scholarly journals Effects of Lead on Hemopoeitic and Iron Status in Iraqi Workers at Lead Batteries Factory

2013 ◽  
Vol 10 (2) ◽  
pp. 388-395
Author(s):  
Baghdad Science Journal
Keyword(s):  
Aminolevulinic Acid ◽  
Early Stage ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Blood Lead ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Lead Levels ◽  
Iron Binding Capacity

The present study aimed to evaluate the effect of lead exposure on hemopoetic system (through the index delta-Aminolevulinic acid dehydratase ?-ALAD activity & hemoglobin concentration (Hb) ) and on iron status (levels of iron Fe, Ferritin Fr, Total iron binding capacity TIBC, percentage of transferine saturation TF%) in 44 Iraqi worker at lead batteries factory. Workers divided into two groups: smokers(n=21) mean aged (37.33±4.82 year)and non smokers(n=23) mean aged(40.78±7.89 year) and 45 healthy subjects mean aged (33.97±5.08)as control group . Activity of ?-ALAD ratio shows significant decrease (p ? 0.05) ,while Hb and hematocrit Hct were non significant (p ? 0.05) in smoker workers more than non smoker as compared to control . The results show a non significant decrease (p ? 0.05) in the sera levels of iron S.Fe, TS%, Fr in all workers as compared to control , the amount of decreasing for smoker more than non smoker except ferritin levels. A significant increases in the level of TIBC in workers as compared to control, this elevation is more in smoker than non smoker workers. In smoker workers, there was a significant positive correlation between the blood lead levels BLLs and Hb, Hct,TIBC whereas a significant negative correlation was observed between BLLs and S.Fe, TS%. In conclusion, the results of this study reveal the importance of monitoring the level of iron status in smoker peoples who dealing or exposure to lead due to the probability injured with anemia and used ?-ALAD ratio to predict the efficiency of their heme synthesis as a new marker for the diagnosis of early stage of anemia.

scholarly journals Iron Metabolism Modification During Repeated Show Jumping Event in Equine Athletes

2017 ◽  
Vol 17 (1) ◽  
pp. 197-204 ◽  
Author(s):  
Giuseppe Piccione ◽  
Maria Rizzo ◽  
Francesca Arfuso ◽  
Daniele Bruschetta ◽  
Elisabetta Giudice ◽  
...  
Keyword(s):  
Health Status ◽  
Physical Performance ◽  
Binding Capacity ◽  
Iron Status ◽  
Recovery Period ◽  
Hemoglobin Concentration ◽  
Repeated Measure ◽  
Iron Binding ◽  
Iron Binding Capacity ◽  
Show Jumping

Abstract In athletic horse the evaluation of iron status is of great importance to improve physical performance and health status of animal. The aim of this study was to evaluate the changes of iron indices following show jumping. Ten regularly trained Italian Saddlebred horses aged 7-8 years (mean body weight 467±12 kg) were subjected to three days jumping competition. Blood samples were collected at 5 time points: T0 (the day before competitions), T1 (immediately after exercise at day 1), T2 (immediately after exercise at day 2), T3 (immediately after exercise at day 3) and during the recovery period T4 (24 h after day 3). On each blood sample the values of red blood cell (RBC), hemoglobin concentration (Hb), hematocrit (Hct), serum iron, ferritin, transferrin, total iron-binding capacity (TIBC) and unsaturated iron-binding capacity (UIBC) were assessed. One-way repeated measure analysis of variance (ANOVA) showed a statistical significant effect of exercise (P<0.05) on all studied parameters. The application of Bonferroni’s post-hoc comparison showed a statistical significant increase in all studied parameters after exercise. These results provide new information about the changes in iron profile of jumper horse following exercise allowing for better evaluation of the health status and physical performance of this athlete horse.

Iron Deficiency and Anemia: A Common Problem in Female Elite Soccer Players

2005 ◽  
Vol 15 (6) ◽  
pp. 689-694 ◽  
Author(s):  
Göran Landahl ◽  
Peter Adolfsson ◽  
Mats Börjesson ◽  
Clas Mannheimer ◽  
Stig Rödjer
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Binding Capacity ◽  
Iron Status ◽  
Hemoglobin Concentration ◽  
Soccer Players ◽  
Deficiency Anemia ◽  
World Cup ◽  
National Team ◽  
Iron Binding Capacity

The objective of the study was to determine the prevalence of iron deficiency and iron deficiency anemia among elite women soccer players. Hemoglobin, serum iron, serum total iron binding capacity, and ferritin were determined in 28 female soccer players called up for the national team. Of the investigated female soccer players, 57% had iron deficiency and 29% iron deficiency anemia 6 months before the FIFA Women’s World Cup. It is concluded that iron deficiency and iron deficiency anemia is common in female soccer players at the top international level. Some might suffer from relative anemia and measurement of hemoglobin alone is not sufficient to reveal relative anemia. Regular monitoring of hemoglobin concentration and iron status is necessary to institute iron supplementation when indicated.

scholarly journals Oxidative Stress in Painters Exposed to Low Lead Levels

2008 ◽  
Vol 59 (3) ◽  
pp. 161-169 ◽  
Author(s):  
Imran Mohammad ◽  
Abbas Mahdi ◽  
Aryapu Raviraja ◽  
Islam Najmul ◽  
Ahmad Iqbal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Aminolevulinic Acid ◽  
Lead Level ◽  
Lead Toxicity ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Control Group ◽  
Zinc Protoporphyrin ◽  
Lead Levels

Oxidative Stress in Painters Exposed to Low Lead LevelsLead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and commercial painters of Lucknow city in Uttar Pradesh, India.Thirty-five painters aged 20 to 50 years who had blood lead levels ≤400 μg L-1were selected for the study from a population of 56 male painters initially screened for blood lead. The control group included an equal number of subjects of the same age group without any occupational exposure to lead.We studied the association between low lead level exposure and antioxidant status and found that blood lead levels in painters were approximately seven times as high as in controls [(219.2 ± 61.9) μg L-1vs. (30.6±10.1) μg L-1, respectively]. Among the biomarkers of lead toxicity a significant decrease in the level of delta-aminolevulinic acid dehydratase [(9.13±4.62) UL-1vs. (39.38±5.05) UL-1] and an increase in the level of zinc protoporphyrin [(187.9±49.8) μg L-1vs. (26.4±5.5) μg L-1] were observed in painters compared to controls. Among antioxidant enzymes, painters showed a significant decrease in catalase [(56.77±11.11) UL-1vs. (230.30±42.55) UL-1] and superoxide dismutase [(0.64±0.19) UL-1 vs. (2.68±0.62) UL-1] compared to controls. Lipid peroxidation was monitored by measuring thiobarbituric acid reactive substances (TBARS) that were expressed in terms of malondialdehyde (MDA) equivalents. Concentration of MDA in plasma was higher in painters than in controls [(7.48±1.31) nmol mL-1vs. (3.08±0.56) nmol mL-1]. Significant changes were also observed in reduced and oxidised glutathione levels. The strong association between blood lead levels and oxidative stress markers in this population suggests that oxidative stress should be considered in the pathogenesis of lead-related diseases among people with low level environmental exposure to lead.

scholarly journals Serum Hepcidin as a Clinical Prognostic Marker to Discriminate the Outcome of Canine Babesiosis

2020 ◽  
Author(s):  
K. Rajamanickam ◽  
V. Leela ◽  
K. Loganathasamy ◽  
Bhaskaran Ravi Latha ◽  
M. Balagangatharathilagar
Keyword(s):  
Binding Capacity ◽  
Iron Status ◽  
Survival Outcome ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substance ◽  
Iron Binding ◽  
Canine Babesiosis ◽  
Nested Polymerase Chain Reaction ◽  
Serum Hepcidin ◽  
Iron Binding Capacity

Background: We aimed to identify the prognostic value of hepcidin in discriminating against the survival outcome of canine babesiosis. Methods: Semi-nested polymerase chain reaction was performed to confirm the presence of infection. Existence of oxidative stress and inflammatory response, changes in systemic iron status and hepcidin level were assessed in the study population. Based on the outcome Babesia infected dogs were classified into survivors (n=18) and non-survivors (n=14) of infection. 32 healthy dogs formed the control group. Conclusion: In non-survivors of infection, serum hepcidin was positively associated with C-reactive protein (P less than 0.01), serum iron (P less than 0.01), transferrin iron-binding capacity (P less than 0.05), unsaturated iron-binding capacity (P less than 0.01), thiobarbituric acid reactive substance (P less than 0.05) and negatively associated with catalase (P less than 0.01), zinc (P less than 0.01) and low haemoglobin density (P less than 0.01). The prognostic cut-off value of hepcidin in discriminating the survivability of infected dogs was 32.32 ng/mL with 100.00% specificity and 92.86 % sensitivity. The area under the curve of hepcidin in discriminating survivability was about 0.984 and Youden’s index was 0.928. Hence, hepcidin can predict the survival outcome of the disease enabling intensive care for animals with a cut-off value of hepcidin more than 32.32 ng/mL.

scholarly journals IRON STATUS IN PREECLAMPSIA

2008 ◽  
Vol 15 (01) ◽  
pp. 74-80
Author(s):  
TASNEEM ZAFAR ◽  
ZAFAR IQBAL
Keyword(s):  
Serum Ferritin ◽  
Serum Iron ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Correlation Study ◽  
Total Iron ◽  
Control Group ◽  
Iron Binding ◽  
Iron Binding Capacity

Objective: To evaluate iron status in pregnancy induced hypertension and role of iron in the etiologyand pathogenesis of pre-eclampsia. Design: Coefficient correlation study. Place and Duration. At Department ofBiochemistry, Frontier Medical College, Abbottabad with collaboration of Department of Obstetrics and Gynecology,Ayub Medical Complex, Abbottabad from March 2006-March 2007. Material and Methods: Study was performed onhundred pregnant women of age ranging between 15-35 years and having gestational age between28 to 34 weeks.Fifty obstetric patients were identified as having pre-eclampsia. Fifty healthy pregnant subjects were taken as controls,having uncomplicated pregnancies and were normotensive throughout gestation and without proteinuria. Results:Results depicts that mean age of pre-eclamptic group was significantly low (P<0.001) as compared to control. Bothparameters, Hemoglobin and Haematocrit were significantly higher (P<0.05) in pre-eclamptic as compared to controls.Serum iron, serum ferritin and transferrin saturation were significantly higher (P<0.001) in pre-eclamptic in comparisonwith control group. Total iron binding capacity and unsaturated iron binding capacity were significantly lower (P<0.001)in pre-eclamptic group when compared to control group. Correlation coefficient between serum iron, total iron bindingcapacity (TIBC), serum ferritin, unsaturated iron binding capacity (UIBC) and systolic and diastolic blood pressure inpre-eclamptic group showed no significant positive correlation in any parameter. Conclusion: It is concluded thathemoglobin, haematocrit, serum iron, serum ferritin and transferrin saturation are significantly increased in pregnantwomen that later develops pre-eclampsia. Excess iron is postulated as casual factor in the oxidative stress ie; in itsradical form, which may be involved in the pathogenesis of pre-eclampsia. Therefore, iron status of pregnant womenshould be assessed before giving iron supplements as these may cause more harm than benefit.

Iron status of adolescent girls from two boarding schools in southern Benin

2008 ◽  
Vol 11 (7) ◽  
pp. 737-746 ◽  
Author(s):  
Halimatou Alaofè ◽  
John Zee ◽  
Romain Dossa ◽  
Huguette Turgeon O’Brien
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Adolescent Girls ◽  
Binding Capacity ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Meat Consumption ◽  
Boarding Schools ◽  
Important Health ◽  
Iron Binding Capacity

AbstractIron deficiency (ID) is the most prevalent micronutrient deficiency in the world, particularly in developing countries. Blood samples and a qualitative FFQ on Fe- and vitamin C-rich foods were obtained in 180 adolescent girls aged 12 to 17 years living in two boarding schools from south Benin. ID, defined as serum ferritin either <20μg/l or 20–50μg/l, plus two of the following parameters: serum Fe<11μmol/l, total iron-binding capacity>73μmol/l or transferrin saturation<20%, was found in 32% of subjects. Anaemia (Hb<120g/l) was found in 51% of adolescents, while 24% suffered from iron-deficiency anaemia (IDA) (ID and Hb<20g/l). After adjusting for confounding factors (age, mother's and father's occupation, household size) in a logistic regression equation, subjects having a low meat consumption (beef, mutton, pork) (<4 times/week) were more than twice as likely to suffer from ID (OR=2·43; 95% CI 1·72, 3·35;P=0·04). Adolescents consuming less fruits (<4 times/week) also had a higher likelihood of suffering from ID (OR=1·53; 95% CI 1·31, 2·80;P=0·03). Finally, subjects whose meat consumption was low were twice as likely to suffer from IDA (OR=2·24; 95% CI 1·01, 4·96;P=0·04). The prevalence of ID represents an important health problem in these Beninese adolescent girls. A higher consumption of Fe-rich foods and of promoters of Fe absorption (meat factor and vitamin C) is recommended to prevent ID deficiency in these subjects.

Evaluation of pteridine metabolism in battery workers chronically exposed to lead

2006 ◽  
Vol 25 (7) ◽  
pp. 353-359 ◽  
Author(s):  
A B Engin ◽  
D Tuzun ◽  
G Sahin
Keyword(s):  
Neurological Disorders ◽  
High Performance ◽  
Aminolevulinic Acid ◽  
Control Group ◽  
Occupationally Exposed ◽  
Lead Levels ◽  
Urinary Lead ◽  
Urinary Neopterin ◽  
Battery Workers ◽  
Increased Activity

Occupationally-exposed lead affects the neuromuscular junction and might cause disturbances in the locomotor activity. This study was undertaken to evaluate pteridine metabolism, in which neurotransmitters are synthesized in battery workers. Urinary neopterin, biopterin and creatinine were measured using high performance liquid chromatography. Serum neopterin concentrations were detected by enzyme-linked immunoassay. Blood dihydropteridine reductase (DHPR) activities and delta-aminolevulinic acid (delta-ALA) were measured spectrophotometrically. Blood and urinary lead were detected by atomic absorption spectroscopy. Significantly increased blood and urinary lead levels, urinary neopterin, biopterin and delta-ALA were found in workers, while DHPR activities were indifferent compared to control group. Urinary creatinine decreased. This is the first study to demonstrate that increased activity of the pteridine pathway results in the accumulation of the neurotransmitters that may be responsible for the neurological disorders.

Silymarin and dimercaptosuccinic acid ameliorate lead-induced nephrotoxicity and genotoxicity in rats

2015 ◽  
Vol 35 (4) ◽  
pp. 398-403 ◽  
Author(s):  
Y Alcaraz-Contreras ◽  
RP Mendoza-Lozano ◽  
ER Martínez-Alcaraz ◽  
M Martínez-Alfaro ◽  
MA Gallegos-Corona ◽  
...  
Keyword(s):  
Lead Acetate ◽  
Chelating Agent ◽  
Blood Lead ◽  
Positive Control ◽  
Dimercaptosuccinic Acid ◽  
Control Group ◽  
Lead Levels ◽  
Group A ◽  
Group B ◽  
Group D

We studied the effect of silymarin and dimercaptosuccinic acid (DMSA), a chelating agent that was administered individually or in combination against lead (Pb) toxicity in rats. Wistar rats (200 ± 20) were randomly divided into five groups. Group A served as a control. Groups B–E were exposed to 2000 ppm of lead acetate in drinking water for 8 weeks. Group B served as a positive control. Group C received silymarin (100 mg kg−1 orally) for 8 weeks. Group D received DMSA (75 mg kg−1 orally) once daily for the last 5 days of treatment. Group E received DMSA and silymarin as groups C and D, respectively. The effect of Pb was evaluated and accordingly the treatments on blood lead levels (BLLs), renal system, and genotoxic effects were calculated using comet assay. The BLLs were significantly increased following the exposition of lead acetate. The administration of silymarin and DMSA provided reduction in BLLs. Silymarin and DMSA provided significant protection on the genotoxic effect of Pb. The toxic effect of Pb on kidneys was also studied. Our data suggest that silymarin and DMSA improve the renal histopathological lesions.

scholarly journals Expression of Salivary miRNA-31 in Oral Submucous Fibrosis

2021 ◽  
pp. 137-144
Author(s):  
Saba Khan ◽  
Saima Akram Butt ◽  
Sobia Hassan ◽  
Rizma Khan
Keyword(s):  
Early Stage ◽  
Oral Submucous Fibrosis ◽  
Significant Negative Correlation ◽  
Fold Change ◽  
Rank Test ◽  
Control Group ◽  
Clinical Parameters ◽  
Expression Levels ◽  
Group I ◽  
Submucous Fibrosis

Objective: The present study aimed to evaluate the salivary miRNA31 expression in controls and cases and associate miRNA31 levels with clinical parameters of oral submucous fibrosis. Methods: This case control study was conducted in a hospital setup. A total of 50 individuals participated in the study with 25 subjects in group I (healthy individuals) and 25 subjects in group II 25 diagnosed cases of (oral submucous fibrosis). The sample size was calculated with open Epi version 3.01.  A detailed assessment of clinical parameters of oral submucous fibrosis was made. Unstimulated saliva samples were collected from all study subjects meeting the inclusion criteria and analysis of saliva samples was done by qRTPCR. Results: The results showed high expression levels of miRNA31 in oral submucous fibrosis as compared to the control group. The study demonstrated significantly higher median fold change of miRNA-31 expression level in OSMF patients as compared to the participants in the control group. Correlation between age of patients and miRNA31 fold change was discerned using the Spearman rank test that demonstrated a non-significant negative correlation. Conclusion: Increased expression levels of miRNA 31 among oral submucous fibrosis as compared to the control group make it a promising salivary biomarker that detects oral submucous fibrosis at an early stage of the disease.

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