scholarly journals Thoughts on Natural Medicinal Chemistry

2019 ◽  
Vol 8 (3) ◽  
pp. 29-34
Author(s):  
Xing Peng ◽  
Meilan Li
Keyword(s):  
Natural Products ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Lead Compounds ◽  
Drug Lead ◽  
Novel Structures

Natural products, with novel structures and broad biological activities, are the main sources of drug lead compounds. Over years, natural products have made outstanding contributions to the fight against viruses. Herein, the article briefly shares some thoughts about natural medicinal chemistry as references for chemists and biologists.

Recent Applications of Benzimidazole as a Privileged Scaffold in Drug Discovery

2020 ◽  
Vol 20 ◽  
Author(s):  
Yongzhen Guo ◽  
Xuben Hou ◽  
Hao Fang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Anticancer Agents ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Great Influence ◽  
Parasitic Infections ◽  
Peptic Ulcers ◽  
Lead Compounds ◽  
Privileged Scaffold

: Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.

Semisynthetic triazoles as an approach in the discovery of Novel Lead Compounds

2021 ◽  
Vol 25 ◽  
Author(s):  
Pedro Alves Bezerra Morais ◽  
Carla Santana Francisco ◽  
Heberth de Paula ◽  
Rayssa Ribeiro ◽  
Mariana Alves Eloy ◽  
...  
Keyword(s):  
Natural Products ◽  
Medicinal Chemistry ◽  
Chemical Space ◽  
Biological Activities ◽  
Post Translational Modification ◽  
Cellular Processes ◽  
Modern Drug ◽  
New Chemical Entities ◽  
Almost All ◽  
The 19Th Century

: Historically, the medicinal chemistry is concerned with the approach of organic chemistry to new drug synthesis. Considering the fruitful collections of new molecular entities, the dedicated efforts for medicinal chemistry are rewarding. Planning and search of new and applicable pharmacologic therapies involve the altruistic nature of the scientists. Since the 19th century, notoriously the application of isolated and characterized plant-derived compounds in modern drug discovery and in various stages of clinical development highlight its viability and significance. Natural products influence a broad range of biological processes, covering transcription, translation, and post-translational modification and being effective modulators of almost all basic cellular processes. The research of new chemical entities through “click chemistry” continuously opens up a map for the remarkable exploration of chemical space in towards leading natural products optimization by structure-activity relationship. Finally, here in this review, we expect to gather a broad knowledge involving triazolic natural products derivatives, synthetic routes, structures, and their biological activities.

scholarly journals Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 670 ◽  
Author(s):  
Xiaoju Dou ◽  
Bo Dong
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Bioactive Compounds ◽  
Natural Compounds ◽  
Marine Animals ◽  
Lead Compounds ◽  
Chemical Structures ◽  
Complex Interactions ◽  
Novel Structures ◽  
Important Drug

Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intricate and novel chemical structures have been identified from ascidians. Some of them have been successfully developed as lead compounds or highly efficient drugs. Although numerous compounds that exist in ascidians have been structurally and functionally identified, their origins are not clear. Interestingly, growing evidence has shown that these natural products not only come from ascidians, but they also originate from symbiotic microbes. This review classifies the identified natural products from ascidians and the associated symbionts. Then, we discuss the diversity of ascidian symbiotic microbe communities, which synthesize diverse natural products that are beneficial for the hosts. Identification of the complex interactions between the symbiont and the host is a useful approach to discovering ways that direct the biosynthesis of novel bioactive compounds with pharmaceutical potentials.

Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity

2018 ◽  
Vol 25 (10) ◽  
pp. 1194-1240 ◽  
Author(s):  
Sara Vitalini ◽  
Serhat S. Cicek ◽  
Sebastian Granica ◽  
Christian Zidorn
Keyword(s):  
Natural Products ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Pathogenic Fungi ◽  
Chemical Diversity ◽  
Limited Information ◽  
Lead Compounds ◽  
Naturally Occurring

Background: Dihydrostilbenoids, a diverse class of natural products differing from stilbenoids by the missing double bond in the ethylene chain linking the aromatic moieties, have been reported from fungi, mosses, ferns, and flowering plants. Objective: Occurrence, structure, and bioactivity of naturally occurring dihydroresveratrol type dihydrostilbenoids are discussed in this review. Method: A Reaxys database search for dihydroresveratrol derivatives with possible substitutions on all atoms, but excluding non-natural products and compounds featuring additional rings involving the ethyl connecting chain, was performed. Results: Structures include simple dihydroresveratrol derivatives, compounds substituted with complex side chains composed of acyl moieties and sugars, and compounds containing polycyclic cores attached to dihydrostilbenoid units. Dihydrostilbenoids have a wide spectrum of bioactivities ranging from expectable antioxidant and anti-inflammatory activities to interesting neuroprotective and anticancer activity. The anticancer activity in particular is very pronounced for some plant-derived dihydrostilbenoids and makes them interesting lead compounds for drug development. Apart from some reports on dihydroresveratrol derivatives as phytoalexins against plant-pathogenic fungi, only very limited information is available on the ecological role of these compounds for the organisms producing them. Conclusion: Dihydrostilbenoids are a class of natural products possessing significant biological activities; their scattered but not ubiquitous occurrence throughout the kingdoms of plants and fungi is not easily explained. We are convinced that future studies will identify new sources of dihydrostilbenoids, and we hope that the present review will inspire such studies and will help in directing such efforts to suitable source organisms and towards promising bioactivities.

Marine Natural Products as A Source of Drug Leads against Respiratory Viruses: Structural and Bioactive Diversity

2020 ◽  
Vol 27 ◽  
Author(s):  
Tian-Tian Sun ◽  
Hua-Jie Zhu ◽  
Fei Cao
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Respiratory Viruses ◽  
Antiviral Activities ◽  
Syncytial Virus ◽  
Effective Drugs ◽  
Drug Leads ◽  
Novel Structures

: Respiratory viruses, including influenza virus, respiratory syncytial virus, coronavirus, et al., have seriously threatened the human health. For example, the outbreak of severe acute respiratory syndrome coronavirus, SARS, affected a large number of countries around the world. Marine organisms, which could produce secondary metabolites with novel structures and abundant biological activities, are an important source for seeking effective drugs against respiratory viruses. This report reviews marine natural products with activities against respiratory viruses, the emphasis of which was put on structures and antiviral activities of these natural products. This review has described 167 marine-derived secondary metabolites with activities against respiratory viruses published during 1981 to 2019. Altogether 102 references are cited in this review article.

Natural Products as Lead Compounds in Medicinal Chemistry

2012 ◽  
pp. 81-126 ◽  
Author(s):  
Eliezer J. Barreiro ◽  
Carlos A. M. Fraga ◽  
Lidia M. Lima
Keyword(s):  
Natural Products ◽  
Medicinal Chemistry ◽  
Lead Compounds

Halogenated Compounds from Corals: Chemical Diversity and Biological Activities

2019 ◽  
Vol 19 (15) ◽  
pp. 1204-1218 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Junhong Liu ◽  
Dayong Shi ◽  
Zheng Li
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Organic Compounds ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Species Structure ◽  
Biological Mechanisms ◽  
Biological Resources ◽  
Lead Compounds ◽  
Novel Structures

: As important marine biological resources, corals produce a large amount of active organic compounds in their secondary metabolic processes, including numerous brominated, chlorinated, and iodinated compounds. These compounds, with novel structures and unique activities, guide the discovery and research of important lead compounds and novel biological mechanisms. Through a large number of literature surveys, this paper summarized a total of 145 halogenated secondary metabolites which were roughly divided into four major classes of terpenes, prostaglandins, steroids and alkaloids, and they were mainly isolated from ten coral families, Ellisellidae, Gorgoniidae, Briareidae, Plexauridae, Anthothelidae, Alcyoniidae, Clavularidae, Tubiporidae, Nephtheidae and Dendrophyllidae to the best of our knowledge. In addition, their organism species, structure composition and biological activity were also discussed in the form of a chart in this essay.

scholarly journals Plants as a Still Unexploited Source of New Drugs

2008 ◽  
Vol 3 (8) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Kurt Hostettmann ◽  
Andrew Marston
Keyword(s):  
Natural Products ◽  
Biomedical Research ◽  
Higher Plants ◽  
Biological Activities ◽  
New Drugs ◽  
Structural Variations ◽  
Lead Compounds ◽  
Infinite Variety

Higher plants are a source of thousands of natural products, with an almost infinite variety of different structural variations. These molecules often have specific functions and many of them have biological activities which can be of use to humans. They may provide lead compounds for the development of new drugs or they may be indispensable tools in biomedical research.

Marine Actinomycetes-derived Natural Products

2020 ◽  
Vol 19 (31) ◽  
pp. 2868-2918 ◽  
Author(s):  
Chengfang Yang ◽  
Rui Qian ◽  
Yao Xu ◽  
Junxi Yi ◽  
Yiwen Gu ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Secondary Metabolites ◽  
Metabolic Pathways ◽  
Biological Activities ◽  
Living Environment ◽  
Marine Actinomycetes ◽  
Bioactive Substances ◽  
Lead Compounds

: Actinomycetes is an abundant resource for discovering a large number of lead compounds, which play an important role in microbial drug discovery. Compared to terrestrial microorganisms, marine actinomycetes have unique metabolic pathways because of their special living environment, which has the potential to produce a variety of bioactive substances. In this paper, secondary metabolites isolated from marine actinomycetes are reviewed (2013-2018), most of which exhibited cytotoxic, antibacterial, and antiviral biological activities.

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