scholarly journals Determinants of failed oxytocin induction among women who gave birth at referral hospitals of Amhara region, Ethiopia, 2018: A case control study

2019 ◽  
Author(s):  
Abenezer Melkie ◽  
Mesafint Ewunetu ◽  
Simegnew Asmer ◽  
Maru Mekie ◽  
Enyew Dagnew
Keyword(s):  
Study Design ◽  
Case Control Study ◽  
Response Rate ◽  
Case Control ◽  
Induction Of Labor ◽  
Bishop Score ◽  
Amhara Region ◽  
Referral Hospitals ◽  
Failed Induction ◽  
Control Study

Abstract Abstract Objective: This study was aimed to identify determinants of failed oxytocin induction among women who gave birth at referral hospitals of Amhara Region, Ethiopia. Unmatched case control study design was employed among 336 women who had oxytocin induction with 2:1 control to case ratio. Results: A total of 336 women were participated in the study giving a response rate of 100% for both cases and controls. The odds of having failed induction were found to be 11.77 times higher among women who had intermediate bishop (AOR=11.77(5.19, 26.71)) compared with counterparts. Likewise, the odds of having failed induction were found to be higher (AOR=6.24, 95%, CI: (3.32, 11.73)), (AOR=2.47, 95%, CI: (1.31, 4.68)), and (AOR=2.16, 95%, CI :( 1.13, 4.16)) among women who are primiparous, those who had emergency oxytocin induction, and women with age ≤30 years respectively. Cervical status shall be seen with care prior to oxytocin induction and repining shall be considered to have better outcome. Keywords: Induction of labor, failed induction, Bishop score, Ethiopia

scholarly journals Determinants of Preterm Birth among Women Who Gave Birth in Amhara Region Referral Hospitals, Northern Ethiopia, 2018: Institutional Based Case Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Abebayehu Melesew Mekuriyaw ◽  
Muhabaw Shumye Mihret ◽  
Ayenew Engida Yismaw
Keyword(s):  
Preterm Birth ◽  
Case Control Study ◽  
Case Control ◽  
Multiple Gestation ◽  
Northern Ethiopia ◽  
Amhara Region ◽  
Premature Rupture ◽  
Referral Hospitals ◽  
Multivariable Analyses ◽  
Control Study

Background. Preterm birth refers to a birth of a baby before 37 completed weeks of gestation and after fetal viability. It is now the leading cause of new born deaths. Although identifying its common risk factors is mandatory to decrease preterm birth and thereby neonatal deaths, there was a dearth of studies in the study area. Objective. The aim of this study was to identify determinants of preterm birth among women who gave birth in Amhara region referral hospitals, Northwest Ethiopia, 2018. Method. An institutional based case-control study was conducted from September 01 to December 01/2018. A total of 405 mothers (135 cases and 270 controls) were included in the study. Multistage sampling technique was employed. Data were collected using structured questionnaire through face to face interview and checklist via Chart review. Data were entered into Epi Info version 7 and export to Statistical Package for Social Sciences (SPSS) version 20 for analysis. Descriptive statics like mean, frequency and percentage was used to describe the characteristics of participants. Both bivariable and multivariable analyses were carried out. Variable having    p-value <0.05 in binary logistic regression were the candidate for multivariable analyses. Finally, the statistical significance of the study was claimed based on the Adjusted Odds Ratio (AOR) with 95% Confidence Interval (CI) and its p-value <0.05. Result. The result of multivariable analysis show that mothers with no formal education (AOR = 2.24; 95% CI: 1.28, 3.91), history of abortion (AOR = 2.92; 95% CI: 1.3, 6.4), multiple gestation (AOR = 4.1; 95% CI: 1.7, 9.8), hemoglobin level <11 gm/dl (AOR = 2.75; 95% CI: 1.11, 7.31), premature rupture of membrane (AOR = 6.4; 95% CI: 3.23, 12.7) and pregnancy induced hypertension (AOR = 4.74; 95% CI: 2.49, 9.0) had statistically significant association with experiencing preterm birth. Conclusion and Recommendation. Most of the determinants of preterm birth found to be modifiable. Thus, putting emphasis for prevention of obstetric and gynecologic complications such as anemia, premature rupture of membrane and abortion would decrease the incidence of preterm birth. Moreover, strengthening Information Communication Education about prevention of preterm birth was recommended.

scholarly journals Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study

2020 ◽  
Vol 4 (1) ◽  
pp. e000830
Author(s):  
Asmamaw Demis Bizuneh ◽  
Birhan Alemnew ◽  
Addisu Getie ◽  
Adam Wondmieneh ◽  
Getnet Gedefaw
Keyword(s):  
Birth Weight ◽  
Neonatal Jaundice ◽  
Case Control Study ◽  
Birth Asphyxia ◽  
Case Control ◽  
Northern Ethiopia ◽  
Amhara Region ◽  
Prolonged Duration ◽  
Referral Hospitals ◽  
Control Study

BackgroundNeonatal jaundice is associated with a significant risk of neonatal morbidity and mortality. It is a major cause of hospital neonatal intensive care unit admission and readmissions during the neonatal period. Hence, the study aimed to identify the determinant factors of neonatal jaundice among neonates admitted at five referral hospitals in Amhara region, Northern Ethiopia.MethodA hospital-based unmatched case-control study design was employed, on 447 neonates (149 cases and 298 controls) at referral hospitals in Amhara region, Northern Ethiopia, from 1 March to 30 July 2019. Consecutive sampling method was used to select both the cases and controls. The collected data were entered into Epi data V.4.2 and then exported into SPSS window V.24 for analysis. Bivariable and multivariable analysis were carried out by using binary logistic regression. A p value of <0.05 was considered as significant difference between cases and controls for the exposure variable of interest.ResultsThe median (±IQR) age of neonate at the time of admission and gestational age were 3±2 days and 38 (±3) weeks, respectively. Prolonged duration of labour (adjusted OR (AOR)=2.45, 95% CI 1.34 to 4.47), being male sex (AOR=3.54, 95% CI 1.99 to 6.29), low birth weight (AOR=5.06, 95% CI 2.61 to 9.82), birth asphyxia (AOR=2.88, 95% CI 1.38 to 5.99), sepsis (AOR=2.49, 95% CI 1.22 to 5.11) and hypothermia (AOR=2.88, 95% CI 2.63 to 14.02) were the determinant factors for neonatal jaundice.ConclusionsProlonged duration of labour, hypothermia, sepsis, birth asphyxia, low birth weight and sex of neonate were independent determinants of neonatal jaundice. Early recognition and management of identified modifiable determinants are the recommended interventions.

scholarly journals Determinants of obstructed labor among women attending intrapartum care in Amhara Region, Northwest Ethiopia: A hospital-based unmatched case–control study

2020 ◽  
Vol 16 ◽  
pp. 174550652094972
Author(s):  
Mulugeta Dile ◽  
Habtamu Demelash ◽  
Lealem Meseret ◽  
Fantu Abebe ◽  
Mulat Adefris ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Case Control Study ◽  
Case Control ◽  
Service Access ◽  
Intrapartum Care ◽  
Amhara Region ◽  
Multivariable Logistic Regression Model ◽  
Obstructed Labor ◽  
Referral Hospitals ◽  
Control Study

Objectives: maternal and neonatal mortality in Ethiopia is a major reproductive health problem. Obstructed labor is one of the leading causes of maternal, fetal, and neonatal morbidity in developing countries. The evidence regarding its determinants at the tertiary level of care is sparse. Therefore, this study aimed to study the determinants of obstructed labor among women attending intrapartum care in Amhara region referral hospitals. Methods: A Hospital-based unmatched case-control study was conducted from March 1stto August 30, 2017. Cases were women whose labor was obstructed (n = 270), and controls were women whose labor was not obstructed (n = 540). Both cases and controls were selected randomly, and a proportional to size allocation was made to the referral hospitals selected for the study. A binary and a multivariable logistic regression model was computed to identify the determinant factors at 95% CI. Results: The mean age of the study participants was 27.66 years (27.4 ± 5.44 for cases and 28.15 ± 6.16 for controls), ranging between 16 and 45 years. Relatively, higher proportions of cases than controls were unable to read and write (58.5%) and were urban residents (53.7%). Distance from hospital, distance from health center, mothers inability to read and write, mothers primary level of education, more than 28 weeks of gestation at the first visit of antenatal care, 37 to 42 weeks at admission, above 42 weeks at admission, women of a merchant spouse, and history of pregnancy-related complications were the positive determinants of obstructed labor. However, mothers whose gestational age was 16 to 28 weeks at the first antenatal care visit were 62% less likely to be exposed to obstructed labor. Conclusions: Obstetric, service-related, and system factors were predictors of obstructed labor. Improving women’s literacy status, health service access, and utilization will help reduce obstructed labor.

scholarly journals Association between plasma leptin and cesarean section after induction of labor: a case control study

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Whitney Cowman ◽  
Sabrina M. Scroggins ◽  
Wendy S. Hamilton ◽  
Alexandra E. Karras ◽  
Noelle C. Bowdler ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Case Control Study ◽  
Maternal Plasma ◽  
Case Control ◽  
Induction Of Labor ◽  
Plasma Samples ◽  
Failed Induction ◽  
Plasma Leptin ◽  
Control Study ◽  
Dysfunctional Labor

Abstract Background Obesity in pregnancy is common, with more than 50% of pregnant women being overweight or obese. Obesity has been identified as an independent predictor of dysfunctional labor and is associated with increased risk of failed induction of labor resulting in cesarean section. Leptin, an adipokine, is secreted from adipose tissue under the control of the obesity gene. Concentrations of leptin increase with increasing percent body fat due to elevated leptin production from the adipose tissue of obese individuals. Interestingly, the placenta is also a major source of leptin production during pregnancy. Leptin has regulatory effects on neuronal tissue, vascular smooth muscle, and nonvascular smooth muscle systems. It has also been demonstrated that leptin has an inhibitory effect on myometrial contractility with both intensity and frequency of contractions decreased. These findings suggest that leptin may play an important role in dysfunctional labor and be associated with the outcome of induction of labor at term. Our aim is to determine whether maternal plasma leptin concentration is indicative of the outcome of induction of labor at term. We hypothesize that elevated maternal plasma leptin levels are associated with a failed term induction of labor resulting in a cesarean delivery. Methods In this case-control study, leptin was measured in 3rd trimester plasma samples. To analyze labor outcomes, 174 women were selected based on having undergone an induction of labor (IOL), (115 women with successful IOL and 59 women with a failed IOL). Plasma samples and clinical information were obtained from the UI Maternal Fetal Tissue Bank (IRB# 200910784). Maternal plasma leptin and total protein concentrations were measured using commercially available assays. Bivariate analyses and logistic regression models were constructed using regression identified clinically significant confounding variables. All variables were tested at significance level of 0.05. Results Women with failed IOL had higher maternal plasma leptin values (0.5 vs 0.3 pg, P = 0.01). These women were more likely to have obesity (mean BMI 32 vs 27 kg/m2, P = 0.0002) as well as require multiple induction methods (93% vs 73%, p = 0.008). Logistic regression showed Bishop score (OR 1.5, p < 0.001), BMI (OR 0.92, P < 0.001), preeclampsia (OR 0.12, P = 0.010), use of multiple methods of induction (OR 0.22, P = 0.008) and leptin (OR 0.42, P = 0.017) were significantly associated with IOL outcome. Specifically, after controlling for BMI, Bishop Score, and preeclampsia, leptin was still predictive of a failed IOL with an odds ratio of 0.47 (P = 0.046). Finally, using leptin as a predictor for fetal outcomes, leptin was also associated with of fetal intolerance of labor, with an odds ratio of 2.3 (P = 0.027). This association remained but failed to meet statistical significance when controlling for successful (IOL) (OR 1.5, P = 0.50). Conclusions Maternal plasma leptin may be a useful tool for determining which women are likely to have a failed induction of labor and for counseling women about undertaking an induction of labor versus proceeding with cesarean delivery.

scholarly journals Does anemia risk for pre-eclampsia? A multi-center, Case control study in Amhara region, Ethiopia.

2019 ◽  
Author(s):  
Almaz Aklilu Getu ◽  
Gedefawe Abeje Fikadu ◽  
Muluken Azage Yenesew ◽  
Simegnew Asmer Getie
Keyword(s):  
Family History ◽  
Twin Pregnancy ◽  
Case Control Study ◽  
Case Control ◽  
Referral Hospital ◽  
Amhara Region ◽  
Referral Hospitals ◽  
History Of ◽  
Family History Of Hypertension ◽  
Control Study

Abstract Objective This study aimed to identify determinants of preeclampsia among women visiting referral hospitals in Amhara region. A hospital-based unmatched case-control study was conducted from February 20, 2016 to May 18, 2016 among 871 women visiting West Amhara referral hospital for prenatal care.Result Advanced age (>35 years) [AOR (95%CI), 3.09(1.80-3.35), being primigravidae [AOR (95%CI), 2.32 (1.61–3.35) family history of hypertension [AOR (95%CI), 4.31 (2.37–7.85)], twin pregnancy [AOR 95%CI, 3.53(1.77–7.06)], and Anemia [AOR (95%CI) = 1.49 (1.06– 2.1)] were determinants of preeclampsia.

scholarly journals Measles Outbreak Investigation in Artuma Fursi Woreda, Oromia Zone, Amhara Region, Ethiopia, 2018: A case control study

2019 ◽  
Author(s):  
Mengistie Kassahun Tariku ◽  
Sewnet Wongiel Misikir
Keyword(s):  
Case Control Study ◽  
Case Fatality ◽  
Case Control ◽  
Amhara Region ◽  
Travel History ◽  
Measles Outbreak ◽  
Vaccination History ◽  
Group 5 ◽  
Study Participants ◽  
Control Study

Abstract Objective: To confirm the existence of Outbreak, describe cases in person, place and time, and identify determinants of the outbreak. Unmatched case control study in the ratio of 1:4 (38 cases and 152 controls) was conducted in Artuma fursi woreda from July 13- August 1 /2018. Data were collected with standard questionnaires. Collected data were entered into Epi Info version 7 and exported to Statistical package for social science (SPSS) version 23 for analysis. Results: A total of 38 cases and 1 death with attack rate and case fatality rate 11.8/100,000 and 2.6% respectively. All study participants had not vaccination history. Females and age group 5-14 were more affected. Being 5-14 years old versus (vs) 15 years [adjusted odd ratio (AOR) =3.53; 95% CI; 1.52-8.45)], contact with cases vs no contact with cases [AOR=2.78; 95% CI; 1.23-8.67] and travel history 7-18 days prior onset of illness vs no travel history [AOR= 2.53; 95% CI; 1.31-7.24] were significantly associated with contracting measles. Routine and supplement immunization should be strengthened to reduce future occurrence of outbreak. Keywords: Measles, outbreak, Artuma fursi woreda

scholarly journals Determinant factors for the occurrence of tuberculosis after initiation of antiretroviral treatment among adult patients living with HIV at Dessie Referral Hospital, South Wollo, Northeast Ethiopia, 2020. A case-control study

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248490
Author(s):  
Mehd Abdu ◽  
Yeshimebet Ali ◽  
Samuel Anteneh ◽  
Mohammed Yesuf ◽  
Adane Birhanu ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Opportunistic Infection ◽  
Study Design ◽  
Random Sampling ◽  
Case Control Study ◽  
Case Control ◽  
Referral Hospital ◽  
Living With Hiv ◽  
Dessie Referral Hospital ◽  
Control Study

Introduction Globally, tuberculosis takes the first rank for the ill-health of people living with HIV/AIDS. Despite the favorable outcome of antiretroviral therapy, the risk of tuberculosis remains higher among HIV patients. This obliges to identify factors for its occurrence and further prevention of drug-resistant tuberculosis. There is a contradiction between different studies and studies conducted in Ethiopia studied poorly the association between adherence to antiretroviral therapy and viral load with tuberculosis. Studies conducted in the study area were limited to cross-sectional study design. Therefore, this study claimed to identify factors determining the occurrence of tuberculosis after initiation of antiretroviral therapy. Methods This study was conducted at Dessie Referral Hospital by using a case-control study design on a sample of 565 with a control: case ratio of 3:1. Participants from controls were selected by systematic random sampling and from cases by consecutive random sampling. The data were collected by interviewing through structured questionnaires and from the medical record. The data were entered into Epi data version 3.1. In the multivariable analysis, variables with a P-value of ≤0.05 were anticipated as independent determinant factors. Result Patients without separate kitchen (AOR: 3.547, 95% CI: 2.137, 5.888), having opportunistic infection (AOR: 3.728, 95% CI: 2.058, 6.753), CD4 count of <350 cells/mm3 (AOR: 3.383, 95% CI: 1.520, 7.528), baseline WHO stage III (AOR: 3.321, 95% CI: 1.688, 6.534) or IV (AOR: 2.900, 95% CI: 1.251, 6.722), don’t taking IPT (AOR: 3.701, 95% CI: 2.228, 6.147) and those who were poorly adherent (AOR: 2.626, 95% CI: 1.272, 5.423) or moderately adherent (AOR: 3.455, 95% CI: 1.885, 6.335) to anti-retroviral therapy were more likely to develop tuberculosis after anti-retroviral therapy initiation. Conclusion Poor housing conditions, having an opportunistic infection, low CD4 count, starting ART at the advanced HIV stage, don’t take IPT, and being poorly adherent to antiretroviral therapy were associated with the occurrence of TB after initiation of ART. The institution should screen for TB as early as possible and strictly follow their drug adherence.

scholarly journals Pneumococcal Conjugate Vaccine impact assessment in Bangladesh

2018 ◽  
Vol 2 ◽  
pp. 21 ◽  
Author(s):  
Abdullah H. Baqui ◽  
Eric D. McCollum ◽  
Samir K. Saha ◽  
Arun K. Roy ◽  
Nabidul H. Chowdhury ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Study Design ◽  
Pneumococcal Conjugate Vaccine ◽  
Case Control Study ◽  
Case Control ◽  
Incident Case ◽  
Vaccine Type ◽  
Before And After ◽  
The Impact ◽  
Control Study

The study examines the impact of the introduction of 10-valent Pneumococcal Conjugate Vaccine (PCV10) into Bangladesh’s national vaccine program. PCV10 is administered to children under 1 year-old; the scheduled ages of administration are at 6, 10, and 18 weeks. The study is conducted in ~770,000 population containing ~90,000 <5 children in Sylhet, Bangladesh and has five objectives: 1) To collect data on community-based pre-PCV incidence rates of invasive pneumococcal diseases (IPD) in 0-59 month-old children in Sylhet, Bangladesh; 2) To evaluate the effectiveness of PCV10 introduction on Vaccine Type (VT) IPD in 3-59 month-old children using an incident case-control study design. Secondary aims include measuring the effects of PCV10 introduction on all IPD in 3-59 month-old children using case-control study design, and quantifying the emergence of Non Vaccine Type IPD; 3) To evaluate the effectiveness of PCV10 introduction on chest radiograph-confirmed pneumonia in children 3-35 months old using incident case-control study design. We will estimate the incidence trend of clinical and radiologically-confirmed pneumonia in 3-35 month-old children in the study area before and after introduction of PCV10; 4) To determine the feasibility and utility of lung ultrasound for the diagnosis of pediatric pneumonia in a large sample of children in a resource-limited setting. We will also evaluate the effectiveness of PCV10 introduction on ultrasound-confirmed pneumonia in 3-35 month-old children using an incident case-control design and to examine the incidence trend of ultrasound-confirmed pneumonia in 3-35 month-old children in the study area before and after PCV10 introduction; and 5) To determine the direct and indirect effects of vaccination status on nasopharyngeal colonization on VT pneumococci among children with pneumonia.  This paper presents the methodology. The study will allow us to conduct a comprehensive and robust assessment of the impact of national introduction of PCV10 on pneumococcal disease in Bangladesh.

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