Supercritical CO2 Assisted Drug Loading and Degradation Behavior and Osteogenicity of Magnesium Alloy Matrix Calcium- Phosphorus-Chitosan-Graphene Oxide Bone Material

Cancer is one of the greatest health challenges in the world. Every year, many people die because of cancer. Chemotherapy is one of the treatment options in cancer disease. Fluorouracil )5-FU( is one of the chemotherapy dr0075gs, but it has relatively low toxic effect on tumor cells when it is used on free form, which also results in its poor efficacy. GO (graphene oxide) has a single-atomic layer and has several functional groups such as epoxide, carbonyl, carboxyl and hydroxyl which makes it a suitable carrier for drug loading. In the present study, we loaded 5-FU on GO nanocarrier to produce GO/5-FU, and characterized it by FT-IR. CT26 Ds-Red adenocarcinoma cell line was treated with GO/5-FU, free 5-FU, GO, and PBS (Phosphate buffer saline). The results showed significant inhibition of the CT26 Ds-Red cells using GO/5-FU compared to free 5-FU (P<0.05). Therefore, loaded 5-FU on GO (GO/5-FU) could be a new approach for optimization of 5-FU tumor cytotoxicity.

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Silver Self-Diffusion in Al2O3/QE22 Magnesium Alloy Matrix Composite

Defect and Diffusion Forum ◽

10.4028/www.scientific.net/ddf.283-286.155 ◽

2009 ◽

Vol 283-286 ◽

pp. 155-160

Author(s):

Ivo Stloukal ◽

Jiří Čermák

Keyword(s):

Magnesium Alloy ◽

Temperature Dependence ◽

Temperature Interval ◽

Matrix Composite ◽

Diffusion Coefficients ◽

Volume Diffusion ◽

Effective Diffusion ◽

Measured Temperature ◽

Alloy Matrix ◽

Self Diffusion

Self-diffusion of 110mAg has been investigated in fiber reinforced QE22 magnesium alloy matrix composite. Short Saffil fibers (97% -Al2O3 + 3% SiO2) were used as reinforcement. The diffusion measurements were carried out in the temperature interval 648 – 728 K by serial sectioning method. The volume diffusion coefficients Dv (alloy without reinforcement) and the effective diffusion coefficients Deff (alloy with reinforcement) were obtained by analysis of the penetration curves. The silver diffusion coefficient in the interface boundary matrix/Saffil Di was also estimated. The temperature dependence of volume diffusion coefficients Dv was compared with previous data measured using 65Zn in the same alloy and with literature data for Zn impurity diffusion in Mg single crystal. It was observed, that the temperature dependence of both Deff and Di was significantly non-linear in the measured temperature interval. This behavior supports previous observations with zinc diffusion in the same alloy.

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An in-situ Degradation Behavior Study of MAO Coating on AZ91D Magnesium Alloy in Aqueous Solutions by SECM

International Journal of Electrochemical Science ◽

10.20964/2017.03.65 ◽

2017 ◽

pp. 2145-2158 ◽

Cited By ~ 1

Author(s):

Yan Xia ◽

Keyword(s):

Magnesium Alloy ◽

Aqueous Solutions ◽

Degradation Behavior ◽

Az91d Magnesium Alloy ◽

Behavior Study ◽

In Situ Degradation

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Fabrication and degradation behavior of micro-arc oxidized biomedical magnesium alloy wires

Surface and Coatings Technology ◽

10.1016/j.surfcoat.2012.10.078 ◽

2012 ◽

Vol 213 ◽

pp. 307-312 ◽

Cited By ~ 32

Author(s):

C.L. Chu ◽

X. Han ◽

J. Bai ◽

F. Xue ◽

P.K. Chu

Keyword(s):

Magnesium Alloy ◽

Degradation Behavior

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Preparation and Characterization of Graphene Oxide Aerogels: Exploring the Limits of Supercritical CO2 Fabrication Methods

Chemistry - A European Journal ◽

10.1002/chem.201803368 ◽

2018 ◽

Vol 24 (59) ◽

pp. 15903-15911 ◽

Cited By ~ 3

Author(s):

Alejandro Borrás ◽

Gil Gonçalves ◽

Gregorio Marbán ◽

Stefania Sandoval ◽

Susana Pinto ◽

...

Keyword(s):

Graphene Oxide ◽

Supercritical Co2

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Graphene and its derivatives as biomedical materials: future prospects and challenges

Interface Focus ◽

10.1098/rsfs.2017.0056 ◽

2018 ◽

Vol 8 (3) ◽

pp. 20170056 ◽

Cited By ~ 38

Author(s):

Arghya Narayan Banerjee

Keyword(s):

Tissue Engineering ◽

Cell Culture ◽

Graphene Oxide ◽

Cell Growth ◽

Drug Loading ◽

Chemical Properties ◽

Culture Cell ◽

Biomedical Materials ◽

Physico Chemical ◽

Bio Imaging

Graphene and its derivatives possess some intriguing properties, which generates tremendous interests in various fields, including biomedicine. The biomedical applications of graphene-based nanomaterials have attracted great interests over the last decade, and several groups have started working on this field around the globe. Because of the excellent biocompatibility, solubility and selectivity, graphene and its derivatives have shown great potential as biosensing and bio-imaging materials. Also, due to some unique physico-chemical properties of graphene and its derivatives, such as large surface area, high purity, good bio-functionalizability, easy solubility, high drug loading capacity, capability of easy cell membrane penetration, etc., graphene-based nanomaterials become promising candidates for bio-delivery carriers. Besides, graphene and its derivatives have also shown interesting applications in the fields of cell-culture, cell-growth and tissue engineering. In this article, a comprehensive review on the applications of graphene and its derivatives as biomedical materials has been presented. The unique properties of graphene and its derivatives (such as graphene oxide, reduced graphene oxide, graphane, graphone, graphyne, graphdiyne, fluorographene and their doped versions) have been discussed, followed by discussions on the recent efforts on the applications of graphene and its derivatives in biosensing, bio-imaging, drug delivery and therapy, cell culture, tissue engineering and cell growth. Also, the challenges involved in the use of graphene and its derivatives as biomedical materials are discussed briefly, followed by the future perspectives of the use of graphene-based nanomaterials in bio-applications. The review will provide an outlook to the applications of graphene and its derivatives, and may open up new horizons to inspire broader interests across various disciplines.

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