scholarly journals Role of Hematological Parameters: RDW, MPV, PDW as Predictive Markers in Prevention of Complications in Uncontrolled Type 2 DM (Diabetes Mellitus)

2020 ◽  
Vol 9 (2 (Part- I)) ◽  
pp. 89-93
Author(s):  
Ramesh S T
Keyword(s):  
Diabetes Mellitus ◽  
Hematological Parameters ◽  
Predictive Markers ◽  
Type 2 Dm

scholarly journals Role of CHA2DS2-VASc score in predicting new-onset atrial fibrillation in patients with type 2 diabetes mellitus with and without hyperosmolar hyperglycaemic state: real-world data from a nationwide cohort

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020065 ◽  
Author(s):  
Wei-Syun Hu ◽  
Cheng-Li Lin
Keyword(s):  
Diabetes Mellitus ◽  
Atrial Fibrillation ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Predictive Ability ◽  
Type 2 Dm ◽  
History Of ◽  
New Onset

PurposeThe objective of the current study was to explore the role of CHA2DS2-VASc score in predicting incidence of atrial fibrillation (AF) in patients with type 2 diabetes mellitus (DM). Furthermore, the use of the CHA2DS2-VASc score for stratifying new-onset AF risk in patients with DM and with/without hyperosmolar hyperglycaemic state (HHS) was also compared.MethodsThe study subjects were identified from Longitudinal Health Insurance Database provided by the National Health Research Institutes. The patients with DM were divided into two groups based on a history of HHS or not. The predictive ability of CHA2DS2-VASc score for stratifying new-onset AF risk in the two groups was calculated using the area under the curve of receiver-operating characteristic (AUROC).ResultsThe present study involved a total of 69 530 patients with type 2 DM. Among them, 1558 patients had a history of HHS, whereas 67 972 patients did not. The AUROC of the CHA2DS2-VASc score as a predictor of incident AF in patients with DM and with/without HHS was 0.67 (95% CI 0.59 to 0.75) and 0.71 (95% CI 0.70 to 0.72), respectively.ConclusionsTo conclude, we reported for the first time on the assessment of CHA2DS2-VASc score for incident AF risk discrimination in patients with type 2 DM. We further found that the predictive ability of the CHA2DS2-VASc score was attenuated in patients with type 2 DM and with HHS in comparison with those without HHS.

scholarly journals Role of comprehensive diabetes care in known diabetes patients from Gujarat state

2020 ◽  
Vol 7 (9) ◽  
pp. 1388
Author(s):  
Rohit Sane ◽  
Rahul Mandole ◽  
Gurudutt Amin ◽  
Pravin Ghadigaokar ◽  
Sneha Paranjape ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Retrospective Study ◽  
First Century ◽  
Obese Patients ◽  
Gujarat State ◽  
Type 2 Dm ◽  
Number Of Patients ◽  
The Mean

Background: Diabetes mellitus (DM) stays as one of the audacious worldwide plagues of the twenty-first century. As per an epidemiological study done in Gujarat, prevalence rate of DM was found to be >8%. CDC therapy is Panchkarma based Ayurvedic therapy for the management of DM. The aim of the present study was to analyze the effectiveness of CDC in patients of DM.Methods: This was a retrospective study conducted at Madhavbaug clinics located in Gujarat, wherein we identified the data of obese patients suffering from type 2 DM (HbA1c ≥6.5%) of either gender and any age. Out of these, data of patients who had been administered CDC with minimum 6 sittings over a span of 12 weeks were considered for the study.Results: Out of 98 patients, number of patients with controlled DM status increased and that with uncontrolled status reduced at week 12, and the mean HbA1c reduced from 8.55 at baseline to 7.15 at week 12 of CDC therapy. Other anthropometric, cardiorespiratory parameters showed statistically significant improvement after 12 week of CDC therapy as compared to baseline, and the consumption of allopathic medications was also significantly reduced.Conclusions: From the findings of the present study, it can be concluded that CDC can serve as effective therapy for management of type 2 DM.

Evaluation of Galectin1 gene, miRNA22 and LncRNA MEG3 in type2 diabetic patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Manar Fouad Ahmed ◽  
Randa Ali-Labib ◽  
Walid Said Zaki ◽  
Marwa Mahmoud Abd El Hameid ◽  
Khaled Mahmoud Makboul
Keyword(s):  
Diabetes Mellitus ◽  
Statistical Significance ◽  
Research Field ◽  
Diabetic Patients ◽  
Healthy Individuals ◽  
Serum Samples ◽  
Type 2 Dm ◽  
Detection And Diagnosis

Abstract Background Diabetes mellitus is considered the ninth major cause of death, biomarkers have been investigated in DM research field to understand the pathophysiology of DM, help in diagnosis and find new therapeutics. This study evaluated the role of Galectin 1, LncRNA MEG3, miR22 in T2DM. Aim of the work we aimed to evaluate the role of galectin 1 expression in type 2 DM and to explore the epigenetic regulatory effect of miRNA22 and LncRNA, MEG3 on gelatin 1 expression in type 2 DM Materials and methods The study included two groups: Fifteen type 2 diabetes mellitus patients and fifteen normal healthy individuals. Blood samples were collected from every participant and serum was separated. Expressions of Gal-1, LncRNA MEG3, miR22 were assessed in each serum sample by quantitative real time polymerase chain reaction (qRT-PCR). Results The study revealed higher levels of gal-1, miR22 and lower levels of MEG3 in serum samples of T2DM Patients compared to normal healthy individuals with statistical significance difference (p < 0.05). Conclusion Gal-1, MEG3, miR22 may play a role in the pathophysiology of T2DM. Studies with larger sample sizes are required to further confirm their role in early detection and diagnosis of T2DM.

510 PERIPHERAL ARTERIAL DIASESE AND TYPE 2 DIABETES MELLITUS: ROLE OF INFLAMMATORY AND HEMATOLOGICAL PARAMETERS

2011 ◽  
Vol 12 (1) ◽  
pp. 108-109
Author(s):  
J. Mancera ◽  
J. Rioja ◽  
M.A. Sánchez-Chaparro ◽  
T. Moreno ◽  
M.R. Sánchez-Pérez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Hematological Parameters ◽  
Peripheral Arterial

scholarly journals A Single-Blinded, Randomized Controlled Study - Role of Probiotics on Glucose and Lipid Metabolism in Patients with Type - 2 Diabetes Mellitus in a Tertiary Care Hospital, Odisha

2021 ◽  
Vol 8 (22) ◽  
pp. 1797-1802
Author(s):  
Santosh Kumar Swain ◽  
Aswini Kumar Rout ◽  
Sriprasad Mohanty ◽  
Prabhat Kumar Padhi ◽  
Roma Rattan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Metabolism ◽  
Intestinal Permeability ◽  
Density Lipoprotein ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Glucose And Lipid Metabolism ◽  
Type 2 Dm

BACKGROUND Diabetes mellitus (DM) is a metabolic disorder, characterized by hyperglycaemia, insulin deficiency and insulin resistance. Along with diet, exercise, and oral antidiabetic drugs (OADs), probiotic intervention in novel food formulations enriched with specific bacterial strains could also be effective. In patients with type 2 DM and obesity, there is alteration in composition of the gut microbiota resulting in moderation of intestinal permeability and increasing endotoxin secretion. The utility of probiotic therapy in the management of type 2 DM has not been fully explored. Probiotics also regulate gut microflora and plasma lipids. The study was designed with a purpose of assessing the role of probiotics in glucose and lipid metabolism and its effectiveness in controlling blood sugar and lipid profile in type 2 DM. METHODS The single-blind randomized controlled study was conducted from February 2019 to January 2020 in the Department of Medicine, SCB Medical College and Hospital, Cuttack, in patients of type 2 DM. A total of 80 patients were included in the study with 40 as cases and another 40 as controls. Statistical analysis was performed using SPSS version 20. The mean ± standard deviation, median and ranges were calculated using chi square test and independent t-test. The level of significance was considered as P < 0.05. RESULTS The FBS and HbA1C levels were decreased by 16 mg / dl and 0.5 % respectively after consuming probiotics (P < 0.001). The total cholesterol, triglyceride, low density lipoprotein was decreased and high density lipoprotein level was increased after taking probiotics which was significant (P < 0.001). Probiotics help in cholesterol reduction through different mechanisms. CONCLUSIONS Probiotics have a definite role in improving glycaemic status and lipid levels in type 2 DM. KEYWORDS Glycosylated Haemoglobin, Type 2 DM, Probiotics, Intestinal Permeability

scholarly journals Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Elena Garcia-Martin ◽  
Marta Cipres ◽  
Isabel Melchor ◽  
Laura Gil-Arribas ◽  
Elisa Vilades ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Disease Duration ◽  
Vascular Complications ◽  
Rnfl Thickness ◽  
Type 2 Dm

Purpose. To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes. Methods. Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. Peripapillary RNFL thickness was assessed using Glaucoma and Axonal Analytics applications. Comparison between patients with the presence/absence of systemic vascular complications and different disease duration was made. Results. Macular GCL was reduced in patients compared to controls (p<0.001). Differences in the macular RNFL thickness were only observed in the outer inferior sector (p=0.033). A reduction in the peripapillary RNFL (average, inferior, and inferotemporal thickness, p<0.05 for all three) was observed in patients using both applications. Patients with chronic systemic vascular complications presented a reduction in the temporal RNFL (p=0.019) compared to patients without complications. The superotemporal RNFL thickness was thinner in patients with longer disease duration. Conclusions. Patients with type 2 DM without diabetic retinopathy and good metabolic control present neurodegeneration affecting neurons in the macular area and axons in different sectors of the optic disc. Systemic vascular complications contributed to further axonal damage in these patients, suggesting a possible role of subclinical ischaemia to retinal neurodegeneration in type 2 DM.

scholarly journals Content of sP-selectin and Cytokines in Blood of Patients with Type 2 Diabetes Mellitus and Arterial Hypertension Depending on Diabetes Compensation Condition

2016 ◽  
Vol 8 (2) ◽  
pp. 123 ◽  
Author(s):  
A. M. Urbanovych ◽  
H. I. Suslyk ◽  
Kh. Yu. Kozlovska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Arterial Hypertension ◽  
Blood Serum ◽  
Assay Method ◽  
Type 2 Dm ◽  
Tnf Α

<p>The goal of our research has been to study sР-selectin and cytokine content changes, namely ІL-2, ІL-6 and TNF-α in blood plasma of patients with type 2 diabetes mellitus with varying compensation for the disease and arterial hypertension, as well as to investigate a possible interrelation between sР-selectin and cytokines. To achieve the goal 137 patients with type 2 diabetes mellitus with AH of the І-ІІ stages and without AH (72 women and 65 men) have been examined. The levels of sР-selectin, ІL-2, ІL-6, TNF-a in blood serum were determined by means of immunoenzymatic assay method. As a result, a reliable increase in sP-selectin level in blood serum has been detected in patients with type 2 diabetes mellitus with deterioration of diabetes compensation along with АH; increase in ІL-6 level in groups with good and satisfactory compensation for diabetes and TNF -α in groups with bad compensation with the presence of АH.<em> </em>A reverse correlation between the content of sP-selectin and TNF-α in groups of those examined with non-compensated type 2 DM, associated with АH and without AH, stronger in a group of patients with type 2 DM and AH. The level of sP-selectin in blood increases with the deterioration of type 2 DM compensation along with AH. Most probable reverse correlations between sP-selectin and TNF-a levels in groups of patients with insufficient compensation for diabetes may indicate a mutually potential role of these factors in the development and progression of type 2 DM decompensation and AH.</p>

scholarly journals CORRELATION BETWEEN THE ROLE OF NURSE AS EDUCATOR AND SELF CARE BEHAVIOUR IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT INTERNAL MEDICINE UNIT OF BINA SEHAT HOSPITAL JEMBER

2017 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Rima Ulfa Fahra ◽  
Nur Widayati ◽  
Jon Hafan Sutawardana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Self Care ◽  
P Value ◽  
Type 2 Dm ◽  
Nurse Role ◽  
Diabetes Patients

Diabetes mellitus (DM) is a chronic disease that requires continuous self-care. Education by nurses can support self-care behavior of patients with type 2 DM. Good knowledge affects self-care of type 2 diabetes patients so that metabolic control can be achieved. This study aimed to identify the correlation between the role of nurse as educator and self-care behaviour in patients with type 2 diabetes mellitus. This research applied a descriptive analytic design with cross sectional approach. A total of 63 respondents were enrolled in this study by using consecutive sampling technique. Data collection was conducted by administering questionnaires of nurse role as educator and Summary of Diabetes Self Care Activities (SDSCA). Data were analyzed by using Spearman correlation test with significance level of 0.05. The result showed that the mean value of nurse role and self-care behaviour was 59.84 and 3.79 respectively. The p value was 0.000 (p<0.05) with the correlation coefficient (r) of 0.851. It indicates that there was a significant correlation between nurse role as educator and self-care behaviour in patients with type 2 DM. The correlation was strong and positive which means the better the nurse's role as educator the better the patient's self-care behaviour. The education gained by the patients can affect the motivation to perform self-care behaviour. This study suggests the importance of nurse role in providing education in type 2 diabetes patients to optimize self-care behaviour.

scholarly journals Association between Periodontitis and Genetic Polymorphisms in Interleukins among Patients with Diabetes Mellitus

2021 ◽  
Vol 9 (4) ◽  
pp. 45
Author(s):  
Hoda M. Abdellatif ◽  
Munerah Saleh Binshabaib ◽  
Heba A. Shawky ◽  
Shatha Subhi ALHarthi
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Polymorphisms ◽  
Gene Polymorphisms ◽  
Data Extraction ◽  
Risk Of Bias ◽  
Type 2 Dm ◽  
Patients With Diabetes ◽  
Pertinent Information

There is a perplexity in the association between interleukin (IL) polymorphisms and periodontitis among patients with and without diabetes mellitus (DM). The aim of the present study was to evaluate indexed data regarding the association between periodontitis and genetic polymorphisms in interleukins among patients with and without DM. The addressed question was “Is there an association between periodontitis and polymorphisms in interleukins among patients with and without DM?” Original studies were included. Indexed databases were searched, and the pattern of the present literature review was customized to summaries’ the pertinent information. Eight studies were included and processed for data extraction. Two studies showed that polymorphisms in IL-1B genes aggravate periodontitis in patients with type-2 DM, and two studies showed that IL-1B genes either do not or are less likely to contribute towards the progression of periodontitis in patients with type-2 DM. Two studies reported that IL genes do not show cross-susceptibility with periodontitis and type-2 DM. One study reported that the primary factor that governs the occurrence and progression of periodontitis in patients with and without type-2 DM is poor routine oral hygiene maintenance. Seven studies had a high risk of bias. The role of IL gene polymorphisms in the development and progression of periodontitis in patients with and without DM remains controversial.

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