risk ◽  
Hematological Parameters ◽  
Added Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Risk Of Death ◽  
Laboratory Results ◽  
Risk Patients ◽  
Hematology Parameters

Of the warning scores in use for recognition of high-risk patients at the Emergency Department (ED), few incorporate laboratory results. Although hematological characteristics have shown prognostic value in small studies, large studies in elderly ED populations are lacking. We studied the association between blood cell and platelet counts and characteristics as well as C-reactive protein (CRP) at ED presentation with mortality in non-multitrauma patients ≥ 65 years. Comparison between survivors and non-survivors showed small, significant differences with AUROCs ranging between 56.6% and 65.2% for 30-day mortality. Combining parameters yielded an evident improvement (AUROC of 70.4%). Efforts should be pursued to study the added value of hematological parameters on top of clinical data when assessing patient risk.

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