scholarly journals Modification of Irisin Level in Overweight/Obese Women during Pregnancy and Its Association with Some Metabolic Risk Factors

2020 ◽  
Vol 17 (3(Suppl.)) ◽  
pp. 1124
Author(s):  
Mohammad Ahmad Hamza ◽  
Yassar Yahya Al Tamer ◽  
Omar Abdulmajeed Al habib
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Maternity Hospital ◽  
Normal Weight ◽  
Metabolic Risk Factors ◽  
Reproductive Age ◽  
Metabolic Risk ◽  
Obese Women

Irisin is a novel myokine and adipokine, its role during pregnancy and its association with some metabolic risk factors especially pre-pregnancy body mass index (pre-BMI) need more evaluation. The aim of the study is to find whether the pre-BMI could predict irisin levels during normal pregnancy and to clarify associations of irisin with some pathological parameters. Irisin levels were estimated by ELISA in sera of 59 normal pregnant women who enrolled from December 2016 to May 2017 at Maternity Hospital, Zakho city, Kurdistan region (Iraq). Thirty-two normal-weight pregnant (pre-BMI≤24.9 kg/m2, Age=24.03 mean±3.7standard deviation) and 27 overweight/obese-pregnant (pre-BMI>25 kg/m2, Age=27.6 mean±3.9 standard deviation) were accounted for each trimester as10: 8 in first trimester, 10:10 in second trimester and12:9 in third trimester respectively. Twenty-two healthy married non-pregnant women of reproductive age served as controls, accounted as 10 normal-weight women (BMI ≤24.9 kg/m2) and 12 overweight/obese women (BMI>25 kg/m2). In pregnant women as a whole, irisin level significantly increased compared to control (p=0.003), and correlated with the pre-BMI, FBS, TP and HOMA2-IR. Pre-BMI and TP predicted irisin levels in a whole study population (p=0.011 and 0.014 respectively). In Overweight/Obese-pregnant, irisin increased significantly by 55.3% in first trimester compared with Overweight/Obese women control, then decreased progressively toward the end of gestation, correlated with TP, Albumin, FBS, HOMA2-IR and negatively correlated with gestational weight gained. TP and FBS independently predicted irisin level in Overweight/Obese-pregnant group. Conclusion: Circulating irisin levels are influenced by pre-BMI, and both of TP and FBS predict irisin levels in overweight/obese pregnant. Irisin level should be a radical factor in future studies for pathological conditions linked to hypoproteinemias such as edema and hepatic disease.

Interleukin-6 G-174C gene polymorphism and serum resistin levels in North Indian women: Potential risk of metabolic syndrome

2010 ◽  
Vol 30 (10) ◽  
pp. 1445-1453 ◽  
Author(s):  
A Gupta ◽  
V Gupta ◽  
AK Singh ◽  
S Tiwari ◽  
S Agrawal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Genetic Polymorphism ◽  
Interleukin 6 ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Obese Women ◽  
Resistin Level ◽  
Indian Women ◽  
Mutant Genotype

The present investigations were aimed to identify the possible association between genetic polymorphism in interleukin-6 (IL-6) G-174C gene, which confers susceptibility to metabolic syndrome, and serum level of resistin in North Indian women. The study population comprised 370 unrelated Indian women (192 having abdominal obesity and 178 controls). Polymorphism in genotype (CC+GC) of IL-6 G-174C gene was determined using a combination of polymerase chain reaction (PCR) and sequence-specific primer with restriction fragment length polymorphism (RFLP) technology. Insulin resistance (IR) and serum resistin level were also analyzed along with metabolic risk factors. Of 192 abdominal obese women, 147 (76.56%) were found to have mutant CC+GC ( p = 0.001) genotype and allele frequency ( p = 0.001), which was significantly higher 45 (23.44%) than non-obese and their respective wild type. The mutant genotype (CC+GC) of IL-6 gene was found to be associated significantly with high triglyceride ( p = 0.025) and resistin level ( p < 0.001), when compared with respective wild genotype (GG) in obese women. Non-obese women with no signs of metabolic risk factors were found to have significantly low level of serum resistin and IR in comparison to obese women having genetic polymorphism for IL-6 G-174C gene. Study suggests that IL-6 G-174C gene is one among the susceptibility loci for metabolic syndrome in North Indian women. Genotype for this polymorphism may prove informative for prediction of genetic risk for metabolic syndrome. Further, high level of serum resistin molecules may be targeted to correlate with metabolic syndrome risk factors and could be used as early prediction marker.

scholarly journals Gestational weight gain in normal weight women and offspring cardio-metabolic risk factors at 20 years of age

2014 ◽  
Vol 39 (4) ◽  
pp. 671-676 ◽  
Author(s):  
L Hrolfsdottir ◽  
D Rytter ◽  
S F Olsen ◽  
B H Bech ◽  
E Maslova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Normal Weight ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Gestational Weight

scholarly journals The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease

2007 ◽  
Vol 157 (5) ◽  
pp. 633-640 ◽  
Author(s):  
Juliet Evans ◽  
Malcolm Collins ◽  
Courtney Jennings ◽  
Lize van der Merwe ◽  
Ingegerd Söderström ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
South African ◽  
Normal Weight ◽  
Visceral Adiposity ◽  
Metabolic Risk Factors ◽  
African Women ◽  
Metabolic Risk ◽  
Black South African ◽  
South African Women

AbstractObjectiveCirculating levels of interleukin (IL)-18 are associated with the metabolic syndrome and risk for the development of cardiovascular disease (CVD). This study investigated the association between the circulating IL-18 levels and the −137 G/C polymorphism within the IL-18 gene with metabolic risk factors for CVD in normal-weight and obese black South African women.MethodsBlood pressure (BP), body composition (dual-energy X-ray absorptiometer), visceral adiposity (computerized tomography), as well as fasting glucose, insulin, lipid profile, IL-18 levels, and IL-18 genotype were measured in 104 normal-weight (body mass index (BMI) ≤25 kg/m2) and 124 obese (BMI≥30 kg/m2) black South African women.ResultsSubjects with a GC genotype (23%) had a greater mean arterial pressure (MAP, 90.6±11.1 vs 85.5±10.3 mmHg, P<0.001) than the subjects with the GG genotype. Serum IL-18 levels were not associated with IL-18 genotype (P=0.985); however, they significantly correlated with percentage of body fat (r=0.25, P<0.001), visceral adiposity (r=0.32, P<0.001), MAP (r=0.22, P=0.001), HOMA-IR (r=0.33, P<0.001), fasting insulin (r=0.25, P<0.001), triglyceride (r=0.16, P<0.05), and high-density lipoprotein-cholesterol (r=−0.14, P<0.05) levels, after adjusting for age and body fatness.ConclusionsWe show for the first time that the GC genotype of the IL-18 −137 G/C polymorphism and the circulating IL-18 levels are independently associated with raised BP. Moreover, fasting IL-18 levels are associated with the other metabolic risk factors for CVD in normal-weight and obese black South African women.

Adiponectin mRNA in adipose tissue and its association with metabolic risk factors in postmenopausal obese women

HORMONES ◽  
2013 ◽  
Vol 12 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Sadashiv ◽  
Sunita Tiwari ◽  
Bhola Nath Paul ◽  
Sandeep Kumar ◽  
Abhijit Chandra ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Obese Women ◽  
Adiponectin Mrna
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